KEGG   PATHWAY: rro05216
Entry
rro05216                    Pathway                                

Name
Thyroid cancer - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells. Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas (PTC and FTC, respectively) to the extremely aggressive undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages. The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements. p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma.
Class
Human Diseases; Cancer: specific types
Pathway map
rro05216  Thyroid cancer
rro05216

Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104653928  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
104663676  CCDC6; LOW QUALITY PROTEIN: coiled-coil domain-containing protein 6 [KO:K09288]
104667790  NCOA4; nuclear receptor coactivator 4 isoform X1 [KO:K09289]
104676442  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
104663504  TPM3; tropomyosin alpha-3 chain isoform X5 [KO:K09290]
104677298  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
115898675  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
104664421  TPR; nucleoprotein TPR [KO:K09291]
104666712  TFG; protein TFG isoform X1 [KO:K09292]
104654600  HRAS; GTPase HRas isoform X1 [KO:K02833]
104669078  NRAS; GTPase NRas [KO:K07828]
104670041  KRAS; GTPase KRas isoform X1 [KO:K07827]
104659700  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
104662575  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104665487  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104676897  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104681150  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104664521  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
104673295  PPARG; peroxisome proliferator-activated receptor gamma isoform X2 [KO:K08530]
104669710  RXRA; retinoic acid receptor RXR-alpha isoform X3 [KO:K08524]
104657982  RXRB; retinoic acid receptor RXR-beta isoform X3 [KO:K08525]
104670175  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
104661662  TP53; cellular tumor antigen p53 [KO:K04451]
104682880  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
104671382  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
104657306  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
104656307  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
104666540  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
104658958  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
104668405  DDB2; DNA damage-binding protein 2 [KO:K10140]
104653753  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
104655589  CDH1; LOW QUALITY PROTEIN: cadherin-1 [KO:K05689]
104670934  CTNNB1; catenin beta-1 [KO:K02105]
104659811  TCF7; transcription factor 7 isoform X9 [KO:K02620]
104659731  TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490]
104664436  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
104670045  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
104674798  MYC; myc proto-oncogene protein [KO:K04377]
104677168  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
Reference
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Related
pathway
rro03320  PPAR signaling pathway
rro04010  MAPK signaling pathway
rro04115  p53 signaling pathway
rro04310  Wnt signaling pathway
rro04520  Adherens junction
KO pathway
ko05216   
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