KEGG   PATHWAY: ptg05204
Entry
ptg05204                    Pathway                                

Name
Chemical carcinogenesis - Panthera tigris altaica (Amur tiger)
Description
It has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens act through a variety of genotoxic and non-genotoxic mechanisms. Genotoxic carcinogens can attack biological macromolecules such as DNA and RNA either directly or indirectly through metabolism, resulting in the formation of adducts with these macromolecules. If DNA adducts escape cellular repair mechanisms and persist, they may lead to miscoding, resulting in permanent mutations. Non-genotoxic carcinogens act by the mechanisms such as induction of inflammation, immunosuppression, formation of reactive oxygen species, activation of receptors, and epigenetic silencing. Together, these genotoxic and non-genotoxic mechanisms can alter signal-transduction pathways that finally result in hypermutability, genomic instability, loss of proliferation control, and resistance to apoptosis - some of the characteristic features of cancer cells.
Class
Human Diseases; Cancer: overview
Pathway map
ptg05204  Chemical carcinogenesis
ptg05204

Organism
Panthera tigris altaica (Amur tiger) [GN:ptg]
Gene
102955781  NAT1; arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
102966939  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
102972472  SULT1A1; sulfotransferase 1A1 [KO:K01014] [EC:2.8.2.1]
102966263  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
102950579  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
102958169  cytochrome P450 2C21-like [KO:K07413] [EC:1.14.14.1]
102957879  cytochrome P450 2C41-like [KO:K07413] [EC:1.14.14.1]
102949568  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
102971089  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
102966922  GSTO1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
102967394  GSTO2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
102955989  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
102962954  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
102970472  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
102960578  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
102959987  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
102960295  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
102958890  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
102958324  GSTA2; glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
102949073  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
102958599  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
102949368  glutathione S-transferase alpha M14-like [KO:K00799] [EC:2.5.1.18]
102949663  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
102949366  GSTM4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
102960863  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
102964863  GSTP1; glutathione S-transferase pi 1 [KO:K23790] [EC:2.5.1.18]
102950403  GSTK1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
102970849  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
102969285  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
102957386  CYP3A131; cytochrome P450 3A12 [KO:K07424] [EC:1.14.14.1]
102957670  cytochrome P450 3A12-like [KO:K07424] [EC:1.14.14.1]
102948685  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
102955772  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit [KO:K04809]
102967279  HSD11B1; hydroxysteroid 11-beta dehydrogenase 1 [KO:K15680] [EC:1.1.1.146]
102963221  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
102962462  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
107180402  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
102951798  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
102959578  UGT1A1; UDP-glucuronosyltransferase 1-1 [KO:K00699] [EC:2.4.1.17]
102967993  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
102968284  UGT2A1; UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
102969051  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
102953099  ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
102969525  ALDH3B1; aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
102964294  ALDH3B2; aldehyde dehydrogenase 3 family member B2 [KO:K00129] [EC:1.2.1.5]
102970414  alcohol dehydrogenase E chain [KO:K13951] [EC:1.1.1.1]
102971197  ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
102971488  ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
102956075  KYAT1; kynurenine aminotransferase 1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
102960707  KYAT3; kynurenine aminotransferase 3 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
Compound
C00027  Hydrogen peroxide
C03012  Naphthalene-1,2-diol
C03621  N-Acetoxy-4-aminobiphenyl
C03622  N-Hydroxy-4-aminobiphenyl
C06547  Ethylene
C06548  Ethylene oxide
C06752  1,2-Dichloroethane
C06754  Chloroacetaldehyde
C06790  Trichloroethene
C06793  Vinyl chloride
C06800  Aflatoxin B1
C06899  Chloral hydrate
C07122  Melphalan
C07490  Trichloroethanol
C07535  Benzo[a]pyrene
C07641  Thiotepa
C10998  4-Aminobiphenyl
C11148  TCE epoxide
C11149  Dichloroacetate
C11150  Trichloroacetate
C14527  Methyl methacrylate
C14556  9-Hydroxybenzo[a]pyrene
C14704  N-Nitrosodimethylamine
C14783  1,2-Naphthoquinone
C14849  Benzo[a]pyrene-9,10-oxide
C14850  Benzo[a]pyrene-7,8-oxide
C14851  Benzo[a]pyrene-4,5-oxide
C14852  Benzo[a]pyrene-7,8-diol
C14853  Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
C14854  9-Hydroxybenzo[a]pyrene-4,5-oxide
C14855  4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
C14856  7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
C14866  Chloral
C14867  Dichloroacetyl chloride
C14868  S-(1,2-Dichlorovinyl)glutathione
C14869  Trichloroethanol glucuronide
C14874  Glutathione episulfonium ion
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C19161  Chromium (VI)
C19164  Sulfur mustard
C19180  2-Amino-3-methylimidazo[4,5-f]quinoline
C19255  MeIQx
C19368  Chromium (III)
C19488  7,12-Dimethylbenz[a]anthracene
C19489  1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
C19490  trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
C19525  Sudan I
C19559  (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C19561  7-Hydroxymethyl-12-methylbenz[a]anthracene
C19562  7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
C19563  4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
C19564  4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
C19565  4-Hydroxy-1-(3-pyridinyl)-1-butanone
C19566  4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19568  N-Nitrosomethanamine
C19569  3-Succinoylpyridine
C19574  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
C19577  1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
C19578  5-(3-Pyridyl)-2-hydroxytetrahydrofuran
C19579  gamma-Hydroxy-3-pyridinebutanoate
C19580  alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581  alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C19582  1-(3-Pyridinyl)-1,4-butanediol
C19586  Aflatoxin B1-exo-8,9-epoxide
C19602  4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
C19603  4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
C19605  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
C19606  NNAL-N-glucuronide
C20280  1-Phenylazo-2,6-dihydroxynaphthalene
C20281  1-(4-Hydroxyphenylazo)-2-naphthol
C20282  1-(4-Hydroxyphenylazo)-naphthalene-2,6-diol
C20283  1-(3,4-Dihydroxyphenylazo)-2-naphthol
C20284  Benzenediazonium
C20285  4-Acetylaminobiphenyl
C20286  2-Hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C20287  2-Acetoxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C20288  N-Sulfonyloxy-PhIP
C20289  N-Hydroxy-IQ
C20290  N-Acetoxy-IQ
C20291  N-Hydroxy-MeIQx
C20293  N-Acetoxy-MeIQx
C20294  Chromium (V)
C20295  Chromium (IV)
C20296  Arsenic (V)
C20298  Arsenic (III)
C20300  Dimethylarsinous acid
C20301  alpha-Hydroxy-NDMA
C20302  Methyldiazonium ion
C20303  Chloroethylene oxide
C20304  S-(2-Chloroethyl)glutathione
C20305  1,2-Dichloroethanol
C20306  Methyldiazohydroxide
C20316  4-Nitrosobiphenyl
C20317  S-(1,2-Dichlorovinyl)-L-cysteine
C20318  S-(1,2-Dichlorovinyl)thiol
C20319  Hydronitroxide radical
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Enterohepatic recirculation of trichloroethanol glucuronide as a significant source of trichloroacetic acid. Metabolites of trichloroethylene.
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Drug Metab Dispos 25:529-35 (1997)
Reference
  Authors
Gwinn MR, Johns DO, Bateson TF, Guyton KZ
  Title
A review of the genotoxicity of 1,2-dichloroethane (EDC).
  Journal
Mutat Res 727:42-53 (2011)
DOI:10.1016/j.mrrev.2011.01.001
Reference
  Authors
Kehe K, Szinicz L
  Title
Medical aspects of sulphur mustard poisoning.
  Journal
Toxicology 214:198-209 (2005)
DOI:10.1016/j.tox.2005.06.014
Reference
  Authors
Matijasevic Z, Volkert MR
  Title
Base excision repair sensitizes cells to sulfur mustard and chloroethyl ethyl sulfide.
  Journal
DNA Repair (Amst) 6:733-41 (2007)
DOI:10.1016/j.dnarep.2006.12.014
Related
pathway
ptg00980  Metabolism of xenobiotics by cytochrome P450
ptg05210  Colorectal cancer
ptg05215  Prostate cancer
ptg05217  Basal cell carcinoma
ptg05218  Melanoma
ptg05219  Bladder cancer
ptg05221  Acute myeloid leukemia
ptg05222  Small cell lung cancer
ptg05223  Non-small cell lung cancer
KO pathway
ko05204   
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