Entry
Name
Cell adhesion molecules - Manis javanica (Malayan pangolin)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Manis javanica (Malayan pangolin) [GN:
mjv ]
Gene
108406263 VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation isoform X1 [KO:K23268 ]
108403763 IGSF11; immunoglobulin superfamily member 11 isoform X1 [KO:K06791 ]
108392246 CD80; T-lymphocyte activation antigen CD80 isoform X3 [KO:K05412 ]
108407381 CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413 ]
108410362 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
108410363 HLA class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
108384187 boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752 ]
108384189 HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752 ]
108384190 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DO beta chain [KO:K06752 ]
108396370 HLA class II histocompatibility antigen, DO alpha chain [KO:K06752 ]
108396399 HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752 ]
108396410 HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752 ]
108401011 HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752 ]
108388563 class I histocompatibility antigen, Gogo-B*0201 alpha chain-like isoform X1 [KO:K06751 ]
108390694 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
108391351 patr class I histocompatibility antigen, A-126 alpha chain-like isoform X2 [KO:K06751 ]
108399725 HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751 ]
108404569 CD8B; T-cell surface glycoprotein CD8 beta chain isoform X1 [KO:K06459 ]
108401936 VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747 ]
108392900 CD40; tumor necrosis factor receptor superfamily member 5 isoform X3 [KO:K03160 ]
108392278 TIGIT; T-cell immunoreceptor with Ig and ITIM domains isoform X1 [KO:K16350 ]
108409094 ESAM; endothelial cell-selective adhesion molecule isoform X1 [KO:K06787 ]
108390221 PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471 ]
108391743 MADCAM1; mucosal addressin cell adhesion molecule 1 isoform X1 [KO:K06779 ]
108408504 glycosylation-dependent cell adhesion molecule 1-like [KO:K06815 ]
Reference
Authors
Barclay AN.
Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
Journal
Reference
Authors
Sharpe AH, Freeman GJ.
Title
The B7-CD28 superfamily.
Journal
Reference
Authors
Grewal IS, Flavell RA.
Title
CD40 and CD154 in cell-mediated immunity.
Journal
Reference
Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
Journal
Reference
Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
Title
Cell adhesion and polarity during immune interactions.
Journal
Reference
Authors
Dejana E.
Title
Endothelial cell-cell junctions: happy together.
Journal
Reference
Authors
Bazzoni G.
Title
The JAM family of junctional adhesion molecules.
Journal
Reference
Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
Title
Endothelial function and hemostasis.
Journal
Reference
Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
Title
Cell adhesion molecules--update.
Journal
Reference
Authors
Muller WA.
Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
Journal
Reference
Authors
Yamagata M, Sanes JR, Weiner JA.
Title
Synaptic adhesion molecules.
Journal
Reference
Authors
Ethell IM, Pasquale EB.
Title
Molecular mechanisms of dendritic spine development and remodeling.
Journal
Reference
Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
Journal
Reference
Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
Journal
Reference
Authors
Dunican DJ, Doherty P.
Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
Journal
Reference
Authors
Girault JA, Peles E.
Title
Development of nodes of Ranvier.
Journal
Reference
Authors
Arroyo EJ, Scherer SS.
Title
On the molecular architecture of myelinated fibers.
Journal
Reference
Authors
Salzer JL.
Title
Polarized domains of myelinated axons.
Journal
Reference
Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
Title
Roles and modes of action of nectins in cell-cell adhesion.
Journal
Reference
Authors
Nakanishi H, Takai Y.
Title
Roles of nectins in cell adhesion, migration and polarization.
Journal
Reference
Authors
Siu MK, Cheng CY.
Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
Journal
Reference
Authors
Lee NP, Cheng CY.
Title
Adaptors, junction dynamics, and spermatogenesis.
Journal
Reference
Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
Journal
Reference
Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
Title
Cadherin-based cell adhesion in neuromuscular development.
Journal
Reference
Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
Journal
Related pathway
mjv04610 Complement and coagulation cascades
mjv04660 T cell receptor signaling pathway
mjv04670 Leukocyte transendothelial migration
KO pathway
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