KEGG   PATHWAY: mcc04072
Entry
mcc04072                    Pathway                                
Name
Phospholipase D signaling pathway - Macaca mulatta (rhesus monkey)
Description
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcc04072  Phospholipase D signaling pathway
mcc04072

Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
698619  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
707725  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
703173  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
704310  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
700236  PDGFC; platelet-derived growth factor C [KO:K05450]
574254  KITLG; kit ligand isoform X1 [KO:K05461]
704534  INS; insulin [KO:K04526]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
697002  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
711353  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
696759  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
706009  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
702041  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
700367  GAB1; GRB2-associated-binding protein 1 [KO:K09593]
700197  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
718982  SHC1; SHC-transforming protein 1 [KO:K06279]
721021  SHC2; SHC-transforming protein 2 [KO:K17447]
574275  SHC3; SHC-transforming protein 3 [KO:K17448]
714611  SHC4; SHC-transforming protein 4 [KO:K17449]
712044  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
698830  HRAS; GTPase HRas [KO:K02833]
707977  KRAS; GTPase KRas [KO:K07827]
709089  NRAS; GTPase NRas [KO:K07828]
716352  MRAS; ras-related protein M-Ras [KO:K07831]
718939  RRAS; ras-related protein R-Ras [KO:K07829]
699700  RRAS2; ras-related protein R-Ras2 [KO:K07830]
714436  RALGDS; ral guanine nucleotide dissociation stimulator isoform X4 [KO:K08732]
710293  ral-GDS-related protein isoform X2 [KO:K08732]
711158  ral-GDS-related protein-like isoform X1 [KO:K08732]
114670406  ral-GDS-related protein-like isoform X1 [KO:K08732]
100426259  ral-GDS-related protein-like [KO:K08732]
106992479  ral-GDS-related protein-like [KO:K08732]
106995524  ral-GDS-related protein-like isoform X1 [KO:K08732]
710997  ral-GDS-related protein-like isoform X1 [KO:K08732]
106995478  ral-GDS-related protein-like isoform X1 [KO:K08732]
713249  ral-GDS-related protein-like isoform X1 [KO:K08732]
703440  RALA; ras-related protein Ral-A [KO:K07834]
695852  RALB; ras-related protein Ral-B [KO:K07835]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
714645  TSC1; hamartin isoform X1 [KO:K07206]
694965  TSC2; tuberin isoform X7 [KO:K07207]
715378  RHEB; GTP-binding protein Rheb [KO:K07208]
106992736  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
706455  RHOA; transforming protein RhoA [KO:K04513]
696052  ARF1; ADP-ribosylation factor 1 [KO:K07937]
708170  ARF6; ADP-ribosylation factor 6 [KO:K07941]
697069  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
714173  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
721002  LOW QUALITY PROTEIN: immunoglobulin heavy variable 4-39 [KO:K06856]
106999628  immunoglobulin heavy variable 4-4 [KO:K06856]
114675805  uncharacterized protein LOC114675805 [KO:K06856]
720935  immunoglobulin heavy variable 4-61 [KO:K06856]
720985  immunoglobulin heavy variable 4-59 [KO:K06856]
714419  uncharacterized protein LOC714419 [KO:K06856]
721083  LOW QUALITY PROTEIN: immunoglobulin heavy variable 4-28 [KO:K06856]
722278  immunoglobulin heavy variable 4-59 [KO:K06856]
106996003  immunoglobulin heavy variable 4-38-2 [KO:K06856]
720452  Ig heavy chain V region MOPC 315 isoform X1 [KO:K06856]
720904  immunoglobulin heavy variable 4-59 isoform X1 [KO:K06856]
114679736  uncharacterized protein LOC114679736 [KO:K06856]
719324  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089]
697830  MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
720291  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma precursor [KO:K07983]
574214  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
704102  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
721573  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
694963  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
716635  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
100533113  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
718510  cytosolic phospholipase A2 gamma isoform X3 [KO:K16342] [EC:3.1.1.4]
707592  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
707690  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
100424593  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
709753  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
717174  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
713301  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
704132  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
716847  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
718088  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
710441  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
700538  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
710007  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
721744  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
715254  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
696414  DGKQ; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
710559  DGKA; diacylglycerol kinase alpha isoform X8 [KO:K00901] [EC:2.7.1.107]
709578  DGKI; diacylglycerol kinase iota isoform X15 [KO:K00901] [EC:2.7.1.107]
714210  DGKD; diacylglycerol kinase delta isoform X4 [KO:K00901] [EC:2.7.1.107]
699967  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
712450  DGKE; diacylglycerol kinase epsilon isoform X1 [KO:K00901] [EC:2.7.1.107]
699337  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
713198  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
695126  DGKK; diacylglycerol kinase kappa isoform X1 [KO:K00901] [EC:2.7.1.107]
721004  PLPP2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
715993  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
706539  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
712729  F2; prothrombin precursor [KO:K01313] [EC:3.4.21.5]
714203  AGT; angiotensinogen isoform X2 [KO:K09821]
717101  AVP; vasopressin-neurophysin 2-copeptin [KO:K05242]
613028  CXCL8; interleukin-8 precursor [KO:K10030]
712773  AGTR1; type-1 angiotensin II receptor isoform X2 [KO:K04166]
707370  F2R; proteinase-activated receptor 1 [KO:K03914]
698736  GRM1; metabotropic glutamate receptor 1 precursor [KO:K04603]
700214  GRM2; metabotropic glutamate receptor 2 precursor [KO:K04605]
706645  GRM3; metabotropic glutamate receptor 3 isoform X1 [KO:K04606]
718489  GRM4; metabotropic glutamate receptor 4 isoform X1 [KO:K04607]
705445  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
713339  GRM6; LOW QUALITY PROTEIN: metabotropic glutamate receptor 6 [KO:K04608]
702731  GRM7; metabotropic glutamate receptor 7 isoform X2 [KO:K04609]
697465  GRM8; metabotropic glutamate receptor 8 [KO:K04610]
717041  AVPR1A; vasopressin V1a receptor [KO:K04226]
695963  AVPR1B; vasopressin V1b receptor [KO:K04227]
697763  AVPR2; vasopressin V2 receptor isoform X2 [KO:K04228]
709208  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
719844  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
710828  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
707170  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
713283  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
705081  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
707535  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
692074  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
700407  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
701951  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
718418  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
718387  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
717764  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100429106  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
712787  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
718144  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
698857  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
722027  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
722023  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
696837  CYTH4; cytohesin-4 [KO:K18441]
710305  CYTH1; cytohesin-1 [KO:K18441]
717713  CYTH3; cytohesin-3 [KO:K18441]
718682  CYTH2; cytohesin-2 [KO:K18441]
694289  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X2 [KO:K04632]
100424899  neuroendocrine secretory protein 55 [KO:K04632]
697230  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
695328  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
693523  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
714684  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
715897  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
707978  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
694730  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
695792  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
706789  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
703967  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X2 [KO:K08014]
698148  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
705300  DNM3; dynamin-3 isoform X3 [KO:K01528] [EC:3.6.5.5]
717697  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
713558  DNM2; dynamin-2 [KO:K23484] [EC:3.6.5.5]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C00639  Prostaglandin F2alpha
C00681  1-Acyl-sn-glycerol 3-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:17245604
  Authors
Oude Weernink PA, Lopez de Jesus M, Schmidt M
  Title
Phospholipase D signaling: orchestration by PIP2 and small GTPases.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 374:399-411 (2007)
DOI:10.1007/s00210-007-0131-4
Reference
PMID:21936578
  Authors
Selvy PE, Lavieri RR, Lindsley CW, Brown HA
  Title
Phospholipase D: enzymology, functionality, and chemical modulation.
  Journal
Chem Rev 111:6064-119 (2011)
DOI:10.1021/cr200296t
Reference
PMID:24995811
  Authors
Brandenburg LO, Pufe T, Koch T
  Title
Role of phospholipase d in g-protein coupled receptor function.
  Journal
Membranes (Basel) 4:302-18 (2014)
DOI:10.3390/membranes4030302
Reference
PMID:17054901
  Authors
Oude Weernink PA, Han L, Jakobs KH, Schmidt M
  Title
Dynamic phospholipid signaling by G protein-coupled receptors.
  Journal
Biochim Biophys Acta 1768:888-900 (2007)
DOI:10.1016/j.bbamem.2006.09.012
Reference
PMID:24990952
  Authors
Foster DA, Salloum D, Menon D, Frias MA
  Title
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).
  Journal
J Biol Chem 289:22583-8 (2014)
DOI:10.1074/jbc.R114.566091
Reference
PMID:16143829
  Authors
Jenkins GM, Frohman MA
  Title
Phospholipase D: a lipid centric review.
  Journal
Cell Mol Life Sci 62:2305-16 (2005)
DOI:10.1007/s00018-005-5195-z
Reference
PMID:19815110
  Authors
Metcalfe DD, Peavy RD, Gilfillan AM
  Title
Mechanisms of mast cell signaling in anaphylaxis.
  Journal
J Allergy Clin Immunol 124:639-46; quiz 647-8 (2009)
DOI:10.1016/j.jaci.2009.08.035
Reference
PMID:18936782
  Authors
Kalesnikoff J, Galli SJ
  Title
New developments in mast cell biology.
  Journal
Nat Immunol 9:1215-23 (2008)
DOI:10.1038/ni.f.216
Reference
PMID:12217395
  Authors
Cockcroft S, Way G, O'Luanaigh N, Pardo R, Sarri E, Fensome A
  Title
Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.
  Journal
Mol Immunol 38:1277-82 (2002)
DOI:10.1016/S0161-5890(02)00075-5
Reference
PMID:19410013
  Authors
Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH
  Title
The roles of phospholipase D in EGFR signaling.
  Journal
Biochim Biophys Acta 1791:862-8 (2009)
DOI:10.1016/j.bbalip.2009.04.007
Reference
PMID:16622417
  Authors
Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH
  Title
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.
  Journal
Nat Cell Biol 8:477-84 (2006)
DOI:10.1038/ncb1401
Reference
PMID:14769825
  Authors
Kam Y, Exton JH
  Title
Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
  Journal
FASEB J 18:311-9 (2004)
DOI:10.1096/fj.03-0731com
Reference
PMID:9310372
  Authors
Kozawa O, Blume-Jensen P, Heldin CH, Ronnstrand L
  Title
Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.
  Journal
Eur J Biochem 248:149-55 (1997)
DOI:10.1111/j.1432-1033.1997.00149.x
Reference
PMID:11042115
  Authors
Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K
  Title
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
  Journal
Biochem J 351 Pt 3:613-9 (2000)
DOI:10.1042/bj3510613
Reference
PMID:11991733
  Authors
Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T
  Title
Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.
  Journal
J Mol Cell Cardiol 34:441-53 (2002)
DOI:10.1006/jmcc.2002.1525
Reference
PMID:10666319
  Authors
Freeman EJ
  Title
The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.
  Journal
Arch Biochem Biophys 374:363-70 (2000)
DOI:10.1006/abbi.1999.1608
Reference
PMID:9119890
  Authors
Naro F, Donchenko V, Minotti S, Zolla L, Molinaro M, Adamo S
  Title
Role of phospholipase C and D signalling pathways in vasopressin-dependent myogenic differentiation.
  Journal
J Cell Physiol 171:34-42 (1997)
DOI:10.1002/(SICI)1097-4652(199704)171:1<34::AID-JCP5>3.0.CO;2-I
Reference
PMID:10807766
  Authors
Murdoch C, Finn A
  Title
Chemokine receptors and their role in inflammation and infectious diseases.
  Journal
Blood 95:3032-43 (2000)
Reference
PMID:8135758
  Authors
Sugiyama T, Sakai T, Nozawa Y, Oka N
  Title
Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.
  Journal
Biochem J 298 ( Pt 2):479-84 (1994)
DOI:10.1042/bj2980479
Reference
PMID:17210675
  Authors
Foster DA
  Title
Regulation of mTOR by phosphatidic acid?
  Journal
Cancer Res 67:1-4 (2007)
DOI:10.1158/0008-5472.CAN-06-3016
Reference
PMID:15310762
  Authors
Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, Ktistakis NT
  Title
Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
  Journal
J Biol Chem 279:44763-74 (2004)
DOI:10.1074/jbc.M405771200
Reference
PMID:23076158
  Authors
Park JB, Lee CS, Jang JH, Ghim J, Kim YJ, You S, Hwang D, Suh PG, Ryu SH
  Title
Phospholipase signalling networks in cancer.
  Journal
Nat Rev Cancer 12:782-92 (2012)
DOI:10.1038/nrc3379
Reference
PMID:19264150
  Authors
Foster DA
  Title
Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.
  Journal
Biochim Biophys Acta 1791:949-55 (2009)
DOI:10.1016/j.bbalip.2009.02.009
Related
pathway
mcc00561  Glycerolipid metabolism
mcc04010  MAPK signaling pathway
mcc04014  Ras signaling pathway
mcc04020  Calcium signaling pathway
mcc04024  cAMP signaling pathway
mcc04071  Sphingolipid signaling pathway
mcc04144  Endocytosis
mcc04150  mTOR signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04664  Fc epsilon RI signaling pathway
KO pathway
ko04072   
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