KEGG   PATHWAY: ola04115
Entry
ola04115                    Pathway                                

Name
p53 signaling pathway - Oryzias latipes (Japanese medaka)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
ola04115  p53 signaling pathway
ola04115

Organism
Oryzias latipes (Japanese medaka) [GN:ola]
Gene
101167063  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
101170645  chek2; serine/threonine-protein kinase Chk2 isoform X2 [KO:K06641] [EC:2.7.11.1]
101157099  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
101170780  chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
101171402  gorab; RAB6-interacting golgin [KO:K19748]
101174634  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
101159186  mdm4; protein Mdm4 isoform X2 [KO:K10127]
100049321  tp53; cellular tumor antigen p53 [KO:K04451]
101166216  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
101160207  uncharacterized protein LOC101160207 [KO:K06625]
101169672  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
101174910  G1/S-specific cyclin-D2 [KO:K10151]
101163574  G1/S-specific cyclin-D2-like [KO:K10151]
101175697  G1/S-specific cyclin-D2 [KO:K10151]
101165722  G1/S-specific cyclin-D1-like [KO:K10152]
101172808  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101168879  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101165981  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101155592  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
101172438  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
101161880  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
101172617  rprm; protein reprimo [KO:K10128]
101159264  reprimo-like protein [KO:K10128]
100049212  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
100049213  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
101162061  G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
100049478  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100049506  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101165223  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101162606  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101174118  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
101155619  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
101163042  growth arrest and DNA damage-inducible protein GADD45 beta isoform X1 [KO:K04402]
111946817  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
101173844  G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
101172757  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101168864  p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
101172833  tumor necrosis factor receptor superfamily member 10B [KO:K04722]
101173230  tumor necrosis factor receptor superfamily member 22 [KO:K04722]
100049400  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100125536  caspase-8 [KO:K04398] [EC:3.4.22.61]
101156492  uncharacterized protein LOC101156492 [KO:K04726]
101168687  apoptosis regulator BAX [KO:K02159]
101168213  apoptosis regulator BAX isoform X2 [KO:K02159]
101172038  siva1; apoptosis regulatory protein Siva [KO:K22744]
101165300  bcl-2-like protein 1 isoform X1 [KO:K04570]
101159503  LOW QUALITY PROTEIN: bcl-2-like protein 1 [KO:K04570]
101163032  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
101163871  ei24; etoposide-induced protein 2.4 homolog isoform X1 [KO:K10134]
101158845  protein shisa-5 [KO:K10135]
101162234  perp; p53 apoptosis effector related to PMP-22 [KO:K10136]
101172804  zmat3; zinc finger matrin-type protein 3 [KO:K10137]
101155925  siah1; E3 ubiquitin-protein ligase SIAH1 isoform X2 [KO:K04506] [EC:2.3.2.27]
101165110  cytochrome c iso-1/iso-2 [KO:K08738]
101171965  cytochrome c iso-1/iso-2 [KO:K08738]
101158654  apaf1; apoptotic protease-activating factor 1 [KO:K02084]
101157857  casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100049215  casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100049265  caspase 3B [KO:K02187] [EC:3.4.22.56]
101167643  apoptosis-inducing factor 2-like [KO:K22745]
101167894  apoptosis-inducing factor 2 [KO:K22745]
101166253  insulin-like growth factor-binding protein 3 [KO:K10138]
101162674  insulin-like growth factor-binding protein 3 [KO:K10138]
105354483  insulin-like growth factor I [KO:K05459]
101168167  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
100529196  serpine1; plasminogen activator inhibitor 1 precursor [KO:K03982]
101169559  adgrb1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
101168284  cd82; CD82 antigen isoform X1 [KO:K06509]
101163200  CD82 antigen [KO:K06509]
101156312  CD82 antigen [KO:K06509]
100302441  thbs1; thrombospondin-1 precursor [KO:K16857]
100302438  thrombospondin-1a precursor [KO:K16857]
101159499  ddb2; DNA damage-binding protein 2 [KO:K10140]
101164326  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
101166844  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
101158912  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
101170524  sestrin-3 isoform X1 [KO:K10141]
101156699  sesn1; sestrin-1 isoform X1 [KO:K10141]
101155285  sestrin-2 isoform X1 [KO:K20394]
101171856  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101173689  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101168435  tsc2; tuberin isoform X1 [KO:K07207]
101169423  steap3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
101170218  cop1; E3 ubiquitin-protein ligase RFWD2 [KO:K10143] [EC:2.3.2.27]
101158860  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
101165649  ccng1; cyclin-G1 [KO:K10145]
101159996  cyclin-G2 isoform X2 [KO:K10146]
101159210  ccng2; cyclin-G2 [KO:K10146]
101165192  ppm1d; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
101156348  protein phosphatase 1D isoform X1 [KO:K10147] [EC:3.1.3.16]
100170633  tp73; tumor protein p73 isoform X2 [KO:K10148]
Reference
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Related
pathway
ola04110  Cell cycle
ola04210  Apoptosis
ola04218  Cellular senescence
KO pathway
ko04115   
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