KEGG   PATHWAY: ppsc03420
Entry
ppsc03420                   Pathway                                

Name
Nucleotide excision repair - Paenibacillus psychroresistens
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
ppsc03420  Nucleotide excision repair
ppsc03420

Other DBs
GO: 0006289
Organism
Paenibacillus psychroresistens [GN:ppsc]
Gene
EHS13_01510  mfd; transcription-repair coupling factor [KO:K03723] [EC:3.6.4.-]
EHS13_15075  uvrA; excinuclease ABC subunit UvrA [KO:K03701]
EHS13_00760  uvrA; excinuclease ABC subunit UvrA [KO:K03701]
EHS13_00755  uvrB; excinuclease ABC subunit UvrB [KO:K03702]
EHS13_08635  uvrC; excinuclease ABC subunit UvrC [KO:K03703]
EHS13_31190  ATP-dependent helicase [KO:K03657] [EC:3.6.4.12]
EHS13_03950  DNA helicase UvrD [KO:K03657] [EC:3.6.4.12]
EHS13_17990  helicase [KO:K03657] [EC:3.6.4.12]
EHS13_00930  pcrA; DNA helicase PcrA [KO:K03657] [EC:3.6.4.12]
EHS13_31935  helicase [KO:K03657] [EC:3.6.4.12]
EHS13_23160  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
EHS13_00935  ligA; NAD-dependent DNA ligase LigA [KO:K01972] [EC:6.5.1.2]
EHS13_19740  DEAD/DEAH box helicase [KO:K10843] [EC:3.6.4.12]
EHS13_31550  ATP-dependent DNA helicase [KO:K10844] [EC:3.6.4.12]
Reference
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases] Japanese
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders] Japanese
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
ppsc03020  RNA polymerase
KO pathway
ko03420   
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