| Entry |
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| Name |
Salivary secretion - Rousettus aegyptiacus (Egyptian rousette)
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| Description |
Saliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for example. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. There are two secretory pathways: protein exocytosis and fluid secretion. Sympathetic stimulation leads to the activation of adenylate cyclase and accumulation of intracellular cAMP. The elevation of cAMP causes the secretion of proteins such as amylase and mucin. In contrast, parasympathetic stimulation activates phospholipase C and causes the elevation of intracellular Ca2+, which leads to fluid secretion; that is, water and ion transport. Ca2+ also induces amylase secretion, but the amount is smaller than that induced by cAMP.
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| Class |
Organismal Systems; Digestive system
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| Pathway map |
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| Other DBs |
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| Organism |
Rousettus aegyptiacus (Egyptian rousette) [GN: ray]
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| Gene |
| 107500067 | GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632] |
| 107515669 | VAMP2; vesicle-associated membrane protein 2 isoform X1 [KO:K13504] |
| 107505691 | ADRA1D; LOW QUALITY PROTEIN: alpha-1D adrenergic receptor [KO:K04137] |
| 107517194 | GNAQ; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634] |
| 107506114 | PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11] |
| 107519930 | PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11] |
| 107497081 | PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11] |
| 107514464 | PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11] |
| 107504134 | ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958] |
| 107497427 | ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959] |
| 107511965 | ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960] |
| 107509410 | ATP1B3; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540] |
| 107512755 | ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540] |
| 107515690 | ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540] |
| 107505043 | FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538] |
| 107517865 | SLC12A2; solute carrier family 12 member 2 isoform X1 [KO:K10951] |
| 107512308 | KCNN4; intermediate conductance calcium-activated potassium channel protein 4 isoform X1 [KO:K04945] |
| 107518064 | KCNMA1; calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936] |
| 107520293 | SLC4A2; LOW QUALITY PROTEIN: anion exchange protein 2 [KO:K13855] |
| 107516983 | TRPV6; transient receptor potential cation channel subfamily V member 6 [KO:K04975] |
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| Compound |
| C01245 | D-myo-Inositol 1,4,5-trisphosphate |
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| Reference |
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| Authors |
Ishikawa Y, Cho G, Yuan Z, Skowronski MT, Pan Y, Ishida H |
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| Title |
Water channels and zymogen granules in salivary glands. |
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| Reference |
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| Authors |
Ishikawa Y, Cho G, Yuan Z, Inoue N, Nakae Y |
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| Title |
Aquaporin-5 water channel in lipid rafts of rat parotid glands. |
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| Reference |
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| Authors |
Ambudkar IS |
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| Title |
Regulation of calcium in salivary gland secretion. |
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| Journal |
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| Reference |
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| Authors |
Ishikawa Y, Ishida H |
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Aquaporin water channel in salivary glands. |
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| Journal |
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| Reference |
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| Authors |
Baum BJ |
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| Title |
Principles of saliva secretion. |
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| Journal |
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| Reference |
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| Authors |
Fujita-Yoshigaki J |
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| Title |
Divergence and convergence in regulated exocytosis: the characteristics of cAMP-dependent enzyme secretion of parotid salivary acinar cells. |
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| Reference |
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| Authors |
Heitzmann D, Warth R |
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Physiology and pathophysiology of potassium channels in gastrointestinal epithelia. |
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| Authors |
Proctor GB, Carpenter GH |
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| Title |
Regulation of salivary gland function by autonomic nerves. |
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| Reference |
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| Authors |
Turner RJ, Sugiya H |
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| Title |
Understanding salivary fluid and protein secretion. |
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| Reference |
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| Authors |
Van Nieuw Amerongen A, Bolscher JG, Veerman EC |
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| Title |
Salivary proteins: protective and diagnostic value in cariology? |
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| Journal |
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| Reference |
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| Authors |
Nakamoto T, Srivastava A, Romanenko VG, Ovitt CE, Perez-Cornejo P, Arreola J, Begenisich T, Melvin JE |
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| Title |
Functional and molecular characterization of the fluid secretion mechanism in human parotid acinar cells. |
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| Reference |
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| Authors |
Melvin JE, Yule D, Shuttleworth T, Begenisich T |
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| Title |
Regulation of fluid and electrolyte secretion in salivary gland acinar cells. |
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| Journal |
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| Reference |
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| Authors |
Catalan MA, Nakamoto T, Melvin JE |
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| Title |
The salivary gland fluid secretion mechanism. |
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| Journal |
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Related
pathway |
| ray04973 | Carbohydrate digestion and absorption |
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| KO pathway |
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| LinkDB |
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