KEGG   PATHWAY: ray04962
ray04962                    Pathway                                

Vasopressin-regulated water reabsorption - Rousettus aegyptiacus (Egyptian rousette)
In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again.
Organismal Systems; Excretory system
Pathway map
ray04962  Vasopressin-regulated water reabsorption

Rousettus aegyptiacus (Egyptian rousette) [GN:ray]
107514976  AVP; vasopressin-neurophysin 2-copeptin [KO:K05242]
107517751  AVPR2; vasopressin V2 receptor [KO:K04228]
107500068  neuroendocrine secretory protein 55-like [KO:K04632]
107500067  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
107514224  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:]
107498506  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:]
107521680  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:]
107519437  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:]
107511590  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:]
107506137  ARHGDIG; rho GDP-dissociation inhibitor 3 [KO:K12462]
107520279  ARHGDIA; rho GDP-dissociation inhibitor 1 [KO:K12462]
107508618  ARHGDIB; rho GDP-dissociation inhibitor 2 [KO:K12462]
107505169  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
107509179  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
107502779  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
107511864  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
107510647  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
107499057  CREB3L2; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
107505683  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
107514259  AQP2; aquaporin-2 [KO:K09865]
107508948  RAB11A; ras-related protein Rab-11A [KO:K07904]
107519907  RAB11B; ras-related protein Rab-11B [KO:K07905]
107521376  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
107520205  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
107503329  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
107499568  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
107508781  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
107519818  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
107509581  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
107503033  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
107501252  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
107502898  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
107501501  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
107497166  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
107516090  DCTN5; dynactin subunit 5 [KO:K10427]
107505788  DCTN6; dynactin subunit 6 [KO:K10428]
107515669  VAMP2; vesicle-associated membrane protein 2 isoform X1 [KO:K13504]
107508174  NSF; vesicle-fusing ATPase [KO:K06027] [EC:]
107504001  STX4; syntaxin-4 isoform X1 [KO:K13502]
107497819  RAB5A; ras-related protein Rab-5A [KO:K07887]
107521267  RAB5B; ras-related protein Rab-5B [KO:K07888]
107513817  RAB5C; ras-related protein Rab-5C [KO:K07889]
107518431  AQP4; aquaporin-4 isoform X1 [KO:K09866]
107502869  AQP3; aquaporin-3 [KO:K09876]
C00001  H2O
C00575  3',5'-Cyclic AMP
Boone M, Deen PM
Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.
Pflugers Arch 456:1005-24 (2008)
Takata K, Matsuzaki T, Tajika Y, Ablimit A, Hasegawa T
Localization and trafficking of aquaporin 2 in the kidney.
Histochem Cell Biol 130:197-209 (2008)
Nielsen S, Kwon TH, Christensen BM, Promeneur D, Frokiaer J, Marples D
Physiology and pathophysiology of renal aquaporins.
J Am Soc Nephrol 10:647-63 (1999)
Marples D, Frokiaer J, Nielsen S
Long-term regulation of aquaporins in the kidney.
Am J Physiol 276:F331-9 (1999)
Ward DT, Hammond TG, Harris HW
Modulation of vasopressin-elicited water transport by trafficking of aquaporin2-containing vesicles.
Annu Rev Physiol 61:683-97 (1999)
Fenton RA, Moeller HB
Recent discoveries in vasopressin-regulated aquaporin-2 trafficking.
Prog Brain Res 170:571-9 (2008)
Nielsen S, Frokiaer J, Marples D, Kwon TH, Agre P, Knepper MA
Aquaporins in the kidney: from molecules to medicine.
Physiol Rev 82:205-44 (2002)
Deen PM, van Balkom BW, Kamsteeg EJ
Routing of the aquaporin-2 water channel in health and disease.
Eur J Cell Biol 79:523-30 (2000)
Bonilla-Felix M
Development of water transport in the collecting duct.
Am J Physiol Renal Physiol 287:F1093-101 (2004)
Uawithya P, Pisitkun T, Ruttenberg BE, Knepper MA
Transcriptional profiling of native inner medullary collecting duct cells from rat kidney.
Physiol Genomics 32:229-53 (2008)
Nguyen MK, Nielsen S, Kurtz I
Molecular pathogenesis of nephrogenic diabetes insipidus.
Clin Exp Nephrol 7:9-17 (2003)
ray04144  Endocytosis
ray04530  Tight junction
KO pathway

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