KEGG   PATHWAY: map05130
Entry
map05130                    Pathway                                

Name
Pathogenic Escherichia coli infection
Description
Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
map05130  Pathogenic Escherichia coli infection
map05130

Module
M00363  EHEC pathogenicity signature, Shiga toxin [PATH:map05130]
M00542  EHEC/EPEC pathogenicity signature, T3SS and effectors [PATH:map05130]
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Reference
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
  Authors
Santos AS, Finlay BB
  Title
Bringing down the host: enteropathogenic and enterohaemorrhagic Escherichia coli effector-mediated subversion of host innate immune pathways.
  Journal
Cell Microbiol 17:318-32 (2015)
DOI:10.1111/cmi.12412
Reference
  Authors
Pearson JS, Hartland EL
  Title
The Inflammatory Response during Enterohemorrhagic Escherichia coli Infection.
  Journal
Microbiol Spectr 2:EHEC-0012-2013 (2014)
DOI:10.1128/microbiolspec.EHEC-0012-2013
Reference
  Authors
Wong AR, Pearson JS, Bright MD, Munera D, Robinson KS, Lee SF, Frankel G, Hartland EL
  Title
Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements.
  Journal
Mol Microbiol 80:1420-38 (2011)
DOI:10.1111/j.1365-2958.2011.07661.x
Reference
  Authors
Lai Y, Rosenshine I, Leong JM, Frankel G
  Title
Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli.
  Journal
Cell Microbiol 15:1796-808 (2013)
DOI:10.1111/cmi.12179
Reference
  Authors
Ugalde-Silva P, Gonzalez-Lugo O, Navarro-Garcia F
  Title
Tight Junction Disruption Induced by Type 3 Secretion System Effectors Injected by Enteropathogenic and Enterohemorrhagic Escherichia coli.
  Journal
Front Cell Infect Microbiol 6:87 (2016)
DOI:10.3389/fcimb.2016.00087
Reference
  Authors
Yen H, Karino M, Tobe T
  Title
Modulation of the Inflammasome Signaling Pathway by Enteropathogenic and Enterohemorrhagic Escherichia coli.
  Journal
Front Cell Infect Microbiol 6:89 (2016)
DOI:10.3389/fcimb.2016.00089
Reference
  Authors
Humphreys D, Singh V, Koronakis V
  Title
Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis.
  Journal
Cell Rep 17:697-707 (2016)
DOI:10.1016/j.celrep.2016.09.039
Reference
  Authors
Dong N, Liu L, Shao F
  Title
A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis.
  Journal
EMBO J 29:1363-76 (2010)
DOI:10.1038/emboj.2010.33
Reference
  Authors
Matsuzawa T, Kuwae A, Yoshida S, Sasakawa C, Abe A.
  Title
Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1.
  Journal
EMBO J 23:3570-82 (2004)
DOI:10.1038/sj.emboj.7600359
Related
pathway
map02040  Flagellar assembly
map03070  Bacterial secretion system
map04064  NF-kappa B signaling pathway
map04210  Apoptosis
map04530  Tight junction
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04810  Regulation of actin cytoskeleton
KO pathway
ko05130   
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