KEGG   PATHWAY: mcc04630
Entry
mcc04630                    Pathway                                

Name
JAK-STAT signaling pathway - Macaca mulatta (rhesus monkey)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcc04630  JAK-STAT signaling pathway
mcc04630

Other DBs
GO: 0007259
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
708017  IL2; interleukin-2 precursor [KO:K05429]
706946  IL3; interleukin-3 precursor [KO:K04736]
574281  IL4; interleukin-4 precursor [KO:K05430]
710622  IL5; interleukin-5 precursor [KO:K05428]
705819  IL6; interleukin-6 precursor [KO:K05405]
574168  IL7; interleukin-7 precursor [KO:K05431]
712292  IL9; interleukin-9 [KO:K05432]
694931  IL10; interleukin-10 precursor [KO:K05443]
722817  IL11; interleukin-11 [KO:K05417]
703205  IL12A; interleukin-12 subunit alpha [KO:K05406]
694747  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
574325  IL13; interleukin-13 precursor [KO:K05435]
699616  IL15; interleukin-15 precursor [KO:K05433]
721163  IL17D; interleukin-17D isoform X1 [KO:K05492]
694806  IL19; LOW QUALITY PROTEIN: interleukin-19 [KO:K05444]
694689  IL20; interleukin-20 [KO:K22667]
708125  IL21; interleukin-21 precursor [KO:K05434]
718047  IL22; interleukin-22 precursor [KO:K05445]
712627  IL23A; interleukin-23 subunit alpha precursor [KO:K05426]
694541  IL24; interleukin-24 [KO:K22668]
709948  IFNA2; interferon alpha-2 precursor [KO:K05414]
709755  IFNA8; interferon alpha-8 [KO:K05414]
710751  interferon alpha-17-like [KO:K05414]
694631  interferon alpha-1/13-like [KO:K05414]
710487  interferon alpha-14 [KO:K05414]
710528  interferon alpha-1/13 [KO:K05414]
710568  interferon alpha-4-like [KO:K05414]
710654  IFNA10; interferon alpha-4 precursor [KO:K05414]
711252  IFNA21; interferon alpha-21 [KO:K05414]
709559  IFNA13; interferon alpha-1/13 precursor [KO:K05414]
711088  interferon alpha-17-like [KO:K05414]
106992322  interferon alpha-17 [KO:K05414]
710848  interferon alpha-17 [KO:K05414]
106995851  IFNA6; interferon alpha-6 [KO:K05414]
114672663  interferon alpha-17-like [KO:K05414]
114672664  interferon alpha-17-like [KO:K05414]
711414  IFNB1; interferon beta precursor [KO:K05415]
574282  IFNG; interferon gamma precursor [KO:K04687]
106993736  IFNE; interferon epsilon [KO:K05442]
707234  IFNK; interferon kappa [KO:K05441]
697161  IFNL1; interferon lambda-1 [KO:K05447]
696117  LOW QUALITY PROTEIN: interferon lambda-2 [KO:K22669]
695997  IFNL3; interferon lambda-3 [KO:K22669]
711329  interferon omega-1 [KO:K05440]
114675730  LOW QUALITY PROTEIN: interferon omega-1-like [KO:K05440]
717994  OSM; oncostatin-M precursor [KO:K05418]
715456  LIF; leukemia inhibitory factor isoform X1 [KO:K05419]
706194  TSLP; thymic stromal lymphopoietin [KO:K05436]
713850  CTF1; cardiotrophin-1 isoform X3 [KO:K05422]
713903  cardiotrophin-2 [KO:K24382]
574371  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
701907  CNTF; ciliary neurotrophic factor [KO:K05420]
698961  CSF3; granulocyte colony-stimulating factor [KO:K05423]
719294  EPO; erythropoietin precursor [KO:K05437]
718156  GH1; somatotropin precursor [KO:K05438]
700885  GHV; growth hormone variant precursor [KO:K05438]
717562  CSH2; chorionic somatomammotropin hormone 2 precursor [KO:K05438]
735307  chorionic somatomammotropin-1 precursor [KO:K05438]
718135  CSH3; chorionic somatommamotropin hormone 3 precursor [KO:K05438]
718116  CSH4; somatotropin precursor [KO:K05438]
114669732  somatotropin-like [KO:K05438]
114669819  somatotropin-like isoform X1 [KO:K05438]
718474  growth hormone variant-like isoform X1 [KO:K05438]
114673168  somatotropin-like [KO:K05438]
114673169  somatotropin-like [KO:K05438]
698728  LEP; leptin precursor [KO:K05424]
100428640  THPO; LOW QUALITY PROTEIN: thrombopoietin [KO:K06854]
707052  PRL; prolactin precursor [KO:K05439]
698619  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
707725  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
703173  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
574300  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
696331  IL2RB; interleukin-2 receptor subunit beta precursor [KO:K05069]
641338  IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070]
106995138  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
114675718  interleukin-3 receptor subunit alpha-like [KO:K04737]
705404  IL4R; interleukin-4 receptor subunit alpha isoform X2 [KO:K05071]
704649  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
716690  IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055]
699869  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
704266  IL9R; interleukin-9 receptor [KO:K05073]
704383  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
706012  IL10RB; interleukin-10 receptor subunit beta isoform X2 [KO:K05135]
700201  IL11RA; interleukin-11 receptor subunit alpha isoform X3 [KO:K05056]
574199  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
700677  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
710986  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
708339  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
712788  IL15RA; interleukin-15 receptor subunit alpha isoform 2 precursor [KO:K05074]
704890  IL20RA; interleukin-20 receptor subunit alpha isoform X3 [KO:K05136]
716769  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
705759  IL21R; interleukin-21 receptor [KO:K05075]
719264  IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138]
711059  IL22RA2; interleukin-22 receptor subunit alpha-2 isoform X1 [KO:K05139]
700440  IL23R; interleukin-23 receptor [KO:K05065]
717549  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
574127  IL6ST; interleukin-6 receptor subunit beta precursor [KO:K05060]
699604  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
699726  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100423877  IFNGR1; interferon gamma receptor 1 precursor [KO:K05132]
699489  IFNGR2; interferon gamma receptor 2 [KO:K05133]
711625  IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140]
693569  OSMR; oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057]
694139  LIFR; leukemia inhibitory factor receptor isoform X1 [KO:K05058]
106995742  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
700959  CNTFR; ciliary neurotrophic factor receptor subunit alpha precursor [KO:K05059]
697508  CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738]
713485  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
714546  EPOR; erythropoietin receptor [KO:K05079]
697986  GHR; growth hormone receptor precursor [KO:K05080]
574126  LEPR; leptin receptor [KO:K05062]
699369  PRLR; prolactin receptor [KO:K05081]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
697002  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
711353  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
677689  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
694184  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
720040  JAK3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
114669853  LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3-like [KO:K11218] [EC:2.7.10.2]
574130  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
693650  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
712694  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
574128  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
693854  STAT4; signal transducer and activator of transcription 4 isoform X2 [KO:K11222]
574129  STAT5A; signal transducer and activator of transcription 5A isoform 2 [KO:K11223]
709760  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
714159  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
701456  CISH; cytokine-inducible SH2-containing protein [KO:K04701]
711180  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
715772  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
715680  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
696146  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
714998  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
693737  SOCS7; suppressor of cytokine signaling 7 isoform X5 [KO:K04699]
704108  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
707407  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
707539  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
713035  BCL2L1; bcl-2-like protein 1 [KO:K04570]
719232  serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
114677751  PIM1; LOW QUALITY PROTEIN: serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
694626  MYC; myc proto-oncogene protein [KO:K04377]
574320  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
710379  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
695215  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
719199  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
701024  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
701613  AOX2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
701502  AOX4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
712941  GFAP; glial fibrillary acidic protein isoform X2 [KO:K05640]
706026  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
695286  STAM2; signal transducing adapter molecule 2 [KO:K04705]
114673846  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X1 [KO:K18026] [EC:3.1.3.48]
714374  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
715335  IRF9; interferon regulatory factor 9 [KO:K04693]
706258  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
704331  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
693445  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
696737  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X4 [KO:K16063] [EC:2.3.2.-]
706775  PIAS3; LOW QUALITY PROTEIN: E3 SUMO-protein ligase PIAS3 [KO:K16064] [EC:2.3.2.-]
714328  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X2 [KO:K16065] [EC:2.3.2.27]
710692  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
712044  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
702041  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
698830  HRAS; GTPase HRas [KO:K02833]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106992736  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
Reference
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Related
pathway
mcc04010  MAPK signaling pathway
mcc04060  Cytokine-cytokine receptor interaction
mcc04110  Cell cycle
mcc04120  Ubiquitin mediated proteolysis
mcc04151  PI3K-Akt signaling pathway
mcc04210  Apoptosis
KO pathway
ko04630   
LinkDB

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