KEGG   PATHWAY: lmu00020
Entry
lmu00020                    Pathway                                

Name
Citrate cycle (TCA cycle) - Lactobacillus mucosae
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
lmu00020  Citrate cycle (TCA cycle)
lmu00020

Module
lmu_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:lmu00020]
Other DBs
GO: 0006099
Organism
Lactobacillus mucosae [GN:lmu]
Gene
LBLM1_04945  isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
LBLM1_05105  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
LBLM1_01160  cytochrome C [KO:K00244] [EC:1.3.5.4]
LBLM1_01155  fumarate hydratase [KO:K01679] [EC:4.2.1.2]
LBLM1_09350  pyruvate carboxylase [KO:K01958] [EC:6.4.1.1]
LBLM1_03825  phosphoenolpyruvate carboxykinase [KO:K01610] [EC:4.1.1.49]
LBLM1_05090  pyruvate dehydrogenase [KO:K00161] [EC:1.2.4.1]
LBLM1_05095  2-oxoisovalerate dehydrogenase [KO:K00162] [EC:1.2.4.1]
LBLM1_05100  dienelactone hydrolase [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 2)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 3)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
lmu00010  Glycolysis / Gluconeogenesis
lmu00053  Ascorbate and aldarate metabolism
lmu00061  Fatty acid biosynthesis
lmu00071  Fatty acid degradation
lmu00220  Arginine biosynthesis
lmu00250  Alanine, aspartate and glutamate metabolism
lmu00280  Valine, leucine and isoleucine degradation
lmu00350  Tyrosine metabolism
lmu00471  D-Glutamine and D-glutamate metabolism
lmu00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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