KEGG   PATHWAY: mun05166
Entry
mun05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Meriones unguiculatus (Mongolian gerbil)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
mun05166  Human T-cell leukemia virus 1 infection
mun05166

Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110547453  Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
110554842  Nrp1; neuropilin-1 isoform X1 [KO:K06724]
110560064  Myc; myc proto-oncogene protein [KO:K04377]
110555647  Trrap; transformation/transcription domain-associated protein isoform X5 [KO:K08874]
110549323  Kat5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
110548628  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
110548001  Itgal; integrin alpha-L isoform X1 [KO:K05718]
110545086  Itgb2; integrin beta-2 [KO:K06464]
110555772  Icam1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
110553931  Hras; GTPase HRas isoform X1 [KO:K02833]
110558913  Kras; GTPase KRas isoform X1 [KO:K07827]
110544642  GTPase NRas [KO:K07828]
110544765  Nras; GTPase NRas [KO:K07828]
110559000  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110555605  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110553796  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
110547978  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110548574  Cd4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
110561879  Tln1; talin-1 isoform X2 [KO:K06271]
110549282  Tln2; talin-2 isoform X1 [KO:K06271]
110546253  Ranbp3; ran-binding protein 3 isoform X1 [KO:K15304]
110540131  GTP-binding nuclear protein Ran-like [KO:K07936]
110550165  Ran; GTP-binding nuclear protein Ran isoform X2 [KO:K07936]
110560526  GTP-binding nuclear protein Ran-like [KO:K07936]
110539822  Xpo1; exportin-1 isoform X1 [KO:K14290]
110545829  Calr; calreticulin [KO:K08057]
110563573  calreticulin-like [KO:K08057]
110557396  Canx; calnexin [KO:K08054]
110555973  Ppp3ca; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
110551992  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
110551668  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
110558957  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
110561325  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
110550273  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
110547352  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
110545902  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110543951  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
110548465  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
110564656  Il2rg; cytokine receptor common subunit gamma [KO:K05070]
110555551  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
110549202  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
110550874  signal transducer and activator of transcription 5A [KO:K11223]
110550889  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
110545874  Il2; interleukin-2 [KO:K05429]
110560079  interleukin-2-like [KO:K05429]
110557144  H-2 class I histocompatibility antigen, D-37 alpha chain-like [KO:K06751]
110557146  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
110562341  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X3 [KO:K06751]
110563045  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
110563046  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
110563052  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
110543171  H-2 class I histocompatibility antigen, K-D alpha chain-like [KO:K06751]
110543428  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
110544579  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
132648276  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
110543095  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
110557135  RT1 class I histocompatibility antigen, AA alpha chain [KO:K06751]
132648299  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
110553258  B2m; beta-2-microglobulin [KO:K08055]
110548993  Fdps; farnesyl pyrophosphate synthase isoform X2 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
110549632  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
110556812  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
110566446  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
110566972  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
110548867  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
110556618  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
110552096  Tspo; translocator protein [KO:K05770]
110548737  Tspo2; translocator protein 2 [KO:K05770]
110546028  Vac14; protein VAC14 homolog isoform X1 [KO:K15305]
110553347  Ranbp1; ran-specific GTPase-activating protein [KO:K15306]
110550201  ran-specific GTPase-activating protein-like [KO:K15306]
110558426  Mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
110566837  Bub1b; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
110564693  Bub3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
110551399  Anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
110557011  Anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
110545634  Cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
110558702  Anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
110545327  Anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
110551292  Cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
110545320  Anapc7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
110558470  Cdc23; cell division cycle protein 23 homolog [KO:K03355]
110547832  Anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
110548824  Anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
110555570  Cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
110558390  Anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
110556264  anaphase-promoting complex subunit 13-like [KO:K12456]
110557542  Anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
110556831  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 15-like [KO:K25228]
110552292  Anapc16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
110552922  Cdc20; cell division cycle protein 20 homolog [KO:K03363]
110555453  Pttg1; securin [KO:K06635]
110552298  Espl1; separin [KO:K02365] [EC:3.4.22.49]
110560855  Ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
110554385  Cdkn2b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
110554386  cyclin-dependent kinase 4 inhibitor B-like [KO:K06621]
110561245  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110546940  Ccnd1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
110550225  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
110546586  Cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
110559633  Ccna2; cyclin-A2 isoform X1 [KO:K06627]
110554919  Ccna1; cyclin-A1 [KO:K06627]
110545702  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
110561277  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
110559398  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
110553592  Rb1; retinoblastoma-associated protein [KO:K06618]
110554547  E2f1; transcription factor E2F1 isoform X1 [KO:K17454]
110545385  E2f2; transcription factor E2F2 [KO:K09389]
110561800  E2f3; transcription factor E2F3 isoform X3 [KO:K06620]
110549468  Atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
110539931  Atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
110549439  Chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
110553166  Chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
110555127  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
110553683  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110549145  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110563512  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110565112  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110556252  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110548394  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110556719  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110558966  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110564898  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110553298  Dlg1; disks large homolog 1 isoform X8 [KO:K12076]
110561175  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110560136  Tnf; LOW QUALITY PROTEIN: tumor necrosis factor [KO:K03156]
110548604  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
110546648  Map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X3 [KO:K04416] [EC:2.7.11.25]
110552225  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
110552285  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110557386  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110562875  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110559727  Jun; transcription factor Jun [KO:K04448]
110553754  Mmp7; matrilysin [KO:K01397] [EC:3.4.24.23]
110559960  Il1r1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
110561822  Il1r2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
110549118  T-cell surface glycoprotein CD3 delta chain [KO:K06450]
110549111  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
110549119  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
110547048  Map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
110552966  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
110544653  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
110556613  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
110562528  Ikbkg; NF-kappa-B essential modulator isoform X3 [KO:K07210]
110562401  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
110558602  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
110549347  Rela; transcription factor p65 isoform X1 [KO:K04735]
110555114  Gps2; G protein pathway suppressor 2 isoform X1 [KO:K15307]
110548571  Ltbr; tumor necrosis factor receptor superfamily member 3 [KO:K03159]
110549441  Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
110554102  Tnfrsf13c; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
110545661  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
110551541  Relb; transcription factor RelB isoform X2 [KO:K09253]
110556458  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
110564730  Zfp36; mRNA decay activator protein ZFP36 [KO:K15308]
110556899  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
110562738  Il15; interleukin-15 isoform X1 [KO:K05433]
110556898  Il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
110539463  Il6; interleukin-6 [KO:K05405]
110561713  Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
110550083  Bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
110542115  Xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
110561197  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
110549244  Tgfb2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
110558214  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
110551136  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
110547249  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
110550301  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
110557887  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
110550715  Smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
110555169  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110550962  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
110555185  Adcy3; adenylate cyclase type 3 isoform X3 [KO:K08043] [EC:4.6.1.1]
110556521  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
110547229  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
110559444  Adcy6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
110560723  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
110561696  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110545944  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
110545842  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110555016  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110550776  Nfyb; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
110543060  class II histocompatibility antigen, M alpha chain [KO:K06752]
110543088  class II histocompatibility antigen, M beta 1 chain isoform X1 [KO:K06752]
110543117  H-2 class II histocompatibility antigen, E-D beta chain-like isoform X1 [KO:K06752]
110543181  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
110543223  H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752]
110543234  rano class II histocompatibility antigen, B-1 beta chain-like [KO:K06752]
110543301  HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X2 [KO:K06752]
110543331  RLA class II histocompatibility antigen, DP alpha-1 chain isoform X1 [KO:K06752]
110544088  H-2 class II histocompatibility antigen, A-F alpha chain [KO:K06752]
110542965  HLA class II histocompatibility antigen, DO beta chain isoform X2 [KO:K06752]
110543034  H-2 class II histocompatibility antigen, E-U alpha chain-like [KO:K06752]
110550351  Srf; serum response factor isoform X1 [KO:K04378]
110548268  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
110543001  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
110550731  Spi1; transcription factor PU.1 isoform X1 [KO:K09438]
110557309  Ets1; protein C-ets-1 isoform X2 [KO:K02678]
110562473  Ets2; protein C-ets-2 [KO:K21932]
110550423  TATA box-binding protein-like 1 isoform X1 [KO:K03120]
110561127  Tbp; TATA-box-binding protein [KO:K03120]
110563414  Tbpl2; TATA box-binding protein-like 2 [KO:K03120]
110546962  Fos; protein c-Fos [KO:K04379]
110558474  Egr1; LOW QUALITY PROTEIN: early growth response protein 1 [KO:K09203]
110549373  Fosl1; fos-related antigen 1 [KO:K04502]
110547601  Egr2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
110551437  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
110549859  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
110555614  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
110549233  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
110554250  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
110561882  Creb3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
110556579  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
110564629  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110554970  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
110565383  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
110549173  Crtc1; CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
110554243  Crtc2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
110553383  Crtc3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
110554089  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
110545943  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
110550895  Kat2a; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
110560862  Kat2b; histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
110551338  Tcf3; transcription factor E2-alpha isoform X1 [KO:K09063]
110556619  Polb; DNA polymerase beta isoform X1 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
110548547  Lck; tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
110560658  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
110563557  Cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
110545360  Tert; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
110556068  Msx1; homeobox protein MSX-1 [KO:K09341]
110561114  Msx2; homeobox protein MSX-2 [KO:K09341]
110549012  Ventx; homeobox protein VENTX isoform X2 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
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Nat Rev Immunol 4:110-22 (2004)
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HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
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Annu Rev Immunol 19:475-96 (2001)
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Inactivation of hTERT transcription by Tax.
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Related
pathway
mun03013  Nucleocytoplasmic transport
mun04010  MAPK signaling pathway
mun04064  NF-kappa B signaling pathway
mun04110  Cell cycle
mun04115  p53 signaling pathway
mun04151  PI3K-Akt signaling pathway
mun04210  Apoptosis
mun04350  TGF-beta signaling pathway
mun04612  Antigen processing and presentation
mun04660  T cell receptor signaling pathway
mun04668  TNF signaling pathway
KO pathway
ko05166   
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