KEGG   PATHWAY: sbq04144
Entry
sbq04144                    Pathway                                
Name
Endocytosis - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
sbq04144  Endocytosis
sbq04144

Other DBs
GO: 0006897
Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101049791  ARF6; ADP-ribosylation factor 6 [KO:K07941]
101035105  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
101044308  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
104649929  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
101037227  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
101035480  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
101028583  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101038089  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
101038308  DNM3; dynamin-3 isoform X2 [KO:K01528] [EC:3.6.5.5]
101039773  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
101048519  clathrin light chain A-like [KO:K04644]
101044263  CLTA; clathrin light chain A isoform X4 [KO:K04644]
101036111  LOW QUALITY PROTEIN: uncharacterized protein LOC101036111 [KO:K04644]
101032662  CLTB; clathrin light chain B [KO:K04645]
101039277  CLTC; clathrin heavy chain 1 isoform X2 [KO:K04646]
101054474  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
101044143  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
101032070  AP2A2; AP-2 complex subunit alpha-2 [KO:K11824]
101050435  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
101045037  AP2M1; AP-2 complex subunit mu [KO:K11826]
101032271  AP2S1; AP-2 complex subunit sigma [KO:K11827]
101037451  EHD2; EH domain-containing protein 2 [KO:K12469]
101030583  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101034142  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
101045294  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
101037957  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
101042469  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
101040653  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
101039593  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
101030435  TFRC; transferrin receptor protein 1 [KO:K06503]
101047461  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101040156  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
101033845  FGFR2; fibroblast growth factor receptor 2 isoform X11 [KO:K05093] [EC:2.7.10.1]
101051421  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101027585  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101039763  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101053489  CBL; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
101035841  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
104653275  CBLC; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
101049648  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X2 [KO:K12470]
101030466  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
101038282  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
101041967  SH3GL2; endophilin-A1 [KO:K11247]
101027951  SH3GLB1; endophilin-B1 [KO:K11248]
101033553  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
101048121  AMPH; amphiphysin [KO:K12562]
101033076  BIN1; myc box-dependent-interacting protein 1 isoform X16 [KO:K12562]
101049296  EPN3; epsin-3 [KO:K12471]
101049679  EPN2; epsin-2 isoform X1 [KO:K12471]
101027855  EPN1; epsin-1 isoform X3 [KO:K12471]
101040514  epidermal growth factor receptor substrate 15 [KO:K12472]
101054045  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X3 [KO:K12472]
104653255  epidermal growth factor receptor substrate 15-like [KO:K12472]
101041454  SPG20; spartin [KO:K19366]
101028535  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X5 [KO:K10591] [EC:2.3.2.26]
101049039  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X6 [KO:K13305] [EC:2.3.2.26]
101036938  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
101033308  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
101032463  RNF41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
101050449  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
101039306  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
101045857  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
101053807  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
101052112  LDLR; low-density lipoprotein receptor [KO:K12473]
101030874  LDLRAP1; low density lipoprotein receptor adapter protein 1 [KO:K12474]
101033665  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
101029550  CCR5; C-C chemokine receptor type 5 [KO:K04180]
101037560  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
101038106  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
101042221  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101051604  GRK1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
101047234  GRK7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
101049133  ADRBK1; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
101027803  ADRBK2; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
101037649  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
101054298  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
101030769  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
101037722  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
101046584  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
101054104  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
101034581  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
101040892  ACTR3; actin-related protein 3 [KO:K18584]
101050762  ACTR3B; actin-related protein 3B [KO:K18584]
101038366  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
101038677  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101035752  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101043265  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 3-like [KO:K05756]
101043531  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
101033977  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X2 [KO:K05754]
101052542  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101037007  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
101031456  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
101049313  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
101049152  HSPA1A; heat shock 70 kDa protein 1A/1B [KO:K03283]
101049467  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
101032912  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101050736  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
101029829  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
101043227  KIAA1033; WASH complex subunit 7 isoform X1 [KO:K18465]
101053233  KIAA0196; WASH complex subunit strumpellin isoform X1 [KO:K18464]
101044731  FAM21C; WASH complex subunit FAM21C isoform X1 [KO:K18462]
101028637  WASH1; LOW QUALITY PROTEIN: WAS protein family homolog 1 [KO:K18461]
101035471  CCDC53; WASH complex subunit CCDC53 isoform X1 [KO:K18463]
101052159  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
101039965  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
101050578  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
101038146  CAPZB; F-actin-capping protein subunit beta [KO:K10365]
101053018  vacuolar protein sorting-associated protein 29 isoform X2 [KO:K18467]
101049781  VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466]
101038430  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
101043801  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
101040655  SNX12; sorting nexin-12 [KO:K17918]
101039311  SNX3; sorting nexin-3 [KO:K17918]
101053106  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
101029729  STAMBP; STAM-binding protein [KO:K11866] [EC:3.4.19.12]
101041825  RAB7A; ras-related protein Rab-7a [KO:K07897]
101048011  HGS; LOW QUALITY PROTEIN: hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
101046949  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
101031112  STAM2; signal transducing adapter molecule 2 [KO:K04705]
101047815  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
101039662  MVB12B; multivesicular body subunit 12B [KO:K12186]
101032601  MVB12A; multivesicular body subunit 12A [KO:K12186]
101051161  VPS28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
101046549  VPS37C; vacuolar protein sorting-associated protein 37C [KO:K12185]
101042286  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
101041364  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
101031806  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
101041977  SNF8; vacuolar-sorting protein SNF8 [KO:K12188]
101031242  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
101037040  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
101052152  CHMP6; charged multivesicular body protein 6 [KO:K12195]
101052308  CHMP4A; charged multivesicular body protein 4a [KO:K12194]
101053230  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
101041494  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
101046810  CHMP3; charged multivesicular body protein 3 isoform X2 [KO:K12193]
101034409  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
101050656  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
101049100  CHMP7; charged multivesicular body protein 7 [KO:K15053]
101040422  VPS4A; vacuolar protein sorting-associated protein 4A [KO:K12196]
101040109  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
101047780  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
101033149  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
101051355  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
101054449  CHMP5; charged multivesicular body protein 5 [KO:K12198]
101030166  IST1; IST1 homolog isoform X1 [KO:K19476]
101039598  PDCD6IP; programmed cell death 6-interacting protein [KO:K12200]
101037985  SPG21; maspardin [KO:K19367]
101041450  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
101040539  sorting nexin-1 isoform X2 [KO:K17917]
101032350  SNX2; sorting nexin-2 [KO:K17917]
101054461  SNX6; sorting nexin-6 [KO:K17920]
101029371  SNX5; sorting nexin-5 [KO:K17920]
101043163  SNX32; sorting nexin-32 isoform X1 [KO:K17920]
101051959  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101047663  HRAS; GTPase HRas isoform X2 [KO:K02833]
101036589  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
101030332  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101047979  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
101052068  RHOA; transforming protein RhoA [KO:K04513]
104650592  ras-like GTP-binding protein O-RHO [KO:K04513]
104652261  RHOC; rho-related GTP-binding protein RhoC [KO:K04513]
101042893  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101043856  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101046108  HLA class I histocompatibility antigen, B-27 alpha chain-like [KO:K06751]
104650390  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
104650398  putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
101032412  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101040674  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101041111  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101033054  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
101040568  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101040877  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like isoform X1 [KO:K06751]
101044935  LOW QUALITY PROTEIN: popy class I histocompatibility antigen, alpha chain E [KO:K06751]
101050220  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101050865  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101029639  folate receptor gamma-like [KO:K13649]
101027813  LOW QUALITY PROTEIN: folate receptor gamma-like [KO:K13649]
101054127  FOLR1; folate receptor alpha [KO:K13649]
101027508  FOLR2; folate receptor beta [KO:K13649]
101039198  CAV1; caveolin-1 isoform X1 [KO:K06278]
101039961  CAV2; caveolin-2 [KO:K12958]
101051489  CAV3; caveolin-3 [KO:K12959]
101044505  EHD3; EH domain-containing protein 3 [KO:K12476]
101037939  EHD4; EH domain-containing protein 4 [KO:K12477]
101049276  EEA1; early endosome antigen 1 [KO:K12478]
101034494  RAB5A; ras-related protein Rab-5A [KO:K07887]
101046115  ras-related protein Rab-5B [KO:K07888]
101045231  RAB5C; ras-related protein Rab-5C [KO:K07889]
101027877  RABEP1; rab GTPase-binding effector protein 1 [KO:K12480]
101048941  ZFYVE20; rabenosyn-5 isoform X1 [KO:K12481]
101037457  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
101038326  RUFY1; RUN and FYVE domain-containing protein 1 [KO:K12482]
101045791  RUFY2; RUN and FYVE domain-containing protein 2 [KO:K12482]
101028231  EHD1; EH domain-containing protein 1 [KO:K12483]
101050520  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
101053710  SNX4; sorting nexin-4 isoform X1 [KO:K17919]
101047861  RAB31; ras-related protein Rab-31 [KO:K07891]
101042497  RAB22A; ras-related protein Rab-22A [KO:K07891]
101045906  RAB10; ras-related protein Rab-10 [KO:K07903]
101052643  RAB8A; ras-related protein Rab-8A [KO:K07901]
101051829  RAB35; ras-related protein Rab-35 [KO:K07876]
101031948  RAB11A; ras-related protein Rab-11A [KO:K07904]
101039329  RAB11B; ras-related protein Rab-11B [KO:K07905]
101042426  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
101027809  RAB11FIP5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
101028556  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
101052085  ZFYVE27; protrudin isoform X1 [KO:K19368]
101042531  KIF5B; kinesin-1 heavy chain [KO:K10396]
101054225  KIF5C; kinesin heavy chain isoform 5C [KO:K10396]
101034824  KIF5A; kinesin heavy chain isoform 5A [KO:K10396]
101037500  RAB11FIP4; rab11 family-interacting protein 4 [KO:K12485]
101050757  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
101039526  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
101035488  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
101031506  PARD6A; partitioning defective 6 homolog alpha isoform X2 [KO:K06093]
101043414  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
101039978  PRKCZ; protein kinase C zeta type isoform X4 [KO:K18952] [EC:2.7.11.13]
101037993  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
101050895  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101028914  SMAP1; stromal membrane-associated protein 1 isoform X3 [KO:K12486]
101035515  SMAP2; stromal membrane-associated protein 2 [KO:K12486]
101031071  GIT1; ARF GTPase-activating protein GIT1 isoform X2 [KO:K05737]
101037396  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
101044748  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2 [KO:K12488]
101042918  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X2 [KO:K12488]
101050213  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X2 [KO:K12488]
101052768  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3 [KO:K12489]
101034845  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
101035844  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
101029736  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
101028604  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
101037093  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
101039065  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
101050142  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 [KO:K12491]
101040226  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
101053122  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
101051849  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X2 [KO:K12493]
101031672  LOW QUALITY PROTEIN: ADP-ribosylation factor GTPase-activating protein 3-like [KO:K12493]
101051809  LOW QUALITY PROTEIN: ADP-ribosylation factor GTPase-activating protein 3-like [KO:K12493]
101053267  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
104652585  PH and SEC7 domain-containing protein 3-like [KO:K12494]
101047609  PH and SEC7 domain-containing protein 3 [KO:K12494]
101036512  PSD4; PH and SEC7 domain-containing protein 4 [KO:K12494]
101031387  PSD2; PH and SEC7 domain-containing protein 2 [KO:K12494]
101031699  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X2 [KO:K12495]
101029230  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X2 [KO:K12495]
101047459  IQSEC2; IQ motif and SEC7 domain-containing protein 2 [KO:K12495]
101042395  CYTH4; cytohesin-4 [KO:K18441]
101043282  CYTH2; cytohesin-2 [KO:K18441]
101029476  CYTH1; cytohesin-1 [KO:K18441]
101042499  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
101038459  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
101036515  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
101045936  GBF1; golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 [KO:K18443]
101035296  ARF1; ADP-ribosylation factor 1 [KO:K07937]
101042434  ARF3; ADP-ribosylation factor 3 [KO:K07938]
101032773  ARF4; ADP-ribosylation factor 4 [KO:K07939]
101051123  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
sbq04060  Cytokine-cytokine receptor interaction
sbq04070  Phosphatidylinositol signaling system
sbq04130  SNARE interactions in vesicular transport
sbq04142  Lysosome
sbq04350  TGF-beta signaling pathway
KO pathway
ko04144   
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