KEGG   PATHWAY: slal04210
Entry
slal04210                   Pathway                                
Name
Apoptosis - Seriola lalandi dorsalis (Yellowtail amberjack)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
slal04210  Apoptosis
slal04210

Other DBs
GO: 0006915
Organism
Seriola lalandi dorsalis (Yellowtail amberjack) [GN:slal]
Gene
111651407  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
111665906  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
111648042  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
111666828  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
111666336  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
111671959  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
111670053  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
111644206  FAS-associated death domain protein-like [KO:K02373]
111669290  FAS-associated death domain protein-like [KO:K02373]
111645657  tumor necrosis factor-like [KO:K03156]
111655660  tumor necrosis factor-like isoform X1 [KO:K03156]
111669911  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
111666877  uncharacterized protein LOC111666877 [KO:K03158]
111646245  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
111671504  cflar; CASP8 and FADD-like apoptosis regulator [KO:K04724]
111666542  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
111648895  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
111671191  casp6; caspase-6 [KO:K04396] [EC:3.4.22.59]
111663309  caspase-3-like [KO:K02187] [EC:3.4.22.56]
111667597  caspase-3-like [KO:K02187] [EC:3.4.22.56]
111664455  caspase-3-like [KO:K04397] [EC:3.4.22.60]
111669656  casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
111660532  bax; apoptosis regulator BAX [KO:K02159]
111669314  apoptosis regulator BAX-like [KO:K02159]
111649156  diablo homolog, mitochondrial-like [KO:K10522]
111653623  diablo homolog, mitochondrial-like [KO:K10522]
111653625  diablo homolog, mitochondrial-like [KO:K10522]
111653415  septin-5-like isoform X1 [KO:K16943]
111647419  septin-5-like isoform X1 [KO:K16943]
111651107  htra2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
111673298  cytochrome c-a [KO:K08738]
111644601  cytochrome c [KO:K08738]
111648908  cytochrome c-like [KO:K08738]
111656499  apaf1; apoptotic protease-activating factor 1 [KO:K02084]
111651602  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
111655452  perforin-1-like [KO:K07818]
111655453  perforin-1-like [KO:K07818]
111655478  perforin-1-like [KO:K07818]
111660482  perforin-1-like [KO:K07818]
111672962  perforin-1-like [KO:K07818]
111672971  perforin-1-like [KO:K07818]
111672972  perforin-1-like [KO:K07818]
111645667  perforin-1-like [KO:K07818]
111660561  perforin-1-like [KO:K07818]
111657490  granzyme B(G,H)-like [KO:K01353] [EC:3.4.21.79]
111668761  granzyme B-like [KO:K01353] [EC:3.4.21.79]
111657487  granzyme B(G,H)-like [KO:K01353] [EC:3.4.21.79]
111657488  granzyme B-like [KO:K01353] [EC:3.4.21.79]
111657489  granzyme E-like [KO:K01353] [EC:3.4.21.79]
111661862  tubulin alpha-8 chain-like [KO:K07374]
111656030  tubulin alpha chain-like [KO:K07374]
111657708  tubulin alpha-1D chain-like [KO:K07374]
111644248  tubulin alpha-8 chain-like isoform X1 [KO:K07374]
111644250  tubulin alpha-1A chain-like [KO:K07374]
111669382  tubulin alpha-1B chain [KO:K07374]
111672406  tubulin alpha-1A chain-like [KO:K07374]
111672452  tubulin alpha-1A chain-like [KO:K07374]
111672454  tubulin alpha chain-like [KO:K07374]
111671505  tubulin alpha chain [KO:K07374]
111671506  tubulin alpha chain-like [KO:K07374]
111671507  tubulin alpha chain-like [KO:K07374]
111650100  tubulin alpha-8 chain [KO:K07374]
111669226  induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
111647584  actin, cytoplasmic 1 [KO:K05692]
111673001  actb; actin, cytoplasmic 1 [KO:K05692]
111648090  sptan1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
111645579  lamin-A-like isoform X1 [KO:K12641]
111655682  lmna; lamin [KO:K12641]
111656945  lmnb2; lamin-B2 [KO:K07611]
111648118  lmnb1; lamin-B1 [KO:K07611]
111669302  lamin-L(III)-like isoform X1 [KO:K07611]
111650588  parp1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
111652224  parp3; poly [ADP-ribose] polymerase 3 [KO:K10798] [EC:2.4.2.30]
111668386  parp2; poly [ADP-ribose] polymerase 2 isoform X1 [KO:K10798] [EC:2.4.2.30]
111673155  parp4; poly [ADP-ribose] polymerase 4 isoform X1 [KO:K10798] [EC:2.4.2.30]
111670619  dffa; DNA fragmentation factor subunit alpha [KO:K02310]
111651607  dffb; DNA fragmentation factor subunit beta [KO:K02311] [EC:3.-.-.-]
111646078  endog; endonuclease G, mitochondrial [KO:K01173]
111658297  apoptosis-inducing factor 1, mitochondrial-like isoform X1 [KO:K04727] [EC:1.-.-.-]
111667565  ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
111663282  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
111647918  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111666015  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111664872  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111653189  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
111667746  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
111655344  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
111673377  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
111668118  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
111647234  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
111647455  calpain-2 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
111669491  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
111651024  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
111649592  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111669521  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111669522  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111658604  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111646809  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
111661486  eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
111646360  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
111671828  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
111659798  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
111653030  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
111668865  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
111655299  ctsc; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
111656646  ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
111646321  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
111646489  cathepsin L-like [KO:K01373] [EC:3.4.22.41]
111659106  pro-cathepsin H-like [KO:K01366] [EC:3.4.22.16]
111666932  pro-cathepsin H-like [KO:K01366] [EC:3.4.22.16]
111668430  cathepsin K-like [KO:K01371] [EC:3.4.22.38]
111644723  cathepsin K-like [KO:K01371] [EC:3.4.22.38]
111668412  cathepsin K-like [KO:K01371] [EC:3.4.22.38]
111669222  cathepsin K-like [KO:K01371] [EC:3.4.22.38]
111669110  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
111660948  ctsl; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
111655907  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
111648248  ctso; cathepsin O [KO:K01374] [EC:3.4.22.42]
111659220  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
111669221  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
111658373  cathepsin Z-like [KO:K08568] [EC:3.4.18.1]
111667853  ctsz; cathepsin Z [KO:K08568] [EC:3.4.18.1]
111644680  cathepsin Z-like [KO:K08568] [EC:3.4.18.1]
111666176  inhibitor of apoptosis protein-like [KO:K16060]
111646416  xiap; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
111668900  baculoviral IAP repeat-containing protein 5.1-A-like [KO:K08731]
111672046  baculoviral IAP repeat-containing protein 5-like [KO:K08731]
111661983  bcl2l11; bcl-2-like protein 11 [KO:K16341]
111649248  bcl-2-like protein 1 [KO:K04570]
111661912  bcl2l1; bcl-2-like protein 1 [KO:K04570]
111649666  apoptosis regulator Bcl-2-like [KO:K02161]
111666676  apoptosis regulator Bcl-2-like [KO:K02161]
111670485  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
111645622  daxx; death domain-associated protein 6 [KO:K02308]
111670509  ripk1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
111646081  disabled homolog 2-interacting protein-like [KO:K19901]
111668037  dab2ip; disabled homolog 2-interacting protein isoform X1 [KO:K19901]
111661628  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
111661471  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
111656807  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111658196  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111664771  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
111646556  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
111666425  bad; bcl2-associated agonist of cell death [KO:K02158]
111666541  jun; transcription factor AP-1 [KO:K04448]
111671973  transcription factor AP-1-like isoform X1 [KO:K04448]
111648134  transcription factor AP-1-like [KO:K04448]
111653021  proto-oncogene c-Fos-like [KO:K04379]
111653033  proto-oncogene c-Fos-like [KO:K04379]
111663204  proto-oncogene c-Fos-like [KO:K04379]
111650698  cellular tumor antigen p53-like [KO:K04451]
111660531  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
111664391  uncharacterized protein LOC111664391 [KO:K04466] [EC:2.7.11.25]
111655428  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
111658207  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
111665990  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
111659926  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
111672507  NF-kappa-B inhibitor alpha-like [KO:K04734]
111673714  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
111665614  LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
111670446  rela; transcription factor p65 isoform X1 [KO:K04735]
111656787  ptpn13; tyrosine-protein phosphatase non-receptor type 13 isoform X1 [KO:K02374]
111671627  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
111661237  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
111645124  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111662605  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
111673084  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
111669329  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111669331  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111654570  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
111666979  p53-induced death domain-containing protein 1-like [KO:K10130]
111669846  casp2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
111669009  nerve growth factor-like [KO:K02582]
111662357  nerve growth factor-like [KO:K02582]
111648761  nerve growth factor-like [KO:K02582]
111655673  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
111646334  interleukin-3 receptor class 2 subunit beta-like [KO:K04738]
111661265  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111670636  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111671654  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
111673607  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
111668884  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111651451  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
111671089  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111670553  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111671597  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111649932  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111666834  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111658643  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
111665447  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111659458  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111673263  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111653974  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111645313  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111661823  hras; GTPase HRas [KO:K02833]
111649083  GTPase HRas-like [KO:K07827]
111655355  kras; GTPase KRas isoform X1 [KO:K07827]
111672203  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111667016  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
111652614  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
111656372  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111657703  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111660943  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26615431
  Authors
Savitskaya MA, Onishchenko GE
  Title
Mechanisms of Apoptosis.
  Journal
Biochemistry (Mosc) 80:1393-417 (2015)
DOI:10.1134/S0006297915110012
Reference
PMID:23803157
  Authors
Schleich K, Lavrik IN
  Title
Mathematical modeling of apoptosis.
  Journal
Cell Commun Signal 11:44 (2013)
DOI:10.1186/1478-811X-11-44
Reference
PMID:15654015
  Authors
Lavrik I, Golks A, Krammer PH
  Title
Death receptor signaling.
  Journal
J Cell Sci 118:265-7 (2005)
DOI:10.1242/jcs.01610
Reference
PMID:15725726
  Authors
Jin Z, El-Deiry WS
  Title
Overview of cell death signaling pathways.
  Journal
Cancer Biol Ther 4:139-63 (2005)
DOI:10.4161/cbt.4.2.1508
Reference
PMID:15322527
  Authors
Benn SC, Woolf CJ
  Title
Adult neuron survival strategies--slamming on the brakes.
  Journal
Nat Rev Neurosci 5:686-700 (2004)
DOI:10.1038/nrn1477
Reference
PMID:12838338
  Authors
Orrenius S, Zhivotovsky B, Nicotera P
  Title
Regulation of cell death: the calcium-apoptosis link.
  Journal
Nat Rev Mol Cell Biol 4:552-65 (2003)
DOI:10.1038/nrm1150
Reference
PMID:19148180
  Authors
Clarke P, Tyler KL
  Title
Apoptosis in animal models of virus-induced disease.
  Journal
Nat Rev Microbiol 7:144-55 (2009)
DOI:10.1038/nrmicro2071
Reference
PMID:22429822
  Authors
Wen X, Lin ZQ, Liu B, Wei YQ
  Title
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer.
  Journal
Cell Prolif 45:217-24 (2012)
DOI:10.1111/j.1365-2184.2012.00814.x
Reference
PMID:25526085
  Authors
Shalini S, Dorstyn L, Dawar S, Kumar S
  Title
Old, new and emerging functions of caspases.
  Journal
Cell Death Differ 22:526-39 (2015)
DOI:10.1038/cdd.2014.216
Reference
PMID:15601572
  Authors
Philchenkov A
  Title
Caspases: potential targets for regulating cell death.
  Journal
J Cell Mol Med 8:432-44 (2004)
DOI:10.1111/j.1582-4934.2004.tb00468.x
Reference
PMID:9894605
  Authors
Stroh C, Schulze-Osthoff K
  Title
Death by a thousand cuts: an ever increasing list of caspase substrates.
  Journal
Cell Death Differ 5:997-1000 (1998)
DOI:10.1038/sj.cdd.4400451
Reference
PMID:23070002
  Authors
Safa AR
  Title
c-FLIP, a master anti-apoptotic regulator.
  Journal
Exp Oncol 34:176-84 (2012)
Reference
PMID:18304445
  Authors
Jeong SY, Seol DW
  Title
The role of mitochondria in apoptosis.
  Journal
BMB Rep 41:11-22 (2008)
DOI:10.5483/bmbrep.2008.41.1.011
Reference
PMID:20533903
  Authors
Parsons MJ, Green DR
  Title
Mitochondria in cell death.
  Journal
Essays Biochem 47:99-114 (2010)
DOI:10.1042/bse0470099
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:24278747
  Authors
Schonthal AH
  Title
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.
  Journal
Scientifica (Cairo) 2012:857516 (2012)
DOI:10.6064/2012/857516
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:16397578
  Authors
Wu J, Kaufman RJ
  Title
From acute ER stress to physiological roles of the Unfolded Protein Response.
  Journal
Cell Death Differ 13:374-84 (2006)
DOI:10.1038/sj.cdd.4401840
Reference
PMID:21914490
  Authors
Repnik U, Stoka V, Turk V, Turk B
  Title
Lysosomes and lysosomal cathepsins in cell death.
  Journal
Biochim Biophys Acta 1824:22-33 (2012)
DOI:10.1016/j.bbapap.2011.08.016
Reference
PMID:22465226
  Authors
Cesen MH, Pegan K, Spes A, Turk B
  Title
Lysosomal pathways to cell death and their therapeutic applications.
  Journal
Exp Cell Res 318:1245-51 (2012)
DOI:10.1016/j.yexcr.2012.03.005
Reference
PMID:26231733
  Authors
Dashzeveg N, Yoshida K
  Title
Cell death decision by p53 via control of the mitochondrial membrane.
  Journal
Cancer Lett 367:108-12 (2015)
DOI:10.1016/j.canlet.2015.07.019
Reference
PMID:22075987
  Authors
Bouchier-Hayes L, Green DR
  Title
Caspase-2: the orphan caspase.
  Journal
Cell Death Differ 19:51-7 (2012)
DOI:10.1038/cdd.2011.157
Reference
PMID:18238895
  Authors
Baptiste-Okoh N, Barsotti AM, Prives C
  Title
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
  Journal
Proc Natl Acad Sci U S A 105:1937-42 (2008)
DOI:10.1073/pnas.0711800105
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:14737178
  Authors
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA.
  Title
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
  Journal
Leukemia 18:189-218 (2004)
DOI:10.1038/sj.leu.2403241
Reference
PMID:9916983
  Authors
Dragovich T, Rudin CM, Thompson CB
  Title
Signal transduction pathways that regulate cell survival and cell death.
  Journal
Oncogene 17:3207-13 (1998)
DOI:10.1038/sj.onc.1202587
Reference
PMID:11520933
  Authors
Sofroniew MV, Howe CL, Mobley WC
  Title
Nerve growth factor signaling, neuroprotection, and neural repair.
  Journal
Annu Rev Neurosci 24:1217-81 (2001)
DOI:10.1146/annurev.neuro.24.1.1217
Reference
PMID:24769728
  Authors
Kristiansen M, Ham J
  Title
Programmed cell death during neuronal development: the sympathetic neuron model.
  Journal
Cell Death Differ 21:1025-35 (2014)
DOI:10.1038/cdd.2014.47
Reference
PMID:18208375
  Authors
Logue SE, Martin SJ
  Title
Caspase activation cascades in apoptosis.
  Journal
Biochem Soc Trans 36:1-9 (2008)
DOI:10.1042/BST0360001
Reference
PMID:19770840
  Authors
Boivin WA, Cooper DM, Hiebert PR, Granville DJ
  Title
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.
  Journal
Lab Invest 89:1195-220 (2009)
DOI:10.1038/labinvest.2009.91
Reference
PMID:20075940
  Authors
Cullen SP, Brunet M, Martin SJ
  Title
Granzymes in cancer and immunity.
  Journal
Cell Death Differ 17:616-23 (2010)
DOI:10.1038/cdd.2009.206
Related
pathway
slal04010  MAPK signaling pathway
slal04020  Calcium signaling pathway
slal04115  p53 signaling pathway
slal04141  Protein processing in endoplasmic reticulum
KO pathway
ko04210   
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