KEGG   PATHWAY: onl04530
Entry
onl04530                    Pathway                                
Name
Tight junction - Oreochromis niloticus (Nile tilapia)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
onl04530  Tight junction
onl04530

Other DBs
GO: 0005923
Organism
Oreochromis niloticus (Nile tilapia) [GN:onl]
Gene
102076613  crb3; protein crumbs homolog 3 [KO:K06090]
102080746  claudin-34 [KO:K06087]
102076489  claudin-34 [KO:K06087]
100694843  putative claudin-24 [KO:K06087]
100698921  claudin-19 [KO:K06087]
100698417  claudin-7-A [KO:K06087]
100694903  claudin-22-like [KO:K06087]
100692463  cldn5; claudin-5 [KO:K06087]
100712468  claudin-10 [KO:K06087]
100690129  putative claudin-24 [KO:K06087]
100710159  claudin-7-A isoform X2 [KO:K06087]
100692754  claudin-15 [KO:K06087]
106097921  claudin-10-like [KO:K06087]
100703394  claudin-7 isoform X2 [KO:K06087]
100707064  claudin-4 [KO:K06087]
100705343  claudin-8 [KO:K06087]
100691770  claudin-4-like [KO:K06087]
100692042  claudin-like protein ZF-A89 [KO:K06087]
100692311  claudin-4-like [KO:K06087]
100692582  claudin-4-like [KO:K06087]
100692852  claudin-4 [KO:K06087]
100693127  claudin-4-like [KO:K06087]
100699626  claudin-11 [KO:K06087]
100710187  putative claudin-24 [KO:K06087]
100696760  claudin-4 [KO:K06087]
100701227  claudin-4-like [KO:K06087]
100709609  claudin-4-like [KO:K06087]
100693052  claudin-4-like [KO:K06087]
100709250  claudin-4-like [KO:K06087]
109203802  claudin-4-like [KO:K06087]
109203804  claudin-4-like [KO:K06087]
109203903  claudin-4-like [KO:K06087]
100711329  claudin-9 [KO:K06087]
100689849  claudin-10-like [KO:K06087]
100698849  cldn14; claudin-14 [KO:K06087]
100700354  claudin-4-like [KO:K06087]
100706022  claudin-4-like [KO:K06087]
100706283  claudin-4-like [KO:K06087]
100708709  claudin-4-like [KO:K06087]
100708978  claudin-4-like [KO:K06087]
100710584  claudin-4-like [KO:K06087]
100710854  claudin-4 [KO:K06087]
100705074  cldn1; claudin-1 [KO:K06087]
100690270  claudin-4 [KO:K06087]
100690559  claudin-20-like [KO:K06087]
100691869  claudin-7 [KO:K06087]
100694939  cldn18; claudin-18 [KO:K06087]
100697376  claudin-4-like [KO:K06087]
100708527  cldn20; claudin-20 [KO:K06087]
102076852  claudin-23 [KO:K06087]
100692699  claudin-23-like [KO:K06087]
100693541  claudin-9 [KO:K06087]
100694350  claudin-17-like [KO:K06087]
100705610  claudin-8-like [KO:K06087]
100694337  claudin-10 isoform X3 [KO:K06087]
100689763  cldn15; claudin-15 [KO:K06087]
100700264  claudin-10-like [KO:K06087]
100701283  claudin-4-like [KO:K06087]
102080286  claudin-4-like isoform X2 [KO:K06087]
100700549  claudin-11 [KO:K06087]
100701009  claudin-4-like [KO:K06087]
100701826  claudin-like protein ZF-A89 [KO:K06087]
100702098  claudin-like protein ZF-A89 [KO:K06087]
100691270  claudin-4-like [KO:K06087]
100691540  claudin-like protein ZF-A89 [KO:K06087]
100692079  claudin-4-like [KO:K06087]
100700473  claudin-3-like [KO:K06087]
100700739  claudin-4 [KO:K06087]
100701555  claudin-4 [KO:K06087]
100707897  claudin-4-like [KO:K06087]
100708167  claudin-9-like [KO:K06087]
100707088  claudin-4-like [KO:K06087]
100700059  claudin-18-like isoform X1 [KO:K06087]
100707895  cldn19; claudin-19 isoform X3 [KO:K06087]
100700852  claudin-15 [KO:K06087]
100695891  claudin-4 [KO:K06087]
100693399  claudin-4-like [KO:K06087]
100693661  claudin-3 [KO:K06087]
102081901  cldn12; claudin-12 [KO:K06087]
100700542  claudin-10-like isoform X1 [KO:K06087]
100695523  occludin [KO:K06088]
100709536  occludin [KO:K06088]
100699711  occludin isoform X2 [KO:K06088]
100697248  occludin [KO:K06088]
100699028  junctional adhesion molecule A isoform X2 [KO:K06089]
100695373  jam2; junctional adhesion molecule B isoform X1 [KO:K06735]
100693014  junctional adhesion molecule B [KO:K06735]
100699692  jam3; junctional adhesion molecule C [KO:K06785]
100706563  junctional adhesion molecule C [KO:K06785]
100709202  bves; blood vessel epicardial substance [KO:K21108]
100705444  cell division control protein 42 homolog isoform X3 [KO:K04393]
100705703  cell division control protein 42 homolog isoform X2 [KO:K04393]
106096466  cell division control protein 42 homolog isoform X1 [KO:K04393]
100712562  cell division control protein 42 homolog [KO:K04393]
100697482  cell division control protein 42 homolog isoform X2 [KO:K04393]
109196582  cell division control protein 42 homolog [KO:K04393]
100705174  cell division control protein 42 homolog isoform X1 [KO:K04393]
100691174  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100696557  cell division control protein 42 homolog [KO:K04393]
100709239  partitioning defective 6 homolog gamma [KO:K06093]
100703449  partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100707851  pard6b; partitioning defective 6 homolog beta [KO:K06093]
100695834  mpp5; MAGUK p55 subfamily member 5 [KO:K06091]
100694553  MAGUK p55 subfamily member 5-A [KO:K06091]
100693564  MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
100690376  mpp4; MAGUK p55 subfamily member 4 [KO:K21109]
100696688  tight junction protein ZO-3 isoform X1 [KO:K06097]
102079315  patj; inaD-like protein isoform X3 [KO:K06092]
100708093  mpdz; multiple PDZ domain protein isoform X3 [KO:K06095]
100707741  multiple PDZ domain protein isoform X1 [KO:K06095]
100703104  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
100697262  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
100696777  angiomotin [KO:K16819]
100692523  amotl2; angiomotin-like protein 2 [KO:K06104]
100692123  angiomotin-like 2a [KO:K06104]
100693200  rho GTPase-activating protein 17 isoform X1 [KO:K20638]
100704392  rho GTPase-activating protein 17 isoform X1 [KO:K20638]
100696401  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
106096418  ras-related C3 botulinum toxin substrate 1-like isoform X3 [KO:K04392]
100697553  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100708583  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100696834  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
100697642  merlin [KO:K16684]
100703197  nf2; merlin [KO:K16684]
100707659  llgl1; LOW QUALITY PROTEIN: lethal(2) giant larvae protein homolog 1 [KO:K06094]
100702767  llgl2; lethal(2) giant larvae protein homolog 2 [KO:K06094]
100697840  LOW QUALITY PROTEIN: discs large homolog 1-like protein [KO:K12076]
100696554  disks large homolog 1 isoform X1 [KO:K12076]
100693933  protein scribble homolog isoform X6 [KO:K16175]
100710281  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100697538  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100705713  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100695673  ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
100710763  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
100705319  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X2 [KO:K04354]
100705301  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
100697745  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
100708080  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
100709897  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform [KO:K04354]
100702913  pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100698856  partitioning defective 3 homolog isoform X1 [KO:K04237]
100698758  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100694077  tiam1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
100697056  LOW QUALITY PROTEIN: tight junction protein ZO-1 [KO:K05701]
100698737  tight junction protein ZO-1 isoform X3 [KO:K05701]
100706697  tjap1; LOW QUALITY PROTEIN: tight junction-associated protein 1 [KO:K06105]
100710568  disks large homolog 2 isoform X1 [KO:K12075]
100707080  dlg3; disks large homolog 3 isoform X12 [KO:K21098]
100709051  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
100701479  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
100703634  cgn; cingulin isoform X1 [KO:K06102]
100710602  LOW QUALITY PROTEIN: cingulin [KO:K06102]
100695471  cingulin-like protein 1 [KO:K21110]
100710129  cgnl1; cingulin-like protein 1 isoform X1 [KO:K21110]
100711616  rho guanine nucleotide exchange factor 2 [KO:K12791]
100704015  rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
100694803  rho-related GTP-binding protein RhoA-D [KO:K04513]
100696538  rho-related GTP-binding protein RhoA-C [KO:K04513]
100710477  rho-related GTP-binding protein RhoA-B [KO:K04513]
100698785  rho-related GTP-binding protein RhoA-C [KO:K04513]
100707445  rho-related GTP-binding protein RhoA-B [KO:K04513]
100534420  gata4; transcription factor GATA-4 [KO:K09183]
100701771  MARVEL domain-containing protein 3 [KO:K21099]
100689917  marveld3; MARVEL domain-containing protein 3 [KO:K21099]
100692379  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100702235  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100704139  mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
100711054  mapk10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
100707786  transcription factor AP-1 [KO:K04448]
100705884  transcription factor AP-1 [KO:K04448]
100703685  transcription factor AP-1 [KO:K04448]
100710776  cftr; cystic fibrosis transmembrane conductance regulator isoform X2 [KO:K05031] [EC:5.6.1.6]
100710125  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100708219  sympk; symplekin isoform X1 [KO:K06100]
100702557  pcna; proliferating cell nuclear antigen [KO:K04802]
100691373  G1/S-specific cyclin-D1 [KO:K04503]
100691051  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
100690421  receptor tyrosine-protein kinase erbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
100691239  runt-related transcription factor 1 [KO:K08367]
100690112  heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
100703840  hspa4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
100706235  Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
100707955  Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
100692529  ezr; ezrin [KO:K08007]
100692424  ezrin [KO:K08007]
100697050  radixin isoform X2 [KO:K05762]
100691947  radixin [KO:K05762]
100710883  moesin isoform X1 [KO:K05763]
100702004  moesin isoform X2 [KO:K05763]
100695466  protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
100692040  protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
100694447  actin, cytoplasmic 2-like isoform X1 [KO:K05692]
100534414  actb; actin, cytoplasmic 1 [KO:K05692]
100693494  voltage-dependent L-type calcium channel subunit alpha-1D isoform X7 [KO:K04851]
100712099  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X18 [KO:K04851]
100704269  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
100703888  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100705501  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X3 [KO:K04431] [EC:2.7.12.2]
100690332  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100692677  proto-oncogene tyrosine-protein kinase Src isoform X4 [KO:K05704] [EC:2.7.10.2]
100700393  src substrate cortactin [KO:K06106]
109194287  src substrate protein p85 [KO:K06106]
106098772  src substrate cortactin [KO:K06106]
100695482  actin-related protein 2 isoform X1 [KO:K17260]
100710986  actr2; actin-related protein 2 [KO:K17260]
100699229  actin-related protein 3 [KO:K18584]
100709824  actin-related protein 3B isoform X1 [KO:K18584]
100711948  actin-related protein 3 [KO:K18584]
100695429  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
100695691  actin-related protein 2/3 complex subunit 1B [KO:K05757]
100704563  actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
100699436  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
100709598  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
100702706  actin-related protein 2/3 complex subunit 4 [KO:K05755]
100696600  actin-related protein 2/3 complex subunit 4 [KO:K05755]
100698314  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
100702953  actin-related protein 2/3 complex subunit 5 [KO:K05754]
100690695  whamm; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
100703588  was; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
100691610  vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100702736  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100699977  cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
100700452  cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
100711771  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
100706038  rab13; ras-related protein Rab-13 [KO:K06109]
100696457  rho guanine nucleotide exchange factor 18 [KO:K21066]
100702965  arhgef18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
100697034  rock1; LOW QUALITY PROTEIN: rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100709780  rock2; rho-associated protein kinase 2 isoform X3 [KO:K17388] [EC:2.7.11.1]
100701417  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100699907  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100690118  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100695850  epb41l4b; band 4.1-like protein 4B isoform X1 [KO:K21111]
100696052  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
100691914  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
100706719  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
100704877  5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
100690798  prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
100694198  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
100691214  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
100697765  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
100703206  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
100710450  5'-AMP-activated protein kinase subunit gamma-2 isoform X5 [KO:K07200]
100691682  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
100690099  myosin-10 isoform X3 [KO:K10352]
100691292  myh11; myosin-11 isoform X1 [KO:K10352]
100699125  myosin-10 isoform X5 [KO:K10352]
100705764  myosin-9 isoform X1 [KO:K10352]
100707073  myh9; myosin-9 isoform X1 [KO:K10352]
100701806  myosin light polypeptide 6 [KO:K12751]
100708807  myosin light polypeptide 6 isoform X1 [KO:K12751]
100697131  myosin regulatory light polypeptide 9 [KO:K12755]
100710463  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
100708845  myosin regulatory light polypeptide 9 [KO:K12757]
100712476  immunoglobulin superfamily member 5 [KO:K06786]
100693507  immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
100708963  magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X30 [KO:K05631]
100696506  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2 [KO:K05631]
102076835  synpo; synaptopodin isoform X1 [KO:K21112]
100696265  alpha-actinin-1 isoform X4 [KO:K05699]
100708272  alpha-actinin-4 isoform X1 [KO:K05699]
102076226  MICAL-like protein 2 isoform X1 [KO:K21068]
100709862  micall2; MICAL-like protein 2 isoform X1 [KO:K21068]
100691063  rab8a; ras-related protein Rab-8A [KO:K07901]
100703352  ras-related protein Rab-8A [KO:K07901]
100691065  ras-related protein Rab-8B [KO:K07902]
100692392  ras-related protein Rab-8B [KO:K07902]
100709723  rap guanine nucleotide exchange factor 6 isoform X5 [KO:K08020]
100692376  ras-related protein Rap-1A [KO:K04353]
100690250  ras-related protein Rap-1A [KO:K04353]
100692535  integrin beta-1 [KO:K05719]
100701319  afdn; LOW QUALITY PROTEIN: afadin [KO:K05702]
100703154  LOW QUALITY PROTEIN: afadin-like [KO:K05702]
100698552  tjp2; tight junction protein ZO-2 isoform X2 [KO:K06098]
100709689  rapgef2; rap guanine nucleotide exchange factor 2 isoform X8 [KO:K08018]
100691801  rap2c; ras-related protein Rap-2c [KO:K07839]
100699976  MARVEL domain-containing protein 2 [KO:K17291]
100709806  MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
100695261  MARVEL domain-containing protein 2 [KO:K17291]
100694867  tubulin alpha-1C chain [KO:K07374]
109197038  tubulin alpha chain [KO:K07374]
109197098  tubulin alpha-1A chain isoform X1 [KO:K07374]
100701978  tubulin alpha-1A chain isoform X1 [KO:K07374]
100702243  tubulin alpha-1C chain [KO:K07374]
100691780  tubulin alpha-1B chain [KO:K07374]
100704491  tubulin alpha chain isoform X1 [KO:K07374]
100709035  tubulin alpha-1B chain [KO:K07374]
100695265  tubulin alpha-8 chain isoform X1 [KO:K07374]
100708793  tubulin alpha chain isoform X1 [KO:K07374]
112841648  tubulin alpha chain-like [KO:K07374]
100704022  tubulin alpha chain [KO:K07374]
109194398  tubulin alpha chain-like [KO:K07374]
109194646  tubulin alpha chain-like [KO:K07374]
109197651  tubulin alpha chain isoform X1 [KO:K07374]
100708257  tubulin alpha-1A chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
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Related
pathway
onl04520  Adherens junction
onl04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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