KEGG   PATHWAY: ngi04630
ngi04630                    Pathway                                

JAK-STAT signaling pathway - Nannospalax galili (Upper Galilee mountains blind mole rat)
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Environmental Information Processing; Signal transduction
Pathway map
ngi04630  JAK-STAT signaling pathway

Other DBs
GO: 0007259
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
103746951  Il2; interleukin 2 [KO:K05429]
103747047  Il4; interleukin 4 [KO:K05430]
103747045  Il5; interleukin 5 [KO:K05428]
103740849  Il6; interleukin 6 [KO:K05405]
103727963  Il7; interleukin 7 [KO:K05431]
103746598  Il9; interleukin 9 [KO:K05432]
103725974  Il10; interleukin 10 [KO:K05443]
103744811  Il11; interleukin 11 [KO:K05417]
103745345  Il12a; interleukin 12A [KO:K05406]
103724546  Il12b; interleukin 12B [KO:K05425]
103747046  Il13; interleukin 13 [KO:K05435]
103742384  Il15; interleukin 15 [KO:K05433]
103726719  Il17d; interleukin 17D [KO:K05492]
103725972  Il19; interleukin 19 [KO:K05444]
103725971  Il20; interleukin 20 [KO:K22667]
103746950  Il21; interleukin 21 [KO:K05434]
103745073  Il22; interleukin 22 [KO:K05445]
103746524  Il23a; interleukin 23 subunit alpha [KO:K05426]
103725970  Il24; interleukin 24 [KO:K22668]
103736148  interferon alpha-12-like [KO:K05414]
103746654  interferon alpha-1-like [KO:K05414]
103746653  interferon alpha-12-like [KO:K05414]
103731654  interferon alpha-13-like [KO:K05414]
103732546  interferon alpha-13-like [KO:K05414]
103743951  Ifnb1; interferon beta 1 [KO:K05415]
103746144  interferon beta-like [KO:K05415]
103745085  Ifng; interferon gamma [KO:K04687]
103730661  Ifne; interferon epsilon [KO:K05442]
103730705  Ifnk; interferon kappa [KO:K05441]
103750791  Ifnl1; interferon lambda-1 [KO:K05447]
103750789  interferon lambda-2-like [KO:K22669]
103750790  interferon lambda-2-like [KO:K22669]
103734248  interferon omega-1-like [KO:K05440]
103740483  Osm; oncostatin M [KO:K05418]
103740454  Lif; leukemia inhibitory factor [KO:K05419]
103752298  Tslp; thymic stromal lymphopoietin [KO:K05436]
103726340  Ctf1; cardiotrophin-1 [KO:K05422]
103726417  cardiotrophin-2 [KO:K24382]
103747042  Csf2; colony stimulating factor 2 [KO:K05427]
103733344  Cntf; ciliary neurotrophic factor [KO:K05420]
103731111  Csf3; colony stimulating factor 3 [KO:K05423]
103733506  Epo; erythropoietin [KO:K05437]
103744748  somatotropin [KO:K05438]
103744567  Lep; leptin [KO:K05424]
103732660  Thpo; thrombopoietin [KO:K06854]
103732939  prolactin-3B1-like [KO:K05439]
103739989  prolactin-8A9-like [KO:K05439]
103739991  prolactin-like [KO:K05439]
103739983  prolactin-like [KO:K05439]
108491197  prolactin-like [KO:K05439]
103739985  prolactin-7B1-like [KO:K05439]
103739984  prolactin-7C1-like [KO:K05439]
108491199  prolactin-3B1-like [KO:K05439]
103739988  prolactin-7B1-like [KO:K05439]
108491200  prolactin-3D4-like [KO:K05439]
103739987  prolactin-7C1-like [KO:K05439]
103751156  prolactin-3B1-like [KO:K05439]
108490016  prolactin-3B1-like [KO:K05439]
103751328  prolactin [KO:K05439]
103728738  prolactin-like [KO:K05439]
103728740  prolactin-5A1-like [KO:K05439]
103728741  prolactin-5A1-like [KO:K05439]
103728734  prolactin-2A1-like [KO:K05439]
103728735  prolactin-like [KO:K05439]
103728739  prolactin-2A1-like [KO:K05439]
103742642  Egf; epidermal growth factor [KO:K04357]
103748699  Pdgfa; platelet derived growth factor subunit A [KO:K04359]
103748570  Pdgfb; platelet derived growth factor subunit B [KO:K17386]
103727306  Il2ra; interleukin 2 receptor subunit alpha [KO:K05068]
103748643  Il2rb; interleukin 2 receptor subunit beta [KO:K05069]
103751955  Il2rg; interleukin 2 receptor subunit gamma [KO:K05070]
103750125  Il3ra; interleukin 3 receptor subunit alpha [KO:K04737]
103741011  Il4r; interleukin 4 receptor [KO:K05071]
103751211  Il5ra; interleukin 5 receptor subunit alpha [KO:K05067]
103751364  Il6r; interleukin 6 receptor [KO:K05055]
103741311  Il7r; interleukin 7 receptor [KO:K05072]
103748240  Il9r; interleukin-9 receptor [KO:K05073]
103748335  Il10ra; interleukin 10 receptor subunit alpha [KO:K05134]
103736456  Il10rb; interleukin 10 receptor subunit beta [KO:K05135]
103741561  Il11ra; interleukin 11 receptor subunit alpha [KO:K05056]
103726945  Il12rb1; interleukin 12 receptor subunit beta 1 [KO:K05063]
103743352  Il12rb2; interleukin 12 receptor subunit beta 2 [KO:K05064]
103743079  Il13ra1; interleukin 13 receptor subunit alpha 1 [KO:K05076]
103740877  Il13ra2; interleukin 13 receptor subunit alpha 2 [KO:K05077]
103727307  Il15ra; interleukin 15 receptor subunit alpha [KO:K05074]
108490034  interleukin-15 receptor subunit alpha-like [KO:K05074]
103724898  Il20ra; interleukin 20 receptor subunit alpha [KO:K05136]
103740975  Il20rb; interleukin 20 receptor subunit beta [KO:K05137]
103741072  Il21r; interleukin 21 receptor [KO:K05075]
103746427  Il22ra1; interleukin 22 receptor subunit alpha 1 [KO:K05138]
103724897  Il22ra2; interleukin 22 receptor subunit alpha 2 [KO:K05139]
103743351  Il23r; interleukin 23 receptor [KO:K05065]
103751909  Il27ra; interleukin 27 receptor subunit alpha [KO:K19598]
103739911  Il6st; interleukin 6 signal transducer [KO:K05060]
103736454  interferon alpha/beta receptor 1-like [KO:K05130]
103736458  Ifnar2; interferon alpha and beta receptor subunit 2 [KO:K05131]
103724895  Ifngr1; interferon gamma receptor 1 [KO:K05132]
103736453  Ifngr2; interferon gamma receptor 2 [KO:K05133]
103746428  Ifnlr1; interferon lambda receptor 1 [KO:K05140]
103741367  Osmr; oncostatin M receptor [KO:K05057]
103741330  Lifr; leukemia inhibitory factor receptor alpha [KO:K05058]
103750124  Crlf2; cytokine receptor-like factor 2 [KO:K05078]
103741568  Cntfr; ciliary neurotrophic factor receptor [KO:K05059]
103750113  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
103748646  cytokine receptor common subunit beta-like [KO:K04738]
103748645  interleukin-3 receptor class 2 subunit beta-like [KO:K04738]
103733325  Csf3r; colony stimulating factor 3 receptor [KO:K05061]
103734578  Epor; erythropoietin receptor [KO:K05079]
103741346  Ghr; growth hormone receptor [KO:K05080]
103732502  Lepr; leptin receptor [KO:K05062]
103743852  Mpl; MPL proto-oncogene, thrombopoietin receptor [KO:K05082]
103735901  Prlr; prolactin receptor [KO:K05081]
103748852  epidermal growth factor receptor [KO:K04361] [EC:]
103734393  Pdgfra; platelet derived growth factor receptor alpha [KO:K04363] [EC:]
103747076  Pdgfrb; platelet derived growth factor receptor beta [KO:K05089] [EC:]
103732475  Jak1; Janus kinase 1 [KO:K11217] [EC:]
103740979  Jak2; Janus kinase 2 [KO:K04447] [EC:]
103726892  Jak3; Janus kinase 3 [KO:K11218] [EC:]
103747562  Tyk2; tyrosine kinase 2 [KO:K11219] [EC:]
103736156  Stat1; signal transducer and activator of transcription 1 [KO:K11220]
103746519  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
103735896  Stat3; signal transducer and activator of transcription 3 [KO:K04692]
103736155  Stat4; signal transducer and activator of transcription 4 [KO:K11222]
103735895  Stat5a; signal transducer and activator of transcription 5A [KO:K11223]
103735893  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
103742927  Stat6; signal transducer and activator of transcription 6 [KO:K11225]
103750144  Cish; cytokine inducible SH2 containing protein [KO:K04701]
103731577  Socs1; suppressor of cytokine signaling 1 [KO:K04694]
103726290  Socs2; suppressor of cytokine signaling 2 [KO:K04695]
103747288  Socs3; suppressor of cytokine signaling 3 [KO:K04696]
103739222  Socs4; suppressor of cytokine signaling 4 [KO:K04697]
103725749  Socs5; suppressor of cytokine signaling 5 [KO:K04698]
103743791  Socs7; suppressor of cytokine signaling 7 [KO:K04699]
103727130  Socs6; suppressor of cytokine signaling 6 [KO:K04699]
103740099  Bcl2; BCL2, apoptosis regulator [KO:K02161]
103729108  Mcl1; BCL2 family apoptosis regulator [KO:K02539]
103731080  Bcl2l1; BCL2 like 1 [KO:K04570]
103739645  Pim1; Pim-1 proto-oncogene, serine/threonine kinase [KO:K04702] [EC:]
103743920  Myc; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
103751498  Ccnd1; cyclin D1 [KO:K04503]
103727547  Ccnd2; cyclin D2 [KO:K10151]
103725891  Ccnd3; cyclin D3 [KO:K10152]
103739652  Cdkn1a; cyclin dependent kinase inhibitor 1A [KO:K06625]
103734495  aldehyde oxidase 2 [KO:K00157] [EC:]
103734373  aldehyde oxidase 4 [KO:K00157] [EC:]
103734384  aldehyde oxidase 3-like [KO:K00157] [EC:]
103734392  Aox1; aldehyde oxidase 1 [KO:K00157] [EC:]
103738305  Gfap; glial fibrillary acidic protein [KO:K05640]
103738121  Stam2; signal transducing adaptor molecule 2 [KO:K04705]
103726508  Stam; signal transducing adaptor molecule [KO:K04705]
103727492  Ptpn6; protein tyrosine phosphatase, non-receptor type 6 [KO:K05697] [EC:]
103739430  Irf9; interferon regulatory factor 9 [KO:K04693]
103743486  Ep300; E1A binding protein p300 [KO:K04498] [EC:]
103744441  Crebbp; CREB binding protein [KO:K04498] [EC:]
103736908  Pias1; protein inhibitor of activated STAT 1 [KO:K04706] [EC:2.3.2.-]
103727841  Pias2; protein inhibitor of activated STAT 2 [KO:K16063] [EC:2.3.2.-]
103729508  Pias3; protein inhibitor of activated STAT 3 [KO:K16064] [EC:2.3.2.-]
103737273  Pias4; protein inhibitor of activated STAT 4 [KO:K16065] [EC:]
103740143  Fhl1; four and a half LIM domains 1 [KO:K14365]
103745559  Ptpn11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:]
103732729  Grb2; growth factor receptor bound protein 2 [KO:K04364]
103743944  Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
103731514  Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
103751075  Hras; HRas proto-oncogene, GTPase [KO:K02833]
103751450  Raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:]
103738596  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:]
103733121  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:]
103742946  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:]
103738715  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103726879  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103730305  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103746884  Akt3; AKT serine/threonine kinase 3 [KO:K04456] [EC:]
103750757  Akt2; AKT serine/threonine kinase 2 [KO:K04456] [EC:]
103752536  Akt1; AKT serine/threonine kinase 1 [KO:K04456] [EC:]
103732897  Mtor; mechanistic target of rapamycin [KO:K07203] [EC:]
Harrison DA
The Jak/STAT pathway.
Cold Spring Harb Perspect Biol 4:a011205 (2012)
Kiu H, Nicholson SE
Biology and significance of the JAK/STAT signalling pathways.
Growth Factors 30:88-106 (2012)
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Direct effects of type I interferons on cells of the immune system.
Clin Cancer Res 17:2619-27 (2011)
Fish EN, Platanias LC
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Mol Cancer Res 12:1691-703 (2014)
Ivanenkov YA, Balakin KV, Lavrovsky Y
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Mini Rev Med Chem 11:55-78 (2011)
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Annu Rev Med 66:311-28 (2015)
Zoranovic T, Grmai L, Bach EA
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
JAKSTAT 2:e25408 (2013)
Ungureanu D, Silvennoinen O
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Sci STKE 2005:pe49 (2005)
Richard AJ, Stephens JM
The role of JAK-STAT signaling in adipose tissue function.
Biochim Biophys Acta 1842:431-9 (2014)
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Neuropathol Appl Neurobiol 41:347-70 (2015)
Hirano T, Ishihara K, Hibi M
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Oncogene 19:2548-56 (2000)
Rane SG, Reddy EP
Janus kinases: components of multiple signaling pathways.
Oncogene 19:5662-79 (2000)
Heim MH
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Eur J Clin Invest 26:1-12 (1996)
ngi04010  MAPK signaling pathway
ngi04060  Cytokine-cytokine receptor interaction
ngi04110  Cell cycle
ngi04120  Ubiquitin mediated proteolysis
ngi04151  PI3K-Akt signaling pathway
ngi04210  Apoptosis
KO pathway

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