KEGG   PATHWAY: sasa04340
sasa04340                   Pathway                                

Hedgehog signaling pathway - Salmo salar (Atlantic salmon)
The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for transduction of the Hedgehog signal in vertebrates. In Hh's absence, the Ptch receptor localizes to the cilium, where it inhibits Smo activation. Gli proteins are phosphorylated by PKA, CKI and GSK3B and partially degraded into truncated Gli repressor form (GliR) that suppresses Hh target gene transcription in the nucleus. In Hh's presence, Ptch disappears from the cilium, and activated Smo contributes to the translocation of the protein complex Gli, Sufu, Kif7 to ciliary tip, where Gli dissociates from the negative regulator Sufu. The production of Gli activator form (GliA) occurs and the increased nuclear accumulation of GliA results in activation transcription of Hh target genes.
Environmental Information Processing; Signal transduction
Pathway map
sasa04340  Hedgehog signaling pathway

Salmo salar (Atlantic salmon) [GN:sasa]
106580561  protein patched homolog 1-like [KO:K06225]
106585152  ptch1; patched 1 [KO:K06225]
106599390  protein patched homolog 1-like [KO:K11101]
106569083  protein patched homolog 1 [KO:K11101]
106609776  smoothened homolog [KO:K06226]
106581955  gpr161; G protein-coupled receptor 161 [KO:K08439]
106592286  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:]
106564260  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:]
106569146  KAPCB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:]
106613442  prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:]
106599750  KAPCB; cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:]
106606839  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:]
106604944  casein kinase I isoform alpha [KO:K08957] [EC:]
106611977  casein kinase I isoform alpha-like [KO:K08957] [EC:]
106596267  casein kinase I isoform gamma-3-like [KO:K08958] [EC:]
106561286  casein kinase I isoform gamma-1-like [KO:K08958] [EC:]
106569837  casein kinase I isoform gamma-2-like [KO:K08958] [EC:]
106573333  casein kinase I isoform gamma-1-like [KO:K08958] [EC:]
106562785  casein kinase I isoform gamma-1 [KO:K08958] [EC:]
100194510  csnk1g2; casein kinase 1 gamma 2a [KO:K08958] [EC:]
106584364  casein kinase I isoform gamma-2-like [KO:K08958] [EC:]
106610228  casein kinase I isoform delta-B [KO:K08959] [EC:]
106589616  csnk1d; casein kinase 1 delta [KO:K08959] [EC:]
106595407  casein kinase I isoform delta-B-like [KO:K08959] [EC:]
106596082  casein kinase I isoform delta-like [KO:K08959] [EC:]
106601228  casein kinase I isoform epsilon [KO:K08960] [EC:]
100195355  kc1e; Casein kinase I isoform epsilon [KO:K08960] [EC:]
106589542  casein kinase I isoform epsilon-like [KO:K08960] [EC:]
106609470  casein kinase I isoform epsilon-like [KO:K08960] [EC:]
106574304  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:]
106582120  gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:]
106586650  glycogen synthase kinase-3 beta [KO:K03083] [EC:]
106575154  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:]
106566129  zinc finger protein GLI1-like [KO:K16797]
106582669  gli1; GLI family zinc finger 1 [KO:K16797]
106574262  zinc finger protein GLI2-like [KO:K16798]
106575189  zinc finger protein GLI2-like [KO:K16798]
106586430  zinc finger protein GLI2-like [KO:K16798]
106582360  zinc finger protein GLI2-like [KO:K16798]
106590190  gli3; GLI family zinc finger 3 [KO:K06230]
106604342  suppressor of fused homolog [KO:K06229]
106576854  suppressor of fused homolog [KO:K06229]
106562252  kinesin-like protein kif7 [KO:K18806]
106587389  kinesin-like protein kif7 [KO:K18806]
106610218  hhip; hedgehog interacting protein [KO:K06231]
106561617  G1/S-specific cyclin-D1-like [KO:K04503]
106562055  G1/S-specific cyclin-D1-like [KO:K04503]
106587137  G1/S-specific cyclin-D1 [KO:K04503]
100306852  ccnd1; cyclin D1 [KO:K04503]
106601568  G1/S-specific cyclin-D2-like [KO:K10151]
106606904  G1/S-specific cyclin-D2-like [KO:K10151]
106561356  G1/S-specific cyclin-D2-like [KO:K10151]
106573197  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
106576262  G1/S-specific cyclin-D2-like [KO:K10151]
100195486  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
106599248  apoptosis regulator Bcl-2-like [KO:K02161]
106569189  apoptosis regulator Bcl-2-like [KO:K02161]
106579593  apoptosis regulator Bcl-2-like [KO:K02161]
106590353  apoptosis regulator Bcl-2-like [KO:K02161]
106569218  cullin-1-like [KO:K03347]
106578388  cullin-1-like [KO:K03347]
106599302  cullin-1 [KO:K03347]
106603254  FBW1B; F-box/WD repeat-containing protein 11-like [KO:K03362]
106604789  F-box/WD repeat-containing protein 11-like [KO:K03362]
106611815  FBW1B; F-box/WD repeat-containing protein 11 [KO:K03362]
106568099  FBW1B; F-box/WD repeat-containing protein 11-like [KO:K03362]
106599328  tiggy-winkle hedgehog protein-like [KO:K11988]
106578610  sonic hedgehog protein A-like [KO:K11988]
106573850  sonic hedgehog protein A-like [KO:K11988]
106569233  tiggy-winkle hedgehog protein-like [KO:K11988]
106590104  shh; sonic hedgehog [KO:K11988]
106574860  indian hedgehog B protein-like [KO:K11989]
106582516  ihh; indian hedgehog [KO:K11989]
106586914  indian hedgehog B protein-like [KO:K11989]
106575859  indian hedgehog B protein-like [KO:K11989]
106567047  dhh; desert hedgehog [KO:K11990]
106579445  brother of CDO-like [KO:K20020]
106590470  brother of CDO-like [KO:K20020]
106561946  growth arrest-specific protein 1-like [KO:K06232]
106570975  growth arrest-specific protein 1-like [KO:K06232]
106568361  growth arrest-specific protein 1-like [KO:K06232]
106594537  growth arrest-specific protein 1-like [KO:K06232]
106581783  lrp2; LDL receptor related protein 2 [KO:K06233]
106579098  low-density lipoprotein receptor-related protein 2-like [KO:K06233]
106586206  low-density lipoprotein receptor-related protein 2-like [KO:K06233]
100196190  cssa28h16orf52; chromosome ssa28 open reading frame, human C16orf52 [KO:K23663]
106592731  uncharacterized protein C16orf52 homolog B [KO:K23663]
106601686  uncharacterized protein C16orf52 homolog B-like [KO:K23663]
106606731  uncharacterized protein C16orf52 homolog B [KO:K23663]
106609997  CP52B; uncharacterized protein C16orf52 homolog B-like [KO:K23663]
106605723  multiple epidermal growth factor-like domains protein 8 [KO:K23664]
106574911  multiple epidermal growth factor-like domains protein 8 [KO:K23664]
106601086  E3 ubiquitin-protein ligase MGRN1-like [KO:K10604] [EC:]
106607363  probable E3 ubiquitin-protein ligase MGRN1 [KO:K10604] [EC:]
106588327  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:]
106601396  E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:]
106607065  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:]
106564903  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:]
106568375  beta-adrenergic receptor kinase 2 [KO:K00910] [EC:]
106563091  beta-adrenergic receptor kinase 2-like [KO:K00910] [EC:]
106563006  beta-adrenergic receptor kinase 2-like [KO:K00910] [EC:]
106565206  ellis-van Creveld syndrome protein-like [KO:K19605]
106565205  limbin-like [KO:K19608]
106603582  arrestin red cell isoform 2 [KO:K04439]
106608931  arrestin red cell isoform 1-like [KO:K04439]
106567894  arrestin red cell isoform 3 [KO:K04439]
106577890  arrestin red cell isoform 1-like [KO:K04439]
106613326  beta-arrestin-1 [KO:K04439]
106604220  kif3a; kinesin family member 3A [KO:K10394]
106592436  kinesin-like protein KIF3A [KO:K10394]
106612218  kinesin-like protein KIF3A [KO:K10394]
106600593  cullin-3-like [KO:K03869]
106580681  cullin-3 [KO:K03869]
106569638  cullin-3-like [KO:K03869]
106612448  cullin-3-like [KO:K03869]
106601600  speckle-type POZ protein [KO:K10523]
106601601  speckle-type POZ protein-like A [KO:K10523]
106579088  speckle-type POZ protein [KO:K10523]
100195374  spop; speckle-type POZ protein [KO:K10523]
C00575  3',5'-Cyclic AMP
Xavier GM, Seppala M, Barrell W, Birjandi AA, Geoghegan F, Cobourne MT
Hedgehog receptor function during craniofacial development.
Dev Biol 415:198-215 (2016)
Briscoe J, Therond PP
The mechanisms of Hedgehog signalling and its roles in development and disease.
Nat Rev Mol Cell Biol 14:416-29 (2013)
Alman BA
The role of hedgehog signalling in skeletal health and disease.
Nat Rev Rheumatol 11:552-60 (2015)
Mooney CJ, Hakimjavadi R, Fitzpatrick E, Kennedy E, Walls D, Morrow D, Redmond EM, Cahill PA
Hedgehog and Resident Vascular Stem Cell Fate.
Stem Cells Int 2015:468428 (2015)
Sasai N, Briscoe J
Primary cilia and graded Sonic Hedgehog signaling.
Wiley Interdiscip Rev Dev Biol 1:753-72 (2012)
Heretsch P, Tzagkaroulaki L, Giannis A
Modulators of the hedgehog signaling pathway.
Bioorg Med Chem 18:6613-24 (2010)
Anderson E, Peluso S, Lettice LA, Hill RE
Human limb abnormalities caused by disruption of hedgehog signaling.
Trends Genet 28:364-73 (2012)
Rohatgi R, Scott MP
Cell biology. Arrestin' movement in cilia.
Science 320:1726-7 (2008)
Yue S, Tang LY, Tang Y, Tang Y, Shen QH, Ding J, Chen Y, Zhang Z, Yu TT, Zhang YE, Cheng SY
Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.
Elife 3:e02555 (2014)
Ok CY, Singh RR, Vega F
Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms.
Am J Pathol 180:2-11 (2012)
Hsia EY, Gui Y, Zheng X
Regulation of Hedgehog signaling by ubiquitination.
Front Biol (Beijing) 10:203-220 (2015)
Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
Dev Cell 44:113-129.e8 (2018)
sasa04120  Ubiquitin mediated proteolysis
KO pathway

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