KEGG   PATHWAY: ncc04340
Entry
ncc04340                    Pathway                                

Name
Hedgehog signaling pathway - Notothenia coriiceps (black rockcod)
Description
The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for transduction of the Hedgehog signal in vertebrates. In Hh's absence, the Ptch receptor localizes to the cilium, where it inhibits Smo activation. Gli proteins are phosphorylated by PKA, CKI and GSK3B and partially degraded into truncated Gli repressor form (GliR) that suppresses Hh target gene transcription in the nucleus. In Hh's presence, Ptch disappears from the cilium, and activated Smo contributes to the translocation of the protein complex Gli, Sufu, Kif7 to ciliary tip, where Gli dissociates from the negative regulator Sufu. The production of Gli activator form (GliA) occurs and the increased nuclear accumulation of GliA results in activation transcription of Hh target genes.
Class
Environmental Information Processing; Signal transduction
Pathway map
ncc04340  Hedgehog signaling pathway
ncc04340

Organism
Notothenia coriiceps (black rockcod) [GN:ncc]
Gene
104961260  protein patched homolog 1-like [KO:K06225]
104943035  protein patched homolog 1-like [KO:K11101]
104956154  smoothened homolog [KO:K06226]
104951950  gpr161; G-protein coupled receptor 161 [KO:K08439]
104960311  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
104956568  cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
104956098  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
104941347  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104967084  casein kinase I isoform gamma-1-like [KO:K08958] [EC:2.7.11.1]
104942790  casein kinase I isoform gamma-2-like [KO:K08958] [EC:2.7.11.1]
104942864  casein kinase I isoform gamma-2 isoform X1 [KO:K08958] [EC:2.7.11.1]
104963492  csnk1d; casein kinase I isoform delta isoform X1 [KO:K08959] [EC:2.7.11.1]
104967472  casein kinase I isoform delta-like [KO:K08959] [EC:2.7.11.1]
104957640  casein kinase I isoform epsilon-like [KO:K08960] [EC:2.7.11.1]
104952807  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
104957933  gli1; zinc finger protein GLI1 [KO:K16797]
104953998  zinc finger protein GLI2-like [KO:K16798]
104960362  gli3; transcriptional activator GLI3 isoform X1 [KO:K06230]
104955159  sufu; suppressor of fused homolog [KO:K06229]
104964887  kif7; kinesin-like protein KIF7 [KO:K18806]
104943157  hhip; hedgehog-interacting protein isoform X1 [KO:K06231]
104967413  G1/S-specific cyclin-D1-like [KO:K04503]
104950786  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
104950090  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
104942288  G1/S-specific cyclin-D2 [KO:K10151]
104954387  G1/S-specific cyclin-D1-like [KO:K10151]
104957668  apoptosis regulator Bcl-2-like [KO:K02161]
104940785  cul1; cullin-1 [KO:K03347]
104953613  F-box/WD repeat-containing protein 11-like [KO:K03362]
104951474  shh; sonic hedgehog protein [KO:K11988]
104963304  indian hedgehog B protein-like [KO:K11989]
104949666  indian hedgehog B protein-like [KO:K11989]
104956876  dhh; desert hedgehog protein [KO:K11990]
104955924  boc; brother of CDO [KO:K20020]
104949592  cell adhesion molecule-related/down-regulated by oncogenes-like [KO:K20033]
104954697  growth arrest-specific protein 1-like [KO:K06232]
104953345  growth arrest-specific protein 1-like [KO:K06232]
104944229  growth arrest-specific protein 1-like [KO:K06232]
104961149  lrp2; low-density lipoprotein receptor-related protein 2 [KO:K06233]
104953591  LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 2-like [KO:K06233]
104947711  uncharacterized protein C16orf52 homolog [KO:K23663]
104958530  uncharacterized protein C16orf52 homolog B-like [KO:K23663]
104953104  mgrn1; E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
104956912  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
104947293  smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
104961960  evc; ellis-van Creveld syndrome protein [KO:K19605]
104961958  evc2; limbin [KO:K19608]
104957279  arrb2; beta-arrestin-2 [KO:K04439]
104966179  cullin-3-like [KO:K03869]
104940878  cullin-3 [KO:K03869]
104946769  spop; speckle-type POZ protein [KO:K10523]
104944418  LOW QUALITY PROTEIN: speckle-type POZ protein-like A [KO:K10523]
Compound
C00575  3',5'-Cyclic AMP
Reference
  Authors
Xavier GM, Seppala M, Barrell W, Birjandi AA, Geoghegan F, Cobourne MT
  Title
Hedgehog receptor function during craniofacial development.
  Journal
Dev Biol 415:198-215 (2016)
DOI:10.1016/j.ydbio.2016.02.009
Reference
  Authors
Briscoe J, Therond PP
  Title
The mechanisms of Hedgehog signalling and its roles in development and disease.
  Journal
Nat Rev Mol Cell Biol 14:416-29 (2013)
DOI:10.1038/nrm3598
Reference
  Authors
Alman BA
  Title
The role of hedgehog signalling in skeletal health and disease.
  Journal
Nat Rev Rheumatol 11:552-60 (2015)
DOI:10.1038/nrrheum.2015.84
Reference
  Authors
Mooney CJ, Hakimjavadi R, Fitzpatrick E, Kennedy E, Walls D, Morrow D, Redmond EM, Cahill PA
  Title
Hedgehog and Resident Vascular Stem Cell Fate.
  Journal
Stem Cells Int 2015:468428 (2015)
DOI:10.1155/2015/468428
Reference
  Authors
Sasai N, Briscoe J
  Title
Primary cilia and graded Sonic Hedgehog signaling.
  Journal
Wiley Interdiscip Rev Dev Biol 1:753-72 (2012)
DOI:10.1002/wdev.43
Reference
  Authors
Heretsch P, Tzagkaroulaki L, Giannis A
  Title
Modulators of the hedgehog signaling pathway.
  Journal
Bioorg Med Chem 18:6613-24 (2010)
DOI:10.1016/j.bmc.2010.07.038
Reference
  Authors
Anderson E, Peluso S, Lettice LA, Hill RE
  Title
Human limb abnormalities caused by disruption of hedgehog signaling.
  Journal
Trends Genet 28:364-73 (2012)
DOI:10.1016/j.tig.2012.03.012
Reference
  Authors
Rohatgi R, Scott MP
  Title
Cell biology. Arrestin' movement in cilia.
  Journal
Science 320:1726-7 (2008)
DOI:10.1126/science.1160448
Reference
  Authors
Yue S, Tang LY, Tang Y, Tang Y, Shen QH, Ding J, Chen Y, Zhang Z, Yu TT, Zhang YE, Cheng SY
  Title
Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.
  Journal
Elife 3:e02555 (2014)
DOI:10.7554/eLife.02555
Reference
  Authors
Ok CY, Singh RR, Vega F
  Title
Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms.
  Journal
Am J Pathol 180:2-11 (2012)
DOI:10.1016/j.ajpath.2011.09.009
Reference
  Authors
Hsia EY, Gui Y, Zheng X
  Title
Regulation of Hedgehog signaling by ubiquitination.
  Journal
Front Biol (Beijing) 10:203-220 (2015)
DOI:10.1007/s11515-015-1343-5
Reference
  Authors
Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R
  Title
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
  Journal
Dev Cell 44:113-129.e8 (2018)
DOI:10.1016/j.devcel.2017.12.003
Related
pathway
ncc04120  Ubiquitin mediated proteolysis
KO pathway
ko04340   
LinkDB

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