KEGG   PATHWAY: mna04923
Entry
mna04923                    Pathway                                

Name
Regulation of lipolysis in adipocytes - Miniopterus natalensis
Description
Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. Lipolysis is under tight hormonal control. During fasting, catecholamines, by binding to Gs-coupled-adrenergic receptors (-AR), activate adenylate cyclase (AC) to increase cAMP and activate protein kinase A (PKA). PKA phosphorylates target protein such as hormone-sensitive lipase (HSL) and perilipin 1 (PLIN). PLIN phosphorylation is a key event in the sequential activation of TAG hydrolysis involving adipose triglyceride lipase (ATGL), HSL, and monoglyceride lipase (MGL). During the fed state, insulin, through activation of phosphodiesterase-3B (PDE-3B), inhibits catecholamine-induced lipolysis via the degradation of cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
mna04923  Regulation of lipolysis in adipocytes
mna04923

Other DBs
GO: 0016042
Organism
Miniopterus natalensis [GN:mna]
Gene
107545279  TSHB; thyrotropin subunit beta [KO:K05251]
107532807  CGA; glycoprotein hormones alpha chain [KO:K08522]
107542654  TSHR; thyrotropin receptor [KO:K04249]
107536422  ADRB1; beta-1 adrenergic receptor [KO:K04141]
107540586  ADRB2; beta-2 adrenergic receptor [KO:K04142]
107535434  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
107529329  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
107529353  neuroendocrine secretory protein 55-like [KO:K04632]
107526004  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
107540528  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
107534062  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
107531740  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
107527242  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
107528232  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
107531029  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
107539500  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
107535777  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
107544336  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107543188  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107531532  NPPA; natriuretic peptides A [KO:K12334]
107543755  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
107543282  PRKG1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
107537152  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
107540409  PLIN1; perilipin-1 [KO:K08768]
107534157  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
107542321  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
107524316  ABHD5; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [KO:K13699] [EC:2.3.1.51]
107525212  MGLL; monoglyceride lipase [KO:K01054] [EC:3.1.1.23]
107539508  fatty acid-binding protein, adipocyte [KO:K08753]
107544890  AQP7; aquaporin-7 isoform X1 [KO:K08771]
107540632  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
107525521  IRS1; LOW QUALITY PROTEIN: insulin receptor substrate 1 [KO:K16172]
107530378  IRS2; LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187]
107526265  IRS4; insulin receptor substrate 4 [KO:K17446]
107532628  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107538463  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107541106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107526728  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107529317  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107535325  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107542383  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107528331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107534199  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107546709  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
107539806  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
107539779  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
107535587  PTGS1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
107546245  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
107536004  ADORA1; adenosine receptor A1 [KO:K04265]
107540123  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
107527501  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
107545320  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
107540752  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
107545079  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
Compound
C00020  AMP
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00212  Adenosine
C00219  Arachidonate
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00788  L-Adrenaline
C00942  3',5'-Cyclic GMP
C01885  1-Acylglycerol
C02140  Corticosterone
Reference
  Authors
Ahmadian M, Wang Y, Sul HS
  Title
Lipolysis in adipocytes.
  Journal
Int J Biochem Cell Biol 42:555-9 (2010)
DOI:10.1016/j.biocel.2009.12.009
Reference
  Authors
Ahmadian M, Duncan RE, Sul HS
  Title
The skinny on fat: lipolysis and fatty acid utilization in adipocytes.
  Journal
Trends Endocrinol Metab 20:424-8 (2009)
DOI:10.1016/j.tem.2009.06.002
Reference
  Authors
Wang S, Soni KG, Semache M, Casavant S, Fortier M, Pan L, Mitchell GA
  Title
Lipolysis and the integrated physiology of lipid energy metabolism.
  Journal
Mol Genet Metab 95:117-26 (2008)
DOI:10.1016/j.ymgme.2008.06.012
Reference
  Authors
Lafontan M
  Title
Historical perspectives in fat cell biology: the fat cell as a model for the investigation of hormonal and metabolic pathways.
  Journal
Am J Physiol Cell Physiol 302:C327-59 (2012)
DOI:10.1152/ajpcell.00168.2011
Reference
  Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
  Title
Regulation of adipocyte lipolysis.
  Journal
Nutr Res Rev 27:63-93 (2014)
DOI:10.1017/S095442241400002X
Reference
  Authors
Proenca AR, Sertie RA, Oliveira AC, Campana AB, Caminhotto RO, Chimin P, Lima FB
  Title
New concepts in white adipose tissue physiology.
  Journal
Braz J Med Biol Res 47:192-205 (2014)
DOI:10.1590/1414-431X20132911
Reference
  Authors
Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS
  Title
Regulation of lipolysis in adipocytes.
  Journal
Annu Rev Nutr 27:79-101 (2007)
DOI:10.1146/annurev.nutr.27.061406.093734
Reference
  Authors
Lafontan M
  Title
Advances in adipose tissue metabolism.
  Journal
Int J Obes (Lond) 32 Suppl 7:S39-51 (2008)
DOI:10.1038/ijo.2008.237
Reference
  Authors
Jaworski K, Sarkadi-Nagy E, Duncan RE, Ahmadian M, Sul HS
  Title
Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue.
  Journal
Am J Physiol Gastrointest Liver Physiol 293:G1-4 (2007)
DOI:10.1152/ajpgi.00554.2006
Reference
  Authors
Thompson D, Karpe F, Lafontan M, Frayn K
  Title
Physical activity and exercise in the regulation of human adipose tissue physiology.
  Journal
Physiol Rev 92:157-91 (2012)
DOI:10.1152/physrev.00012.2011
Reference
  Authors
Lafontan M, Langin D
  Title
Lipolysis and lipid mobilization in human adipose tissue.
  Journal
Prog Lipid Res 48:275-97 (2009)
DOI:10.1016/j.plipres.2009.05.001
Reference
  Authors
Arner P, Langin D
  Title
Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance.
  Journal
Trends Endocrinol Metab 25:255-62 (2014)
DOI:10.1016/j.tem.2014.03.002
Reference
  Authors
Brasaemle DL
  Title
Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis.
  Journal
J Lipid Res 48:2547-59 (2007)
DOI:10.1194/jlr.R700014-JLR200
Reference
  Authors
Lampidonis AD, Rogdakis E, Voutsinas GE, Stravopodis DJ
  Title
The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis.
  Journal
Gene 477:1-11 (2011)
DOI:10.1016/j.gene.2011.01.007
Reference
  Authors
Bickel PE, Tansey JT, Welte MA
  Title
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.
  Journal
Biochim Biophys Acta 1791:419-40 (2009)
DOI:10.1016/j.bbalip.2009.04.002
Related
pathway
mna00561  Glycerolipid metabolism
mna00590  Arachidonic acid metabolism
mna04022  cGMP-PKG signaling pathway
mna04024  cAMP signaling pathway
mna04910  Insulin signaling pathway
KO pathway
ko04923   
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