KEGG   PATHWAY: sasa04912
Entry
sasa04912                   Pathway                                
Name
GnRH signaling pathway - Salmo salar (Atlantic salmon)
Description
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
Class
Organismal Systems; Endocrine system
Pathway map
sasa04912  GnRH signaling pathway
sasa04912

Organism
Salmo salar (Atlantic salmon) [GN:sasa]
Gene
106608723  GnRH1; progonadoliberin-3 [KO:K05252]
106565314  progonadoliberin-2 [KO:K05252]
106579869  gnrh1; gonadotropin releasing hormone 1 [KO:K05252]
100136578  gnrh; gonadotrophin releasing hormone [KO:K05252]
100196110  gon2; Progonadoliberin-2 [KO:K05252]
106580535  gonadotropin-releasing hormone II receptor-like [KO:K04280]
106605452  gonadotropin-releasing hormone II receptor-like [KO:K04280]
106573532  gonadotropin-releasing hormone II receptor-like [KO:K04280]
106570199  gonadotropin-releasing hormone II receptor-like [KO:K04280]
106561195  gnrhr4; gonadotropin-releasing hormone II receptor-like [KO:K04280]
106588559  gonadotropin-releasing hormone II receptor-like [KO:K04280]
106566693  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
106571962  gnas; GNAS complex locus [KO:K04632]
106599721  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
106569164  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
106584068  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
106560395  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
106570343  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
106588693  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
106584132  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
106605024  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
106607897  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
106608969  adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
106582348  adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
106586396  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
106566714  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
106572701  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
106571946  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
106567013  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
106562384  adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
106587576  adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
106611404  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
106568630  adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
106590289  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106590466  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106601887  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106601890  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106606489  adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
106564461  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106564466  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106592286  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
106564260  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
106569146  KAPCB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106613442  prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106599750  KAPCB; cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
106606839  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
106591110  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
106607446  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
106564394  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
100195072  atf4; Cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
106562028  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
106568348  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
106580086  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
106585689  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
106584406  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04635]
106574495  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04635]
106575390  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04635]
106613802  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
106599624  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
106608040  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
106608062  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
106608066  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
106610872  plcb2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
106610916  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
106571556  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
106571557  plcb4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
106578106  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
106583165  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
106565476  inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
106582863  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
106565749  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
100196824  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
106573309  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
106572092  inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
106566485  inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
106601272  CALM; calmodulin [KO:K02183]
106605143  CALM; calmodulin [KO:K02183]
106603160  calmodulin [KO:K02183]
106608223  CALM; calmodulin [KO:K02183]
106611171  calm1; calmodulin 1 [KO:K02183]
100195847  call4; Calmodulin-like protein 4 [KO:K02183]
106566003  calml6; calmodulin like 6 [KO:K02183]
106612378  CALM; calmodulin [KO:K02183]
106563500  CALM; calmodulin [KO:K02183]
106562770  calmodulin-like protein 4 [KO:K02183]
106560757  calml4; calmodulin like 4 [KO:K02183]
100194628  calm2; calmodulin 2 [KO:K02183]
100194629  CALM; calmodulin 2 (phosphorylase kinase, delta)-3 [KO:K02183]
106597685  calmodulin-like protein 4 [KO:K02183]
106597678  calmodulin-like protein 4 [KO:K02183]
106606853  calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
106569240  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
106602935  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
100380644  kcc2d; calcium/calmodulin-dependent protein kinase type II delta chain [KO:K04515] [EC:2.7.11.17]
106562908  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
106597964  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
106597932  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
106563741  calcium/calmodulin-dependent protein kinase type II subunit alpha-like [KO:K04515] [EC:2.7.11.17]
106597963  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
100380658  kcc2g; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
106597631  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
106597965  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
106597934  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
106576966  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
106577507  calcium/calmodulin-dependent protein kinase type II delta chain [KO:K04515] [EC:2.7.11.17]
106584897  calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
106597904  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
106597817  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
106597116  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
106597790  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
106589429  calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
106597844  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
106597935  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
106564882  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
106594520  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
106563990  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
106563994  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
106593748  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
106565545  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
106565827  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
106583214  KPCD; protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
106595901  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
100195900  kpcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
106566685  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
106571974  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
106583449  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
106565299  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
106572493  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
106567031  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
106583479  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
106565294  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
106571505  map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
106562896  mitogen-activated protein kinase kinase kinase 1-like [KO:K04416] [EC:2.7.11.25]
106574243  mitogen-activated protein kinase kinase kinase 2-like [KO:K04420] [EC:2.7.11.25]
106575171  mitogen-activated protein kinase kinase kinase 2-like [KO:K04420] [EC:2.7.11.25]
106606859  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
106590696  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
106595351  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
106611248  mitogen-activated protein kinase kinase kinase 4-like [KO:K04428] [EC:2.7.11.25]
106589750  mitogen-activated protein kinase kinase kinase 4-like [KO:K04428] [EC:2.7.11.25]
106601934  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
106606355  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
106606359  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100136944  mkk6a; mitogen-activated protein kinase kinase 6a [KO:K04433] [EC:2.7.12.2]
100192337  mkk6b; MAPK kinase 6b [KO:K04433] [EC:2.7.12.2]
100192338  mkk6c; MAPK kinase 6c [KO:K04433] [EC:2.7.12.2]
106609456  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
106609457  MK12; mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106561402  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106566975  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106566983  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
106573286  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106572737  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106572761  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106566105  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106566106  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106576243  MK12; mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106576244  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
100137046  p38b; mitogen activated protein kinase p38b [KO:K04441] [EC:2.7.11.24]
100196619  mk13; Mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100136932  p38a; mitogen activated protein kinase p38a [KO:K04441] [EC:2.7.11.24]
106586755  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
106599096  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
106560559  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
106576937  pla2g4f; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
106577847  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
106577820  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
106577823  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
106583972  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
106603602  phospholipase D2-like [KO:K01115] [EC:3.1.4.4]
106567877  phospholipase D2-like [KO:K01115] [EC:3.1.4.4]
106574566  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
106578373  pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
106586037  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
106565074  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
106572626  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
106567112  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
106583686  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
106576553  CDC42; cell division control protein 42 homolog [KO:K04393]
106605852  cell division control protein 42 homolog [KO:K04393]
106569986  CDC42; cell division control protein 42 homolog [KO:K04393]
106565619  CDC42; cell division control protein 42 homolog [KO:K04393]
106567263  cdc42; cell division control protein 42 homolog [KO:K04393]
106572399  CDC42; cell division control protein 42 homolog [KO:K04393]
106588426  cell division control protein 42 homolog [KO:K04393]
106583122  CDC42; cell division control protein 42 homolog [KO:K04393]
106601504  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
106578855  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
106589490  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
100196891  map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
106587435  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
106564723  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
106604288  mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
106560362  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
106604910  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
106568502  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
106576863  mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
106579004  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
106563760  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
106589346  mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
106600411  jun; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
106613963  JUN; transcription factor AP-1-like [KO:K04448]
106569413  transcription factor AP-1-like [KO:K04448]
106568560  transcription factor AP-1-like [KO:K04448]
106584280  JUN; transcription factor AP-1-like [KO:K04448]
106572830  transcription factor AP-1-like [KO:K04448]
100380386  gthb2; Gonadotropin subunit beta-2 [KO:K08521]
106610688  glycoprotein hormones alpha chain 1-like [KO:K08522]
106610036  glycoprotein hormones alpha chain 2-like [KO:K08522]
100136440  glha2; pituitary alpha-2 glycoprotein hormone subunit precursor [KO:K08522]
100286517  glha1; Glycoprotein hormones alpha chain 1 [KO:K08522]
100136362  gonadotropin subunit beta-1 [KO:K05250]
106603693  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
106608317  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
106571025  ptk2b; protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
106562416  MMP2; 72 kDa type IV collagenase-like [KO:K01398] [EC:3.4.24.24]
100194903  mmp2; matrix metalloproteinase 2 [KO:K01398] [EC:3.4.24.24]
106600280  matrix metalloproteinase-14-like [KO:K07763] [EC:3.4.24.80]
106608848  matrix metalloproteinase-14-like [KO:K07763] [EC:3.4.24.80]
106569443  matrix metalloproteinase-14-like [KO:K07763] [EC:3.4.24.80]
106577791  matrix metalloproteinase-14-like [KO:K07763] [EC:3.4.24.80]
106604317  proheparin-binding EGF-like growth factor [KO:K08523]
106603916  proheparin-binding EGF-like growth factor [KO:K08523]
106612135  proheparin-binding EGF-like growth factor [KO:K08523]
106600426  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
106569312  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
106579586  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
106590362  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
106587111  growth factor receptor-bound protein 2-like [KO:K04364]
106607067  growth factor receptor-bound protein 2 [KO:K04364]
106564671  growth factor receptor-bound protein 2-like [KO:K04364]
100306767  grb2; growth factor receptor-bound protein 2 [KO:K04364]
106601599  sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
106584773  son of sevenless homolog 1-like [KO:K03099]
106611443  son of sevenless homolog 2-like [KO:K03099]
106564790  son of sevenless homolog 1-like [KO:K03099]
106573361  GTPase HRas-like [KO:K02833]
100196603  rash; GTPase HRas [KO:K02833]
106601908  GTPase HRas-like [KO:K07827]
106606379  GTPase HRas-like [KO:K07827]
106561428  GTPase KRas [KO:K07827]
100380437  rask; GTPase KRas [KO:K07827]
106571905  RAF1b; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
106566757  RAF1a; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
100136351  raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
106584829  map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106600441  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
106613775  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106569535  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
100194780  mp2k2; Dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106570952  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106600714  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
106592057  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
100380511  mk03; Mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
106566498  ETS domain-containing protein Elk-1-like [KO:K04375]
106603906  early growth response protein 1-like [KO:K09203]
106604926  early growth response protein 1-like [KO:K09203]
106611930  early growth response protein 1-like [KO:K09203]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:15350605
  Authors
Ruf F, Sealfon SC.
  Title
Genomics view of gonadotrope signaling circuits.
  Journal
Trends Endocrinol Metab 15:331-8 (2004)
DOI:10.1016/j.tem.2004.07.008
Reference
PMID:15613448
  Authors
Harrison GS, Wierman ME, Nett TM, Glode LM.
  Title
Gonadotropin-releasing hormone and its receptor in normal and malignant cells.
  Journal
Endocr Relat Cancer 11:725-48 (2004)
DOI:10.1677/erc.1.00777
Reference
PMID:15982836
  Authors
Pawson AJ, McNeilly AS.
  Title
The pituitary effects of GnRH.
  Journal
Anim Reprod Sci 88:75-94 (2005)
DOI:10.1016/j.anireprosci.2005.05.010
Reference
  Authors
DeGroot LJ, Jameson JL (ed).
  Title
Endocrinology (Fifth edition)
  Journal
Elsevier Saunders (2006)
Reference
PMID:10707049
  Authors
Naor Z, Benard O, Seger R.
  Title
Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor.
  Journal
Trends Endocrinol Metab 11:91-9 (2000)
DOI:10.1016/S1043-2760(99)00232-5
Reference
PMID:14596811
  Authors
Ruf F, Fink MY, Sealfon SC.
  Title
Structure of the GnRH receptor-stimulated signaling network: insights from genomics.
  Journal
Front Neuroendocrinol 24:181-99 (2003)
DOI:10.1016/S0091-3022(03)00027-X
Reference
PMID:12943720
  Authors
Farshori PQ, Shah BH, Arora KK, Martinez-Fuentes A, Catt KJ.
  Title
Activation and nuclear translocation of PKCdelta, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells.
  Journal
J Steroid Biochem Mol Biol 85:337-47 (2003)
DOI:10.1016/S0960-0760(03)00226-7
Reference
PMID:15080147
  Authors
Shah BH, Catt KJ.
  Title
Matrix metalloproteinases in reproductive endocrinology.
  Journal
Trends Endocrinol Metab 15:47-9 (2004)
DOI:10.1016/j.tem.2004.01.004
Reference
PMID:12963732
  Authors
Roelle S, Grosse R, Aigner A, Krell HW, Czubayko F, Gudermann T.
  Title
Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone.
  Journal
J Biol Chem 278:47307-18 (2003)
DOI:10.1074/jbc.M304377200
Reference
PMID:18708085
  Authors
Naor Z
  Title
Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.
  Journal
Front Neuroendocrinol 30:10-29 (2009)
DOI:10.1016/j.yfrne.2008.07.001
Related
pathway
sasa04010  MAPK signaling pathway
sasa04020  Calcium signaling pathway
sasa04060  Cytokine-cytokine receptor interaction
sasa04080  Neuroactive ligand-receptor interaction
KO pathway
ko04912   
LinkDB

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