KEGG   PATHWAY: sbq05216
sbq05216                    Pathway                                

Thyroid cancer - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells. Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas (PTC and FTC, respectively) to the extremely aggressive undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages. The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements. p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma.
Human Diseases; Cancer: specific types
Pathway map
sbq05216  Thyroid cancer

Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
101053966  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:]
101037811  CCDC6; coiled-coil domain-containing protein 6 [KO:K09288]
101046425  NCOA4; LOW QUALITY PROTEIN: nuclear receptor coactivator 4 [KO:K09289]
101035626  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:]
101052619  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
101038731  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
101052248  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
101040194  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
101053929  TPR; nucleoprotein TPR [KO:K09291]
101027540  TFG; protein TFG isoform X1 [KO:K09292]
101047663  HRAS; GTPase HRas isoform X2 [KO:K02833]
101036877  NRAS; GTPase NRas [KO:K07828]
101047035  KRAS; GTPase KRas isoform X1 [KO:K07827]
101052142  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:]
101040361  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:]
101036151  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:]
101038546  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:]
101043202  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:]
101036832  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
101028278  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
101044148  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
101040304  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
101040247  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
101043647  TP53; cellular tumor antigen p53 [KO:K04451]
101041919  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
101030208  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101039106  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101047513  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101050177  BAX; apoptosis regulator BAX [KO:K02159]
101041291  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101027903  DDB2; DNA damage-binding protein 2 isoform X2 [KO:K10140]
101034259  POLK; DNA polymerase kappa [KO:K03511] [EC:]
101049706  CDH1; cadherin-1 [KO:K05689]
101043327  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
101029076  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
101033762  TCF7L1; transcription factor 7-like 1 [KO:K04490]
101037011  TCF7L2; transcription factor 7-like 2 [KO:K04491]
101047688  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
101047066  MYC; myc proto-oncogene protein isoform X2 [KO:K04377]
101047858  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
Kondo T, Ezzat S, Asa SL.
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
Nat Rev Cancer 6:292-306 (2006)
Chiloeches A, Marais R.
Is BRAF the Achilles' Heel of thyroid cancer?
Clin Cancer Res 12:1661-4 (2006)
Reddi HV, McIver B, Grebe SK, Eberhardt NL
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
Endocrinology 148:932-5 (2007)
Santoro M, Melillo RM, Fusco A.
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
Eur J Endocrinol 155:645-653 (2006)
Pierotti MA, Greco A.
Oncogenic rearrangements of the NTRK1/NGF receptor.
Cancer Lett 232:90-8 (2006)
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
Molecular pathology of well-differentiated thyroid carcinomas.
Virchows Arch 447:787-93 (2005)
Gimm O.
Thyroid cancer.
Cancer Lett 163:143-56 (2001)
Williams D.
Cancer after nuclear fallout: lessons from the Chernobyl accident.
Nat Rev Cancer 2:543-9 (2002)
sbq03320  PPAR signaling pathway
sbq04010  MAPK signaling pathway
sbq04115  p53 signaling pathway
sbq04310  Wnt signaling pathway
sbq04520  Adherens junction
KO pathway

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