Entry Name Fc epsilon RI signaling pathway - Rattus norvegicus (rat)
Description Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map rno04664 Fc epsilon RI signaling pathway
Ortholog table Other DBs Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 25047 Fcer1a; high affinity immunoglobulin epsilon receptor subunit alpha precursor [KO:K08089 ]
25316 Ms4a2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090 ]
25441 Fcer1g; high affinity immunoglobulin epsilon receptor subunit gamma precursor [KO:K07983 ]
54259 Inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084 ] [EC:3.1.3.86 ]
25738 Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116 ] [EC:3.1.4.11 ]
29337 Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
134484121 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
363875 Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
366957 Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
688319 Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861 ]
363855 Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform 1 [KO:K04431 ] [EC:2.7.12.2 ]
116630 Csf2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
295378 Vav3; guanine nucleotide exchange factor VAV3 [KO:K05730 ]
296603 Vav2; guanine nucleotide exchange factor VAV2 [KO:K05730 ]
84477 Gab2; GRB2-associated-binding protein 2 [KO:K08091 ]
81511 Lat; linker for activation of T-cells family member 1 [KO:K07362 ]
81504 Grb2; growth factor receptor-bound protein 2 [KO:K04364 ]
367858 Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833 ]
58960 Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369 ] [EC:2.7.12.2 ]
29624 Alox5ap; arachidonate 5-lipoxygenase-activating protein [KO:K20735 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kawakami T, Galli SJ.
Title Regulation of mast-cell and basophil function and survival by IgE.
Journal Reference Authors Siraganian RP.
Title Mast cell signal transduction from the high-affinity IgE receptor.
Journal Reference Authors Janeway CA, Travers P, Walport M, Shlomchik MJ.
Title Immunobiology 6th edition
Journal Garland Science Publishing (2005)
Reference Authors Turner H, Kinet JP.
Title Signalling through the high-affinity IgE receptor Fc epsilonRI.
Journal Reference Authors Gilfillan AM, Tkaczyk C.
Title Integrated signalling pathways for mast-cell activation.
Journal Reference Authors Nadler MJ, Matthews SA, Turner H, Kinet JP.
Title Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
Journal Reference Authors Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
Title Essential role for Gab2 in the allergic response.
Journal Reference Authors Nadler MJ, Kinet JP.
Title Uncovering new complexities in mast cell signaling.
Journal Related rno04070 Phosphatidylinositol signaling system
KO pathway LinkDB All DBs
