KEGG PATHWAY: mna03420

KEGG

PATHWAY: mna03420

Entry

mna03420                    Pathway

Name

Nucleotide excision repair - Miniopterus natalensis (Natal long-fingered bat)

Description

Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.

Class

Genetic Information Processing; Replication and repair

Pathway map

Nucleotide excision repair

Other DBs

GO:

Organism

Miniopterus natalensis (Natal long-fingered bat) [GN:mna]

Gene

RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]

CUL4B; cullin-4B isoform X1 [KO:K10609]

CUL4A; cullin-4A isoform X1 [KO:K10609]

DDB1; DNA damage-binding protein 1 isoform X1 [KO:K10610]

DDB2; DNA damage-binding protein 2 [KO:K10140]

XPC; DNA repair protein complementing XP-C cells [KO:K10838]

RAD23A; UV excision repair protein RAD23 homolog A [KO:K10839]

RAD23B; UV excision repair protein RAD23 homolog B [KO:K10839]

CETN2; centrin-2 isoform X1 [KO:K10840]

ERCC8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]

ERCC6; DNA excision repair protein ERCC-6 [KO:K10841]

UVSSA; UV-stimulated scaffold protein A isoform X1 [KO:K23720]

POLR2A; DNA-directed RNA polymerase II subunit RPB1 [KO:K03006] [EC:2.7.7.6]

POLR2B; DNA-directed RNA polymerase II subunit RPB2 [KO:K03010] [EC:2.7.7.6]

POLR2C; DNA-directed RNA polymerase II subunit RPB3 [KO:K03011]

POLR2D; DNA-directed RNA polymerase II subunit RPB4 [KO:K03012]

POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 [KO:K03013]

POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 [KO:K03014]

POLR2G; DNA-directed RNA polymerase II subunit RPB7 [KO:K03015]

POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 [KO:K03016]

POLR2I; DNA-directed RNA polymerase II subunit RPB9 [KO:K03017]

POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform X1 [KO:K03009]

POLR2J; DNA-directed RNA polymerase II subunit RPB11-a [KO:K03008]

POLR2M; protein GRINL1A [KO:K21987]

CDK7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]

MNAT1; CDK-activating kinase assembly factor MAT1 [KO:K10842]

CCNH; cyclin-H isoform X1 [KO:K06634]

ERCC3; TFIIH basal transcription factor complex helicase XPB subunit [KO:K10843] [EC:5.6.2.4]

ERCC2; TFIIH basal transcription factor complex helicase XPD subunit [KO:K10844] [EC:5.6.2.3]

GTF2H5; general transcription factor IIH subunit 5 [KO:K10845]

GTF2H1; general transcription factor IIH subunit 1 [KO:K03141]

GTF2H2; general transcription factor IIH subunit 2 [KO:K03142]

GTF2H3; general transcription factor IIH subunit 3 [KO:K03143]

GTF2H4; general transcription factor IIH subunit 4 [KO:K03144]

DNA repair protein complementing XP-G cells isoform X1 [KO:K10846]

XPA; DNA repair protein complementing XP-A cells isoform X1 [KO:K10847]

RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]

RPA2; replication protein A 32 kDa subunit isoform X1 [KO:K10739]

RPA3; replication protein A 14 kDa subunit [KO:K10740]

RPA4; replication protein A 30 kDa subunit [KO:K10741]

ERCC4; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]

ERCC1; DNA excision repair protein ERCC-1 [KO:K10849]

POLD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]

POLD2; DNA polymerase delta subunit 2 [KO:K02328]

POLD3; DNA polymerase delta subunit 3 isoform X1 [KO:K03504]

POLD4; DNA polymerase delta subunit 4 [KO:K03505]

POLE; DNA polymerase epsilon catalytic subunit A isoform X1 [KO:K02324] [EC:2.7.7.7]

POLE2; DNA polymerase epsilon subunit 2 [KO:K02325] [EC:2.7.7.7]

POLE3; DNA polymerase epsilon subunit 3 [KO:K02326] [EC:2.7.7.7]

PCNA; proliferating cell nuclear antigen [KO:K04802]

RFC1; replication factor C subunit 1 isoform X1 [KO:K10754]

RFC2; replication factor C subunit 2 [KO:K10755]

RFC4; replication factor C subunit 4 [KO:K10755]

RFC3; replication factor C subunit 3 [KO:K10756]

RFC5; replication factor C subunit 5 [KO:K10756]

LIG1; DNA ligase 1 isoform X1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]

Reference

Authors

Sugasawa K.

Title

[Molecular mechanism of mammalian nucleotide excision repair]

Journal

Tanpakushitsu Kakusan Koso 46:893-901 (2001)

Reference

Authors

Nakatsu Y.

Title

[Transcription-coupled repair and Cockayne syndrome]

Journal

Tanpakushitsu Kakusan Koso 46:908-15 (2001)

Reference

Authors

Nakagawa N, Masui R, Kuramitsu S.

Title

[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]

Journal

Tanpakushitsu Kakusan Koso 46:968-75 (2001)

Reference

Authors

Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.

Title

Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.

Journal

Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020

Reference

Authors

Saldivar JS, Wu X, Follen M, Gershenson D.

Title

Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.

Journal

Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043

Reference

Authors

Sugasawa K.

Title

[DNA repair pathways involving Cul4A ubiquitin ligases]

Journal

Tanpakushitsu Kakusan Koso 51:1339-44 (2006)

Reference

Authors

Ito S, Ando D, Tanaka K.

Title

[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]

Journal

Tanpakushitsu Kakusan Koso 52:1823-31 (2007)

Related
pathway

RNA polymerase

Ubiquitin mediated proteolysis

KO pathway

LinkDB

DBGET integrated database retrieval system