KEGG   PATHWAY: pcw04218
Entry
pcw04218                    Pathway                                
Name
Cellular senescence - Phascolarctos cinereus (koala)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
pcw04218  Cellular senescence
pcw04218

Other DBs
GO: 0090398
Organism
Phascolarctos cinereus (koala) [GN:pcw]
Gene
110202366  TGFB1; transforming growth factor beta-1 [KO:K13375]
110205565  TGFB2; LOW QUALITY PROTEIN: transforming growth factor beta-2 [KO:K13376]
110208305  TGFB3; transforming growth factor beta-3 [KO:K13377]
110214564  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
110212998  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
110207982  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
110205871  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
110201194  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
110210989  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110209152  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
110197171  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
110218698  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
110203289  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
110213446  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
110211462  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
110207491  RBL2; LOW QUALITY PROTEIN: retinoblastoma-like protein 2 [KO:K16332]
110216806  E2F1; transcription factor E2F1 [KO:K17454]
110206051  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
110208713  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
110210428  E2F4; transcription factor E2F4 [KO:K04682]
110214683  E2F5; transcription factor E2F5 [KO:K04682]
110204454  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110208219  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110199476  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
110223395  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110216530  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110209293  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110196617  FOXO1; forkhead box protein O1 [KO:K07201]
110222927  FOXO3; forkhead box protein O3 [KO:K09408]
110217257  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
110210908  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
110207433  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
110195790  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
110203128  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
110199325  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
110199390  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
110203695  HLA class I histocompatibility antigen, B-8 alpha chain-like [KO:K06751]
110223003  HLA class I histocompatibility antigen, B-40 alpha chain-like [KO:K06751]
110223021  HLA class I histocompatibility antigen, B-35 alpha chain-like isoform X1 [KO:K06751]
110223022  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
110202415  HLA class I histocompatibility antigen, A-69 alpha chain-like isoform X1 [KO:K06751]
110202416  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
110218416  zinc-alpha-2-glycoprotein-like isoform X1 [KO:K06751]
110218421  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
110218435  zinc-alpha-2-glycoprotein-like isoform X1 [KO:K06751]
110218436  zinc-alpha-2-glycoprotein-like isoform X1 [KO:K06751]
110218438  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
110218444  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
110199312  H-2 class I histocompatibility antigen, D-D alpha chain-like isoform X1 [KO:K06751]
110218456  zinc-alpha-2-glycoprotein-like [KO:K06751]
110218463  zinc-alpha-2-glycoprotein-like isoform X1 [KO:K06751]
110218465  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
110199902  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
110193352  KRAS; GTPase KRas isoform X1 [KO:K07827]
110219182  NRAS; GTPase NRas [KO:K07828]
110203410  GTPase NRas-like [KO:K07828]
110203411  GTPase HRas-like [KO:K07828]
110202309  GTPase HRas-like [KO:K07828]
110219916  RRAS; LOW QUALITY PROTEIN: ras-related protein R-Ras [KO:K07829]
110221061  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
110208214  MRAS; ras-related protein M-Ras [KO:K07831]
110202954  HRAS; GTPase HRas isoform X1 [KO:K02833]
110205475  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110202713  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110203042  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110198888  TSC1; hamartin [KO:K07206]
110221953  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
110201965  RHEB; GTP-binding protein Rheb [KO:K07208]
110199207  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
110199935  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110216385  SIRT1; LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
110222963  CCNA2; cyclin-A2 [KO:K06627]
110195227  CCNA1; LOW QUALITY PROTEIN: cyclin-A1 [KO:K06627]
110220000  LOW QUALITY PROTEIN: cyclin-A2-like [KO:K06627]
110216794  MYBL2; myb-related protein B isoform X1 [KO:K21769]
110205516  LIN9; protein lin-9 homolog isoform X1 [KO:K21773]
110201763  LIN37; protein lin-37 homolog [KO:K21774]
110208336  LIN52; protein lin-52 homolog isoform X1 [KO:K21775]
110209754  LIN54; protein lin-54 homolog isoform X1 [KO:K21776]
110206251  RBBP4; histone-binding protein RBBP4 isoform X1 [KO:K10752]
110218721  FOXM1; forkhead box protein M1 isoform X1 [KO:K09406]
110216083  MYC; myc proto-oncogene protein [KO:K04377]
110201193  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
110211045  MDM2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
110194271  TP53; cellular tumor antigen p53 [KO:K04451]
110219544  RASSF5; ras association domain-containing protein 5 [KO:K08015]
110194552  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
110212306  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
110219091  HIPK1; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
110216272  HIPK2; homeodomain-interacting protein kinase 2 [KO:K08826] [EC:2.7.11.1]
110202784  HIPK4; homeodomain-interacting protein kinase 4 isoform X1 [KO:K08826] [EC:2.7.11.1]
110192610  HIPK3; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
110206445  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110196829  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
110195486  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
110204892  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110205943  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110197417  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
110221918  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110215167  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110192574  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
110223168  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
110219359  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
110217326  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110217327  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110205920  MAPK11; LOW QUALITY PROTEIN: mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
110205921  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
110212964  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
110223449  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
110195907  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
110216425  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
110216613  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
110205363  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
110202696  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
110218030  MRE11; LOW QUALITY PROTEIN: double-strand break repair protein MRE11 [KO:K10865]
110211698  RAD50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
110203267  NBN; nibrin isoform X1 [KO:K10867]
110214947  ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
110215254  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
110195485  RAD9A; cell cycle checkpoint control protein RAD9A isoform X1 [KO:K10994] [EC:3.1.11.2]
110196780  RAD9B; cell cycle checkpoint control protein RAD9B [KO:K10995]
110214593  RAD1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
110201898  HUS1; checkpoint protein HUS1 isoform X1 [KO:K10903]
110197214  ATR; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
110218134  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
110217106  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
110216726  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
110207632  GATA4; transcription factor GATA-4 [KO:K09183]
110222879  TRAF3IP2; LOW QUALITY PROTEIN: adapter protein CIKS [KO:K21124]
110209686  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
110195563  RELA; transcription factor p65 isoform X1 [KO:K04735]
110192428  IL1A; interleukin-1 alpha [KO:K04383]
110213115  IL6; interleukin-6 [KO:K05405]
110209794  interleukin-8-like isoform X1 [KO:K10030]
110197536  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
110194266  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
110207589  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
110219609  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
110220618  ZFP36L1; mRNA decay activator protein ZFP36L1 isoform X1 [KO:K18753]
110218510  ZFP36L2; mRNA decay activator protein ZFP36L2 isoform X1 [KO:K18753]
110197022  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110203574  TRPV4; LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 4 [KO:K04973]
110203550  TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
110195314  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
110213557  CAPN11; LOW QUALITY PROTEIN: calpain-11 [KO:K01367] [EC:3.4.22.52]
110205536  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
110217739  CALM1; calmodulin [KO:K02183]
110197786  CALML6; calmodulin-like protein 6 [KO:K02183]
110218482  CALM2; calmodulin [KO:K02183]
110199039  calmodulin-A-like [KO:K02183]
110202401  CALM3; calmodulin isoform X1 [KO:K02183]
110205749  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
110209680  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110221443  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110200396  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110207663  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
110208752  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
110206666  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
110210380  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110197863  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
110195613  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
110193334  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
110217180  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
110212779  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
110209837  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
110220099  LOW QUALITY PROTEIN: ADP/ATP translocase 3-like [KO:K05863]
110222593  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
110211722  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
110221481  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
110196425  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
110221459  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
pcw04020  Calcium signaling pathway
pcw04068  FoxO signaling pathway
pcw04110  Cell cycle
pcw04115  p53 signaling pathway
pcw04150  mTOR signaling pathway
KO pathway
ko04218   
LinkDB

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