KEGG   PATHWAY: slal04110
Entry
slal04110                   Pathway                                
Name
Cell cycle - Seriola lalandi dorsalis (Yellowtail amberjack)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
slal04110  Cell cycle
slal04110

Other DBs
GO: 0000278
Organism
Seriola lalandi dorsalis (Yellowtail amberjack) [GN:slal]
Gene
111647809  G1/S-specific cyclin-D1-like [KO:K04503]
111670038  G1/S-specific cyclin-D1-like [KO:K04503]
111669291  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
111660519  G1/S-specific cyclin-D2-like [KO:K10151]
111660040  G1/S-specific cyclin-D2-like [KO:K10151]
111666072  G1/S-specific cyclin-D2-like [KO:K10151]
111660864  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
111667889  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
111658435  cyclin-dependent kinase 6-like isoform X1 [KO:K02091] [EC:2.7.11.22]
111656924  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
111653978  rb1; retinoblastoma-associated protein [KO:K06618]
111644267  rbl1; retinoblastoma-like protein 1 [KO:K04681]
111647411  retinoblastoma-like protein 2 [KO:K16332]
111672285  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
111664729  abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
111650093  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
111672915  hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
111671433  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
111655259  e2f1; transcription factor E2F1 [KO:K17454]
111655894  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
111657207  e2f3; transcription factor E2F3 [KO:K06620]
111671419  transcription factor E2F3-like [KO:K06620]
111646255  transcription factor E2F4-like [KO:K04682]
111669142  transcription factor E2F5-like [KO:K04682]
111666103  e2f4; transcription factor E2F4 [KO:K04682]
111662174  tfdp1; transcription factor Dp-1 [KO:K04683]
111662131  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111662255  transforming growth factor beta-1-like [KO:K13375]
111655785  transforming growth factor beta-2-like [KO:K13376]
111664155  tgfb2; transforming growth factor beta-2 [KO:K13376]
111653047  transforming growth factor beta-3-like [KO:K13377]
111663127  tgfb3; transforming growth factor beta-3 [KO:K13377]
111648020  mothers against decapentaplegic homolog 2 [KO:K04500]
111655756  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
111666993  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
111661150  mothers against decapentaplegic homolog 3 [KO:K23605]
111664827  mothers against decapentaplegic homolog 4-like [KO:K04501]
111644705  mothers against decapentaplegic homolog 4-like [KO:K04501]
111669183  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
111645724  mothers against decapentaplegic homolog 4 [KO:K04501]
111649068  transcriptional regulator Myc-like isoform X1 [KO:K04377]
111662034  transcriptional regulator Myc-2-like [KO:K04377]
111656568  myc; myc proto-oncogene protein [KO:K04377]
111656207  zbtb17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
111670409  cyclin-dependent kinase 4 inhibitor D-like [KO:K04685]
111651876  cyclin-dependent kinase 4 inhibitor C-like [KO:K06622]
111664501  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
111650370  cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
111651967  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
111650420  cyclin-dependent kinase inhibitor 1C-like [KO:K09993]
111644338  cyclin-dependent kinase inhibitor 1B-like [KO:K09993]
111660719  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
111651995  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
111649541  G1/S-specific cyclin-E2-like [KO:K06626]
111672273  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
111644688  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
111667739  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
111659985  skp1; S-phase kinase-associated protein 1 [KO:K03094]
111647272  cul1; cullin-1 isoform X1 [KO:K03347]
111647571  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
111648076  skp2; S-phase kinase-associated protein 2 [KO:K03875]
111662685  ccna1; cyclin-A1 [KO:K06627]
111644649  ccna2; cyclin-A2 [KO:K06627]
111650294  cyclin-A2-like [KO:K06627]
111658782  cell division control protein 6 homolog [KO:K02213]
111669438  cdt1; DNA replication factor Cdt1 [KO:K10727]
111671583  orc1; origin recognition complex subunit 1 [KO:K02603]
111666582  orc2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
111644743  orc3; origin recognition complex subunit 3 [KO:K02605]
111670354  orc4; origin recognition complex subunit 4 [KO:K02606]
111660012  orc5; origin recognition complex subunit 5 [KO:K02607]
111644284  mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
111661333  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
111653294  mcm4; DNA replication licensing factor MCM4 isoform X1 [KO:K02212] [EC:5.6.2.3]
111673743  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
111666468  mcm6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
111648313  mcm7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
111660998  cdc45; cell division control protein 45 homolog [KO:K06628]
111650445  ticrr; treslin [KO:K26117]
111657189  mtbp; mdm2-binding protein isoform X1 [KO:K26116]
111661238  cdc7; cell division cycle 7-related protein kinase [KO:K02214] [EC:2.7.11.1]
111650828  dbf4; protein DBF4 homolog A [KO:K06629]
111657090  uncharacterized protein LOC111657090 [KO:K06629]
111669394  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
111650108  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
111656616  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
111665458  cntd2; cyclin N-terminal domain-containing protein 2 [KO:K21770]
111667104  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
111672807  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
111644779  ywhaq; 14-3-3 protein theta [KO:K16197]
111645416  14-3-3 protein beta/alpha-1 [KO:K16197]
111659366  14-3-3 protein zeta/delta-like [KO:K16197]
111664154  14-3-3 protein zeta-like [KO:K16197]
111667172  14-3-3 protein beta/alpha-1-like [KO:K16197]
111671290  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
111656080  14-3-3 protein epsilon [KO:K06630]
111650672  14-3-3 protein gamma-B-like [KO:K16198]
111663934  ywhag; 14-3-3 protein gamma [KO:K16198]
111672930  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
111654312  wee1-like protein kinase 1-A [KO:K06632] [EC:2.7.11.1]
111646661  wee1-like protein kinase 1-A [KO:K06632] [EC:2.7.11.1]
111647704  wee1-like protein kinase 1-A [KO:K06632] [EC:2.7.11.1]
111666058  wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
111652267  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
111651558  ccnh; cyclin-H [KO:K06634]
111660264  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
111645306  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
111651170  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
111657528  cdc27; cell division cycle protein 27 homolog [KO:K03350]
111665035  cell division cycle protein 27 homolog [KO:K03350]
111660125  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
111644882  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
111653849  cdc16; cell division cycle protein 16 homolog [KO:K03353]
111648033  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
111666235  cdc23; cell division cycle protein 23 homolog [KO:K03355]
111673192  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
111660402  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
111670249  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
111666109  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
111655307  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
111660209  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
111654419  cdc20; cell division cycle protein 20 homolog [KO:K03363]
111654938  cdc20b; cell division cycle protein 20 homolog B isoform X1 [KO:K03363]
111648205  securin-like isoform X1 [KO:K06635]
111667822  espl1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
111670667  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
111647695  structural maintenance of chromosomes protein 1B-like [KO:K06636]
111668517  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
111658095  double-strand-break repair protein rad21 homolog [KO:K06670]
111657822  double-strand-break repair protein rad21 homolog [KO:K06670]
111654199  double-strand-break repair protein rad21-like protein 1 [KO:K06670]
111646473  cohesin subunit SA-2-like [KO:K06671]
111648284  stag3; cohesin subunit SA-3 [KO:K06671]
111654007  cohesin subunit SA-2-like [KO:K06671]
111665784  cohesin subunit SA-2-like [KO:K06671]
111665814  stag1; cohesin subunit SA-1 [KO:K06671]
111653943  transcriptional regulator ATRX-like [KO:K10779]
111658574  atrx; transcriptional regulator ATRX [KO:K10779]
111653357  ddx11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:3.6.4.13]
111660936  nipped-B-like protein A [KO:K06672]
111664801  nipped-B-like protein A [KO:K06672]
111653552  MAU2 chromatid cohesion factor homolog [KO:K11266]
111652602  MAU2 chromatid cohesion factor homolog [KO:K11266]
111667118  hdac8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
111672761  esco2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
111662673  pds5b; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
111664091  pds5a; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
111663764  wapl; wings apart-like protein homolog [KO:K25163]
111664363  wings apart-like protein homolog [KO:K25163]
111671885  cdca5; sororin [KO:K17390]
111648179  aurora kinase B-like [KO:K11479] [EC:2.7.11.1]
111659296  sgo1; shugoshin 1 isoform X1 [KO:K11580]
111670703  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
111659986  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
111651955  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
111652704  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
111670499  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
111649884  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
111655990  ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
111654333  ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
111661463  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
111672623  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
111666431  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
111646209  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
111658894  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
111660902  ndc80; kinetochore protein NDC80 homolog [KO:K11547]
111661535  knl1; kinetochore scaffold 1 isoform X1 [KO:K11542]
111658024  ttk; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
111672999  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
111668008  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
111656219  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
111652451  bub1b; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
111660191  bub3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
111645188  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
111652766  trip13; pachytene checkpoint protein 2 homolog isoform X1 [KO:K22399]
111669544  mad2l1bp; MAD2L1-binding protein [KO:K26093]
111652616  fizzy-related protein homolog [KO:K03364]
111670545  fizzy-related protein homolog [KO:K03364]
111650176  fizzy-related protein homolog isoform X1 [KO:K03364]
111645275  fbxo5; F-box only protein 5 [KO:K10292]
111668188  cdc14a; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
111645157  dual specificity protein phosphatase CDC14B-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
111648357  dual specificity protein phosphatase CDC14AB-like [KO:K06639] [EC:3.1.3.16 3.1.3.48]
111667502  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
111646106  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
111647585  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
111665543  LOW QUALITY PROTEIN: CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
111648260  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
111665869  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
111654570  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
111657669  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
111650698  cellular tumor antigen p53-like [KO:K04451]
111671627  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
111661237  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
111645124  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111662605  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
111673084  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
111669329  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111669331  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111661011  pcna; proliferating cell nuclear antigen [KO:K04802]
111666155  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
111649055  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
Reference
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Oncogene 25:5263-7 (2006)
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PMID:15838516
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Cobrinik D
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Pocket proteins and cell cycle control.
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Oncogene 24:2796-809 (2005)
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Reference
PMID:17568790
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  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
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Nat Rev Cancer 7:495-507 (2007)
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Reference
PMID:9832503
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  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
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Genes Dev 12:3499-511 (1998)
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Transcriptional regulation of the cyclin D1 gene at a glance.
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J Cell Sci 121:3853-7 (2008)
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CDK inhibitors: positive and negative regulators of G1-phase progression.
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Genes Dev 13:1501-12 (1999)
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Reference
PMID:12809600
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Shi Y, Massague J.
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Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
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Cell 113:685-700 (2003)
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PMID:12925736
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Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
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Proc Natl Acad Sci U S A 100:10231-6 (2003)
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Reference
PMID:16212951
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Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
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Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
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Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
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Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
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Nature 408:307-10 (2000)
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Reference
PMID:7973727
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Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Science 266:1376-80 (1994)
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Reference
PMID:9889196
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  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
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EMBO J 18:396-410 (1999)
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Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
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EMBO J 16:343-54 (1997)
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Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
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Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
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Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
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Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
slal03030  DNA replication
slal04010  MAPK signaling pathway
slal04120  Ubiquitin mediated proteolysis
slal04210  Apoptosis
KO pathway
ko04110   
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