KEGG   PATHWAY: oaa05206
Entry
oaa05206                    Pathway                                
Name
MicroRNAs in cancer - Ornithorhynchus anatinus (platypus)
Description
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Class
Human Diseases; Cancer: overview
Pathway map
oaa05206  MicroRNAs in cancer
oaa05206

Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100314595  MIR17; oan-miR-17 [KO:K17002]
100314550  MIR19A; oan-miR-19a-5p [KO:K17005]
100314688  MIR19B-1; oan-miR-19b-1-5p [KO:K23559]
104796910  MIR19B-2; oan-miR-19b-2-5p [KO:K23559]
100314636  MIR20A-1; oan-miR-20a-5p [KO:K17006]
100314731  MIR20A-2; oan-miR-20a-5p [KO:K17006]
100314671  MIR92A-2; oan-miR-92a-2-5p [KO:K17008]
100314653  MIR92A-1; oan-miR-92a-1-5p [KO:K17008]
100074365  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100314635  MIR221; oan-miR-221-5p [KO:K17010]
100314670  MIR222A; oan-miR-222a-5p [KO:K17011]
100090228  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100314554  MIR21; oan-miR-21-5p [KO:K16863]
103170776  TIMP3; metalloproteinase inhibitor 3 isoform X1 [KO:K16866]
100314596  MIRLET7F-1; oan-let-7f-5p [KO:K16980]
100314620  MIRLET7B; oan-let-7b-5p [KO:K16980]
100314561  MIRLET7F-2; oan-let-7f-5p [KO:K16980]
100314581  MIRLET7D; oan-let-7d-5p [KO:K16980]
100314720  MIRLET7G; oan-let-7g-5p [KO:K16980]
100314497  MIRLET7E; oan-let-7e-5p [KO:K16980]
104794699  MIRLET7C-1; oan-let-7c-5p [KO:K17397]
100085430  KRAS; GTPase KRas isoform X1 [KO:K07827]
100091822  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100085311  CDC25A; M-phase inducer phosphatase 1 isoform X2 [KO:K06645] [EC:3.1.3.48]
100075940  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
114816405  HMGA2; high mobility group protein HMGI-C [KO:K09283]
114807400  high mobility group protein HMGI-C-like [KO:K09283]
100314556  MIR15A; oan-miR-15a-5p [KO:K16986]
100314520  MIR15B; oan-miR-15b-5p [KO:K16987]
100314454  MIR15C; oan-miR-15c-5p [KO:K16987]
100314521  MIR16B; oan-miR-16b-5p [KO:K16988]
100314698  MIR16C; oan-miR-16c-5p [KO:K16988]
100314734  MIR16A; oan-miR-16a-5p [KO:K16988]
100075081  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100088940  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100075784  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
100087197  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100314543  MIR126; oan-miR-126-5p [KO:K16978]
100092854  CRK; adapter molecule crk isoform X1 [KO:K04438]
100076081  CRKL; crk-like protein [KO:K04438]
100314459  MIR1A; oan-miR-1a-5p [KO:K16972]
100314732  MIR1B; oan-miR-1b [KO:K16972]
100080036  HDAC4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
100087869  HDAC5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
100078237  FOXP1; forkhead box protein P1 isoform X1 [KO:K23582]
100082122  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
100079345  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100314442  MIR29A-1; oan-miR-29a-1-5p [KO:K16995]
100314651  MIR29B-1; oan-miR-29b-5p [KO:K16996]
100314611  MIR29B-2; oan-miR-29b-3p [KO:K16996]
100314618  MIR29A-2; oan-miR-29a-2-5p [KO:K16997]
100077964  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
100089985  DNMT3B; DNA (cytosine-5)-methyltransferase 3B isoform X1 [KO:K17399] [EC:2.1.1.37]
100314551  MIR133C; oan-miR-133c [KO:K16970]
100314460  MIR133A-1; oan-miR-133a-5p [KO:K16970]
104794695  MIR133A-2; oan-miR-133a-5p [KO:K16970]
100314759  MIR133B; oan-miR-133b-5p [KO:K16971]
114807992  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
100075894  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100077009  VEGFA; vascular endothelial growth factor A [KO:K05448]
100076732  ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
100080176  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
100314441  MIR183; oan-miR-183 [KO:K17116]
100090068  EZR; ezrin [KO:K08007]
100314691  MIR125; oan-miR-125-5p [KO:K16994]
100080517  PDCD4; programmed cell death protein 4 [KO:K16865]
100314549  MIR143; oan-miR-143-5p [KO:K17023]
100314662  MIR192; oan-miR-192-5p [KO:K17131]
100314508  MIR194-2; oan-miR-194-5p [KO:K17371]
100314715  MIR194-1; oan-miR-194 [KO:K17371]
100080510  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100076960  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
100314502  MIR215; oan-miR-215-5p [KO:K17167]
100314569  MIR30E; oan-miR-30e-5p [KO:K17110]
100314517  MIR30D; oan-miR-30d-5p [KO:K17110]
100314475  MIR30A; oan-miR-30a-5p [KO:K17110]
100314518  MIR30B; oan-miR-30b-5p [KO:K17111]
100314474  MIR30C-2; oan-miR-30c-5p [KO:K17040]
104794724  MIR30C-1; oan-miR-30c-5p [KO:K17040]
100080319  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
100079640  SPRY2; protein sprouty homolog 2 [KO:K17383]
114807635  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100090328  SERPINB5; serpin B5 [KO:K10139]
100314498  MIR155; oan-miR-155-5p [KO:K17009]
100314700  MIR205; oan-miR-205-5p [KO:K17150]
100314490  MIR27B; oan-miR-27b-5p [KO:K17113]
100075025  ST14; suppressor of tumorigenicity 14 protein isoform X1 [KO:K08670] [EC:3.4.21.109]
100079784  CYP1B1; cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
100314539  MIR31; oan-miR-31-5p [KO:K17183]
100314674  MIR99; oan-miR-99-5p [KO:K17367]
100314721  MIR100; oan-miR-100-5p [KO:K17041]
100079751  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100090165  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
100078505  1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [KO:K07436] [EC:1.14.15.16]
100091139  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100079793  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100075676  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
100081838  TP63; tumor protein 63 isoform X7 [KO:K10149]
100085918  ZEB2; zinc finger E-box-binding homeobox 2 isoform X1 [KO:K23560]
100081685  FSCN1; fascin [KO:K23551]
100078239  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
100314574  MIR10B; oan-miR-10b-5p [KO:K17393]
100084660  HOXD10; homeobox protein Hox-D10 [KO:K09295]
100084473  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
114816134  BMF; bcl-2-modifying factor [KO:K17460]
103169124  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
100314699  MIR363; oan-miR-363-5p [KO:K17036]
100314755  MIR96; oan-miR-96-5p [KO:K17114]
100314542  MIR10A; oan-miR-10a-5p [KO:K16864]
100314491  MIR23B; oan-miR-23b-5p [KO:K17394]
100314769  MIR122; oan-miR-122-5p [KO:K17020]
100086267  SLC7A1; high affinity cationic amino acid transporter 1 [KO:K13863]
100073573  CCNG1; cyclin-G1 isoform X1 [KO:K10145]
107547784  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
100314725  MIR150; oan-miR-150-5p [KO:K17024]
100083723  STMN1; stathmin [KO:K04381]
100087932  STAT3; signal transducer and activator of transcription 3 isoform X2 [KO:K04692]
100079391  MYC; myc proto-oncogene protein [KO:K04377]
100087105  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
114809992  HRAS; GTPase HRas [KO:K02833]
100074671  NRAS; GTPase NRas [KO:K07828]
100314499  MIR26-1; oan-miR-26-5p [KO:K16984]
100087896  DNMT1; DNA (cytosine-5)-methyltransferase 1 isoform X1 [KO:K00558] [EC:2.1.1.37]
100314462  MIR135B-1; oan-miR-135b-5p [KO:K17144]
104796905  MIR135B-2; oan-miR-135b-5p [KO:K17144]
100082114  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100682203  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
103170729  IRS1; insulin receptor substrate 1 [KO:K16172]
100080187  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100082075  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
103167126  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100088657  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
100086270  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100073788  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100074273  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100314623  MIR200A; oan-miR-200a-5p [KO:K17015]
100314483  MIR200B; oan-miR-200b-5p [KO:K17016]
100075003  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X4 [KO:K12886]
100092383  RECK; reversion-inducing cysteine-rich protein with Kazal motifs [KO:K17461]
100314762  MIR124A-1; oan-miR-124a-5p [KO:K17126]
100314464  MIR137B; oan-miR-137b-5p [KO:K17369]
100314652  MIR137A; oan-miR-137a-5p [KO:K17369]
100090475  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
100314626  MIR7-2; oan-miR-7-5p [KO:K17365]
100314643  MIR7-1; oan-miR-7-5p [KO:K17365]
114805830  IRS2; insulin receptor substrate 2 [KO:K07187]
100092718  NOTCH1; neurogenic locus notch homolog protein 1 isoform X2 [KO:K02599]
100081510  NOTCH2; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 2 [KO:K20994]
103167042  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
100075752  polycomb complex protein BMI-1 [KO:K11459]
100314742  MIR146A; oan-miR-146a-5p [KO:K17012]
100075102  MMP16; matrix metalloproteinase-16 [KO:K07996] [EC:3.4.24.-]
100314451  MIR181A-1; oan-miR-181a-5p [KO:K17025]
104796906  MIR181A-2; oan-miR-181a-5p [KO:K17025]
104796406  MIR181A-3; oan-miR-181a-5p [KO:K17025]
100314697  MIR181B-1; oan-miR-181b-5p [KO:K17026]
104794708  MIR181B-2; oan-miR-181b-5p [KO:K17026]
100078971  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
114809105  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
114816636  suppressor of cytokine signaling 1-like [KO:K04694]
100076581  CD44; CD44 antigen isoform X1 [KO:K06256]
100314580  MIR103-1; oan-miR-103-1-5p [KO:K16989]
100314669  MIR107; oan-miR-107-5p [KO:K16989]
100314771  MIR103-2; oan-miR-103-2-5p [KO:K16989]
100079488  DICER1; endoribonuclease Dicer [KO:K11592] [EC:3.1.26.-]
100086058  FZD3; frizzled-3 [KO:K02329]
100090507  ITGA5; integrin alpha-5 [KO:K06484]
100076248  RDX; radixin isoform X1 [KO:K05762]
100073519  RHOA; transforming protein RhoA isoform X2 [KO:K04513]
100079193  transforming protein RhoA-like [KO:K04513]
100314446  MIR193; oan-miR-193-5p [KO:K17148]
100079618  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
114813317  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
100074975  ZFPM2; zinc finger protein ZFPM2 isoform X1 [KO:K17442]
100087119  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100084112  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
100083748  SOX4; transcription factor SOX-4 [KO:K23581]
100084981  TNR; tenascin-R [KO:K06252]
100084954  TNN; tenascin-N isoform X1 [KO:K06252]
100076692  TNC; tenascin isoform X1 [KO:K06252]
100089817  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
100314500  MIR206; oan-miR-206-5p [KO:K16973]
100314471  MIR451; oan-miR-451 [KO:K17172]
100077826  ABCB1; ATP-dependent translocase ABCB1 [KO:K05658] [EC:7.6.2.2]
100087202  ABCC1; multidrug resistance-associated protein 1 isoform X1 [KO:K05665] [EC:7.6.2.3]
100314557  MIR214; oan-miR-214-5p [KO:K17151]
103167900  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
114813305  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100085755  EFNA1; ephrin-A1 [KO:K05462]
100082899  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100085461  EFNA2; ephrin-A2 [KO:K05462]
100086594  ADAM15; disintegrin and metalloproteinase domain-containing protein 15 [KO:K05462]
114807932  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
100092988  THBS1; thrombospondin-1 [KO:K16857]
100088865  IGF2BP1; insulin-like growth factor 2 mRNA-binding protein 1 isoform X2 [KO:K17391]
100078047  TRIM71; E3 ubiquitin-protein ligase TRIM71 [KO:K12035] [EC:2.3.2.27]
100314538  MIR34A; oan-miR-34a-5p [KO:K16983]
104794715  MIR34B; oan-miR-34b-5p [KO:K16983]
100314612  MIR9-2; oan-miR-9-5p [KO:K16977]
100314437  MIR9-1; oan-miR-9-5p [KO:K16977]
100083819  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100314638  MIR199; oan-miR-199-5p [KO:K17118]
100078925  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100086096  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100085480  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100086487  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100079107  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100074181  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100085442  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100075806  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100084071  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100075221  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
100092821  TP53; cellular tumor antigen p53 [KO:K04451]
100080712  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
100075524  MDM4; protein Mdm4 isoform X1 [KO:K10127]
100084432  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100078757  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100076776  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100314506  MIR101-1; oan-miR-101 [KO:K17129]
100314746  MIR101-2; oan-miR-101 [KO:K17129]
100089456  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100080362  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100087942  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100084645  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100078989  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
114808180  SHC1; SHC-transforming protein 1 [KO:K06279]
100081033  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100314440  MIR129; oan-miR-129-5p [KO:K17368]
100085757  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100079459  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100083932  cyclin-dependent kinase 4 inhibitor B-like [KO:K06621]
100087014  E2F1; transcription factor E2F1 [KO:K17454]
100085053  E2F2; transcription factor E2F2 [KO:K09389]
100314591  MIR32; oan-miR-32-5p [KO:K17039]
100073859  BCL2L11; bcl-2-like protein 11 isoform X2 [KO:K16341]
114805743  MARCKS; myristoylated alanine-rich C-kinase substrate [KO:K12561]
100077247  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
100314717  MIR449A; oan-miR-449a [KO:K17377]
100093591  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100078158  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
100073485  EZH2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
100088607  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
103169199  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
100077037  SIRT1; LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
100090103  WNT3A; LOW QUALITY PROTEIN: protein Wnt-3a [KO:K00312]
100085703  CDCA5; sororin [KO:K17390]
100085602  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
100079648  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
103168168  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
100085616  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
100092512  VIM; vimentin [KO:K07606]
Reference
PMID:18817506
  Authors
Lee YS, Dutta A
  Title
MicroRNAs in cancer.
  Journal
Annu Rev Pathol 4:199-227 (2009)
DOI:10.1146/annurev.pathol.4.110807.092222
Reference
PMID:21402473
  Authors
Babashah S, Soleimani M
  Title
The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.
  Journal
Eur J Cancer 47:1127-37 (2011)
DOI:10.1016/j.ejca.2011.02.008
Reference
PMID:19630570
  Authors
Garzon R, Calin GA, Croce CM
  Title
MicroRNAs in Cancer.
  Journal
Annu Rev Med 60:167-79 (2009)
DOI:10.1146/annurev.med.59.053006.104707
Reference
PMID:23075324
  Authors
Chen PS, Su JL, Hung MC
  Title
Dysregulation of microRNAs in cancer.
  Journal
J Biomed Sci 19:90 (2012)
DOI:10.1186/1423-0127-19-90
Reference
PMID:22035854
  Authors
Ling H, Zhang W, Calin GA
  Title
Principles of microRNA involvement in human cancers.
  Journal
Chin J Cancer 30:739-48 (2011)
DOI:10.5732/cjc.011.10243
Reference
PMID:22351564
  Authors
Iorio MV, Croce CM
  Title
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
  Journal
EMBO Mol Med 4:143-59 (2012)
DOI:10.1002/emmm.201100209
Reference
PMID:21742789
  Authors
Sayed D, Abdellatif M
  Title
MicroRNAs in development and disease.
  Journal
Physiol Rev 91:827-87 (2011)
DOI:10.1152/physrev.00006.2010
Reference
PMID:22345301
  Authors
Wang Q, Wang S, Wang H, Li P, Ma Z
  Title
MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment.
  Journal
Exp Biol Med (Maywood) 237:227-35 (2012)
DOI:10.1258/ebm.2011.011192
Reference
PMID:22580099
  Authors
Song JH, Meltzer SJ
  Title
MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers.
  Journal
Gastroenterology 143:35-47.e2 (2012)
DOI:10.1053/j.gastro.2012.05.003
Reference
PMID:23462054
  Authors
Chu Y, Zhu H, Lv L, Zhou Y, Huo J
  Title
MiRNA s in oesophageal squamous cancer.
  Journal
Neth J Med 71:69-75 (2013)
Reference
PMID:19773200
  Authors
Kan T, Meltzer SJ
  Title
MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.
  Journal
Curr Opin Pharmacol 9:727-32 (2009)
DOI:10.1016/j.coph.2009.08.009
Reference
PMID:20128019
  Authors
Smith CM, Watson DI, Michael MZ, Hussey DJ
  Title
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
  Journal
World J Gastroenterol 16:531-7 (2010)
DOI:10.3748/wjg.v16.i5.531
Reference
PMID:23165235
  Authors
Song S, Ajani JA
  Title
The role of microRNAs in cancers of the upper gastrointestinal tract.
  Journal
Nat Rev Gastroenterol Hepatol 10:109-18 (2013)
DOI:10.1038/nrgastro.2012.210
Reference
PMID:21565290
  Authors
Liu WH, Yeh SH, Chen PJ
  Title
Role of microRNAs in hepatitis B virus replication and pathogenesis.
  Journal
Biochim Biophys Acta 1809:678-85 (2011)
DOI:10.1016/j.bbagrm.2011.04.008
Reference
PMID:23091478
  Authors
Hrasovec S, Glavac D
  Title
MicroRNAs as Novel Biomarkers in Colorectal Cancer.
  Journal
Front Genet 3:180 (2012)
DOI:10.3389/fgene.2012.00180
Reference
PMID:22926415
  Authors
Liu H
  Title
MicroRNAs in breast cancer initiation and progression.
  Journal
Cell Mol Life Sci 69:3587-99 (2012)
DOI:10.1007/s00018-012-1128-9
Reference
PMID:20345848
  Authors
Li SD, Zhang JR, Wang YQ, Wan XP
  Title
The role of microRNAs in ovarian cancer initiation and progression.
  Journal
J Cell Mol Med 14:2240-9 (2010)
DOI:10.1111/j.1582-4934.2010.01058.x
Reference
PMID:23316212
  Authors
Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA
  Title
Characteristic patterns of microRNA expression in human bladder cancer.
  Journal
Front Genet 3:310 (2012)
DOI:10.3389/fgene.2012.00310
Reference
PMID:20221895
  Authors
Saini S, Majid S, Dahiya R
  Title
Diet, microRNAs and prostate cancer.
  Journal
Pharm Res 27:1014-26 (2010)
DOI:10.1007/s11095-010-0086-x
Related
pathway
oaa05210  Colorectal cancer
oaa05214  Glioma
oaa05215  Prostate cancer
oaa05219  Bladder cancer
oaa05222  Small cell lung cancer
oaa05223  Non-small cell lung cancer
KO pathway
ko05206   
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