Entry
Name
GABAergic synapse - Mus musculus (house mouse)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
105727 Slc38a1; solute carrier family 38, member 1 [KO:K14990 ]
67760 Slc38a2; solute carrier family 38, member 2 [KO:K14207 ]
22348 Slc32a1; solute carrier family 32 (GABA vesicular transporter), member 1 [KO:K15015 ]
14394 Gabra1; gamma-aminobutyric acid type A receptor subunit alpha 1 [KO:K05175 ]
14395 Gabra2; gamma-aminobutyric acid type A receptor subunit alpha 2 [KO:K05175 ]
14396 Gabra3; gamma-aminobutyric acid type A receptor subunit alpha 3 [KO:K05175 ]
14397 Gabra4; gamma-aminobutyric acid type A receptor subunit alpha 4 [KO:K05175 ]
110886 Gabra5; gamma-aminobutyric acid type A receptor subunit alpha 5 [KO:K05175 ]
14399 Gabra6; gamma-aminobutyric acid type A receptor subunit alpha 6 [KO:K05175 ]
14400 Gabrb1; gamma-aminobutyric acid type A receptor subunit beta 1 [KO:K05181 ]
14402 Gabrb3; GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3 [KO:K05181 ]
14401 Gabrb2; gamma-aminobutyric acid type A receptor subunit beta 2 [KO:K05181 ]
14405 Gabrg1; gamma-aminobutyric acid type A receptor subunit gamma 1 [KO:K05186 ]
14406 Gabrg2; gamma-aminobutyric acid type A receptor, subunit gamma 2 [KO:K05186 ]
14407 Gabrg3; gamma-aminobutyric acid type A receptor, subunit gamma 3 [KO:K05186 ]
14403 Gabrd; gamma-aminobutyric acid (GABA) A receptor, subunit delta [KO:K05184 ]
14404 Gabre; gamma-aminobutyric acid (GABA) A receptor, subunit epsilon [KO:K05185 ]
57249 Gabrq; gamma-aminobutyric acid type A receptor subunit theta [KO:K05192 ]
216643 Gabrp; gamma-aminobutyric acid type A receptor subunit pi [KO:K05189 ]
15114 Hap1; huntingtin-associated protein 1 [KO:K04647 ]
57436 Gabarapl1; GABA type A receptor associated protein like 1 [KO:K08341 ]
56486 Gabarap; gamma-aminobutyric acid receptor associated protein [KO:K08341 ]
93739 Gabarapl2; GABA type A receptor associated protein like 2 [KO:K08341 ]
70827 Trak2; trafficking protein, kinesin binding 2 [KO:K15374 ]
57138 Slc12a5; solute carrier family 12, member 5 [KO:K23967 ]
14408 Gabrr1; gamma-aminobutyric acid type A receptor subunit rho 1 [KO:K05190 ]
14409 Gabrr2; gamma-aminobutyric acid type A receptor subunit rho 2 [KO:K05190 ]
328699 Gabrr3; gamma-aminobutyric acid type A receptor subunit rho 3 [KO:K05190 ]
12286 Cacna1a; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [KO:K04344 ]
12287 Cacna1b; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849 ]
12288 Cacna1c; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850 ]
12289 Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851 ]
54652 Cacna1f; calcium channel, voltage-dependent, alpha 1F subunit [KO:K04853 ]
12292 Cacna1s; calcium channel, voltage-dependent, L type, alpha 1S subunit [KO:K04857 ]
54393 Gabbr1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615 ]
242425 Gabbr2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615 ]
14681 Gnao1; guanine nucleotide binding protein, alpha O [KO:K04534 ]
14688 Gnb1; guanine nucleotide binding protein (G protein), beta 1 [KO:K04536 ]
14693 Gnb2; guanine nucleotide binding protein (G protein), beta 2 [KO:K04537 ]
14695 Gnb3; guanine nucleotide binding protein (G protein), beta 3 [KO:K07825 ]
14696 Gnb4; guanine nucleotide binding protein (G protein), beta 4 [KO:K04538 ]
14697 Gnb5; guanine nucleotide binding protein (G protein), beta 5 [KO:K04539 ]
14702 Gng2; guanine nucleotide binding protein (G protein), gamma 2 [KO:K07826 ]
14704 Gng3; guanine nucleotide binding protein (G protein), gamma 3 [KO:K04540 ]
14706 Gng4; guanine nucleotide binding protein (G protein), gamma 4 [KO:K04541 ]
14708 Gng7; guanine nucleotide binding protein (G protein), gamma 7 [KO:K04543 ]
14709 Gng8; guanine nucleotide binding protein (G protein), gamma 8 [KO:K04544 ]
14700 Gng10; guanine nucleotide binding protein (G protein), gamma 10 [KO:K04545 ]
66066 Gng11; guanine nucleotide binding protein (G protein), gamma 11 [KO:K04546 ]
14701 Gng12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347 ]
64337 Gng13; guanine nucleotide binding protein (G protein), gamma 13 [KO:K04547 ]
14699 Gngt1; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [KO:K04548 ]
14710 Gngt2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 [KO:K04549 ]
16522 Kcnj6; potassium inwardly-rectifying channel, subfamily J, member 6 [KO:K05000 ]
232333 Slc6a1; solute carrier family 6 (neurotransmitter transporter, GABA), member 1 [KO:K05034 ]
14412 Slc6a13; solute carrier family 6 (neurotransmitter transporter, GABA), member 13 [KO:K05046 ]
243616 Slc6a11; solute carrier family 6 (neurotransmitter transporter, GABA), member 11 [KO:K05044 ]
14411 Slc6a12; solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 [KO:K05045 ]
76257 Slc38a3; solute carrier family 38, member 3 [KO:K13576 ]
209837 Slc38a5; solute carrier family 38, member 5 [KO:K14992 ]
Compound
Reference
Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
Title
Neuropsychopharmacology: The fifth generation of progress
Journal
Reference
Authors
Farrant M, Kaila K
Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
Journal
Reference
Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
Journal
Reference
Authors
Pinard A, Seddik R, Bettler B
Title
GABAB receptors: physiological functions and mechanisms of diversity.
Journal
Reference
Authors
Chalifoux JR, Carter AG
Title
GABAB receptor modulation of synaptic function.
Journal
Reference
Authors
Padgett CL, Slesinger PA
Title
GABAB receptor coupling to G-proteins and ion channels.
Journal
Reference
Authors
Emson PC
Title
GABA(B) receptors: structure and function.
Journal
Reference
Authors
Kornau HC
Title
GABA(B) receptors and synaptic modulation.
Journal
Reference
Authors
Jacob TC, Moss SJ, Jurd R
Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
Journal
Reference
Authors
Kneussel M
Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
Journal
Reference
Authors
Luscher B, Fuchs T, Kilpatrick CL
Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
Journal
Reference
Authors
Arancibia-Carcamo IL, Kittler JT
Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
Journal
Reference
Authors
Bak LK, Schousboe A, Waagepetersen HS
Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
Journal
Reference
Authors
Conti F, Minelli A, Melone M
Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
Journal
Reference
Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
Title
GABAergic dysfunction in mood disorders.
Journal
Reference
Authors
Chebib M, Johnston GA
Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
Journal
Related pathway
mmu00250 Alanine, aspartate and glutamate metabolism
KO pathway
LinkDB
All DBs