KEGG   PATHWAY: mdo05200
Entry
mdo05200                    Pathway                                
Name
Pathways in cancer - Monodelphis domestica (gray short-tailed opossum)
Class
Human Diseases; Cancer: overview
Pathway map
mdo05200  Pathways in cancer
mdo05200

Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100010164  DCC; DCC netrin 1 receptor [KO:K06765]
654273  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
654275  caspase-3-like protein 2 [KO:K02187] [EC:3.4.22.56]
100027338  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
100010013  APPL1; adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 [KO:K08733]
100027800  CDH1; cadherin 1 [KO:K05689]
100022896  CTNNB1; catenin beta 1 [KO:K02105]
100010936  CTNNA3; catenin alpha 3 [KO:K05691]
100019630  CTNNA2; catenin alpha 2 [KO:K05691]
100020276  CTNNA1; catenin alpha 1 [KO:K05691]
100016298  AXIN1; axin 1 [KO:K02157]
100024610  AXIN2; axin 2 [KO:K04385]
100013592  APC; APC, WNT signaling pathway regulator [KO:K02085]
100020785  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
100012447  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
100017589  TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
100030368  TCF7L1; transcription factor 7 like 1 [KO:K04490]
100021451  TCF7L2; transcription factor 7 like 2 [KO:K04491]
100011783  LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
100031079  BIRC5; baculoviral IAP repeat containing 5 [KO:K08731]
100032344  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
100013257  CCND1; cyclin D1 [KO:K04503]
100032741  WNT1; Wnt family member 1 [KO:K03209]
100011991  WNT2; Wnt family member 2 [KO:K00182]
100033140  WNT2B; Wnt family member 2B [KO:K00182]
100024702  WNT3; Wnt family member 3 [KO:K00312]
100025651  WNT3A; Wnt family member 3A [KO:K00312]
100026048  WNT4; Wnt family member 4 [KO:K00408]
100012859  WNT5A; Wnt family member 5A [KO:K00444]
100021212  WNT5B; Wnt family member 5B [KO:K00444]
100010861  WNT6; Wnt family member 6 [KO:K00445]
100014091  WNT7B; Wnt family member 7B [KO:K00572]
100028905  WNT7A; Wnt family member 7A [KO:K00572]
100027787  WNT8B; Wnt family member 8B [KO:K00714]
100024816  WNT8A; Wnt family member 8A [KO:K00714]
100025627  WNT9A; Wnt family member 9A [KO:K01064]
100024657  WNT9B; Wnt family member 9B [KO:K01064]
100010973  WNT10A; Wnt family member 10A [KO:K01357]
100028529  WNT11; Wnt family member 11 [KO:K01384]
100012964  WNT16; Wnt family member 16 [KO:K01558]
100027981  FZD1; frizzled class receptor 1 [KO:K02432]
100019281  FZD7; frizzled class receptor 7 [KO:K02432]
100023490  FZD2; frizzled class receptor 2 [KO:K02235]
100030835  FZD3; frizzled class receptor 3 [KO:K02329]
100025855  FZD4; frizzled class receptor 4 [KO:K02354]
100016198  FZD5; frizzled class receptor 5 [KO:K02375]
100018016  FZD8; frizzled class receptor 8 [KO:K02375]
100023959  FZD6; frizzled class receptor 6 [KO:K02376]
100028967  FZD10; frizzled class receptor 10 [KO:K02842]
100029447  FZD9; frizzled class receptor 9 [KO:K02842]
100018443  LRP6; LDL receptor related protein 6 [KO:K03068]
100022502  LRP5L; LDL receptor related protein 5 like [KO:K03068]
100012147  LRP5; LDL receptor related protein 5 [KO:K03068]
100010047  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
100022768  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
100617787  DVL2; dishevelled segment polarity protein 2 [KO:K02353]
100022170  FRAT2; FRAT2, WNT signaling pathway regulator [KO:K03096]
100015821  F2; coagulation factor II, thrombin [KO:K01313] [EC:3.4.21.5]
100029465  AGT; angiotensinogen [KO:K09821]
100010071  F2R; coagulation factor II thrombin receptor [KO:K03914]
100015541  proteinase-activated receptor 4-like [KO:K04236]
100015642  proteinase-activated receptor 4-like [KO:K04236]
100016607  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103103209  lysophosphatidic acid receptor 1-A-like [KO:K04289]
100014105  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100012415  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
100020275  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100015472  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103102093  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
100017858  AGTR1; angiotensin II receptor type 1 [KO:K04166]
100010453  GNA12; G protein subunit alpha 12 [KO:K04346]
100024566  GNA13; G protein subunit alpha 13 [KO:K04639]
100030904  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
100023997  ARHGEF11; Rho guanine nucleotide exchange factor 11 [KO:K12331]
100026753  PLEKHG5; pleckstrin homology and RhoGEF domain containing G5 [KO:K19464]
100021110  RHOA; ras homolog family member A [KO:K04513]
100618269  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100032706  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
100016207  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
100016627  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
100013052  GNAI1; G protein subunit alpha i1 [KO:K04630]
100030095  GNAI3; G protein subunit alpha i3 [KO:K04630]
100032986  GNAI2; G protein subunit alpha i2 [KO:K04630]
100026455  PTGER1; prostaglandin E receptor 1 [KO:K04258]
100015803  PTGER2; prostaglandin E receptor 2 [KO:K04259]
100029509  PTGER3; prostaglandin E receptor 3 [KO:K04260]
103105351  prostaglandin E2 receptor EP3 subtype-like [KO:K04260]
100018547  PTGER4; prostaglandin E receptor 4 [KO:K04261]
100021523  GNAS; GNAS complex locus [KO:K04632]
100029582  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
100030463  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
100013164  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
100025332  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
100030872  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
100019274  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
100013823  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
100026554  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
100013831  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
100011211  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
100026861  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100032298  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100010736  GNB1; G protein subunit beta 1 [KO:K04536]
100017392  GNB2; G protein subunit beta 2 [KO:K04537]
100013759  GNB3; G protein subunit beta 3 [KO:K07825]
100013546  GNB4; G protein subunit beta 4 [KO:K04538]
100031383  GNB5; G protein subunit beta 5 [KO:K04539]
100010452  GNG3; G protein subunit gamma 3 [KO:K04540]
100021132  GNG4; G protein subunit gamma 4 [KO:K04541]
100011015  GNG5; G protein subunit gamma 5 [KO:K04542]
100014687  GNG7; G protein subunit gamma 7 [KO:K04543]
100016961  GNG8; G protein subunit gamma 8 [KO:K04544]
100018189  GNG10; G protein subunit gamma 10 [KO:K04545]
100016914  GNG12; G protein subunit gamma 12 [KO:K04347]
100010184  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
100017439  GNG13; G protein subunit gamma 13 [KO:K04547]
100018838  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
100023705  COL4A1; collagen type IV alpha 1 chain [KO:K06237]
100021728  COL4A4; collagen type IV alpha 4 chain [KO:K06237]
100023678  COL4A2; collagen type IV alpha 2 chain [KO:K06237]
100025514  collagen alpha-5(IV) chain [KO:K06237]
100021663  COL4A3; collagen type IV alpha 3 chain [KO:K06237]
100015923  LAMA1; laminin subunit alpha 1 [KO:K05637]
100030895  LAMA2; laminin subunit alpha 2 [KO:K05637]
100011544  LAMA3; laminin subunit alpha 3 [KO:K06240]
100026192  LAMA5; laminin subunit alpha 5 [KO:K06240]
100029499  LAMA4; laminin subunit alpha 4 [KO:K06241]
100010605  LAMB1; laminin subunit beta 1 [KO:K05636]
100027514  LAMB2; laminin subunit beta 2 [KO:K06243]
100619627  laminin subunit beta-2-like [KO:K06243]
100021649  LAMB3; laminin subunit beta 3 [KO:K06244]
100010505  LAMB4; laminin subunit beta 4 [KO:K06245]
100023945  LAMC1; laminin subunit gamma 1 [KO:K05635]
100023967  LAMC2; laminin subunit gamma 2 [KO:K06246]
100015877  LAMC3; laminin subunit gamma 3 [KO:K06247]
100014118  FN1; fibronectin 1 [KO:K05717]
100031498  ITGA2; integrin subunit alpha 2 [KO:K06481]
100023354  ITGA2B; integrin subunit alpha 2b [KO:K06476]
100022489  ITGA3; integrin subunit alpha 3 [KO:K06482]
100018376  ITGA6; integrin subunit alpha 6 [KO:K06485]
100028127  ITGAV; integrin subunit alpha V [KO:K06487]
100018342  ITGB1; integrin subunit beta 1 [KO:K05719]
100027188  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
100010412  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
100017332  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100024769  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
100019317  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100032726  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
100616957  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
100013036  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100020925  NKX3-1; NK3 homeobox 1 [KO:K09348]
100014564  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100019947  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
100027373  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100027952  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
100033031  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100022918  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
100011769  NFKBIA; NFKB inhibitor alpha [KO:K04734]
100014446  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
100029209  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
100030053  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
100024802  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
100024271  NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
100016570  BCL2; BCL2, apoptosis regulator [KO:K02161]
100010782  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
100010741  baculoviral IAP repeat-containing protein 2-like [KO:K16060]
100016651  XIAP; X-linked inhibitor of apoptosis [KO:K04725] [EC:2.3.2.27]
100025295  BIRC7; baculoviral IAP repeat containing 7 [KO:K16061]
100010654  BCL2L1; BCL2 like 1 [KO:K04570]
100015491  TRAF1; TNF receptor associated factor 1 [KO:K03172]
100017243  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
100017361  TRAF3; TNF receptor associated factor 3 [KO:K03174]
100020121  TRAF4; TNF receptor associated factor 4 [KO:K09848]
100022268  TRAF5; TNF receptor associated factor 5 [KO:K09849]
100010055  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
100619675  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
100014573  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
100010269  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
100011566  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
100031246  BAD; BCL2 associated agonist of cell death [KO:K02158]
100021587  FOXO1; forkhead box O1 [KO:K07201]
100021398  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
103092862  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
497248  TP53; tumor protein p53 [KO:K04451]
100014923  CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
100029103  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
100619549  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
100012317  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
100015312  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
100031184  CBL; Cbl proto-oncogene [KO:K04707] [EC:2.3.2.27]
100012174  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
100011470  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
100029407  PIM1; Pim-1 proto-oncogene, serine/threonine kinase [KO:K04702] [EC:2.7.11.1]
100019195  PIM2; Pim-2 proto-oncogene, serine/threonine kinase [KO:K08806] [EC:2.7.11.1]
103103071  KNG1; kininogen 1 [KO:K03898]
100026601  EDN1; endothelin 1 [KO:K16366]
100023962  BDKRB1; bradykinin receptor B1 [KO:K03915]
100023990  BDKRB2; bradykinin receptor B2 [KO:K03916]
100018535  EDNRA; endothelin receptor type A [KO:K04197]
100013240  EDNRB; endothelin receptor type B [KO:K04198]
100011605  GNAQ; G protein subunit alpha q [KO:K04634]
100009763  GNA11; G protein subunit alpha 11 [KO:K04635]
100033281  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
100031660  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
100031869  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
100031263  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
100024674  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
100013346  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
100619184  IL2; interleukin 2 [KO:K05429]
100018747  IL5; interleukin 5 [KO:K05428]
103104339  IL6; interleukin 6 [KO:K05405]
103106447  IL7; interleukin 7 [KO:K05431]
100018516  IL12A; interleukin 12A [KO:K05406]
100030276  IL12B; interleukin 12B [KO:K05425]
103103487  IL13; interleukin 13 [KO:K05435]
103092205  IL15; interleukin 15 [KO:K05433]
100018159  EPO; erythropoietin [KO:K05437]
100021311  IFN7; type I interferon 7 [KO:K05414]
100021419  interferon tau-2-like [KO:K05414]
100021467  interferon alpha-16-like [KO:K05414]
100021290  IFN3; type I interferon 3 [KO:K05414]
100021340  IFN4; type I interferon 4 [KO:K05414]
100021368  interferon tau-2-like [KO:K05414]
100021487  IFN2; type I interferon 2 [KO:K05414]
103093188  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
100025393  IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
100619507  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
103094311  IL3RA; interleukin 3 receptor subunit alpha [KO:K04737]
103092514  IL4R; interleukin 4 receptor [KO:K05071]
103105584  CSF2RB; colony stimulating factor 2 receptor beta common subunit [KO:K04738]
100022206  IL5RA; interleukin 5 receptor subunit alpha [KO:K05067]
100020561  IL6R; interleukin 6 receptor [KO:K05055]
100017284  IL6ST; interleukin 6 signal transducer [KO:K05060]
100020565  IL7R; interleukin 7 receptor [KO:K05072]
103105099  IL12RB1; interleukin 12 receptor subunit beta 1 [KO:K05063]
103105069  IL12RB2; interleukin 12 receptor subunit beta 2 [KO:K05064]
100022626  IL13RA1; interleukin 13 receptor subunit alpha 1 [KO:K05076]
103092906  IL15RA; interleukin 15 receptor subunit alpha [KO:K05074]
100619782  IL23R; interleukin 23 receptor [KO:K05065]
100010880  EPOR; erythropoietin receptor [KO:K05079]
103092556  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
100031565  IFNGR1; interferon gamma receptor 1 [KO:K05132]
103106298  IFNGR2; interferon gamma receptor 2 [KO:K05133]
100033382  EML4; echinoderm microtubule associated protein like 4 [KO:K15420]
100031373  ALK; anaplastic lymphoma receptor tyrosine kinase [KO:K05119] [EC:2.7.10.1]
100031728  RASGRP1; RAS guanyl releasing protein 1 [KO:K04350]
100031591  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
100013191  RASGRP4; RAS guanyl releasing protein 4 [KO:K12363]
100031307  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
100017930  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
100010720  JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
100011382  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100028917  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
100617910  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
100012148  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
100012132  VEGFA; vascular endothelial growth factor A [KO:K05448]
100028411  VEGFB; vascular endothelial growth factor B [KO:K16858]
100023623  PGF; placental growth factor [KO:K16859]
100031803  VEGFD; vascular endothelial growth factor D [KO:K05449]
100013301  VEGFC; vascular endothelial growth factor C [KO:K05449]
100032790  TGFA; transforming growth factor alpha [KO:K08774]
100619143  EGF; epidermal growth factor [KO:K04357]
100029625  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100017172  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
100020951  PDGFA; platelet derived growth factor subunit A [KO:K04359]
100012899  PDGFB; platelet derived growth factor subunit B [KO:K17386]
100013088  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100028943  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100021295  IGF1; insulin like growth factor 1 [KO:K05459]
100020095  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100021399  KITLG; KIT ligand [KO:K05461]
100017501  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
103103582  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
100025262  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
100016122  HGF; hepatocyte growth factor [KO:K05460]
100013788  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
100023197  FGF1; fibroblast growth factor 1 [KO:K18496]
619384  FGF2; fibroblast growth factor 2 [KO:K18497]
100012692  FGF10; fibroblast growth factor 10 [KO:K04358]
100019563  FGF6; fibroblast growth factor 6 [KO:K04358]
100025923  FGF7; fibroblast growth factor 7 [KO:K04358]
100014690  FGF5; fibroblast growth factor 5 [KO:K04358]
100031074  FGF18; fibroblast growth factor 18 [KO:K04358]
100012499  FGF16; fibroblast growth factor 16 [KO:K04358]
100021631  FGF4; fibroblast growth factor 4 [KO:K04358]
100023400  FGF8; fibroblast growth factor 8 [KO:K04358]
100021692  FGF3; fibroblast growth factor 3 [KO:K04358]
100030474  FGF17; fibroblast growth factor 17 [KO:K04358]
100021885  FGF20; fibroblast growth factor 20 [KO:K04358]
100024639  FGF22; fibroblast growth factor 22 [KO:K04358]
100023928  FGF9; fibroblast growth factor 9 [KO:K04358]
100021575  FGF19; fibroblast growth factor 19 [KO:K22603]
100019656  FGF23; fibroblast growth factor 23 [KO:K22428]
100029852  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
100025727  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
100023287  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100031838  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100022894  GRB2; growth factor receptor bound protein 2 [KO:K04364]
100618058  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
100029256  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
100032921  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
554186  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
554197  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
100022523  GTPase NRas-like [KO:K07828]
100017615  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
100024057  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
100015410  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100018410  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100018044  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100028096  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100012916  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100018774  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
100018285  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
100016808  ETS1; ETS proto-oncogene 1, transcription factor [KO:K02678]
100012472  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
100020585  MMP2; matrix metallopeptidase 2 [KO:K01398] [EC:3.4.24.24]
100022144  MMP9; matrix metallopeptidase 9 [KO:K01403] [EC:3.4.24.35]
100023722  IL8; interleukin-8 [KO:K10030]
100017874  RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
100016023  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
100019861  NCOA4; nuclear receptor coactivator 4 [KO:K09289]
100618744  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
100015402  TPM3; tropomyosin 3 [KO:K09290]
100019129  TPR; translocated promoter region, nuclear basket protein [KO:K09291]
100013086  TFG; TRK-fused gene [KO:K09292]
100028653  RASSF1; Ras association domain family member 1 [KO:K09850]
100014771  RASSF5; Ras association domain family member 5 [KO:K08015]
100024136  STK4; serine/threonine kinase 4 [KO:K04411]
100022106  DAPK3; death associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
100023465  DAPK2; death associated protein kinase 2 [KO:K08803] [EC:2.7.11.1]
100012765  DAPK1; death associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
100023666  death-associated protein kinase 2-like [KO:K08803] [EC:2.7.11.1]
100013020  death-associated protein kinase 1-like [KO:K08803] [EC:2.7.11.1]
100032696  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
100027579  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
100617037  ELK1; ELK1, ETS transcription factor [KO:K04375]
100021688  CALM3; calmodulin 3 [KO:K02183]
100018191  CALM1; calmodulin 1 [KO:K02183]
100032171  CALM2; calmodulin 2 [KO:K02183]
100025795  CALML4; calmodulin like 4 [KO:K02183]
100015722  calmodulin-alpha-like [KO:K02183]
100022649  calmodulin-alpha-like [KO:K02183]
100011784  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
100010898  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
100024521  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
100028973  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
100017777  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
100011023  RALA; RAS like proto-oncogene A [KO:K07834]
100010449  RALB; RAS like proto-oncogene B [KO:K07835]
100016824  RALBP1; ralA binding protein 1 [KO:K08773]
100023099  CDC42; cell division cycle 42 [KO:K04393]
100009767  cell division control protein 42 homolog [KO:K04393]
100026992  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
100017517  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
100029873  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
100009769  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
100618309  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
100028089  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
100618895  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100026381  PAX8; paired box 8 [KO:K09293]
100025091  PPARG; peroxisome proliferator activated receptor gamma [KO:K08530]
100019466  RXRA; retinoid X receptor alpha [KO:K08524]
100027006  RXRB; retinoid X receptor beta [KO:K08525]
100016615  RXRG; retinoid X receptor gamma [KO:K08526]
100024675  RARB; retinoic acid receptor beta [KO:K08528]
100027187  ESR1; estrogen receptor 1 [KO:K08550]
100027583  ESR2; estrogen receptor 2 [KO:K08551]
100025270  NCOA1; nuclear receptor coactivator 1 [KO:K09101] [EC:2.3.1.48]
100029605  NCOA3; nuclear receptor coactivator 3 [KO:K11256] [EC:2.3.1.48]
100026039  PPARD; peroxisome proliferator activated receptor delta [KO:K04504]
100012969  JUP; junction plakoglobin [KO:K10056]
100032135  ZBTB16; zinc finger and BTB domain containing 16 [KO:K10055]
100015353  RARA; retinoic acid receptor alpha [KO:K08527]
100017104  CCNA2; cyclin A2 [KO:K06627]
100027136  CCNA1; cyclin A1 [KO:K06627]
100029464  PML; promyelocytic leukemia [KO:K10054] [EC:2.3.2.-]
100025525  RUNX1; runt related transcription factor 1 [KO:K08367]
100022190  RUNX1T1; RUNX1 translocation partner 1 [KO:K10053]
100016353  SPI1; Spi-1 proto-oncogene [KO:K09438]
100012502  CEBPA; CCAAT/enhancer binding protein alpha [KO:K09055]
103094977  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
100031592  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
100028926  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
554242  CDKN2A; cyclin-dependent kinase inhibitor 2A [KO:K06621]
100032280  E2F1; E2F transcription factor 1 [KO:K17454]
100009746  E2F2; E2F transcription factor 2 [KO:K09389]
100017977  E2F3; E2F transcription factor 3 [KO:K06620]
100022806  MAX; MYC associated factor X [KO:K04453]
100619919  ZBTB17; zinc finger and BTB domain containing 17 [KO:K10500]
100021947  CDKN2B; cyclin dependent kinase inhibitor 2B [KO:K04685]
100021675  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100016259  CCND2; cyclin D2 [KO:K10151]
100027538  CCND3; cyclin D3 [KO:K10152]
100021385  CKS1B; CDC28 protein kinase regulatory subunit 1B [KO:K02219]
100013874  CKS2; CDC28 protein kinase regulatory subunit 2 [KO:K02219]
100014810  SKP1; S-phase kinase associated protein 1 [KO:K03094]
100013348  CUL1; cullin 1 [KO:K03347]
100013521  RBX1; ring-box 1 [KO:K03868] [EC:2.3.2.32]
100020421  SKP2; S-phase kinase associated protein 2 [KO:K03875]
100014623  CCNE1; cyclin E1 [KO:K06626]
100022654  CCNE2; cyclin E2 [KO:K06626]
100030421  G1/S-specific cyclin-E2-like [KO:K06626]
100022630  RB1; RB transcriptional corepressor 1 [KO:K06618]
100010225  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
100016952  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
100014651  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
100030412  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
100027503  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
100016157  DDB2; damage specific DNA binding protein 2 [KO:K10140]
100021792  DNA damage-binding protein 2-like [KO:K10140]
100014509  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
103104146  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
100020078  MITF; melanogenesis associated transcription factor [KO:K09455]
100019183  TGFB1; transforming growth factor beta 1 [KO:K13375]
100017548  TGFB2; transforming growth factor beta 2 [KO:K13376]
100017937  TGFB3; transforming growth factor beta 3 [KO:K13377]
100011507  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
100031897  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
100014493  SMAD2; SMAD family member 2 [KO:K04500]
100018703  SMAD3; SMAD family member 3 [KO:K23605]
100010143  SMAD4; SMAD family member 4 [KO:K04501]
100012479  MECOM; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
100025014  CTBP1; C-terminal binding protein 1 [KO:K04496] [EC:1.1.1.428]
100010586  CTBP2; C-terminal binding protein 2 [KO:K04496] [EC:1.1.1.428]
100022756  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100032301  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
100011682  MLH1; mutL homolog 1 [KO:K08734]
100033358  MSH2; mutS homolog 2 [KO:K08735]
100015958  MSH3; mutS homolog 3 [KO:K08736]
100033356  MSH6; mutS homolog 6 [KO:K08737]
100049015  BRCA2; BRCA2, DNA repair associated [KO:K08775]
100027424  RAD51; RAD51 recombinase [KO:K04482]
100031941  FADD; Fas associated via death domain [KO:K02373]
100017025  CASP18; caspase-18 [KO:K04398] [EC:3.4.22.61]
100617599  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100021895  BID; BH3 interacting domain death agonist [KO:K04726]
100020711  BBC3; BCL2 binding component 3 [KO:K10132]
100033215  BCL2L11; BCL2 like 11 [KO:K16341]
100010620  cytochrome c [KO:K08738]
100026811  cytochrome c, testis-specific-like [KO:K08738]
100013051  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
100027500  CASP7; caspase 7 [KO:K04397] [EC:3.4.22.60]
100012710  KEAP1; kelch like ECH associated protein 1 [KO:K10456]
100026605  NFE2L2; nuclear factor, erythroid 2 like 2 [KO:K05638]
100024355  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
100030714  heme oxygenase 1-like [KO:K00510] [EC:1.14.14.18]
100028121  NQO1; NAD(P)H quinone dehydrogenase 1 [KO:K00355] [EC:1.6.5.2]
100030124  GSTM1; glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
100016032  GSTT2B; glutathione S-transferase theta 2B [KO:K00799] [EC:2.5.1.18]
100011354  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
100022188  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
100014035  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
100017050  GSTA3; glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
100017091  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
100012866  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
100033072  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
100022164  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
100027420  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
100016934  glutathione S-transferase alpha I-like [KO:K00799] [EC:2.5.1.18]
100017013  GSTA3; glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
100015886  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
100618766  GSTP1; glutathione S-transferase pi 1 [KO:K23790] [EC:2.5.1.18]
100015072  TXNRD1; thioredoxin reductase 1 [KO:K22182] [EC:1.8.1.9]
100026851  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
100024305  VHL; von Hippel-Lindau tumor suppressor [KO:K03871]
100028060  ELOC; elongin C [KO:K03872]
100018279  ELOB; elongin B [KO:K03873]
100018154  CUL2; cullin 2 [KO:K03870]
100013679  EGLN3; egl-9 family hypoxia inducible factor 3 [KO:K09592] [EC:1.14.11.29]
100029166  EGLN1; egl-9 family hypoxia inducible factor 1 [KO:K09592] [EC:1.14.11.29]
100018431  EGLN2; egl-9 family hypoxia inducible factor 2 [KO:K09592] [EC:1.14.11.29]
100027739  FH; fumarate hydratase [KO:K01679] [EC:4.2.1.2]
100027212  HIF1A; hypoxia inducible factor 1 alpha subunit [KO:K08268]
100033364  EPAS1; endothelial PAS domain protein 1 [KO:K09095]
100017492  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
100013571  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 [KO:K15589]
100028102  EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
100013876  CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
100026702  SLC2A1; solute carrier family 2 member 1 [KO:K07299]
100033275  JAG1; jagged 1 [KO:K06052]
100014054  JAG2; jagged 2 [KO:K21635]
100014594  DLL3; delta like canonical Notch ligand 3 [KO:K06051]
100032054  DLL4; delta like canonical Notch ligand 4 [KO:K06051]
100032690  DLL1; delta like canonical Notch ligand 1 [KO:K06051]
100616999  NOTCH1; notch 1 [KO:K02599]
100013355  NOTCH2; notch 2 [KO:K20994]
100012590  NOTCH3; notch 3 [KO:K20995]
100025710  NOTCH4; notch 4 [KO:K20996]
100011897  HES1; hes family bHLH transcription factor 1 [KO:K06054]
100027474  HES4; hes family bHLH transcription factor 4 [KO:K06054]
100027928  HES5; hes family bHLH transcription factor 5 [KO:K06055]
100027956  transcription factor HES-5-like [KO:K06055]
100019853  HEY1; hes related family bHLH transcription factor with YRPW motif 1 [KO:K09091]
100032013  HEYL; hes related family bHLH transcription factor with YRPW motif-like [KO:K09091]
100024117  HEY2; hes related family bHLH transcription factor with YRPW motif 2 [KO:K09091]
100032078  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
100016531  SHH; sonic hedgehog [KO:K11988]
100014019  PTCH1; patched 1 [KO:K06225]
100015195  SMO; smoothened, frizzled class receptor [KO:K06226]
100617418  KIF7; kinesin family member 7 [KO:K18806]
100022892  SUFU; SUFU negative regulator of hedgehog signaling [KO:K06229]
100011403  GLI2; GLI family zinc finger 2 [KO:K16798]
100616982  GLI3; GLI family zinc finger 3 [KO:K06230]
100031674  BMP2; bone morphogenetic protein 2 [KO:K21283]
100010652  BMP4; bone morphogenetic protein 4 [KO:K04662]
100019071  HHIP; hedgehog interacting protein [KO:K06231]
100024924  PTCH2; patched 2 [KO:K11101]
100025885  AR; androgen receptor [KO:K08557]
100017761  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
100013102  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
100014854  HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  Superoxide
C00735  Cortisol
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
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pathway
mdo03320  PPAR signaling pathway
mdo04010  MAPK signaling pathway
mdo04020  Calcium signaling pathway
mdo04024  cAMP signaling pathway
mdo04060  Cytokine-cytokine receptor interaction
mdo04066  HIF-1 signaling pathway
mdo04110  Cell cycle
mdo04115  p53 signaling pathway
mdo04150  mTOR signaling pathway
mdo04151  PI3K-Akt signaling pathway
mdo04210  Apoptosis
mdo04310  Wnt signaling pathway
mdo04330  Notch signaling pathway
mdo04340  Hedgehog signaling pathway
mdo04350  TGF-beta signaling pathway
mdo04370  VEGF signaling pathway
mdo04510  Focal adhesion
mdo04512  ECM-receptor interaction
mdo04520  Adherens junction
mdo04630  JAK-STAT signaling pathway
mdo04915  Estrogen signaling pathway
KO pathway
ko05200   
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