KEGG   PATHWAY: pmur03420Help
pmur03420                   Pathway                                

Nucleotide excision repair - Protobothrops mucrosquamatus (Taiwan habu)
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
pmur03420  Nucleotide excision repair

Ortholog table
pmur_M00262  DNA polymerase delta complex [PATH:pmur03420]
Other DBs
GO: 0006289
Protobothrops mucrosquamatus (Taiwan habu) [GN:pmur]
107285413  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:]
107302745  CUL4B; cullin-4B [KO:K10609]
107292639  DDB1; LOW QUALITY PROTEIN: DNA damage-binding protein 1 [KO:K10610]
107301286  DNA damage-binding protein 1-like [KO:K10610]
107289836  DDB2; DNA damage-binding protein 2 [KO:K10140]
107295642  XPC; DNA repair protein complementing XP-C cells [KO:K10838]
107285133  RAD23A; UV excision repair protein RAD23 homolog A isoform X1 [KO:K10839]
107292291  RAD23B; UV excision repair protein RAD23 homolog B [KO:K10839]
107293163  CETN2; centrin-2 [KO:K10840]
107295768  ERCC8; DNA excision repair protein ERCC-8 [KO:K10570]
107293949  ERCC6; DNA excision repair protein ERCC-6 [KO:K10841]
107301385  DNA excision repair protein ERCC-6-like [KO:K10841]
107300604  CDK7; cyclin-dependent kinase 7 [KO:K02202] [EC:]
107290953  MNAT1; CDK-activating kinase assembly factor MAT1 [KO:K10842]
107302941  CCNH; cyclin-H isoform X1 [KO:K06634]
107300936  cyclin-H-like [KO:K06634]
107302065  general transcription and DNA repair factor IIH helicase subunit XPB [KO:K10843] [EC:]
107302007  general transcription and DNA repair factor IIH helicase subunit XPB [KO:K10843] [EC:]
107291651  ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD [KO:K10844] [EC:]
107297341  GTF2H5; general transcription factor IIH subunit 5 [KO:K10845]
107290710  GTF2H1; general transcription factor IIH subunit 1 [KO:K03141]
107289745  general transcription factor IIH subunit 2 [KO:K03142]
107301134  general transcription factor IIH subunit 2-like [KO:K03142]
107285458  GTF2H3; general transcription factor IIH subunit 3 isoform X1 [KO:K03143]
107295942  GTF2H4; LOW QUALITY PROTEIN: general transcription factor IIH subunit 4 [KO:K03144]
107298146  general transcription factor IIH subunit 4-like [KO:K03144]
107301511  DNA repair protein complementing XP-G cells-like [KO:K10846]
107282310  ERCC5; LOW QUALITY PROTEIN: DNA repair protein complementing XP-G cells [KO:K10846]
107295772  DNA repair protein complementing XP-A cells homolog [KO:K10847]
107299497  DNA repair protein complementing XP-A cells homolog [KO:K10847]
107296194  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
107300767  replication protein A 70 kDa DNA-binding subunit-like [KO:K07466]
107288015  RPA2; replication protein A 32 kDa subunit [KO:K10739]
107283682  RPA3; replication protein A 14 kDa subunit [KO:K10740]
107293802  ERCC4; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
107285642  ERCC1; DNA excision repair protein ERCC-1 [KO:K10849]
107282401  POLD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:]
107286229  POLD2; DNA polymerase delta subunit 2 [KO:K02328]
107287041  POLD3; DNA polymerase delta subunit 3 [KO:K03504]
107296657  POLD4; DNA polymerase delta subunit 4 [KO:K03505]
107301313  DNA polymerase epsilon catalytic subunit A-like [KO:K02324] [EC:]
107285443  POLE; DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:]
107298233  POLE2; DNA polymerase epsilon subunit 2 [KO:K02325] [EC:]
107302552  POLE3; DNA polymerase epsilon subunit 3 [KO:K02326] [EC:]
107299622  POLE4; DNA polymerase epsilon subunit 4 [KO:K03506] [EC:]
107283633  PCNA; proliferating cell nuclear antigen [KO:K04802]
107299038  replication factor C subunit 1-like [KO:K10754]
107299681  replication factor C subunit 1 [KO:K10754]
107302798  RFC1; replication factor C subunit 1 [KO:K10754]
107293330  RFC4; LOW QUALITY PROTEIN: replication factor C subunit 4 [KO:K10755]
107302352  RFC2; replication factor C subunit 2 isoform X1 [KO:K10755]
107292839  RFC5; replication factor C subunit 5 isoform X1 [KO:K10756]
107286810  RFC3; replication factor C subunit 3 [KO:K10756]
107297952  DNA ligase 1-like [KO:K10747] [EC:]
107285325  LIG1; DNA ligase 1 [KO:K10747] [EC:]
Sugasawa K.
[Molecular mechanism of mammalian nucleotide excision repair] Japanese
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Nakatsu Y.
[Transcription-coupled repair and Cockayne syndrome] Japanese
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Nakagawa N, Masui R, Kuramitsu S.
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8] Japanese
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
Neuroscience 145:1388-96 (2007)
Saldivar JS, Wu X, Follen M, Gershenson D.
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
Gynecol Oncol 107:S56-71 (2007)
Sugasawa K.
[DNA repair pathways involving Cul4A ubiquitin ligases] Japanese
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Ito S, Ando D, Tanaka K.
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders] Japanese
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
KO pathway
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