KEGG   PATHWAY: mna04612
Entry
mna04612                    Pathway                                

Name
Antigen processing and presentation - Miniopterus natalensis
Class
Organismal Systems; Immune system
Pathway map
mna04612  Antigen processing and presentation
mna04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Miniopterus natalensis [GN:mna]
Gene
107527227  IFNG; interferon gamma [KO:K04687]
107538974  TNF; tumor necrosis factor [KO:K03156]
107531677  PSME1; proteasome activator complex subunit 1 isoform X1 [KO:K06696]
107531680  PSME2; proteasome activator complex subunit 2 [KO:K06697]
107528922  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
107539014  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
107538950  heat shock 70 kDa protein 1 [KO:K03283]
107540605  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
107545657  HSPA2; heat shock-related 70 kDa protein 2 [KO:K03283]
107525401  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
107536915  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
107536502  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
107538488  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
107538961  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
107525813  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
107546126  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
107546127  class I histocompatibility antigen, Gogo-C*0101/C*0102 alpha chain-like [KO:K06751]
107528441  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
107535485  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
107528428  CANX; calnexin [KO:K08054]
107536290  B2M; beta-2-microglobulin [KO:K08055]
107535925  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
107541519  CALR; calreticulin [KO:K08057]
107538021  calreticulin-like [KO:K08057]
107541594  TAPBP; tapasin [KO:K08058]
107542669  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653]
107542666  TAP2; antigen peptide transporter 2 [KO:K05654]
107528628  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
107528645  CD8B; T-cell surface glycoprotein CD8 beta chain isoform X1 [KO:K06459]
107531685  uncharacterized protein LOC107531685 [KO:K10784]
107543999  LOW QUALITY PROTEIN: NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
107544001  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
107543998  natural killer cells antigen CD94-like [KO:K06516]
107535326  IFI30; gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
107531602  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
107527504  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
107545174  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
107536419  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
107544122  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
107542667  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
107542672  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
107542674  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
107545091  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
107545092  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
107535226  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
107543082  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
107544923  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
107539106  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
107544013  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
107539146  RFX5; DNA-binding protein RFX5 [KO:K08061]
107535352  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
107525164  RFXAP; regulatory factor X-associated protein [KO:K08063]
107524712  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
107536891  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
107545156  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
107531181  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
Reference
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
mna03050  Proteasome
mna04650  Natural killer cell mediated cytotoxicity
mna04660  T cell receptor signaling pathway
KO pathway
ko04612   
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