KEGG   PATHWAY: otw04510
Entry
otw04510                    Pathway                                

Name
Focal adhesion - Oncorhynchus tshawytscha (Chinook salmon)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
otw04510  Focal adhesion
otw04510

Other DBs
GO: 0005925
Organism
Oncorhynchus tshawytscha (Chinook salmon) [GN:otw]
Gene
112237051  collagen alpha-1(I) chain-like [KO:K06236]
112258533  collagen alpha-1(I) chain-like [KO:K06236]
112264350  col1a2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
112225909  collagen alpha-1(I) chain-like [KO:K06236]
112229484  LOW QUALITY PROTEIN: collagen alpha-2(I) chain-like [KO:K06236]
112224508  collagen alpha-1(I) chain-like isoform X1 [KO:K06236]
112259622  collagen alpha-1(I) chain-like [KO:K06236]
112215806  collagen alpha-1(II) chain-like isoform X1 [KO:K19719]
112240032  collagen alpha-1(II) chain-like [KO:K19719]
112222151  collagen alpha-1(II) chain-like [KO:K19719]
112238339  LOW QUALITY PROTEIN: collagen alpha-1(II) chain-like [KO:K19719]
112241545  collagen alpha-1(IV) chain-like [KO:K06237]
112264997  collagen alpha-4(IV) chain-like isoform X1 [KO:K06237]
112215073  collagen alpha-5(IV) chain-like [KO:K06237]
112214511  collagen alpha-6(IV) chain-like isoform X1 [KO:K06237]
112226402  collagen alpha-1(IV) chain-like [KO:K06237]
112216685  collagen alpha-5(IV) chain-like [KO:K06237]
112225415  LOW QUALITY PROTEIN: collagen alpha-1(IV) chain-like [KO:K06237]
112260235  LOW QUALITY PROTEIN: collagen alpha-3(IV) chain-like [KO:K06237]
112241524  collagen alpha-2(IV) chain-like isoform X1 [KO:K06237]
112225026  collagen alpha-2(IV) chain-like [KO:K06237]
112260956  collagen alpha-2(IV) chain-like [KO:K06237]
112237840  LOW QUALITY PROTEIN: collagen alpha-5(IV) chain-like [KO:K06237]
112224903  col6a2; collagen alpha-2(VI) chain [KO:K06238]
112226431  collagen alpha-2(VI) chain-like [KO:K06238]
112225082  collagen alpha-3(VI) chain-like isoform X1 [KO:K06238]
112237136  LOW QUALITY PROTEIN: collagen alpha-2(VI) chain-like [KO:K06238]
112240769  collagen alpha-1(VI) chain-like [KO:K06238]
112224060  collagen alpha-3(VI) chain-like [KO:K06238]
112239893  LOW QUALITY PROTEIN: collagen alpha-6(VI) chain-like [KO:K06238]
112234309  collagen alpha-2(IX) chain-like [KO:K08131]
112222169  collagen alpha-3(IX) chain-like [KO:K08131]
112245726  collagen alpha-1(IX) chain-like [KO:K08131]
112245729  collagen alpha-1(IX) chain-like [KO:K08131]
112264428  col9a2; collagen alpha-2(IX) chain [KO:K08131]
112265231  collagen alpha-1(IX) chain-like [KO:K08131]
112215778  collagen alpha-3(IX) chain-like [KO:K08131]
112222547  collagen alpha-1(I) chain-like [KO:K08131]
112216475  LOW QUALITY PROTEIN: laminin subunit alpha-1-like [KO:K05637]
112227507  LOW QUALITY PROTEIN: laminin subunit alpha-1-like [KO:K05637]
112217557  LOW QUALITY PROTEIN: laminin subunit alpha-2-like [KO:K05637]
112244527  laminin subunit alpha-3-like [KO:K06240]
112259612  laminin subunit alpha-3-like [KO:K06240]
112227373  LOW QUALITY PROTEIN: laminin subunit alpha-3-like [KO:K06240]
112250058  laminin subunit alpha-4-like [KO:K06241]
112217524  laminin subunit alpha-4-like [KO:K06241]
112215049  laminin subunit beta-1-like [KO:K05636]
112252624  laminin subunit beta-1-like [KO:K05636]
112216823  laminin subunit beta-1-like [KO:K05636]
112251200  laminin subunit beta-1-like [KO:K05636]
112221344  laminin subunit beta-2-like [KO:K06243]
112216009  lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
112254873  laminin subunit beta-3-like [KO:K06244]
112244792  laminin subunit beta-3-like [KO:K06244]
112252623  lamb4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
112226965  laminin subunit gamma-1-like isoform X1 [KO:K05635]
112260448  laminin subunit gamma-1-like [KO:K05635]
112260449  laminin subunit gamma-2-like [KO:K06246]
112226966  laminin subunit gamma-2-like [KO:K06246]
112230880  lamc3; laminin subunit gamma-3 isoform X1 [KO:K06247]
112219921  laminin subunit gamma-3-like [KO:K06247]
112224134  chondroadherin-like [KO:K06248]
112223616  chondroadherin-like [KO:K06248]
112232336  LOW QUALITY PROTEIN: reelin-like [KO:K06249] [EC:3.4.21.-]
112232479  LOW QUALITY PROTEIN: reelin-like [KO:K06249] [EC:3.4.21.-]
112217958  thrombospondin-1-like [KO:K16857]
112233141  thrombospondin-1-like [KO:K16857]
112261815  thrombospondin-1-like [KO:K16857]
112246248  thrombospondin-4-B-like [KO:K04659]
112214476  thrombospondin-4-B-like [KO:K04659]
112264679  LOW QUALITY PROTEIN: thrombospondin-3b-like [KO:K04659]
112228464  thrombospondin-3a-like [KO:K04659]
112229692  thrombospondin-3b-like [KO:K04659]
112224605  thbs2; thrombospondin-2 isoform X1 [KO:K04659]
112248575  thrombospondin-4-B-like [KO:K04659]
112257427  thrombospondin-4-B-like [KO:K04659]
112222833  thrombospondin-3a-like [KO:K04659]
112251545  thrombospondin-4-like [KO:K04659]
112253319  thrombospondin-4-like [KO:K04659]
112236423  thrombospondin-2-like [KO:K04659]
112239140  LOW QUALITY PROTEIN: fibronectin-like [KO:K05717]
112225680  fn1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
112216718  LOW QUALITY PROTEIN: vitronectin-like [KO:K06251]
112234737  vitronectin-like [KO:K06251]
112265462  vitronectin-like [KO:K06251]
112262650  tenascin-like isoform X1 [KO:K06252]
112233319  tenascin-X-like [KO:K06252]
112265330  tenascin-like isoform X1 [KO:K06252]
112229790  tenascin-X-like [KO:K06252]
112226951  tenascin-N-like [KO:K06252]
112226953  tenascin-R-like isoform X1 [KO:K06252]
112260458  tenascin-R-like isoform X1 [KO:K06252]
112260459  tenascin-N-like isoform X1 [KO:K06252]
112230791  tenascin-like isoform X1 [KO:K06252]
112220314  tenascin-like isoform X1 [KO:K06252]
112264777  LOW QUALITY PROTEIN: tenascin-like [KO:K06252]
112219683  itga1; integrin alpha-1 isoform X1 [KO:K06480]
112259461  integrin alpha-1-like [KO:K06480]
112219685  integrin alpha-2-like isoform X1 [KO:K06481]
112257296  integrin alpha-2-like [KO:K06481]
112258495  integrin alpha-IIb-like [KO:K06476]
112258519  integrin alpha-3-like isoform X1 [KO:K06482]
112223646  itga3; integrin alpha-3 isoform X1 [KO:K06482]
112220187  integrin alpha-4-like [KO:K06483]
112232316  integrin alpha-4-like [KO:K06483]
112232498  integrin alpha-4-like [KO:K06483]
112254036  integrin alpha-4-like [KO:K06483]
112254061  integrin alpha-4-like [KO:K06483]
112239204  integrin alpha-4-like [KO:K06483]
112246216  integrin alpha-5-like isoform X1 [KO:K06484]
112267689  integrin alpha-5-like isoform X1 [KO:K06484]
112215221  integrin alpha-5-like [KO:K06484]
112254975  integrin alpha-5-like isoform X1 [KO:K06484]
112225238  integrin alpha-6-like isoform X1 [KO:K06485]
112220515  integrin alpha-6-like [KO:K06485]
112220540  integrin alpha-6-like [KO:K06485]
112226662  integrin alpha-6-like isoform X1 [KO:K06485]
112226606  integrin alpha-6-like isoform X1 [KO:K06485]
112236612  itga6; integrin alpha-6 isoform X1 [KO:K06485]
112246274  integrin alpha-7-like [KO:K06583]
112255075  integrin alpha-7-like [KO:K06583]
112244635  itga8; LOW QUALITY PROTEIN: integrin alpha-8 [KO:K06584]
112222541  integrin alpha-8-like [KO:K06584]
112224592  LOW QUALITY PROTEIN: integrin alpha-9-like [KO:K06585]
112238315  LOW QUALITY PROTEIN: integrin alpha-9-like [KO:K06585]
112235545  integrin alpha-10-like [KO:K06586]
112218294  itga11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
112239256  LOW QUALITY PROTEIN: integrin alpha-V-like [KO:K06487]
112237229  integrin alpha-V-like [KO:K06487]
112227000  integrin beta-1-like [KO:K05719]
112228042  integrin beta-1-like isoform X1 [KO:K05719]
112260414  integrin beta-1-like isoform X1 [KO:K05719]
112215587  integrin beta-1-like [KO:K05719]
112215590  integrin beta-1-like [KO:K05719]
112223770  integrin beta-3-like isoform X1 [KO:K06493]
112258603  integrin beta-3-like [KO:K06493]
112224778  LOW QUALITY PROTEIN: integrin beta-4-like [KO:K06525]
112233642  LOW QUALITY PROTEIN: integrin beta-4-like [KO:K06525]
112237626  LOW QUALITY PROTEIN: integrin beta-4-like [KO:K06525]
112238437  integrin beta-5-like [KO:K06588]
112225600  integrin beta-5-like isoform X1 [KO:K06588]
112255159  integrin beta-6-like [KO:K06589]
112266506  itgb6; integrin beta-6 [KO:K06589]
112247447  integrin beta-6-like [KO:K06589]
112254586  integrin beta-7-like isoform X1 [KO:K06590]
112216380  integrin beta-7-like isoform X1 [KO:K06590]
112217664  integrin beta-7-like isoform X1 [KO:K06590]
112241368  platelet-derived growth factor subunit A-like [KO:K04359]
112239316  platelet-derived growth factor subunit A-like [KO:K04359]
112240061  platelet-derived growth factor subunit B-like [KO:K17386]
112240982  putative uncharacterized protein DDB_G0291608 [KO:K17386]
112236859  platelet-derived growth factor D-like [KO:K05450]
112237077  platelet-derived growth factor D-like [KO:K05450]
112247795  platelet-derived growth factor D-like [KO:K05450]
112221054  platelet-derived growth factor C-like [KO:K05450]
112256335  platelet-derived growth factor C-like [KO:K05450]
112256330  egf; pro-epidermal growth factor [KO:K04357]
112214206  insulin-like growth factor I isoform X1 [KO:K05459]
112217005  insulin-like growth factor I isoform X1 [KO:K05459]
112234081  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
112221165  vegfb; vascular endothelial growth factor B [KO:K05448]
112217670  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
112250395  vascular endothelial growth factor A-A-like [KO:K05448]
112223181  vascular endothelial growth factor A-A isoform X1 [KO:K05448]
112250555  vascular endothelial growth factor A-like isoform X1 [KO:K16859]
112256717  placenta growth factor-like [KO:K16859]
112233191  placenta growth factor-like [KO:K16859]
112261758  placenta growth factor-like [KO:K16859]
112234531  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
112231122  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
112246255  vascular endothelial growth factor C-like [KO:K05449]
112229039  vascular endothelial growth factor C-like [KO:K05449]
112252444  hepatocyte growth factor-like isoform X1 [KO:K05460]
112245248  hepatocyte growth factor-like isoform X1 [KO:K05460]
112249110  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
112251129  platelet-derived growth factor receptor alpha-like isoform X1 [KO:K04363] [EC:2.7.10.1]
112251205  platelet-derived growth factor receptor alpha-like isoform X1 [KO:K04363] [EC:2.7.10.1]
112256098  platelet-derived growth factor receptor beta-like isoform X1 [KO:K05089] [EC:2.7.10.1]
112220770  platelet-derived growth factor receptor beta-like isoform X1 [KO:K05089] [EC:2.7.10.1]
112229041  platelet-derived growth factor receptor beta-like isoform X1 [KO:K05089] [EC:2.7.10.1]
112218557  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
112252377  LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
112249135  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
112232691  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
112226767  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
112215338  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
112260663  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
112227760  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
112233568  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
112216488  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1-like [KO:K05096] [EC:2.7.10.1]
112227702  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1-like [KO:K05096] [EC:2.7.10.1]
112256198  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
112220893  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
112252650  hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
112219021  hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
112223875  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112255048  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
112221781  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
112267038  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
112216306  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
112265084  rho GTPase-activating protein 35-like isoform X1 [KO:K05732]
112257727  rho GTPase-activating protein 35-like [KO:K05732]
112228679  rho GTPase-activating protein 35-like [KO:K05732]
112266677  rho GTPase-activating protein 35-like [KO:K05732]
112244951  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
112256837  rho GTPase-activating protein 5-like [KO:K13709]
112244890  transforming protein RhoA-like [KO:K04513]
112232600  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
112254214  rho-related GTP-binding protein RhoA-D [KO:K04513]
112254254  rho-related GTP-binding protein RhoA-D [KO:K04513]
112222049  rho-related GTP-binding protein RhoA-C [KO:K04513]
112222098  rho-related GTP-binding protein RhoA-B [KO:K04513]
112216064  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
112254897  transforming protein RhoA-like [KO:K04513]
112226775  rho-associated protein kinase 1-like isoform X1 [KO:K04514] [EC:2.7.11.1]
112260654  rho-associated protein kinase 1-like isoform X1 [KO:K04514] [EC:2.7.11.1]
112261645  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
112246839  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
112217395  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
112232894  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
112215535  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
112255301  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
112249714  LOW QUALITY PROTEIN: myosin regulatory light chain 2, atrial isoform-like [KO:K12754]
112214243  myosin regulatory light polypeptide 9 [KO:K12755]
112246201  myosin regulatory light polypeptide 9-like [KO:K12755]
112254956  myosin regulatory light polypeptide 9-like [KO:K12755]
112257917  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K12756]
112228530  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like isoform X1 [KO:K12756]
112215662  myosin regulatory light polypeptide 9-like [KO:K12757]
112227962  myosin regulatory light polypeptide 9 [KO:K12757]
112259027  myosin regulatory light chain 2, skeletal muscle isoform type 2-like [KO:K12758]
112258967  myosin regulatory light chain 2, skeletal muscle isoform type 2-like [KO:K12758]
112263934  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
112259017  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
112248359  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
112223856  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
112260058  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like isoform X1 [KO:K06269] [EC:3.1.3.16]
112250506  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
112258985  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
112217890  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
112214774  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
112245361  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
112263044  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
112221953  protein phosphatase 1 regulatory subunit 12B-like [KO:K12329]
112216138  protein phosphatase 1 regulatory subunit 12B-like isoform X1 [KO:K12329]
112245575  protein phosphatase 1 regulatory subunit 12C-like isoform X1 [KO:K17457]
112264608  protein phosphatase 1 regulatory subunit 12C-like isoform X1 [KO:K17457]
112245503  protein phosphatase 1 regulatory subunit 12C-like isoform X1 [KO:K17457]
112245504  protein phosphatase 1 regulatory subunit 12C-like isoform X1 [KO:K17457]
112234141  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
112222068  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
112225163  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
112249079  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
112246651  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
112225996  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
112226830  myosin light chain kinase 3-like [KO:K00907] [EC:2.7.11.18]
112235615  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
112250079  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
112250823  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
112227340  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
112260798  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
112220399  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like isoform X1 [KO:K00889] [EC:2.7.1.68]
112252223  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
112248588  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
112235372  putative PIP5K1A and PSMD4-like protein [KO:K00889] [EC:2.7.1.68]
112263935  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
112230514  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
112266614  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
112240902  actin, cytoplasmic 1 [KO:K05692]
112218594  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
112252413  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
112245255  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
112223208  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
112266430  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
112266436  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
112265290  alpha-actinin-4-like isoform X1 [KO:K05699]
112266874  alpha-actinin-4 isoform X1 [KO:K05699]
112218574  talin-2-like [KO:K06271]
112249374  LOW QUALITY PROTEIN: talin-2-like [KO:K06271]
112219996  talin-1-like [KO:K06271]
112222449  LOW QUALITY PROTEIN: filamin-A-like [KO:K04437]
112232341  filamin-C-like [KO:K04437]
112241106  filamin-A-like [KO:K04437]
112236628  LOW QUALITY PROTEIN: filamin-A-like [KO:K04437]
112214278  LOW QUALITY PROTEIN: filamin-C-like [KO:K04437]
112232475  filamin-C-like [KO:K04437]
112255105  flnb; filamin-B [KO:K04437]
112237703  filamin-A-like [KO:K04437]
112263036  flocculation protein FLO11-like isoform X1 [KO:K05760]
112254785  pxn; paxillin isoform X1 [KO:K05760]
112248400  caskin-1-like isoform X1 [KO:K05760]
112267274  integrin-linked protein kinase-like [KO:K06272] [EC:2.7.11.1]
112265713  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
112222506  LOW QUALITY PROTEIN: zyxin-like [KO:K06273]
112267174  vasodilator-stimulated phosphoprotein-like isoform X1 [KO:K06274]
112239349  LOW QUALITY PROTEIN: vinculin-like [KO:K05700]
112257962  vcl; vinculin isoform X1 [KO:K05700]
112245009  vinculin-like isoform X1 [KO:K05700]
112249152  alpha-parvin-like [KO:K06275]
112252602  alpha-parvin-like [KO:K06275]
112218162  parvb; beta-parvin isoform X1 [KO:K06275]
112218163  parvg; gamma-parvin [KO:K06275]
112263678  alpha-parvin [KO:K06275]
112224117  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
112219534  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
112223683  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
112250387  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112256640  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
112225150  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
112261841  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112230362  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
112265711  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112224566  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112265172  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
112217662  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
112225427  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
112241148  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112253937  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
112253980  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
112266570  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
112239225  catenin beta-1-like [KO:K02105]
112239227  catenin beta-1 isoform X1 [KO:K02105]
112230347  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
112265049  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
112229535  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
112245979  focal adhesion kinase 1-like [KO:K05725] [EC:2.7.10.2]
112267269  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112216060  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
112232603  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
112260202  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
112227144  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
112251044  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112260699  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
112250738  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
112260309  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
112244626  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
112250879  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112252131  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
112226747  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
112248937  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
112230790  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112253032  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112254533  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112224277  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112223442  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112215524  vav3; guanine nucleotide exchange factor VAV3 [KO:K05730]
112230527  LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2-like [KO:K05730]
112219368  guanine nucleotide exchange factor VAV2-like [KO:K05730]
112239456  guanine nucleotide exchange factor VAV3-like [KO:K05730]
112259508  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112239957  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
112224481  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112258954  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
112259231  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
112234040  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
112240485  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
112259175  ras-related C3 botulinum toxin substrate 3-like isoform X1 [KO:K07861]
112224482  rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
112234003  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
112265443  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
112250960  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
112245139  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
112236105  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
112228863  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
112265297  serine/threonine-protein kinase PAK 4-like [KO:K05734] [EC:2.7.11.1]
112266882  serine/threonine-protein kinase PAK 4-like [KO:K05734] [EC:2.7.11.1]
112217822  serine/threonine-protein kinase PAK 5-like isoform X1 [KO:K05736] [EC:2.7.11.1]
112250569  serine/threonine-protein kinase PAK 5-like isoform X1 [KO:K05736] [EC:2.7.11.1]
112249908  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
112255751  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
112262320  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
112233276  cell division control protein 42 homolog [KO:K04393]
112222725  cell division control protein 42 homolog [KO:K04393]
112229837  cell division control protein 42 homolog [KO:K04393]
112254527  cell division control protein 42 homolog isoform X1 [KO:K04393]
112218284  cell division control protein 42 homolog isoform X1 [KO:K04393]
112221931  cell division control protein 42 homolog isoform X1 [KO:K04393]
112264818  cell division control protein 42 homolog isoform X1 [KO:K04393]
112237883  cell division control protein 42 homolog [KO:K04393]
112216155  cell division control protein 42 homolog isoform X1 [KO:K04393]
112252351  breast cancer anti-estrogen resistance protein 1-like isoform X1 [KO:K05726]
112230946  crk-like protein [KO:K04438]
112258044  adapter molecule crk-like [KO:K04438]
112265169  adapter molecule crk-like [KO:K04438]
112220384  crk-like protein [KO:K04438]
112258186  adapter molecule crk-like [KO:K04438]
112266812  adapter molecule crk-like [KO:K04438]
112228388  adapter molecule crk-like [KO:K04438]
112248224  rap guanine nucleotide exchange factor 1-like isoform X1 [KO:K06277]
112263306  rap guanine nucleotide exchange factor 1-like isoform X1 [KO:K06277]
112247636  rap guanine nucleotide exchange factor 1-like isoform X1 [KO:K06277]
112230757  rap guanine nucleotide exchange factor 1-like isoform X1 [KO:K06277]
112221873  ras-related protein Rap-1b isoform X1 [KO:K04353]
112254221  ras-related protein Rap-1A-like [KO:K04353]
112254261  ras-related protein Rap-1A-like [KO:K04353]
112216212  ras-related protein Rap-1A-like [KO:K04353]
112221097  ras-related protein Rap-1A-like [KO:K04353]
112252764  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
112220751  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
112252352  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
112224208  LOW QUALITY PROTEIN: mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
112231415  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
112219617  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112257338  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
112223506  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112260691  transcription factor AP-1-like [KO:K04448]
112251077  transcription factor AP-1-like [KO:K04448]
112226753  transcription factor AP-1-like [KO:K04448]
112248681  transcription factor AP-1-like isoform X1 [KO:K04448]
112257314  transcription factor AP-1-like [KO:K04448]
112219784  transcription factor AP-1-like [KO:K04448]
112218852  caveolin-1 [KO:K06278]
112252651  caveolin-1-like [KO:K06278]
112218853  caveolin-2-like [KO:K12958]
112252652  cav2; caveolin-2 [KO:K12958]
112255282  caveolin-2-like [KO:K12958]
112254822  caveolin-2-like isoform X1 [KO:K12958]
112223176  caveolin-2-like [KO:K12958]
112262828  caveolin-2-like [KO:K12958]
112217080  cav3; caveolin-3 [KO:K12959]
112254824  caveolin-3-like [KO:K12959]
112215023  caveolin-3-like [KO:K12959]
112255496  caveolin-3-like [KO:K12959]
112250060  tyrosine-protein kinase Fyn-like isoform X1 [KO:K05703] [EC:2.7.10.2]
112217528  tyrosine-protein kinase Fyn-like [KO:K05703] [EC:2.7.10.2]
112222667  SHC-transforming protein 1-like [KO:K06279]
112250883  SHC-transforming protein 2-like isoform X1 [KO:K17447]
112235421  SHC-transforming protein 2-like isoform X1 [KO:K17447]
112257355  LOW QUALITY PROTEIN: SHC-transforming protein 3-like [KO:K17448]
112234492  LOW QUALITY PROTEIN: growth factor receptor-bound protein 2-like [KO:K04364]
112234604  LOW QUALITY PROTEIN: growth factor receptor-bound protein 2-like [KO:K04364]
112230281  growth factor receptor-bound protein 2-like [KO:K04364]
112264096  growth factor receptor-bound protein 2-like [KO:K04364]
112265983  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112230419  son of sevenless homolog 1-like isoform X1 [KO:K03099]
112262240  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
112252501  GTPase HRas-like [KO:K02833]
112245216  GTPase HRas-like [KO:K02833]
112218668  GTPase HRas [KO:K02833]
112215764  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
112222214  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
112262497  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
112262493  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
112251950  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
112251959  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
112215780  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
112237408  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
112222342  ETS domain-containing protein Elk-3-like isoform X1 [KO:K04375]
112218887  G1/S-specific cyclin-D1-like [KO:K04503]
112252678  G1/S-specific cyclin-D1-like isoform X1 [KO:K04503]
112263573  G1/S-specific cyclin-D1 [KO:K04503]
112249039  G1/S-specific cyclin-D1-like [KO:K04503]
112214224  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
112252585  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112216983  G1/S-specific cyclin-D2-like [KO:K10151]
112218786  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
112259254  LOW QUALITY PROTEIN: G1/S-specific cyclin-D1-like [KO:K10151]
112254562  G1/S-specific cyclin-D2-like [KO:K10152]
112235685  LOW QUALITY PROTEIN: inhibitor of apoptosis protein-like [KO:K16060]
112246336  LOW QUALITY PROTEIN: putative inhibitor of apoptosis [KO:K16060]
112255900  E3 ubiquitin-protein ligase XIAP-like isoform X1 [KO:K04725] [EC:2.3.2.27]
112236582  E3 ubiquitin-protein ligase XIAP-like [KO:K04725] [EC:2.3.2.27]
112228809  bcl2-associated agonist of cell death-like [KO:K02158]
112237949  bcl2-associated agonist of cell death-like [KO:K02158]
112227752  apoptosis regulator Bcl-2-like [KO:K02161]
112233575  apoptosis regulator Bcl-2-like [KO:K02161]
112260550  apoptosis regulator Bcl-2-like [KO:K02161]
112232698  apoptosis regulator Bcl-2-like [KO:K02161]
112226859  apoptosis regulator Bcl-2-like [KO:K02161]
112215344  apoptosis regulator Bcl-2-like [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
otw04010  MAPK signaling pathway
otw04060  Cytokine-cytokine receptor interaction
otw04070  Phosphatidylinositol signaling system
otw04110  Cell cycle
otw04310  Wnt signaling pathway
otw04512  ECM-receptor interaction
otw04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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