KEGG   PATHWAY: rro04630
Entry
rro04630                    Pathway                                

Name
JAK-STAT signaling pathway - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
rro04630  JAK-STAT signaling pathway
rro04630

Other DBs
GO: 0007259
Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104661748  IL2; interleukin-2 [KO:K05429]
104659849  IL3; interleukin-3 [KO:K04736]
104659834  IL4; interleukin-4 isoform X1 [KO:K05430]
104659838  IL5; interleukin-5 [KO:K05428]
104675233  IL6; interleukin-6 isoform X1 [KO:K05405]
104665836  IL7; interleukin-7 [KO:K05431]
104659785  IL9; interleukin-9 [KO:K05432]
104661740  IL10; interleukin-10 [KO:K05443]
104674791  IL11; interleukin-11 isoform X1 [KO:K05417]
104665012  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
104669104  IL12B; interleukin-12 subunit beta [KO:K05425]
104659835  IL13; interleukin-13 isoform X1 [KO:K05435]
104671768  IL15; interleukin-15 isoform X1 [KO:K05433]
104668275  IL17D; interleukin-17D [KO:K05492]
104661741  IL19; interleukin-19 isoform X1 [KO:K05444]
104664194  IL20; interleukin-20 [KO:K22667]
104661749  IL21; interleukin-21 [KO:K05434]
104658677  IL22; interleukin-22 [KO:K05445]
104673677  IL23A; interleukin-23 subunit alpha [KO:K05426]
104664191  IL24; interleukin-24 [KO:K22668]
104670273  interferon alpha-1/13 [KO:K05414]
104670275  IFNA8; interferon alpha-8 [KO:K05414]
104670276  interferon alpha-1/13-like [KO:K05414]
104670278  IFNA6; interferon alpha-6 [KO:K05414]
104670280  interferon alpha-14 [KO:K05414]
104670290  interferon alpha-4 [KO:K05414]
104670292  interferon alpha-10-like [KO:K05414]
104680728  interferon alpha-10 [KO:K05414]
115893964  interferon alpha-4 [KO:K05414]
115893973  interferon alpha-10-like [KO:K05414]
104670295  IFNB1; interferon beta [KO:K05415]
104664085  IFNG; interferon gamma [KO:K04687]
104671750  IFNE; interferon epsilon [KO:K05442]
104679003  IFNK; interferon kappa [KO:K05441]
104676155  IFNL1; interferon lambda-1 [KO:K05447]
104676158  interferon lambda-3 [KO:K22669]
104676156  interferon lambda-3-like [KO:K22669]
104670274  interferon omega-1-like [KO:K05440]
104670294  interferon omega-1 [KO:K05440]
104659494  OSM; oncostatin-M isoform X1 [KO:K05418]
104659483  LIF; leukemia inhibitory factor [KO:K05419]
104658606  TSLP; thymic stromal lymphopoietin [KO:K05436]
104661556  CTF1; cardiotrophin-1 [KO:K05422]
104661595  cardiotrophin-2 [KO:K24382]
104659848  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
104680417  CNTF; ciliary neurotrophic factor [KO:K05420]
104655117  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
104673627  EPO; erythropoietin isoform X1 [KO:K05437]
104675453  somatotropin isoform X1 [KO:K05438]
104675456  somatotropin-like isoform X1 [KO:K05438]
104675458  somatotropin-like isoform X2 [KO:K05438]
104675500  somatotropin-like [KO:K05438]
104675501  somatotropin-like isoform X1 [KO:K05438]
104675502  somatotropin-like isoform X1 [KO:K05438]
104674424  LEP; leptin precursor [KO:K05424]
104664621  THPO; LOW QUALITY PROTEIN: thrombopoietin [KO:K06854]
104654795  PRL; prolactin isoform X1 [KO:K05439]
104682421  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
104664975  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
104682558  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
104664846  IL2RA; interleukin-2 receptor subunit alpha isoform X4 [KO:K05068]
104682498  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
104656782  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
104663347  IL3RA; interleukin-3 receptor subunit alpha isoform X2 [KO:K04737]
104665638  IL4R; LOW QUALITY PROTEIN: interleukin-4 receptor subunit alpha [KO:K05071]
104657349  IL5RA; interleukin-5 receptor subunit alpha isoform X2 [KO:K05067]
104663493  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
104662030  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
104659540  IL9R; interleukin-9 receptor isoform X2 [KO:K05073]
104669797  LOW QUALITY PROTEIN: interleukin-9 receptor-like [KO:K05073]
104665564  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
104658749  IL10RB; interleukin-10 receptor subunit beta isoform X2 [KO:K05135]
104680015  IL11RA; interleukin-11 receptor subunit alpha isoform X2 [KO:K05056]
104680608  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X2 [KO:K05063]
104657309  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
104664105  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
104657075  IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077]
104664843  IL15RA; interleukin-15 receptor subunit alpha isoform X4 [KO:K05074]
104675018  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
104663558  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
104670204  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
104656114  IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138]
104675020  IL22RA2; interleukin-22 receptor subunit alpha-2 isoform X1 [KO:K05139]
104657311  IL23R; interleukin-23 receptor [KO:K05065]
104661055  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
104680478  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
104658750  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
104658748  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
104675021  IFNGR1; interferon gamma receptor 1 [KO:K05132]
104658778  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
104656113  IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140]
104665752  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
104665755  LIFR; leukemia inhibitory factor receptor isoform X1 [KO:K05058]
104663343  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
104680008  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
104663344  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
104682491  CSF2RB; cytokine receptor common subunit beta isoform X3 [KO:K04738]
104660161  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
104670444  EPOR; erythropoietin receptor [KO:K05079]
104667785  GHR; growth hormone receptor [KO:K05080]
104664347  LEPR; leptin receptor isoform X2 [KO:K05062]
104669027  MPL; thrombopoietin receptor isoform X2 [KO:K05082]
104678745  PRLR; prolactin receptor [KO:K05081]
104675886  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104658857  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
104670408  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104668074  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
104665700  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
104660959  JAK3; tyrosine-protein kinase JAK3 isoform X2 [KO:K11218] [EC:2.7.10.2]
104670479  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
104675282  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
104673676  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
104680286  STAT3; signal transducer and activator of transcription 3 isoform X3 [KO:K04692]
104675283  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
104680310  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
104680321  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
104682375  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
104666850  CISH; cytokine-inducible SH2-containing protein isoform X2 [KO:K04701]
104667710  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
104678596  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
104677022  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
104669147  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
104663176  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
104658789  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
104674880  SOCS7; suppressor of cytokine signaling 7 isoform X2 [KO:K04699]
104682248  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
104681074  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
104653720  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
104682943  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
104674798  MYC; myc proto-oncogene protein [KO:K04377]
104677168  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104658979  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
104667309  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
104682880  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
104670457  LOW QUALITY PROTEIN: aldehyde oxidase 2-like [KO:K00157] [EC:1.2.3.1]
104670351  LOW QUALITY PROTEIN: aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
104670357  aldehyde oxidase 1 isoform X2 [KO:K00157] [EC:1.2.3.1]
104654731  GFAP; glial fibrillary acidic protein isoform X1 [KO:K05640]
104669802  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
104655327  STAM; signal transducing adapter molecule 1 isoform X2 [KO:K04705]
104671929  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X1 [KO:K18026] [EC:3.1.3.48]
104680085  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X2 [KO:K05697] [EC:3.1.3.48]
104662694  IRF9; interferon regulatory factor 9 [KO:K04693]
115897716  interferon regulatory factor 9 [KO:K04693]
104673260  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
104672289  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
104662589  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
104680745  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
104671049  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
104665429  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X1 [KO:K16065] [EC:2.3.2.27]
104682452  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
104674419  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
104681311  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
104663024  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
104682751  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
104654600  HRAS; GTPase HRas isoform X1 [KO:K02833]
104673299  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
104663050  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104665061  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104670605  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104662124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104675620  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104680672  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104673041  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104676121  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104654186  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115893905  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104654362  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
Reference
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Related
pathway
rro04010  MAPK signaling pathway
rro04060  Cytokine-cytokine receptor interaction
rro04110  Cell cycle
rro04120  Ubiquitin mediated proteolysis
rro04151  PI3K-Akt signaling pathway
rro04210  Apoptosis
KO pathway
ko04630   
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