Entry
Name
MAPK signaling pathway - Sinocyclocheilus grahami (golden-line barbel)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Sinocyclocheilus grahami (golden-line barbel) [GN:
sgh ]
Gene
107556305 voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344 ]
107570979 voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344 ]
107582970 voltage-dependent P/Q-type calcium channel subunit alpha-1A-like isoform X1 [KO:K04344 ]
107571502 voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344 ]
107595700 voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849 ]
107587427 probable voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849 ]
107548771 voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849 ]
107560222 voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849 ]
107590584 voltage-dependent L-type calcium channel subunit alpha-1C-like [KO:K04850 ]
107589041 voltage-dependent L-type calcium channel subunit alpha-1C-like [KO:K04850 ]
107581799 voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851 ]
107549565 voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851 ]
107594982 LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851 ]
107582429 voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851 ]
107549680 voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852 ]
107562853 voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852 ]
107599003 voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852 ]
107565520 voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852 ]
107548248 voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853 ]
107549945 voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853 ]
107550115 voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853 ]
107552774 voltage-dependent T-type calcium channel subunit alpha-1G-like isoform X1 [KO:K04854 ]
107564847 voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854 ]
107564851 voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854 ]
107581769 voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855 ]
107592392 voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855 ]
107556199 voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856 ]
107558512 voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856 ]
107551144 voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856 ]
107561340 voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856 ]
107550462 dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1 [KO:K04857 ]
107572552 dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857 ]
107591792 dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857 ]
107590440 voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858 ]
107563411 cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858 ]
107559841 voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858 ]
107558272 voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859 ]
107595439 voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859 ]
107587574 voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859 ]
107553873 voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860 ]
107581790 voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860 ]
107582378 voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1 [KO:K04860 ]
107574657 voltage-dependent calcium channel subunit alpha-2/delta-4-like isoform X1 [KO:K04861 ]
107590835 voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861 ]
107591101 LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861 ]
107552492 voltage-dependent L-type calcium channel subunit beta-1-like [KO:K04862 ]
107567406 cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862 ]
107601146 voltage-dependent L-type calcium channel subunit beta-2-like [KO:K04863 ]
107558158 voltage-dependent L-type calcium channel subunit beta-2-like [KO:K04863 ]
107559955 voltage-dependent L-type calcium channel subunit beta-2-like [KO:K04863 ]
107601341 voltage-dependent L-type calcium channel subunit beta-3-like [KO:K04864 ]
107570227 voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864 ]
107594466 voltage-dependent L-type calcium channel subunit beta-3-like [KO:K04864 ]
107555918 cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865 ]
107566792 voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865 ]
107596082 voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865 ]
107596307 voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04865 ]
107569457 voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866 ]
107586374 voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866 ]
107548678 voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866 ]
107578828 voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866 ]
107565857 voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866 ]
107555104 voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867 ]
107558510 voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867 ]
107551139 voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867 ]
107590403 voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868 ]
107601254 voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868 ]
107590766 voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868 ]
107565565 cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868 ]
107586376 voltage-dependent calcium channel gamma-4 subunit-like isoform X1 [KO:K04869 ]
107577463 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869 ]
107548710 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869 ]
107565862 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869 ]
107569463 voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870 ]
107571175 voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870 ]
107586339 voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870 ]
107589389 voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871 ]
107549474 voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871 ]
107598398 voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871 ]
107599526 voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871 ]
107589388 voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872 ]
107549472 voltage-dependent calcium channel gamma-7 subunit-like isoform X1 [KO:K04872 ]
107598394 voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872 ]
107599530 voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872 ]
107589386 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873 ]
107549473 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873 ]
107598392 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873 ]
107599529 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873 ]
107581709 gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346 ]
107551713 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347 ]
107555383 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347 ]
107564436 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347 ]
107565612 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347 ]
107589094 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107586120 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107553709 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107571543 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107551448 rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349 ]
107602219 ras-specific guanine nucleotide-releasing factor 2-like [KO:K12326 ]
107548987 ras-specific guanine nucleotide-releasing factor 2-like isoform X1 [KO:K12326 ]
107555492 rasgrf2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326 ]
107587539 ras-specific guanine nucleotide-releasing factor 2-like [KO:K12326 ]
107548350 rap guanine nucleotide exchange factor 2-like isoform X1 [KO:K08018 ]
107566698 rap guanine nucleotide exchange factor 2-like isoform X1 [KO:K08018 ]
107563229 platelet-derived growth factor subunit A-like isoform X1 [KO:K04359 ]
107569132 pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
107559552 adenylate cyclase, terminal-differentiation specific-like [KO:K17386 ]
107579754 vascular endothelial growth factor A-A-like isoform X1 [KO:K05448 ]
107564512 vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448 ]
107559057 vascular endothelial growth factor A-A-like isoform X1 [KO:K05448 ]
107575298 snake venom vascular endothelial growth factor toxin ICPP-like isoform X1 [KO:K16859 ]
107596749 tumor necrosis factor receptor superfamily member 16-like [KO:K02583 ]
107560558 tumor necrosis factor receptor superfamily member 16-like isoform X1 [KO:K02583 ]
107566195 tumor necrosis factor receptor superfamily member 16-like [KO:K02583 ]
107568444 tumor necrosis factor receptor superfamily member 16-like [KO:K02583 ]
107581538 tumor necrosis factor receptor superfamily member 16-like [KO:K02583 ]
107569198 tumor necrosis factor receptor superfamily member 16-like isoform X1 [KO:K02583 ]
107568392 atf4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374 ]
107585034 cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374 ]
107596732 tumor necrosis factor receptor superfamily member 1A-like [KO:K03158 ]
107550806 tumor necrosis factor receptor superfamily member 1A-like [KO:K03158 ]
107565829 tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158 ]
107593391 tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158 ]
107597819 tumor necrosis factor ligand superfamily member 6-like [KO:K04389 ]
107581522 tumor necrosis factor ligand superfamily member 6-like [KO:K04389 ]
107554068 tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390 ]
107583548 tumor necrosis factor receptor superfamily member 6-like [KO:K04390 ]
107571767 ras-related C3 botulinum toxin substrate 3-like isoform X1 [KO:K07861 ]
107582398 cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
107585960 tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
107594616 tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171 ]
107584943 myeloid differentiation primary response protein MyD88-like [KO:K04729 ]
107591285 myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
107589289 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
107591447 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
107600042 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
107602833 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
107551712 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
107597151 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
107578769 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
107553537 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
107564442 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
107591738 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
107559165 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
107555372 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
107555091 tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
107558968 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like [KO:K04404 ]
107568749 tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
107558448 evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial-like isoform X1 [KO:K04405 ]
107597881 evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial-like [KO:K04405 ]
107566132 C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434 ]
107572995 C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434 ]
107589201 mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434 ]
107599899 C-Jun-amino-terminal kinase-interacting protein 2-like isoform X1 [KO:K04435 ]
107567271 mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436 ]
107552451 C-Jun-amino-terminal kinase-interacting protein 3-like [KO:K04436 ]
107563708 nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446 ]
107592032 nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446 ]
107566268 nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333 ]
107563458 nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333 ]
107555722 nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333 ]
107548920 nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333 ]
107566410 ddit3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452 ]
107563477 map2k5; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463 ] [EC:2.7.12.2 ]
107601822 nuclear factor NF-kappa-B p100 subunit-like isoform X1 [KO:K04469 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
Title
MAP kinases.
Journal
Reference
Authors
Tanoue T, Nishida E.
Title
Docking interactions in the mitogen-activated protein kinase cascades.
Journal
Reference
Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
Title
MAPK pathways in radiation responses.
Journal
Reference
Authors
Huang EJ, Reichardt LF.
Title
Trk receptors: roles in neuronal signal transduction.
Journal
Reference
Authors
Harper SJ, LoGrasso P.
Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
Journal
Reference
Authors
Takeda K, Ichijo H
Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
Journal
Reference
Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
Title
Transcriptional regulation by the MAP kinase signaling cascades.
Journal
Reference
Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Journal
Reference
Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Reference
Authors
Chu WM
Title
Tumor necrosis factor.
Journal
Reference
Authors
Newton K, Dixit VM
Title
Signaling in innate immunity and inflammation.
Journal
Reference
Authors
Gaestel M, Kotlyarov A, Kracht M
Title
Targeting innate immunity protein kinase signalling in inflammation.
Journal
Reference
Authors
Ajibade AA, Wang HY, Wang RF
Title
Cell type-specific function of TAK1 in innate immune signaling.
Journal
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Related pathway
sgh04070 Phosphatidylinositol signaling system
KO pathway
LinkDB
All DBs