KEGG   PATHWAY: pon04630
Entry
pon04630                    Pathway                                

Name
JAK-STAT signaling pathway - Pongo abelii (Sumatran orangutan)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
pon04630  JAK-STAT signaling pathway
pon04630

Other DBs
GO: 0007259
Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100455248  IL2; interleukin-2 [KO:K05429]
100447057  IL3; interleukin-3 [KO:K04736]
100451705  IL4; interleukin-4 isoform X1 [KO:K05430]
100450694  IL5; interleukin-5 [KO:K05428]
100453941  IL6; interleukin-6 isoform X2 [KO:K05405]
100447454  IL7; interleukin-7 isoform X1 [KO:K05431]
100440198  IL9; interleukin-9 [KO:K05432]
100446386  IL10; interleukin-10 [KO:K05443]
100452433  IL11; interleukin-11 [KO:K05417]
100444807  IL12A; interleukin-12 subunit alpha [KO:K05406]
100435254  IL12B; interleukin-12 subunit beta [KO:K05425]
100451066  IL13; interleukin-13 isoform X1 [KO:K05435]
100456813  IL15; interleukin-15 [KO:K05433]
100448961  IL17D; interleukin-17D [KO:K05492]
100445757  IL19; interleukin-19 isoform X2 [KO:K05444]
100445374  IL20; interleukin-20 [KO:K22667]
100455621  IL21; interleukin-21 [KO:K05434]
100444770  IL22; interleukin-22 [KO:K05445]
100452384  IL23A; interleukin-23 subunit alpha [KO:K05426]
100444774  IL24; interleukin-24 isoform X1 [KO:K22668]
100459543  interferon alpha-10 [KO:K05414]
100432532  IFNA8; interferon alpha-8 [KO:K05414]
100432906  IFNA2; interferon alpha-2 [KO:K05414]
100434036  IFNA6; interferon alpha-6 [KO:K05414]
100434796  interferon alpha-5 [KO:K05414]
100435169  interferon alpha-14 [KO:K05414]
100438871  interferon alpha-17-like [KO:K05414]
100439978  IFNA21; interferon alpha-21 [KO:K05414]
100432153  interferon alpha-1/13 [KO:K05414]
100445711  interferon alpha-10-like [KO:K05414]
100438149  interferon alpha-4-like [KO:K05414]
100437034  interferon alpha-4-like [KO:K05414]
100433301  interferon alpha-1/13-like [KO:K05414]
112134962  interferon alpha-10-like [KO:K05414]
100443523  interferon alpha-4-like [KO:K05414]
100441074  IFNB1; interferon beta [KO:K05415]
100444043  IFNG; interferon gamma [KO:K04687]
100431405  IFNE; interferon epsilon [KO:K05442]
100453716  IFNK; interferon kappa [KO:K05441]
100460595  interferon lambda-1 [KO:K05447]
100459981  interferon lambda-3 [KO:K22669]
100458631  interferon lambda-3-like [KO:K22669]
100440345  interferon omega-1 [KO:K05440]
100448170  OSM; oncostatin-M isoform X1 [KO:K05418]
100447794  LIF; leukemia inhibitory factor [KO:K05419]
100457198  TSLP; thymic stromal lymphopoietin [KO:K05436]
100462417  CTF1; cardiotrophin-1 isoform X1 [KO:K05422]
100431324  cardiotrophin-2 [KO:K24382]
100447424  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
103891808  CNTF; ciliary neurotrophic factor [KO:K05420]
100442480  CSF3; granulocyte colony-stimulating factor isoform X2 [KO:K05423]
100459890  EPO; erythropoietin isoform X1 [KO:K05437]
100446663  chorionic somatomammotropin hormone 2 isoform X2 [KO:K05438]
100447767  growth hormone variant isoform X1 [KO:K05438]
100448861  GH1; somatotropin isoform X2 [KO:K05438]
103892869  chorionic somatomammotropin hormone 2-like isoform X1 [KO:K05438]
100440463  LEP; leptin isoform X1 [KO:K05424]
100452053  THPO; thrombopoietin isoform X1 [KO:K06854]
100450466  PRL; prolactin [KO:K05439]
100455021  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100440212  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100460243  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100440118  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
100460977  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
100454903  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
100462256  interleukin-3 receptor subunit alpha [KO:K04737]
100449812  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
100450437  IL5RA; interleukin-5 receptor subunit alpha isoform X2 [KO:K05067]
100459702  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
100461835  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
100461113  IL9R; interleukin-9 receptor [KO:K05073]
100436549  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
100442754  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
100190822  IL11RA; interleukin-11 receptor subunit alpha precursor [KO:K05056]
100435478  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
100456779  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
100457694  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
100441311  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
100439247  IL15RA; interleukin-15 receptor subunit alpha isoform X6 [KO:K05074]
100455762  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
100458031  IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
100450175  IL21R; interleukin-21 receptor isoform X2 [KO:K05075]
100454377  IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138]
100456367  IL22RA2; interleukin-22 receptor subunit alpha-2 isoform X1 [KO:K05139]
100458963  IL23R; interleukin-23 receptor [KO:K05065]
100432479  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
100451191  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
100443118  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100441293  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100171593  IFNGR1; interferon gamma receptor 1 precursor [KO:K05132]
100442383  IFNGR2; interferon gamma receptor 2 [KO:K05133]
100450173  IFNLR1; interferon lambda receptor 1 isoform X2 [KO:K05140]
100440306  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
100439694  LIFR; leukemia inhibitory factor receptor [KO:K05058]
100455669  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
100452697  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
100452320  LOW QUALITY PROTEIN: granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
100457063  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
100433338  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
100452294  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
100451189  GHR; growth hormone receptor isoform X2 [KO:K05080]
100461924  LEPR; leptin receptor [KO:K05062]
100448006  MPL; thrombopoietin receptor isoform X1 [KO:K05082]
100294567  PRLR; prolactin receptor precursor [KO:K05081]
100459280  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
100431735  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100460001  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100433477  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100172517  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
100433988  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100439493  TYK2; LOW QUALITY PROTEIN: non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100173683  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100452011  STAT2; signal transducer and activator of transcription 2 isoform X3 [KO:K11221]
100171541  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100436344  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
100461695  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
100462537  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
100173709  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
100450314  CISH; cytokine-inducible SH2-containing protein isoform X2 [KO:K04701]
100445635  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
100440378  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
100446544  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
100171842  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
100437083  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
100438503  SOCS7; suppressor of cytokine signaling 7 [KO:K04699]
100172146  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
100938429  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
100436188  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
100453051  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100461844  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
100456735  MYC; myc proto-oncogene protein [KO:K04377]
100171625  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100457978  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100452570  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100453682  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100939468  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
100451794  AOX4; LOW QUALITY PROTEIN: aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
100172719  GFAP; glial fibrillary acidic protein [KO:K05640]
100446981  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
100444798  STAM2; signal transducing adapter molecule 2 [KO:K04705]
100445655  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X5 [KO:K18026] [EC:3.1.3.48]
103892420  tyrosine-protein phosphatase non-receptor type 2 [KO:K18026] [EC:3.1.3.48]
100448471  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
100455089  IRF9; interferon regulatory factor 9 [KO:K04693]
100455260  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
100445634  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
100450652  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X2 [KO:K04706] [EC:2.3.2.-]
100454767  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
100461795  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
100440650  PIAS4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
100189735  FHL1; four and a half LIM domains protein 1 precursor [KO:K14365]
100440983  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100173972  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100434331  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100458733  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100459427  HRAS; GTPase HRas [KO:K02833]
100173732  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100432846  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100453779  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103889133  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100174298  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100173589  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100437617  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100454279  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100448114  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100442100  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100456786  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
Reference
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Related
pathway
pon04010  MAPK signaling pathway
pon04060  Cytokine-cytokine receptor interaction
pon04110  Cell cycle
pon04120  Ubiquitin mediated proteolysis
pon04151  PI3K-Akt signaling pathway
pon04210  Apoptosis
KO pathway
ko04630   
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