KEGG   PATHWAY: sgh04012
Entry
sgh04012                    Pathway                                
Name
ErbB signaling pathway - Sinocyclocheilus grahami (golden-line barbel)
Description
The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. Signaling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the various signaling pathways. The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB receptors. Similarly, the phosphatidylinositol-3-kinase (PI-3K) pathway is directly or indirectly activated by most ErbBs. Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or the Cbl E3 ubiquitin protein ligase.
Class
Environmental Information Processing; Signal transduction
Pathway map
sgh04012  ErbB signaling pathway
sgh04012

Organism
Sinocyclocheilus grahami (golden-line barbel) [GN:sgh]
Gene
107602591  pro-epidermal growth factor-like [KO:K04357]
107569836  pro-epidermal growth factor-like [KO:K04357]
107568177  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
107554803  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
107566457  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
107599721  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
107560555  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
107573419  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
107557477  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [KO:K01116] [EC:3.1.4.11]
107562619  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [KO:K01116] [EC:3.1.4.11]
107587040  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like [KO:K05859] [EC:3.1.4.11]
107587041  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like [KO:K05859] [EC:3.1.4.11]
107559804  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
107568545  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
107563926  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
107595950  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
107601404  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
107561852  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
107562980  calcium/calmodulin-dependent protein kinase type II delta 2 chain-like [KO:K04515] [EC:2.7.11.17]
107581888  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
107561529  calcium/calmodulin-dependent protein kinase type II delta 1 chain [KO:K04515] [EC:2.7.11.17]
107554545  calcium/calmodulin-dependent protein kinase type II delta chain isoform X1 [KO:K04515] [EC:2.7.11.17]
107562154  calcium/calmodulin-dependent protein kinase type II subunit alpha-like [KO:K04515] [EC:2.7.11.17]
107588949  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
107597268  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
107601773  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
107556610  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
107569462  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
107586338  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
107590404  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
107601253  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107564527  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107590741  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
107549470  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
107598407  LOW QUALITY PROTEIN: protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
107585540  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
107601723  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K04707] [EC:2.3.2.27]
107548831  E3 ubiquitin-protein ligase CBL-B-like [KO:K22517] [EC:2.3.2.27]
107576804  E3 ubiquitin-protein ligase CBL-B-like [KO:K22517] [EC:2.3.2.27]
107551841  signal transducer and activator of transcription 5B-like [KO:K11224]
107568282  signal transducer and activator of transcription 5B-like [KO:K11224]
107560759  signal transducer and activator of transcription 5B-like [KO:K11224]
107556764  signal transducer and activator of transcription 5B-like [KO:K11224]
107590469  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
107558752  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
107552863  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
107559761  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
107587873  focal adhesion kinase 1-like [KO:K05725] [EC:2.7.10.2]
107589229  crk-like protein [KO:K04438]
107592606  adapter molecule crk-like [KO:K04438]
107591716  crk-like protein [KO:K04438]
107585573  adapter molecule crk-like [KO:K04438]
107597931  tyrosine-protein kinase ABL1-like isoform X1 [KO:K06619] [EC:2.7.10.2]
107577903  tyrosine-protein kinase ABL1-like [KO:K06619] [EC:2.7.10.2]
107566858  tyrosine-protein kinase ABL1-like [KO:K06619] [EC:2.7.10.2]
107603207  Abelson tyrosine-protein kinase 2-like [KO:K08887] [EC:2.7.10.2]
107599009  Abelson tyrosine-protein kinase 2-like isoform X1 [KO:K08887] [EC:2.7.10.2]
107588047  cytoplasmic protein NCK1-like isoform X1 [KO:K07365]
107600141  cytoplasmic protein NCK1-like isoform X1 [KO:K07365]
107550612  cytoplasmic protein NCK1-like isoform X1 [KO:K07365]
107585026  cytoplasmic protein NCK1-like [KO:K07365]
107571035  cytoplasmic protein NCK2-like [KO:K19862]
107602910  cytoplasmic protein NCK2-like isoform X1 [KO:K19862]
107551075  cytoplasmic protein NCK2-like [KO:K19862]
107559915  cytoplasmic protein NCK2-like [KO:K19862]
107596325  cytoplasmic protein NCK2-like [KO:K19862]
107594372  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
107591323  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
107557297  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
107574590  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
107599100  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
107566210  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
107592622  serine/threonine-protein kinase PAK 4-like isoform X1 [KO:K05734] [EC:2.7.11.1]
107585589  serine/threonine-protein kinase PAK 4-like isoform X1 [KO:K05734] [EC:2.7.11.1]
107564328  pak7; serine/threonine-protein kinase PAK 7 isoform X1 [KO:K05736] [EC:2.7.11.1]
107557903  serine/threonine-protein kinase PAK 7-like isoform X1 [KO:K05736] [EC:2.7.11.1]
107552880  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
107557016  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
107560170  pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
107564586  serine/threonine-protein kinase PAK 6-like isoform X1 [KO:K05735] [EC:2.7.11.1]
107570719  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
107575628  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
107601595  dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
107556463  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
107602992  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
107567797  map2k7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
107566214  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107565387  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107584639  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
107588610  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
107548633  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
107590058  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
107571265  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107581481  transcription factor AP-1-like [KO:K04448]
107597804  transcription factor AP-1-like [KO:K04448]
107563389  transcription factor AP-1-like isoform X1 [KO:K04448]
107584885  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
107591748  probetacellulin-like isoform X1 [KO:K09783]
107557065  proheparin-binding EGF-like growth factor [KO:K08523]
107559299  proheparin-binding EGF-like growth factor [KO:K08523]
107587125  proheparin-binding EGF-like growth factor [KO:K08523]
107590028  proheparin-binding EGF-like growth factor [KO:K08523]
107551889  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
107593907  receptor tyrosine-protein kinase erbB-3-like isoform X1 [KO:K05084] [EC:2.7.10.1]
107581402  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
107591118  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
107564117  pro-neuregulin-1, membrane-bound isoform-like [KO:K05455]
107575152  pro-neuregulin-1, membrane-bound isoform-like isoform X1 [KO:K05455]
107559265  pro-neuregulin-2, membrane-bound isoform-like [KO:K05456]
107589101  pro-neuregulin-2, membrane-bound isoform-like [KO:K05456]
107560662  pro-neuregulin-2, membrane-bound isoform-like isoform X1 [KO:K05456]
107557058  pro-neuregulin-2, membrane-bound isoform-like isoform X1 [KO:K05456]
107556197  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
107557316  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
107565289  LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
107555909  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
107556266  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
107590690  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
107594952  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
107582132  SHC-transforming protein 1-like [KO:K06279]
107593314  SHC-transforming protein 2-like isoform X1 [KO:K17447]
107586398  SHC-transforming protein 2-like isoform X1 [KO:K17447]
107585661  SHC-transforming protein 3-like [KO:K17448]
107599382  SHC-transforming protein 3-like [KO:K17448]
107602286  growth factor receptor-bound protein 2-like [KO:K04364]
107573530  growth factor receptor-bound protein 2-like [KO:K04364]
107561023  growth factor receptor-bound protein 2 [KO:K04364]
107583254  growth factor receptor-bound protein 2-A isoform X1 [KO:K04364]
107571995  son of sevenless homolog 1-like [KO:K03099]
107602966  son of sevenless homolog 2-like isoform X1 [KO:K03099]
107553213  son of sevenless homolog 2-like [KO:K03099]
107562482  son of sevenless homolog 1-like [KO:K03099]
107562835  GTPase HRas-like isoform X1 [KO:K02833]
107558311  GTPase HRas-like [KO:K02833]
107600445  GTPase HRas-like [KO:K02833]
107596435  GTPase HRas isoform X1 [KO:K02833]
107567516  GTPase HRas-like [KO:K07827]
107549277  ras-like protein isoform X1 [KO:K07827]
107560753  GTPase HRas-like [KO:K07827]
107595236  ras-like protein isoform X1 [KO:K07827]
107598969  GTPase NRas-like [KO:K07828]
107566814  GTPase NRas [KO:K07828]
107592338  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
107595004  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
107560707  serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
107594271  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107564278  raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107571214  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
107555780  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
107583767  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
107596971  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107575785  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107596877  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107552672  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107586388  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107590568  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107599610  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107599134  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107567791  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107584016  transcriptional regulator Myc-B isoform X1 [KO:K04377]
107558335  transcriptional regulator Myc-1 [KO:K04377]
107589955  transcriptional regulator Myc-2 [KO:K04377]
107550557  gab1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
107598765  GRB2-associated-binding protein 1-like [KO:K09593]
107563798  pro-neuregulin-3, membrane-bound isoform-like [KO:K05457]
107566665  pro-neuregulin-3, membrane-bound isoform-like [KO:K05457]
107557971  pro-neuregulin-3, membrane-bound isoform-like [KO:K05457]
107555324  pro-neuregulin-3, membrane-bound isoform-like [KO:K05457]
107589359  pro-neuregulin-4, membrane-bound isoform-like [KO:K05458]
107557989  pro-neuregulin-4, membrane-bound isoform-like [KO:K05458]
107574159  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107567258  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
107551780  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107571432  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107571564  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
107586517  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107598784  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
107550618  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
107594617  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107586063  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
107595995  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
107556985  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107600587  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107593753  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107564028  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107550532  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107565536  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107557843  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107598536  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107587842  akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107565462  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107585271  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107572728  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107572734  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107594289  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107594963  serine/threonine-protein kinase mTOR-like [KO:K07203] [EC:2.7.11.1]
107564227  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
107576702  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107582630  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107548877  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107597508  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107589258  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
107591688  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
107588192  bcl2-associated agonist of cell death-like [KO:K02158]
107559611  bcl2-associated agonist of cell death-like [KO:K02158]
107568298  bcl2-associated agonist of cell death-like [KO:K02158]
107562077  bcl2-associated agonist of cell death-like [KO:K02158]
107567912  bcl2-associated agonist of cell death-like [KO:K02158]
107567916  bcl2-associated agonist of cell death-like [KO:K02158]
107551994  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107559500  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
107569048  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
107549588  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
107553888  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
107590325  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
107558598  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
107569753  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
107572358  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
107601015  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
107562144  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14967450
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
PMID:11252954
  Authors
Yarden Y, Sliwkowski MX.
  Title
Untangling the ErbB signalling network.
  Journal
Nat Rev Mol Cell Biol 2:127-37 (2001)
DOI:10.1038/35052073
Reference
PMID:16829981
  Authors
Citri A, Yarden Y.
  Title
EGF-ERBB signalling: towards the systems level.
  Journal
Nat Rev Mol Cell Biol 7:505-16 (2006)
DOI:10.1038/nrm1962
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Related
pathway
sgh04010  MAPK signaling pathway
sgh04020  Calcium signaling pathway
sgh04110  Cell cycle
sgh04150  mTOR signaling pathway
KO pathway
ko04012   
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