KEGG   PATHWAY: ola04310
Entry
ola04310                    Pathway                                
Name
Wnt signaling pathway - Oryzias latipes (Japanese medaka)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
ola04310  Wnt signaling pathway
ola04310

Other DBs
GO: 0016055
Organism
Oryzias latipes (Japanese medaka) [GN:ola]
Gene
101170431  porcn; protein-serine O-palmitoleoyltransferase porcupine isoform X2 [KO:K00181] [EC:2.3.1.250]
101155172  protein-serine O-palmitoleoyltransferase porcupine [KO:K00181] [EC:2.3.1.250]
100125456  wnt1; proto-oncogene Wnt-1 isoform X2 [KO:K03209]
100529167  wnt2bb; wingless-type MMTV integration site family, member 2Bb [KO:K00182]
101164972  protein Wnt-2b-A [KO:K00182]
101162030  protein Wnt-2 [KO:K00182]
101155545  wnt3a; protein Wnt-3a [KO:K00312]
101174231  wnt3; proto-oncogene Wnt-3 [KO:K00312]
100301591  wnt4b; wingless-type MMTV integration site family member 4b precursor [KO:K00408]
100301590  wnt4; protein Wnt-4 precursor [KO:K00408]
100049184  wnt5b; protein Wnt-5b precursor [KO:K00444]
101160069  protein Wnt-5a [KO:K00444]
101174712  wnt6; protein Wnt-6 isoform X1 [KO:K00445]
101155025  protein Wnt-7b isoform X2 [KO:K00572]
101172241  wnt7a; protein Wnt-7a [KO:K00572]
101174500  protein Wnt-7a isoform X1 [KO:K00572]
101170723  protein Wnt-7b isoform X4 [KO:K00572]
101171501  protein Wnt-8a [KO:K00714]
101171257  protein Wnt-8-like [KO:K00714]
101154972  protein Wnt-8b [KO:K00714]
101173867  protein Wnt-9b [KO:K01064]
101155800  wnt9a; protein Wnt-9a [KO:K01064]
101170092  wnt10b; protein Wnt-10b [KO:K01357]
101174473  wnt10a; protein Wnt-10a [KO:K01357]
101155217  wnt11; protein Wnt-11 isoform X1 [KO:K01384]
101164219  wnt16; protein Wnt-16 [KO:K01558]
101159320  uncharacterized protein LOC101159320 [KO:K01645]
101157515  carboxylesterase notum2 [KO:K19882] [EC:3.1.1.98]
101171916  notum; palmitoleoyl-protein carboxylesterase NOTUM [KO:K19882] [EC:3.1.1.98]
101173510  sost; sclerostin [KO:K16834]
110015588  dickkopf-related protein 2-like [KO:K02165]
101159297  dickkopf-related protein 2-like [KO:K02165]
101172518  dickkopf-related protein 1 isoform X3 [KO:K02165]
101172222  dkk2; dickkopf-related protein 2 [KO:K02165]
101160187  serpinf1; pigment epithelium-derived factor [KO:K19614]
100049476  sfrp1; secreted frizzled-related protein 1 precursor [KO:K02166]
101159245  sfrp2; secreted frizzled-related protein 2 [KO:K02176]
101171428  secreted frizzled-related protein 2 [KO:K02176]
101168409  secreted frizzled-related protein 3 [KO:K25481]
101162946  sfrp5; secreted frizzled-related protein 5 [KO:K02222]
100820725  rspo1; R-spondin-1 precursor [KO:K19471]
100820726  rspo2; R-spondin-2 precursor [KO:K23097]
100820730  rspo3; R-spondin-3 precursor [KO:K23098]
101167435  lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1 [KO:K04309]
101157030  lgr5; leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1 [KO:K04308]
101156653  lgr6; leucine-rich repeat-containing G-protein coupled receptor 6 precursor [KO:K08399]
101168566  rnf43; E3 ubiquitin-protein ligase RNF43 [KO:K15694] [EC:2.3.2.27]
101158028  znrf3; E3 ubiquitin-protein ligase ZNRF3 isoform X1 [KO:K16273] [EC:2.3.2.27]
101170298  frizzled-1-like [KO:K02432]
101163619  frizzled-7 [KO:K02432]
101156794  frizzled-7-like [KO:K02432]
101165060  fzd2; frizzled-2 [KO:K02235]
101164863  fzd3; frizzled-3 isoform X3 [KO:K02329]
101170336  frizzled-3 isoform X1 [KO:K02329]
101169962  fzd4; frizzled-4 [KO:K02354]
101155718  frizzled-8 [KO:K02375]
101155728  fzd8; frizzled-8 [KO:K02375]
101163367  frizzled-5 [KO:K02375]
101161672  fzd6; frizzled-6 [KO:K02376]
101161314  fzd10; frizzled-10 [KO:K02842]
101174936  fzd9; frizzled-9 [KO:K02842]
101167185  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
101172212  lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
101174630  bambi; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
101175348  protein APCDD1 [KO:K25812]
101166122  protein APCDD1-like [KO:K25812]
101175322  csnk1e; casein kinase I isoform X2 [KO:K08960] [EC:2.7.11.1]
105356509  casein kinase I [KO:K08960] [EC:2.7.11.1]
101164937  protein Daple-like isoform X1 [KO:K25811]
101165393  dvl1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
101157324  dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
101163770  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
111948976  frat2; GSK-3-binding protein FRAT2 [KO:K03096]
101163644  casein kinase II subunit alpha' isoform X2 [KO:K03097] [EC:2.7.11.1]
101171988  csnk2a2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
101156432  casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
101155859  casein kinase II subunit beta [KO:K03115]
101175345  casein kinase II subunit beta isoform X1 [KO:K03115]
101157204  nkd1; protein naked cuticle homolog 1 isoform X2 [KO:K03213]
101162315  nkd2; protein naked cuticle homolog 2 isoform X1 [KO:K03213]
101156122  uncharacterized protein LOC101156122 isoform X1 [KO:K03344]
101170738  cxxc4; CXXC-type zinc finger protein 4 [KO:K03344]
101165680  sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
101174787  gsk3b; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
101166738  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
101171502  catenin beta-1 [KO:K02105]
101155494  axin-1 isoform X1 [KO:K02157]
101155852  axin1; axin-1 isoform X1 [KO:K02157]
101159441  axin-2 [KO:K04385]
101156143  axin2; axin-2 isoform X1 [KO:K04385]
101162682  apc; adenomatous polyposis coli protein [KO:K02085]
101169683  apc2; adenomatous polyposis coli protein 2 [KO:K02085]
101155263  csnk1a1; casein kinase I isoform X2 [KO:K08957] [EC:2.7.11.1]
101162309  tcf7; transcription factor 7 isoform X1 [KO:K02620]
101162335  transcription factor 7-like 1-A [KO:K02620]
111947120  transcription factor 7-like 1-A [KO:K02620]
100820729  tcf7l1; transcription factor 7-like 1 [KO:K04490]
111948314  transcription factor 7-like 1-A isoform X1 [KO:K04490]
101169492  tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
101167344  lef1; lymphoid enhancer-binding factor 1 isoform X3 [KO:K04492]
101164513  lzts2; leucine zipper putative tumor suppressor 2 isoform X1 [KO:K26471]
101159847  leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
101175156  ctnnbip1; beta-catenin-interacting protein 1 isoform X2 [KO:K04493]
101165921  cby1; protein chibby homolog 1 [KO:K23402]
101165425  chd8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:5.6.2.-]
101175344  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
100304455  sox17; transcription factor SOX-17 [KO:K04495]
101164069  ctbp1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
101168811  RNA-binding protein 33 isoform X1 [KO:K04496] [EC:1.1.1.428]
101158706  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
101175355  ctbp2; C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
100049394  transducin-like enhancer protein 3-A isoform X1 [KO:K04497]
100125463  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
101157442  transducin-like enhancer protein 4 isoform X1 [KO:K04497]
101168352  transducin-like enhancer protein 3-B isoform X5 [KO:K04497]
100125464  transducin-like enhancer protein 4 isoform X2 [KO:K04497]
101157205  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
101168153  catenin delta-2 isoform X1 [KO:K23491]
101155770  CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
101168870  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101160197  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101163392  CREB-binding protein isoform X5 [KO:K04498] [EC:2.3.1.48]
101175391  ruvbl1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
101168872  mothers against decapentaplegic homolog 4 [KO:K04501]
101173916  mothers against decapentaplegic homolog 4 [KO:K04501]
101163504  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
101169523  mothers against decapentaplegic homolog 3 [KO:K23605]
101164271  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
105356874  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
101162387  nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101168711  serine/threonine-protein kinase NLK2 [KO:K04468] [EC:2.7.11.24]
101164933  myc; myc proto-oncogene protein [KO:K04377]
101171524  c-myc17; uncharacterized protein LOC101171524 [KO:K04377]
101174822  transcription factor AP-1 [KO:K04448]
101173011  jun; transcription factor AP-1 [KO:K04448]
101160956  transcription factor AP-1 [KO:K04448]
101169672  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
101174910  G1/S-specific cyclin-D2 [KO:K10151]
101163574  G1/S-specific cyclin-D2-like [KO:K10151]
101175697  G1/S-specific cyclin-D2 [KO:K10151]
101165722  G1/S-specific cyclin-D1-like [KO:K10152]
101171259  wisp1; WNT1-inducible-signaling pathway protein 1 [KO:K22471]
100049393  ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
101154844  presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
101160964  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101163742  cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101170876  cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
101160305  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
100049321  tp53; cellular tumor antigen p53 [KO:K04451]
101155925  siah1; E3 ubiquitin-protein ligase SIAH1 isoform X2 [KO:K04506] [EC:2.3.2.27]
101155638  cacybp; calcyclin-binding protein [KO:K04507]
101173567  skp1; S-phase kinase-associated protein 1 [KO:K03094]
101173456  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
101165003  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
101170720  F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
101174029  fbxw11; F-box/WD repeat-containing protein 11 isoform X2 [KO:K03362]
101155471  cul1; cullin-1 [KO:K03347]
101170590  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
101160491  glypican-6 [KO:K08110]
101166863  ror1; inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:2.7.10.1]
101175048  ror2; tyrosine-protein kinase transmembrane receptor ROR2 isoform X1 [KO:K05123] [EC:2.7.10.1]
101164793  ryk; tyrosine-protein kinase RYK [KO:K05128] [EC:2.7.10.1]
101163605  vangl2; vang-like protein 2 [KO:K04510]
101170632  vang-like protein 1 [KO:K04510]
101165035  vangl1; vang-like protein 1 isoform X1 [KO:K04510]
101168539  prickle-like protein 2 [KO:K04511]
101172411  prickle3; prickle planar cell polarity protein 3 isoform X3 [KO:K04511]
101170923  prickle1; prickle-like protein 1 [KO:K04511]
101164394  prickle2; prickle-like protein 2 isoform X1 [KO:K04511]
101165857  prickle-like protein 1 isoform X1 [KO:K04511]
101168237  invs; inversin [KO:K19626]
101155891  disheveled-associated activator of morphogenesis 1 [KO:K04512]
101171211  daam2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
101174553  daam1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
101155194  rho-related GTP-binding protein RhoA-C [KO:K04513]
101158607  transforming protein RhoA-like [KO:K04513]
101160539  rho-related GTP-binding protein RhoA-C [KO:K04513]
101167618  rho-related GTP-binding protein RhoA-B [KO:K04513]
101173444  transforming protein RhoA isoform X2 [KO:K04513]
101172697  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101159717  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101159016  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101175028  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101158699  ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
101163549  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105354522  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101157952  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101168799  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101164997  mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
101158978  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100049465  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101175365  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100049529  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100049535  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101172698  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101156912  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
101168431  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
101160009  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101159287  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
101170191  calcium/calmodulin-dependent protein kinase type II delta chain isoform X1 [KO:K04515] [EC:2.7.11.17]
101172229  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
101170226  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X11 [KO:K04515] [EC:2.7.11.17]
101156706  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101162612  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101168142  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101172250  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101169815  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101168674  calcineurin subunit B type 1-like [KO:K06268]
101161991  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
101159746  protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
101160465  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105353642  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101161464  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101164921  protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
101161493  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101158005  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101171005  nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
101165879  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
101173291  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101172896  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
101164749  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
ola04010  MAPK signaling pathway
ola04110  Cell cycle
ola04115  p53 signaling pathway
ola04120  Ubiquitin mediated proteolysis
ola04350  TGF-beta signaling pathway
ola04510  Focal adhesion
ola04520  Adherens junction
KO pathway
ko04310   
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