KEGG   PATHWAY: nle05205
Entry
nle05205                    Pathway                                
Name
Proteoglycans in cancer - Nomascus leucogenys (northern white-cheeked gibbon)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
nle05205  Proteoglycans in cancer
nle05205

Organism
Nomascus leucogenys (northern white-cheeked gibbon) [GN:nle]
Gene
100587652  CD44; CD44 antigen isoform X3 [KO:K06256]
100602214  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100600009  CTTN; src substrate cortactin isoform X1 [KO:K06106]
100598393  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
100601700  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100588468  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100599935  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
100600253  VAV1; proto-oncogene vav [KO:K05730]
100582219  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100595274  HRAS; GTPase HRas isoform X1 [KO:K02833]
100593773  KRAS; GTPase KRas isoform X1 [KO:K07827]
100592103  NRAS; GTPase NRas [KO:K07828]
100602757  RRAS; ras-related protein R-Ras [KO:K07829]
100604922  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
100581488  MRAS; ras-related protein M-Ras [KO:K07831]
100582848  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100582599  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100595311  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100579506  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100591827  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100600574  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100584480  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100604516  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100596536  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
100605245  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100596002  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100580202  ESR1; estrogen receptor isoform X2 [KO:K08550]
100605736  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100598167  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100598411  ACTB; actin, cytoplasmic 1 [KO:K05692]
100597513  FLNA; filamin-A isoform X1 [KO:K04437]
100588769  PAK1; serine/threonine-protein kinase PAK 1 isoform X2 [KO:K04409] [EC:2.7.11.1]
100605316  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100581841  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
100607291  RHOA; transforming protein RhoA [KO:K04513]
100586590  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100585294  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
100604126  ANK1; ankyrin-1 isoform X1 [KO:K10380]
100582056  ANK2; ankyrin-2 isoform X8 [KO:K09255]
100586449  ANK3; LOW QUALITY PROTEIN: ankyrin-3 [KO:K09259]
100600534  GAB1; GRB2-associated-binding protein 1 isoform X4 [KO:K09593]
100588218  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100580872  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100584384  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100605788  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100591270  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100599301  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100604331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100587864  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100587109  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100581293  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
100603005  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100605408  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
100587142  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100602476  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100592313  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
100596166  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
100602658  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X4 [KO:K07532]
100599747  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4 [KO:K05860] [EC:3.1.4.11]
100587159  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100599135  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
100585914  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100597007  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100600165  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100591995  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100580290  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X30 [KO:K04515] [EC:2.7.11.17]
100606707  NANOG; homeobox protein NANOG isoform X1 [KO:K10164]
100603290  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:3.6.4.13]
100591249  DROSHA; ribonuclease 3 isoform X1 [KO:K03685] [EC:3.1.26.3]
100598877  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100598644  TWIST2; twist-related protein 2 [KO:K09069]
100588413  TWIST1; twist-related protein 1 [KO:K09069]
100586307  HOXD10; homeobox protein Hox-D10 [KO:K09295]
100594075  DCN; decorin [KO:K04660]
100595306  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
100593288  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100594291  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100593010  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
115831277  LOW QUALITY PROTEIN: putative 3-phosphoinositide-dependent protein kinase 2 [KO:K06276] [EC:2.7.11.1]
100606492  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100593862  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100591782  EIF4B; eukaryotic translation initiation factor 4B isoform X2 [KO:K03258]
100601574  RPS6; 40S ribosomal protein S6 [KO:K02991]
100600765  40S ribosomal protein S6-like [KO:K02991]
100597255  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100595808  CAV1; caveolin-1 [KO:K06278]
100596151  CAV2; caveolin-2 isoform X1 [KO:K12958]
100591755  CAV3; caveolin-3 [KO:K12959]
100598143  CD63; CD63 antigen [KO:K06497]
100599083  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100585064  CASP3; caspase-3 isoform X3 [KO:K02187] [EC:3.4.22.56]
100581386  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
100604724  TLR2; toll-like receptor 2 [KO:K10159]
100601154  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
100584426  PDCD4; programmed cell death protein 4 [KO:K16865]
100583968  TNF; tumor necrosis factor [KO:K03156]
100579267  interleukin-12 subunit beta [KO:K05425]
115837257  interleukin-12 subunit beta-like [KO:K05425]
100590102  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100598496  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100589322  MYC; myc proto-oncogene protein [KO:K04377]
100583002  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100588621  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
100597662  TFAP4; transcription factor AP-4 isoform X1 [KO:K09108]
100601396  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100604569  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100597172  MET; hepatocyte growth factor receptor isoform X3 [KO:K05099] [EC:2.7.10.1]
100607272  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
100594545  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
100603886  THBS1; thrombospondin-1 [KO:K16857]
100597186  MMP2; 72 kDa type IV collagenase isoform X1 [KO:K01398] [EC:3.4.24.24]
100587873  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
100595797  LUM; lumican [KO:K08122]
100597719  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100580318  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100601465  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
100583326  TP53; cellular tumor antigen p53 [KO:K04451]
100596183  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
100589735  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100596185  HPSE; heparanase isoform X1 [KO:K07964] [EC:3.2.1.166]
100595775  HPSE2; inactive heparanase-2 isoform X1 [KO:K07965] [EC:3.2.1.-]
100604383  SDC1; syndecan-1 [KO:K06257]
100581844  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
100581691  PLAUR; urokinase plasminogen activator surface receptor isoform X1 [KO:K03985]
100604090  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100595865  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100588661  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
100595108  ITGB1; integrin beta-1 [KO:K05719]
100592274  VTN; vitronectin [KO:K06251]
100604485  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100593791  ITGB3; integrin beta-3 [KO:K06493]
100601303  FN1; fibronectin isoform X2 [KO:K05717]
100592156  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
100586296  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100587307  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100597685  FZD7; frizzled-7 [KO:K02432]
100605346  FZD1; frizzled-1 [KO:K02432]
100580071  FZD2; frizzled-2 [KO:K02235]
100589994  FZD3; frizzled-3 [KO:K02329]
100588311  FZD4; frizzled-4 [KO:K02354]
100589091  FZD5; frizzled-5 [KO:K02375]
100593717  FZD8; frizzled-8 [KO:K02375]
100603705  FZD6; frizzled-6 [KO:K02376]
100607762  FZD10; frizzled-10 [KO:K02842]
100592375  FZD9; frizzled-9 [KO:K02842]
100606925  ITGA5; integrin alpha-5 [KO:K06484]
100606458  SDC2; syndecan-2 [KO:K16336]
100581958  EZR; ezrin isoform X1 [KO:K08007]
100601297  RDX; radixin isoform X2 [KO:K05762]
100601428  MSN; moesin [KO:K05763]
100602319  SDC4; syndecan-4 isoform X2 [KO:K16338]
100593123  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
100602423  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100600345  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
100602671  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100605369  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
100590165  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100600495  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
100591458  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100604145  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100591651  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100590939  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100601464  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105737838  NUDT16L1; tudor-interacting repair regulator protein isoform X1 [KO:K16867]
100587836  PXN; paxillin isoform X1 [KO:K05760]
100600047  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
100582128  GPC1; glypican-1 [KO:K08107]
100585821  IGF2; insulin-like growth factor II isoform X2 [KO:K13769]
100591673  GPC3; glypican-3 isoform X1 [KO:K08109]
100607954  WNT2B; protein Wnt-2b isoform X2 [KO:K00182]
100600353  WNT2; protein Wnt-2 [KO:K00182]
100606846  WNT3A; protein Wnt-3a isoform X2 [KO:K00312]
100599381  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100604353  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
100602014  WNT5A; protein Wnt-5a [KO:K00444]
100596686  WNT5B; protein Wnt-5b [KO:K00444]
100606818  WNT6; protein Wnt-6 [KO:K00445]
100579580  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
100593900  WNT7A; protein Wnt-7a [KO:K00572]
100586052  WNT8A; protein Wnt-8a isoform X2 [KO:K00714]
100603238  WNT8B; protein Wnt-8b [KO:K00714]
100606502  WNT9A; protein Wnt-9a [KO:K01064]
100602760  WNT9B; protein Wnt-9b isoform X1 [KO:K01064]
100607164  WNT10A; protein Wnt-10a [KO:K01357]
100587640  WNT10B; protein Wnt-10b [KO:K01357]
100594864  WNT11; protein Wnt-11 [KO:K01384]
100605294  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
100582247  SHH; sonic hedgehog protein isoform X1 [KO:K11988]
100580536  IHH; indian hedgehog protein [KO:K11989]
100581789  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
100585701  SMO; smoothened homolog isoform X1 [KO:K06226]
100603335  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
100604414  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
100583577  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X8 [KO:K04345] [EC:2.7.11.11]
100579779  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100607741  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100595369  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
100600225  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100580599  MAPK11; mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
100580531  HSPB2; heat shock protein beta-2 [KO:K09543]
100599057  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
nle04010  MAPK signaling pathway
nle04020  Calcium signaling pathway
nle04066  HIF-1 signaling pathway
nle04150  mTOR signaling pathway
nle04151  PI3K-Akt signaling pathway
nle04210  Apoptosis
nle04310  Wnt signaling pathway
nle04340  Hedgehog signaling pathway
nle04350  TGF-beta signaling pathway
nle04370  VEGF signaling pathway
nle04510  Focal adhesion
nle04520  Adherens junction
nle04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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