KEGG   PATHWAY: mpah04390
Entry
mpah04390                   Pathway                                

Name
Hippo signaling pathway - Mus pahari (shrew mouse)
Description
Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor Salvador and LATS1 and LATS2. In response to high cell densities, activated LATS1/2 phosphorylates the transcriptional coactivators YAP and TAZ, promoting its cytoplasmic localization, leading to cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated at low cell density, YAP/TAZ translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. YAP/TAZ also interacts with other transcriptional factors or signaling molecules, by which Hippo pathway-mediated processes are interconnected with those of other key signaling cascades, such as those mediated by TGF-beta and Wnt growth factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
mpah04390  Hippo signaling pathway
mpah04390

Other DBs
GO: 0035329
Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110318424  Crb2; protein crumbs homolog 2 [KO:K16681]
110321774  Crb1; protein crumbs homolog 1 isoform X1 [KO:K16681]
110337655  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
110337228  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
110318782  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
110333218  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
110322937  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
110319896  Prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
110323027  Patj; inaD-like protein isoform X1 [KO:K06092]
110324364  Mpp5; MAGUK p55 subfamily member 5 [KO:K06091]
110313316  Amot; angiomotin [KO:K16819]
110327706  Yap1; transcriptional coactivator YAP1 isoform X1 [KO:K16687]
110320091  Wwtr1; WW domain-containing transcription regulator protein 1 isoform X1 [KO:K16820]
110337432  Cdh1; cadherin-1 isoform X1 [KO:K05689]
110327504  Limd1; LIM domain-containing protein 1 [KO:K16682]
110325431  Ajuba; LIM domain-containing protein ajuba [KO:K16682]
110328413  Wtip; Wilms tumor protein 1-interacting protein [KO:K16682]
110330198  Nf2; merlin isoform X1 [KO:K16684]
110331237  Wwc1; protein KIBRA isoform X1 [KO:K16685]
110324431  Frmd6; FERM domain-containing protein 6 isoform X1 [KO:K16822]
110324307  Sav1; protein salvador homolog 1 [KO:K16686]
110334720  Stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
110330820  Rassf6; ras association domain-containing protein 6 isoform X1 [KO:K09854]
110327714  Rassf1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
110336304  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
110331422  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
110328279  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
110337932  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
110325313  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
110330369  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
110332843  Ppp2r2b; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
110318923  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
110325918  Lats2; serine/threonine-protein kinase LATS2 isoform X1 [KO:K08791] [EC:2.7.11.1]
110338161  Lats1; serine/threonine-protein kinase LATS1 [KO:K08791] [EC:2.7.11.1]
110315942  Mob1a; MOB kinase activator 1A isoform X1 [KO:K06685]
110330335  Mob1b; MOB kinase activator 1B [KO:K06685]
110312794  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
110317198  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
110324329  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110321776  Tp53bp2; apoptosis-stimulating of p53 protein 2 [KO:K16823]
110331764  Llgl1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
110331461  Llgl2; lethal(2) giant larvae protein homolog 2 [KO:K06094]
110334588  Scrib; protein scribble homolog isoform X1 [KO:K16175]
110329715  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
110333507  Dlg2; disks large homolog 2 isoform X1 [KO:K12075]
110314132  Dlg3; disks large homolog 3 isoform X1 [KO:K21098]
110332219  Dlg4; disks large homolog 4 isoform X1 [KO:K11828]
110325828  Dlg5; disks large homolog 5 isoform X1 [KO:K24050]
110332251  Csnk1d; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
110334729  casein kinase I [KO:K08960] [EC:2.7.11.1]
110331061  Fbxw11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
110337956  Btrc; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
110322900  Tp73; tumor protein p73 isoform X1 [KO:K10148]
110336584  Bbc3; bcl-2-binding component 3 [KO:K10132]
110315959  Tead4; transcriptional enhancer factor TEF-3 isoform X1 [KO:K09448]
110322324  Tead1; transcriptional enhancer factor TEF-1 isoform X1 [KO:K09448]
110319868  Tead2; transcriptional enhancer factor TEF-4 isoform X1 [KO:K09448]
110337942  Tead3; transcriptional enhancer factor TEF-5 [KO:K09448]
110338078  Ctgf; connective tissue growth factor [KO:K06827]
110321463  Gli2; zinc finger protein GLI2 [KO:K16798]
110330966  Areg; amphiregulin [KO:K09782]
110332414  Birc5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
110331008  Afp; alpha-fetoprotein [KO:K16144]
110326926  Itgb2; integrin beta-2 [KO:K06464]
110330040  LOW QUALITY PROTEIN: integrin beta-2-like protein [KO:K06464]
110333309  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110336543  Tgfb1; transforming growth factor beta-1 isoform X1 [KO:K13375]
110321649  Tgfb2; transforming growth factor beta-2 isoform X1 [KO:K13376]
110324521  Tgfb3; transforming growth factor beta-3 [KO:K13377]
110322784  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
110327573  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
110333104  Smad7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
110332834  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
110327577  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
110333204  Smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
110313068  Serpine1; plasminogen activator inhibitor 1 [KO:K03982]
110318284  Bmp2; bone morphogenetic protein 2 [KO:K21283]
110325391  Bmp4; bone morphogenetic protein 4 [KO:K04662]
110327432  Bmp5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
110333720  Bmp6; bone morphogenetic protein 6 isoform X1 [KO:K16620]
110318109  Bmp7; bone morphogenetic protein 7 isoform X1 [KO:K16621]
110323468  Bmp8a; bone morphogenetic protein 8A isoform X1 [KO:K16622]
110318839  Gdf5; growth/differentiation factor 5 [KO:K04664]
110338911  Gdf6; growth/differentiation factor 6 [KO:K20012]
110324858  Gdf7; growth/differentiation factor 7 isoform X1 [KO:K20013]
110327048  Amh; muellerian-inhibiting factor [KO:K04665]
110325344  Bmpr1a; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
110319737  Bmpr1b; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
110321925  Bmpr2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
110337251  Smad1; mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676]
110318968  Id1; DNA-binding protein inhibitor ID-1 [KO:K04680]
110324496  Id2; DNA-binding protein inhibitor ID-2 [KO:K17693]
110335204  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
110316416  Wnt2; protein Wnt-2 [KO:K00182]
110320339  Wnt2b; protein Wnt-2b [KO:K00182]
110331952  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
110331285  Wnt3a; protein Wnt-3a [KO:K00312]
110323343  Wnt4; protein Wnt-4 isoform X1 [KO:K00408]
110316538  Wnt5b; protein Wnt-5b [KO:K00444]
110325571  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
110321884  Wnt6; protein Wnt-6 [KO:K00445]
110316305  Wnt7a; protein Wnt-7a [KO:K00572]
110335001  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
110330357  Wnt8b; protein Wnt-8b [KO:K00714]
110333515  Wnt8a; protein Wnt-8a [KO:K00714]
110331284  Wnt9a; protein Wnt-9a isoform X1 [KO:K01064]
110332442  Wnt9b; protein Wnt-9b [KO:K01064]
110335137  Wnt10b; protein Wnt-10b isoform X1 [KO:K01357]
110322230  Wnt10a; protein Wnt-10a [KO:K01357]
110325401  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
110317136  Wnt16; protein Wnt-16 [KO:K01558]
110316646  Fzd1; frizzled-1 [KO:K02432]
110321753  Fzd7; frizzled-7 [KO:K02432]
110331922  Fzd2; frizzled-2 [KO:K02235]
110325524  Fzd3; frizzled-3 [KO:K02329]
110325899  Fzd4; frizzled-4 [KO:K02354]
110321741  Fzd5; frizzled-5 [KO:K02375]
110333155  Fzd8; frizzled-8 [KO:K02375]
110334890  Fzd6; frizzled-6 [KO:K02376]
110339184  Fzd10; frizzled-10 [KO:K02842]
110312856  Fzd9; frizzled-9 [KO:K02842]
110329595  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
110323116  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
110331183  Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
110318313  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
110313584  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
110324236  Ywhaq; LOW QUALITY PROTEIN: 14-3-3 protein theta [KO:K16197]
110331575  Ywhae; 14-3-3 protein epsilon [KO:K06630]
110312793  Ywhag; 14-3-3 protein gamma [KO:K16198]
110330275  Ywhah; 14-3-3 protein eta [KO:K16198]
110329614  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110328516  Ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
110333195  Apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
110326173  Apc2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
110338127  Axin1; axin-1 isoform X1 [KO:K02157]
110331423  Axin2; axin-2 [KO:K04385]
110328966  Nkd2; protein naked cuticle homolog 2 isoform X1 [KO:K03213]
110337316  Nkd1; protein naked cuticle homolog 1 isoform X1 [KO:K03213]
110332085  Tcf7; transcription factor 7 isoform X1 [KO:K02620]
110315696  Tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
110313411  Tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
110319903  Lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
110334656  Myc; myc proto-oncogene protein [KO:K04377]
110322378  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
110315929  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
110335402  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
110320382  Sox2; transcription factor SOX-2 [KO:K16796]
110329750  Snai2; zinc finger protein SNAI2 [KO:K05706]
110321877  baculoviral IAP repeat-containing protein 2 [KO:K16060]
110327576  baculoviral IAP repeat-containing protein 2-like [KO:K16060]
110328081  baculoviral IAP repeat-containing protein 3 [KO:K16060]
110313074  Actb; actin, cytoplasmic 1 [KO:K05692]
110316267  Ctnna2; catenin alpha-2 isoform X1 [KO:K05691]
110333109  Ctnna1; catenin alpha-1 isoform X1 [KO:K05691]
110326998  Ctnna3; catenin alpha-3 isoform X1 [KO:K05691]
Reference
  Authors
Schroeder MC, Halder G
  Title
Regulation of the Hippo pathway by cell architecture and mechanical signals.
  Journal
Semin Cell Dev Biol 23:803-11 (2012)
DOI:10.1016/j.semcdb.2012.06.001
Reference
  Authors
Zhao B, Tumaneng K, Guan KL
  Title
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
  Journal
Nat Cell Biol 13:877-83 (2011)
DOI:10.1038/ncb2303
Reference
  Authors
Mauviel A, Nallet-Staub F, Varelas X
  Title
Integrating developmental signals: a Hippo in the (path)way.
  Journal
Oncogene 31:1743-56 (2012)
DOI:10.1038/onc.2011.363
Reference
  Authors
Zhao B, Li L, Guan KL
  Title
Hippo signaling at a glance.
  Journal
J Cell Sci 123:4001-6 (2010)
DOI:10.1242/jcs.069070
Reference
  Authors
Zhao B, Li L, Lei Q, Guan KL
  Title
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
  Journal
Genes Dev 24:862-74 (2010)
DOI:10.1101/gad.1909210
Reference
  Authors
Tremblay AM, Camargo FD
  Title
Hippo signaling in mammalian stem cells.
  Journal
Semin Cell Dev Biol 23:818-26 (2012)
DOI:10.1016/j.semcdb.2012.08.001
Reference
  Authors
Halder G, Johnson RL
  Title
Hippo signaling: growth control and beyond.
  Journal
Development 138:9-22 (2011)
DOI:10.1242/dev.045500
Reference
  Authors
Ramos A, Camargo FD
  Title
The Hippo signaling pathway and stem cell biology.
  Journal
Trends Cell Biol 22:339-46 (2012)
DOI:10.1016/j.tcb.2012.04.006
Reference
  Authors
Pan D
  Title
The hippo signaling pathway in development and cancer.
  Journal
Dev Cell 19:491-505 (2010)
DOI:10.1016/j.devcel.2010.09.011
Reference
  Authors
Bao Y, Hata Y, Ikeda M, Withanage K
  Title
Mammalian Hippo pathway: from development to cancer and beyond.
  Journal
J Biochem 149:361-79 (2011)
DOI:10.1093/jb/mvr021
Reference
  Authors
Zhao B, Lei QY, Guan KL
  Title
The Hippo-YAP pathway: new connections between regulation of organ size and cancer.
  Journal
Curr Opin Cell Biol 20:638-46 (2008)
DOI:10.1016/j.ceb.2008.10.001
Reference
  Authors
Chan SW, Lim CJ, Chen L, Chong YF, Huang C, Song H, Hong W
  Title
The Hippo pathway in biological control and cancer development.
  Journal
J Cell Physiol 226:928-39 (2011)
DOI:10.1002/jcp.22435
Reference
  Authors
Zeng Q, Hong W
  Title
The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals.
  Journal
Cancer Cell 13:188-92 (2008)
DOI:10.1016/j.ccr.2008.02.011
Reference
  Authors
Badouel C, Garg A, McNeill H
  Title
Herding Hippos: regulating growth in flies and man.
  Journal
Curr Opin Cell Biol 21:837-43 (2009)
DOI:10.1016/j.ceb.2009.09.010
Reference
  Authors
Buttitta LA, Edgar BA
  Title
How size is controlled: from Hippos to Yorkies.
  Journal
Nat Cell Biol 9:1225-7 (2007)
DOI:10.1038/ncb1107-1225
Reference
  Authors
Liu AM, Wong KF, Jiang X, Qiao Y, Luk JM
  Title
Regulators of mammalian Hippo pathway in cancer.
  Journal
Biochim Biophys Acta 1826:357-64 (2012)
DOI:10.1016/j.bbcan.2012.05.006
Reference
  Authors
Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G
  Title
Hippo and rassf1a Pathways: A Growing Affair.
  Journal
Mol Biol Int 2012:307628 (2012)
DOI:10.1155/2012/307628
Reference
  Authors
Halder G, Dupont S, Piccolo S
  Title
Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
  Journal
Nat Rev Mol Cell Biol 13:591-600 (2012)
DOI:10.1038/nrm3416
Reference
  Authors
Varelas X, Wrana JL
  Title
Coordinating developmental signaling: novel roles for the Hippo pathway.
  Journal
Trends Cell Biol 22:88-96 (2012)
DOI:10.1016/j.tcb.2011.10.002
Reference
  Authors
Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD
  Title
Yap1 acts downstream of alpha-catenin to control epidermal proliferation.
  Journal
Cell 144:782-95 (2011)
DOI:10.1016/j.cell.2011.02.031
Related
pathway
mpah04120  Ubiquitin mediated proteolysis
mpah04310  Wnt signaling pathway
mpah04350  TGF-beta signaling pathway
mpah04520  Adherens junction
mpah04530  Tight junction
KO pathway
ko04390   
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