Entry
Name
Nucleotide excision repair - Salmo salar (Atlantic salmon)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Salmo salar (Atlantic salmon) [GN:
sasa ]
Gene
106572264 xpc; XPC complex subunit, DNA damage recognition and repair factor [KO:K10838 ]
106601193 RD23A; UV excision repair protein RAD23 homolog A-like [KO:K10839 ]
106580591 ercc8; ERCC excision repair 8, CSA ubiquitin ligase complex subunit [KO:K10570 ]
106576868 ercc6; ERCC excision repair 6, chromatin remodeling factor [KO:K10841 ]
100196851 polr2c; polymerase (RNA) II (DNA directed) polypeptide C [KO:K03011 ]
106569462 RPAB1; DNA-directed RNA polymerases I, II, and III subunit RPABC1 [KO:K03013 ]
106573578 RPAB1; DNA-directed RNA polymerases I, II, and III subunit RPABC1-like [KO:K03013 ]
106601222 RPAB2; DNA-directed RNA polymerases I, II, and III subunit RPABC2 [KO:K03014 ]
106607142 RPAB2; DNA-directed RNA polymerases I, II, and III subunit RPABC2-like [KO:K03014 ]
106604162 RPB7; DNA-directed RNA polymerase II subunit RPB7-like [KO:K03015 ]
106562324 RPAB5; DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007 ]
106587512 RPAB5; DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007 ]
106570789 RPAB4; DNA-directed RNA polymerases I, II, and III subunit RPABC4-like [KO:K03009 ]
106589136 RPAB4; DNA-directed RNA polymerases I, II, and III subunit RPABC4 [KO:K03009 ]
106567670 RPB11; DNA-directed RNA polymerase II subunit RPB11-a [KO:K03008 ]
106612933 replication protein A 70 kDa DNA-binding subunit-like [KO:K07466 ]
100196763 rfa1; Replication protein A 70 kDa DNA-binding subunit [KO:K07466 ]
106589551 ercc4; ERCC excision repair 4, endonuclease catalytic subunit [KO:K10848 ] [EC:3.1.-.-]
100286713 ercc1; ERCC excision repair 1, endonuclease non-catalytic subunit [KO:K10849 ]
Reference
Authors
Sugasawa K.
Title
[Molecular mechanism of mammalian nucleotide excision repair]
Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
Authors
Nakatsu Y.
Title
[Transcription-coupled repair and Cockayne syndrome]
Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
Authors
Nakagawa N, Masui R, Kuramitsu S.
Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
Journal
Reference
Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
Journal
Reference
Authors
Sugasawa K.
Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
Authors
Ito S, Ando D, Tanaka K.
Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related pathway
KO pathway
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