KEGG   PATHWAY: ocu03015
Entry
ocu03015                    Pathway                                
Name
mRNA surveillance pathway - Oryctolagus cuniculus (rabbit)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
ocu03015  mRNA surveillance pathway
ocu03015

Other DBs
GO: 0071028
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100357449  nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
100339832  nuclear cap-binding protein subunit 2 [KO:K12883]
103346328  regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
100341564  regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
100356723  RNA-binding protein 8A isoform X1 [KO:K12876]
100344696  protein mago nashi homolog 2 [KO:K12877]
100354873  protein mago nashi homolog isoform X2 [KO:K12877]
127489291  protein mago nashi homolog [KO:K12877]
100358381  protein CASC3 [KO:K14323]
127486475  eukaryotic initiation factor 4A-III [KO:K13025] [EC:3.6.4.13]
100356364  histone deacetylase complex subunit SAP18 [KO:K14324]
100339760  pinin [KO:K13114]
100338262  apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
100344881  RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
100339723  ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:3.6.4.13]
100340393  ATP-dependent RNA helicase DDX19B isoform X2 [KO:K18655] [EC:3.6.4.13]
100351460  mRNA export factor GLE1 [KO:K18723]
100347351  nuclear RNA export factor 1 isoform X1 [KO:K14284]
100342837  nuclear RNA export factor 2 [KO:K14284]
103351963  nuclear RNA export factor 2 isoform X1 [KO:K14284]
100340535  nuclear RNA export factor 2 isoform X2 [KO:K14284]
100339773  nuclear RNA export factor 2 isoform X1 [KO:K14284]
100338777  nuclear RNA export factor 3 [KO:K14284]
100339936  NTF2-related export protein 2 isoform X1 [KO:K14285]
100351903  NTF2-related export protein 1 [KO:K14285]
100349333  spliceosome RNA helicase DDX39B [KO:K12812] [EC:3.6.4.13]
100342436  partner of Y14 and mago isoform X1 [KO:K14294]
127487401  partner of Y14 and mago isoform X1 [KO:K14294]
100342974  serine/arginine repetitive matrix protein 1 isoform X5 [KO:K13171]
100353425  LOW QUALITY PROTEIN: serine/arginine repetitive matrix protein 1-like [KO:K13171]
127487071  LOW QUALITY PROTEIN: serine/arginine repetitive matrix protein 1-like [KO:K13171]
100340242  mRNA-capping enzyme [KO:K13917] [EC:2.7.7.50 3.6.1.74]
100340576  mRNA cap guanine-N7 methyltransferase isoform X1 [KO:K00565] [EC:2.1.1.56]
100352362  RNA-binding protein FUS [KO:K13098]
100339629  TAR DNA-binding protein 43 [KO:K23600]
100345355  polyadenylate-binding protein 2 isoform X1 [KO:K14396]
127488515  LOW QUALITY PROTEIN: polyadenylate-binding protein 2-like [KO:K14396]
100342787  cleavage and polyadenylation specificity factor subunit 5 isoform X1 [KO:K14397]
100357226  cleavage and polyadenylation specificity factor subunit 5-like [KO:K14397]
100353973  cleavage and polyadenylation specificity factor subunit 7 isoform X2 [KO:K14398]
100340648  cleavage and polyadenylation specificity factor subunit 6 isoform X4 [KO:K14398]
100338861  poly(A) polymerase alpha isoform X1 [KO:K14376] [EC:2.7.7.19]
100352625  poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
100344714  poly(A) polymerase gamma isoform X1 [KO:K14376] [EC:2.7.7.19]
100350312  polyribonucleotide 5'-hydroxyl-kinase Clp1 isoform X1 [KO:K14399] [EC:2.7.1.78]
100347292  pre-mRNA cleavage complex 2 protein Pcf11 isoform X3 [KO:K14400]
127485576  cleavage and polyadenylation specificity factor subunit 1 isoform X1 [KO:K14401]
100346821  cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
100354833  cleavage and polyadenylation specificity factor subunit 3 [KO:K14403] [EC:3.1.27.-]
100346062  cleavage and polyadenylation specificity factor subunit 4 isoform X2 [KO:K14404]
100342324  putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
100341056  pre-mRNA 3'-end-processing factor FIP1 isoform X9 [KO:K14405]
100356036  pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
100346627  WD repeat-containing protein 82 [KO:K14962]
100009587  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100009298  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100353054  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103346471  RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
100337928  RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like [KO:K15544] [EC:3.1.3.16]
100349788  RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like [KO:K15544] [EC:3.1.3.16]
100349354  cleavage stimulation factor subunit 1 [KO:K14406]
100342333  cleavage stimulation factor subunit 2 isoform X2 [KO:K14407]
100344475  LOW QUALITY PROTEIN: cleavage stimulation factor subunit 2 tau variant-like [KO:K14407]
100357418  cleavage stimulation factor subunit 2 tau variant [KO:K14407]
100339047  cleavage stimulation factor subunit 3 [KO:K14408]
100348044  symplekin [KO:K06100]
100342991  RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
100352797  RNA-binding protein Musashi homolog 1 isoform X1 [KO:K14411]
127485675  DAZ-associated protein 1 isoform X1 [KO:K14411]
100351201  polyadenylate-binding protein 1-like isoform X1 [KO:K13126]
100340846  polyadenylate-binding protein 4 isoform X3 [KO:K13126]
100353191  polyadenylate-binding protein 4-like [KO:K13126]
100342434  polyadenylate-binding protein 1 [KO:K13126]
100350595  polyadenylate-binding protein 5 [KO:K13126]
100356494  polyadenylate-binding protein 1-like 2 [KO:K13126]
100340779  polyadenylate-binding protein 1-like [KO:K13126]
100340865  polyadenylate-binding protein 1-like [KO:K13126]
100009553  ETF1; eukaryotic peptide chain release factor subunit 1 [KO:K03265]
100355899  LOW QUALITY PROTEIN: eukaryotic peptide chain release factor subunit 1-like [KO:K03265]
100355660  eukaryotic peptide chain release factor GTP-binding subunit ERF3B [KO:K03267]
100008618  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
127482716  regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:3.6.4.13 5.6.2.3]
100354055  regulator of nonsense transcripts 2 isoform X2 [KO:K14327]
100354937  serine/threonine-protein kinase SMG1 isoform X1 [KO:K08873] [EC:2.7.11.1]
100339791  nonsense-mediated mRNA decay factor SMG7 isoform X2 [KO:K14409]
100341361  nonsense-mediated mRNA decay factor SMG5 [KO:K11125]
100355820  telomerase-binding protein EST1A isoform X1 [KO:K11124] [EC:3.1.-.-]
100009252  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100009300  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100355092  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100355758  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
100328617  PPP2R2C; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform [KO:K04354]
100009139  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
100328616  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
100348286  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100355159  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2 [KO:K11583]
100356580  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
100353545  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2 [KO:K11583]
100009434  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
100346997  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
100009533  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100009216  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
100009215  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
100338746  HBS1-like protein isoform X1 [KO:K14416]
100344574  protein pelota homolog [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
ocu03013  Nucleocytoplasmic transport
ocu03018  RNA degradation
ocu03040  Spliceosome
KO pathway
ko03015   
LinkDB

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