KEGG   PATHWAY: rro04924
rro04924                    Pathway                                

Renin secretion - Rhinopithecus roxellana (golden snub-nosed monkey)
The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. Renin is synthesized, stored in, and released into circulation by the juxtaglomerular (JG) cells of the kidney. Secretion of renin from JG cells at the organ level is controlled by the four main mechanisms: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and several hormones acting locally within the JG apparatus. Renin secretion at the level of renal JG cells appears to be controlled mainly by classic second messengers, namely cAMP, cGMP, and free cytosolic calcium concentration. While cAMP generally stimulates renin release and the intracellular calcium concentration suppresses the exocytosis of renin, the effects of cGMP in the regulation of the renin system are more complex as it both may stimulate or inhibit renin release.
Organismal Systems; Endocrine system
Pathway map
rro04924  Renin secretion

Other DBs
GO: 0002001
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
104659193  ADRB1; beta-1 adrenergic receptor [KO:K04141]
104680760  ADRB2; beta-2 adrenergic receptor [KO:K04142]
104679651  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
104655475  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
104663741  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
104663739  AQP1; aquaporin-1 [KO:K09864]
104669170  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
104676931  PTGER4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
104663797  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
104663799  neuroendocrine secretory protein 55 [KO:K04632]
104668142  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:]
104654871  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:]
104662061  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:]
104677489  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:]
104661051  LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:]
104680220  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
104662238  KCNMA1; calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936]
104654225  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:]
104666593  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3 [KO:K13755] [EC:]
104670555  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:]
104660878  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:]
104681940  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:]
104667395  REN; renin isoform X1 [KO:K01380] [EC:]
104674493  ADORA1; adenosine receptor A1 isoform X2 [KO:K04265]
104655987  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
104667102  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
104673307  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
104666279  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
104682225  CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027]
104682226  CLCA2; calcium-activated chloride channel regulator 2 isoform X1 [KO:K05028]
104654088  calcium-activated chloride channel regulator 1-like isoform X1 [KO:K05030]
104654086  CLCA4; calcium-activated chloride channel regulator 4 isoform X1 [KO:K05030]
104659017  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
104672388  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
104661816  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X5 [KO:K04853]
104661868  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104654043  KCNJ2; inward rectifier potassium channel 2 [KO:K04996]
104657358  EDN1; endothelin-1 [KO:K16366]
104654910  EDN2; endothelin-2 [KO:K16367]
104663806  EDN3; endothelin-3 isoform X3 [KO:K05227]
104660209  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
104671550  AGTR1; type-1 angiotensin II receptor [KO:K04166]
104663314  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
104655777  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:]
104673127  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:]
104668296  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:]
104659669  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:]
104664252  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
104675331  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
104658948  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104662055  calmodulin [KO:K02183]
104663170  CALM2; calmodulin-2 [KO:K02183]
104680741  calmodulin-alpha-like [KO:K02183]
104670544  CALM1; calmodulin-1 [KO:K02183]
104673406  CALM3; calmodulin-3 [KO:K02183]
104664834  CALML5; calmodulin-like protein 5 [KO:K02183]
104664835  CALML3; calmodulin-like protein 3 [KO:K02183]
104653554  CALML6; calmodulin-like protein 6 isoform X2 [KO:K02183]
104662590  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
104674211  calmodulin-alpha-like [KO:K02183]
104656871  calmodulin-like [KO:K02183]
104663969  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:]
104663623  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:]
104669965  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:]
104675975  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
104670806  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
104653917  calcineurin subunit B type 1 [KO:K06268]
104658100  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:]
104655958  GUCY1A2; guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:]
104662724  LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:]
104658102  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:]
104657551  NPPA; natriuretic peptides A [KO:K12334]
104663522  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:]
104654813  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:]
104679114  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:]
104670705  AGT; angiotensinogen [KO:K09821]
104675473  angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:]
104675505  LOW QUALITY PROTEIN: angiotensin-converting enzyme-like protein Ace3 [KO:K01283] [EC:]
C00001  H2O
C00002  ATP
C00008  ADP
C00020  AMP
C00076  Calcium cation
C00212  Adenosine
C00238  Potassium cation
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00788  L-Adrenaline
C00873  Angiotensin I
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02135  Angiotensin II
Kurtz A
Renin release: sites, mechanisms, and control.
Annu Rev Physiol 73:377-99 (2011)
Schweda F, Friis U, Wagner C, Skott O, Kurtz A
Renin release.
Physiology (Bethesda) 22:310-9 (2007)
Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C
Physiology of kidney renin.
Physiol Rev 90:607-73 (2010)
Friis UG, Madsen K, Stubbe J, Hansen PB, Svenningsen P, Bie P, Skott O, Jensen BL
Regulation of renin secretion by renal juxtaglomerular cells.
Pflugers Arch 465:25-37 (2013)
Kim SM, Briggs JP, Schnermann J
Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway.
Clin Exp Nephrol 16:17-24 (2012)
Kurtz A
Control of renin synthesis and secretion.
Am J Hypertens 25:839-47 (2012)
Kurtz A, Wagner C
Cellular control of renin secretion.
J Exp Biol 202:219-25 (1999)
Persson PB
Renin: origin, secretion and synthesis.
J Physiol 552:667-71 (2003)
Schweda F, Kurtz A
Cellular mechanism of renin release.
Acta Physiol Scand 181:383-90 (2004)
Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM
Classical Renin-Angiotensin system in kidney physiology.
Compr Physiol 4:1201-28 (2014)
Harrison-Bernard LM
The renal renin-angiotensin system.
Adv Physiol Educ 33:270-4 (2009)
Schnermann J, Briggs JP
Synthesis and secretion of renin in mice with induced genetic mutations.
Kidney Int 81:529-38 (2012)
Ryan MJ, Black TA, Millard SL, Gross KW, Hajduczok G
Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells.
Am J Physiol Heart Circ Physiol 283:H2458-65 (2002)
Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schutz G, Schweda F
Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
J Am Soc Nephrol 18:1150-6 (2007)
rro04020  Calcium signaling pathway
rro04022  cGMP-PKG signaling pathway
rro04024  cAMP signaling pathway
rro04614  Renin-angiotensin system
KO pathway

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