Entry
Name
Cytokine-cytokine receptor interaction - Odobenus rosmarus divergens (Pacific walrus)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
oro04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Odobenus rosmarus divergens (Pacific walrus) [GN:
oro ]
Gene
101365120 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
101367122 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
101365427 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
101385561 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
101381319 FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389 ]
101362116 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
101371152 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
101376926 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
105757318 TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
101386757 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
101362402 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
101378376 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
101383342 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
101365786 tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
101377516 TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476 ]
101383763 IL3RA; LOW QUALITY PROTEIN: interleukin-3 receptor subunit alpha [KO:K04737 ]
101383473 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
105757391 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066 ]
101371898 IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X2 [KO:K05076 ]
101363367 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077 ]
101377969 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
101368221 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
101373105 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
101376489 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
101369960 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
101362999 IL20RB; LOW QUALITY PROTEIN: interleukin-20 receptor subunit beta [KO:K05137 ]
101386839 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
101372518 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
101362195 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
101368733 TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152 ]
105757975 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
101369551 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
101381888 TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160 ]
101378085 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
101366184 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
101367854 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163 ]
101365058 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
101374351 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
101379212 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
101382236 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
101372219 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
101381578 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
101380574 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
101365223 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
101365528 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X2 [KO:K05154 ]
101382325 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
101381760 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
101373142 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
101377711 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
101372723 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
LinkDB
All DBs