KEGG   PATHWAY: map00512
Entry
map00512                    Pathway                                

Name
Mucin type O-glycan biosynthesis
Description
O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine.
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
map00512  Mucin type O-glycan biosynthesis
map00512

Module
M00056  O-glycan biosynthesis, mucin type core [PATH:map00512]
Other DBs
GO: 0006493
Reference
  Authors
Brockhausen I.
  Title
Pathways of O-glycan biosynthesis in cancer cells.
  Journal
Biochim Biophys Acta 1473:67-95 (1999)
DOI:10.1016/S0304-4165(99)00170-1
Reference
  Authors
Iwai T, Inaba N, Naundorf A, Zhang Y, Gotoh M, Iwasaki H, Kudo T, Togayachi A, Ishizuka Y, Nakanishi H, Narimatsu H.
  Title
Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans.
  Journal
J Biol Chem 277:12802-9 (2002)
DOI:10.1074/jbc.M112457200
Reference
  Authors
Korekane H, Taguchi T, Sakamoto Y, Honke K, Dohmae N, Salminen H, Toivonen S, Helin J, Takio K, Renkonen O, Taniguchi N.
  Title
Purification and cDNA cloning of UDP-GlcNAc:GlcNAcbeta1-3Galbeta1-4Glc(NAc)-R [GlcNAc to Gal]beta1,6N-acetylglucosaminyltransferase from rat small intestine: a major carrier of dIGnT activity in rat small intestine.
  Journal
Glycobiology 13:387-400 (2003)
DOI:10.1093/glycob/cwg044
Reference
  Authors
van Die I, van Tetering A, Schiphorst WE, Sato T, Furukawa K, van den Eijnden DH.
  Title
The acceptor substrate specificity of human beta4-galactosyltransferase V indicates its potential function in O-glycosylation.
  Journal
FEBS Lett 450:52-6 (1999)
DOI:10.1016/S0014-5793(99)00462-7
Reference
  Authors
Marcos NT, Pinho S, Grandela C, Cruz A, Samyn-Petit B, Harduin-Lepers A, Almeida R, Silva F, Morais V, Costa J, Kihlberg J, Clausen H, Reis CA
  Title
Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen.
  Journal
Cancer Res 64:7050-7 (2004)
DOI:10.1158/0008-5472.CAN-04-1921
Reference
  Authors
Lee YC, Kaufmann M, Kitazume-Kawaguchi S, Kono M, Takashima S, Kurosawa N, Liu H, Pircher H, Tsuji S
  Title
Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc  III and IV.
  Journal
J Biol Chem 274:11958-67 (1999)
DOI:10.1074/jbc.274.17.11958
Reference
  Authors
Kudelka MR, Ju T, Heimburg-Molinaro J, Cummings RD
  Title
Simple sugars to complex disease--mucin-type O-glycans in cancer.
  Journal
Adv Cancer Res 126:53-135 (2015)
DOI:10.1016/bs.acr.2014.11.002
Reference
  Authors
Yeh JC, Hiraoka N, Petryniak B, Nakayama J, Ellies LG, Rabuka D, Hindsgaul O, Marth JD, Lowe JB, Fukuda M
  Title
Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase.
  Journal
Cell 105:957-69 (2001)
DOI:10.1016/S0092-8674(01)00394-4
Related
pathway
map00533  Glycosaminoglycan biosynthesis - keratan sulfate
KO pathway
ko00512   
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