KEGG   PATHWAY: ola04115
ola04115                    Pathway                                

p53 signaling pathway - Oryzias latipes (Japanese medaka)
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Cellular Processes; Cell growth and death
Pathway map
ola04115  p53 signaling pathway

Oryzias latipes (Japanese medaka) [GN:ola]
101167063  atm; serine-protein kinase ATM [KO:K04728] [EC:]
101170645  chek2; serine/threonine-protein kinase Chk2 isoform X2 [KO:K06641] [EC:]
101157099  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:]
101170780  chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:]
101171402  gorab; RAB6-interacting golgin [KO:K19748]
101174634  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:]
101159186  mdm4; protein Mdm4 isoform X2 [KO:K10127]
100049321  tp53; cellular tumor antigen p53 [KO:K04451]
101166216  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
101160207  uncharacterized protein LOC101160207 [KO:K06625]
101169672  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
101174910  G1/S-specific cyclin-D2 [KO:K10151]
101163574  G1/S-specific cyclin-D2-like [KO:K10151]
101175697  G1/S-specific cyclin-D2 [KO:K10151]
101165722  G1/S-specific cyclin-D1-like [KO:K10152]
101172808  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:]
101168879  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:]
101165981  cyclin-dependent kinase 6 [KO:K02091] [EC:]
101155592  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
101172438  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
101161880  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:]
101172617  rprm; protein reprimo [KO:K10128]
101159264  reprimo-like protein [KO:K10128]
100049212  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
100049213  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
101162061  G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
100049478  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:]
100049506  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101165223  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101162606  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101174118  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
101155619  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
101163042  growth arrest and DNA damage-inducible protein GADD45 beta isoform X1 [KO:K04402]
111946817  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
101173844  G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
101172757  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101168864  p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
101172833  tumor necrosis factor receptor superfamily member 10B [KO:K04722]
101173230  tumor necrosis factor receptor superfamily member 22 [KO:K04722]
100049400  casp8; caspase-8 [KO:K04398] [EC:]
100125536  caspase-8 [KO:K04398] [EC:]
101156492  uncharacterized protein LOC101156492 [KO:K04726]
101168687  apoptosis regulator BAX [KO:K02159]
101168213  apoptosis regulator BAX isoform X2 [KO:K02159]
101172038  siva1; apoptosis regulatory protein Siva [KO:K22744]
101165300  bcl-2-like protein 1 isoform X1 [KO:K04570]
101159503  LOW QUALITY PROTEIN: bcl-2-like protein 1 [KO:K04570]
101163032  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
101163871  ei24; etoposide-induced protein 2.4 homolog isoform X1 [KO:K10134]
101158845  protein shisa-5 [KO:K10135]
101162234  perp; p53 apoptosis effector related to PMP-22 [KO:K10136]
101172804  zmat3; zinc finger matrin-type protein 3 [KO:K10137]
101155925  siah1; E3 ubiquitin-protein ligase SIAH1 isoform X2 [KO:K04506] [EC:]
101165110  cytochrome c iso-1/iso-2 [KO:K08738]
101171965  cytochrome c iso-1/iso-2 [KO:K08738]
101158654  apaf1; apoptotic protease-activating factor 1 [KO:K02084]
101157857  casp9; caspase-9 isoform X1 [KO:K04399] [EC:]
100049215  casp3; caspase-3 [KO:K02187] [EC:]
100049265  caspase 3B [KO:K02187] [EC:]
101167643  apoptosis-inducing factor 2-like [KO:K22745]
101167894  apoptosis-inducing factor 2 [KO:K22745]
101166253  insulin-like growth factor-binding protein 3 [KO:K10138]
101162674  insulin-like growth factor-binding protein 3 [KO:K10138]
105354483  insulin-like growth factor I [KO:K05459]
101168167  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
100529196  serpine1; plasminogen activator inhibitor 1 precursor [KO:K03982]
101169559  adgrb1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
101168284  cd82; CD82 antigen isoform X1 [KO:K06509]
101163200  CD82 antigen [KO:K06509]
101156312  CD82 antigen [KO:K06509]
100302441  thbs1; thrombospondin-1 precursor [KO:K16857]
100302438  thrombospondin-1a precursor [KO:K16857]
101159499  ddb2; DNA damage-binding protein 2 [KO:K10140]
101164326  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:]
101166844  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:]
101158912  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:]
101170524  sestrin-3 isoform X1 [KO:K10141]
101156699  sesn1; sestrin-1 isoform X1 [KO:K10141]
101155285  sestrin-2 isoform X1 [KO:K20394]
101171856  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:]
101173689  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:]
101168435  tsc2; tuberin isoform X1 [KO:K07207]
101169423  steap3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
101170218  cop1; E3 ubiquitin-protein ligase RFWD2 [KO:K10143] [EC:]
101158860  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:]
101165649  ccng1; cyclin-G1 [KO:K10145]
101159996  cyclin-G2 isoform X2 [KO:K10146]
101159210  ccng2; cyclin-G2 [KO:K10146]
101165192  ppm1d; protein phosphatase 1D [KO:K10147] [EC:]
101156348  protein phosphatase 1D isoform X1 [KO:K10147] [EC:]
100170633  tp73; tumor protein p73 isoform X2 [KO:K10148]
Levine AJ, Hu W, Feng Z.
The P53 pathway: what questions remain to be explored?
Cell Death Differ 13:1027-36 (2006)
Harris SL, Levine AJ.
The p53 pathway: positive and negative feedback loops.
Oncogene 24:2899-908 (2005)
Balint E E, Vousden KH.
Activation and activities of the p53 tumour suppressor protein.
Br J Cancer 85:1813-23 (2001)
Taylor WR, Stark GR.
Regulation of the G2/M transition by p53.
Oncogene 20:1803-15 (2001)
Hofseth LJ, Hussain SP, Harris CC.
p53: 25 years after its discovery.
Trends Pharmacol Sci 25:177-81 (2004)
Pietenpol JA, Stewart ZA.
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
Toxicology 181-182:475-81 (2002)
Tokino T, Nakamura Y.
The role of p53-target genes in human cancer.
Crit Rev Oncol Hematol 33:1-6 (2000)
Hermeking H, Benzinger A.
14-3-3 proteins in cell cycle regulation.
Semin Cancer Biol 16:183-92 (2006)
Sherr CJ.
Divorcing ARF and p53: an unsettled case.
Nat Rev Cancer 6:663-73 (2006)
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Cancer Res 67:3043-53 (2007)
Resnick-Silverman L, Manfredi JJ
Two Faces of SIVA.
Cancer Discov 5:581-3 (2015)
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
J Cell Sci 122:2651-61 (2009)
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
J Carcinog 8:2 (2009)
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
FEBS Lett 524:163-71 (2002)
ola04110  Cell cycle
ola04210  Apoptosis
ola04218  Cellular senescence
KO pathway

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