KEGG   PATHWAY: pov04115
pov04115                    Pathway                                

p53 signaling pathway - Paralichthys olivaceus (Japanese flounder)
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Cellular Processes; Cell growth and death
Pathway map
pov04115  p53 signaling pathway

Paralichthys olivaceus (Japanese flounder) [GN:pov]
109634588  atm; serine-protein kinase ATM [KO:K04728] [EC:]
109645723  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:]
109640857  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:]
109628292  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:]
109644696  gorab; RAB6-interacting golgin [KO:K19748]
109643735  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:]
109629250  mdm4; protein Mdm4 isoform X1 [KO:K10127]
109634900  cellular tumor antigen p53-like isoform X1 [KO:K04451]
109629024  LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1-like [KO:K06625]
109625110  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
109642994  G1/S-specific cyclin-D1-like isoform X1 [KO:K04503]
109632688  G1/S-specific cyclin-D2-like [KO:K10151]
109623974  G1/S-specific cyclin-D2-like [KO:K10151]
109629233  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
109629352  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:]
109634060  cyclin-dependent kinase 4-like [KO:K02091] [EC:]
109631907  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:]
109640569  G1/S-specific cyclin-E2-like [KO:K06626]
109625045  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
109645281  G1/S-specific cyclin-E2-like [KO:K06626]
109629344  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:]
109634075  reprimo-like protein [KO:K10128]
109631249  rprm; protein reprimo [KO:K10128]
109640910  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
109647535  G2/mitotic-specific cyclin-B2-like [KO:K21770]
109634457  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
109639858  cyclin-dependent kinase 1-like [KO:K02087] [EC:]
109644407  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109637499  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
109636370  growth arrest and DNA damage-inducible protein GADD45 beta-like isoform X1 [KO:K04402]
109639301  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109625451  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
109643194  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
109624619  gtse1; G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
109631170  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
109623964  pidd1; p53-induced death domain-containing protein 1 [KO:K10130]
109633911  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
109626051  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
109637364  caspase-8-like isoform X1 [KO:K04398] [EC:]
109641073  caspase-8-like [KO:K04398] [EC:]
109631024  caspase-8-like [KO:K04398] [EC:]
109639913  uncharacterized protein LOC109639913 isoform X1 [KO:K04726]
109631661  apoptosis regulator BAX-like [KO:K02159]
109625138  apoptosis regulator BAX-like [KO:K02159]
109634241  bax; apoptosis regulator BAX [KO:K02159]
109627930  siva1; apoptosis regulatory protein Siva [KO:K22744]
109645834  bcl-2-like protein 1 [KO:K04570]
109630859  bcl-2-like protein 1 isoform X1 [KO:K04570]
109640281  apoptosis regulator Bcl-2-like [KO:K02161]
109636381  tp53i3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
109628832  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
109635623  protein shisa-5-like [KO:K10135]
109644160  perp; p53 apoptosis effector related to PMP-22 [KO:K10136]
109640234  zmat3; zinc finger matrin-type protein 3 [KO:K10137]
109640530  E3 ubiquitin-protein ligase Siah1 [KO:K04506] [EC:]
109631327  cytochrome c-b [KO:K08738]
109631651  cytochrome c-a-like [KO:K08738]
109635887  cytochrome c [KO:K08738]
109632693  apaf1; apoptotic protease-activating factor 1 [KO:K02084]
109630724  casp9; caspase-9 [KO:K04399] [EC:]
109639599  caspase-3-like [KO:K02187] [EC:]
109631395  caspase-3-like [KO:K02187] [EC:]
109647473  aifm2; apoptosis-inducing factor 2 [KO:K22745]
109639207  insulin-like growth factor-binding protein 3 [KO:K10138]
109641634  insulin-like growth factor-binding protein 3 [KO:K10138]
109643988  insulin-like growth factor-binding protein 3 [KO:K10138]
109639654  insulin-like growth factor I [KO:K05459]
109640767  igf1; insulin-like growth factor I [KO:K05459]
109637625  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
109645433  CD82 antigen-like [KO:K06509]
109623949  cd82; CD82 antigen [KO:K06509]
109627896  thrombospondin-1-like [KO:K16857]
109636170  thrombospondin-1-like [KO:K16857]
109624175  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
109638772  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:]
109648224  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:]
109636079  sesn1; sestrin-1 isoform X1 [KO:K10141]
109631914  sestrin-2-like isoform X1 [KO:K20394]
109644901  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:]
109634811  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:]
109627333  tuberin-like [KO:K07207]
109627588  tuberin-like [KO:K07207]
109639745  steap3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
109646596  rfwd2; E3 ubiquitin-protein ligase RFWD2 [KO:K10143] [EC:]
109633589  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:]
109643935  ccng1; cyclin-G1 [KO:K10145]
109637130  cyclin-G2-like [KO:K10146]
109646257  cyclin-G2-like [KO:K10146]
109628727  ppm1d; protein phosphatase 1D isoform X1 [KO:K10147] [EC:]
109630878  tp73; tumor protein p73 isoform X1 [KO:K10148]
Levine AJ, Hu W, Feng Z.
The P53 pathway: what questions remain to be explored?
Cell Death Differ 13:1027-36 (2006)
Harris SL, Levine AJ.
The p53 pathway: positive and negative feedback loops.
Oncogene 24:2899-908 (2005)
Balint E E, Vousden KH.
Activation and activities of the p53 tumour suppressor protein.
Br J Cancer 85:1813-23 (2001)
Taylor WR, Stark GR.
Regulation of the G2/M transition by p53.
Oncogene 20:1803-15 (2001)
Hofseth LJ, Hussain SP, Harris CC.
p53: 25 years after its discovery.
Trends Pharmacol Sci 25:177-81 (2004)
Pietenpol JA, Stewart ZA.
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
Toxicology 181-182:475-81 (2002)
Tokino T, Nakamura Y.
The role of p53-target genes in human cancer.
Crit Rev Oncol Hematol 33:1-6 (2000)
Hermeking H, Benzinger A.
14-3-3 proteins in cell cycle regulation.
Semin Cancer Biol 16:183-92 (2006)
Sherr CJ.
Divorcing ARF and p53: an unsettled case.
Nat Rev Cancer 6:663-73 (2006)
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Cancer Res 67:3043-53 (2007)
Resnick-Silverman L, Manfredi JJ
Two Faces of SIVA.
Cancer Discov 5:581-3 (2015)
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
J Cell Sci 122:2651-61 (2009)
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
J Carcinog 8:2 (2009)
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
FEBS Lett 524:163-71 (2002)
pov04110  Cell cycle
pov04210  Apoptosis
pov04218  Cellular senescence
KO pathway

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