KEGG   PATHWAY: slal04218
Entry
slal04218                   Pathway                                
Name
Cellular senescence - Seriola lalandi dorsalis (Yellowtail amberjack)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
slal04218  Cellular senescence
slal04218

Other DBs
GO: 0090398
Organism
Seriola lalandi dorsalis (Yellowtail amberjack) [GN:slal]
Gene
111662255  transforming growth factor beta-1-like [KO:K13375]
111655785  transforming growth factor beta-2-like [KO:K13376]
111664155  tgfb2; transforming growth factor beta-2 [KO:K13376]
111653047  transforming growth factor beta-3-like [KO:K13377]
111663127  tgfb3; transforming growth factor beta-3 [KO:K13377]
111673055  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
111664183  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
111644571  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
111657623  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
111648020  mothers against decapentaplegic homolog 2 [KO:K04500]
111655756  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
111666993  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
111661150  mothers against decapentaplegic homolog 3 [KO:K23605]
111670409  cyclin-dependent kinase 4 inhibitor D-like [KO:K04685]
111667889  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
111658435  cyclin-dependent kinase 6-like isoform X1 [KO:K02091] [EC:2.7.11.22]
111656924  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
111647809  G1/S-specific cyclin-D1-like [KO:K04503]
111670038  G1/S-specific cyclin-D1-like [KO:K04503]
111669291  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
111660519  G1/S-specific cyclin-D2-like [KO:K10151]
111660040  G1/S-specific cyclin-D2-like [KO:K10151]
111666072  G1/S-specific cyclin-D2-like [KO:K10151]
111660864  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
111653978  rb1; retinoblastoma-associated protein [KO:K06618]
111644267  rbl1; retinoblastoma-like protein 1 [KO:K04681]
111647411  retinoblastoma-like protein 2 [KO:K16332]
111672285  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
111655259  e2f1; transcription factor E2F1 [KO:K17454]
111655894  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
111657207  e2f3; transcription factor E2F3 [KO:K06620]
111671419  transcription factor E2F3-like [KO:K06620]
111646255  transcription factor E2F4-like [KO:K04682]
111669142  transcription factor E2F5-like [KO:K04682]
111666103  e2f4; transcription factor E2F4 [KO:K04682]
111661265  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111670636  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111671654  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
111673607  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
111668884  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111651451  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
111671089  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111670553  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111671597  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111649932  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111666834  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111654758  LOW QUALITY PROTEIN: forkhead box protein O1-A-like [KO:K07201]
111666300  forkhead box protein O1-A-like [KO:K07201]
111658316  foxo3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
111665879  forkhead box protein O3-like [KO:K09408]
111660073  forkhead box protein O6-like [KO:K09408]
111660719  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
111651995  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
111667739  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
111649541  G1/S-specific cyclin-E2-like [KO:K06626]
111672273  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
111644688  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
111663050  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
111666253  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
111647354  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111661204  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111645640  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
111645642  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
111645643  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
111645644  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111644701  hereditary hemochromatosis protein homolog [KO:K06751]
111664121  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111664195  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111661187  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
111661201  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
111649083  GTPase HRas-like [KO:K07827]
111655355  kras; GTPase KRas isoform X1 [KO:K07827]
111655614  rras; ras-related protein R-Ras [KO:K07830]
111654503  rras2; ras-related protein R-Ras2 [KO:K07830]
111659477  ras-related protein R-Ras2-like [KO:K07830]
111667451  mras; ras-related protein M-Ras [KO:K07831]
111661823  hras; GTPase HRas [KO:K02833]
111665447  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111659458  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111673263  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111653974  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111645313  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111650122  tsc1; hamartin [KO:K07206]
111646396  hamartin-like isoform X1 [KO:K07206]
111666666  tsc2; tuberin isoform X1 [KO:K07207]
111659043  tuberin-like [KO:K07207]
111655861  rheb; GTP-binding protein Rheb [KO:K07208]
111667847  GTP-binding protein Rheb-like [KO:K07208]
111656119  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
111670050  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111655103  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111669537  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
111662685  ccna1; cyclin-A1 [KO:K06627]
111644649  ccna2; cyclin-A2 [KO:K06627]
111650294  cyclin-A2-like [KO:K06627]
111668570  mybl2; myb-related protein B [KO:K21769]
111650555  lin9; protein lin-9 homolog [KO:K21773]
111665012  lin37; protein lin-37 homolog isoform X1 [KO:K21774]
111663135  lin52; protein lin-52 homolog [KO:K21775]
111666847  lin54; protein lin-54 homolog [KO:K21776]
111669284  histone-binding protein RBBP7 isoform X1 [KO:K10752]
111652462  histone-binding protein RBBP4 isoform X1 [KO:K10752]
111673315  histone-binding protein RBBP4-like [KO:K10752]
111660052  foxm1; forkhead box protein M1 [KO:K09406]
111649068  transcriptional regulator Myc-like isoform X1 [KO:K04377]
111662034  transcriptional regulator Myc-2-like [KO:K04377]
111656568  myc; myc proto-oncogene protein [KO:K04377]
111657669  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
111650698  cellular tumor antigen p53-like [KO:K04451]
111667859  rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
111646646  fbxw11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
111645924  hipk3; homeodomain-interacting protein kinase 3 [KO:K08826] [EC:2.7.11.1]
111669370  homeodomain-interacting protein kinase 1-like isoform X1 [KO:K08826] [EC:2.7.11.1]
111655578  homeodomain-interacting protein kinase 3-like isoform X1 [KO:K08826] [EC:2.7.11.1]
111667790  homeodomain-interacting protein kinase 1-like isoform X1 [KO:K08826] [EC:2.7.11.1]
111661810  hipk2; homeodomain-interacting protein kinase 2 [KO:K08826] [EC:2.7.11.1]
111652244  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
111665361  serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like [KO:K06269] [EC:3.1.3.16]
111670459  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
111647878  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
111661496  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111660545  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
111651017  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111672203  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111667016  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
111652614  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
111656372  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111657703  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111660943  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111657880  protein c-ets-1-B isoform X1 [KO:K02678]
111655649  protein c-ets-1-B-like isoform X1 [KO:K02678]
111667949  protein c-ets-1-B-like [KO:K02678]
111657787  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
111664323  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111650024  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
111670673  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
111667674  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111667284  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111653210  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
111661800  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111667336  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
111671627  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
111661237  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
111645124  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111662605  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
111673084  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
111669329  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111669331  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111669394  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
111650108  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
111656616  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
111665458  cntd2; cyclin N-terminal domain-containing protein 2 [KO:K21770]
111667104  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
111655962  mre11; double-strand break repair protein MRE11 [KO:K10865]
111672118  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
111650915  nbn; nibrin [KO:K10867]
111654570  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
111649055  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
111662800  rad9a; cell cycle checkpoint control protein RAD9A isoform X1 [KO:K10994] [EC:3.1.11.2]
111647976  rad9b; cell cycle checkpoint control protein RAD9B [KO:K10995]
111664825  rad1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
111653882  hus1; checkpoint protein HUS1 [KO:K10903]
111665869  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
111666155  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
111665615  sequestosome-1-like isoform X1 [KO:K14381]
111653029  gata4; transcription factor GATA-4 [KO:K09183]
111671716  adapter protein CIKS-like [KO:K21124]
111672905  traf3ip2; adapter protein CIKS [KO:K21124]
111651010  adapter protein CIKS-like isoform X1 [KO:K21124]
111665614  LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
111670446  rela; transcription factor p65 isoform X1 [KO:K04735]
111659317  interleukin-6-like [KO:K05405]
111664504  interleukin-8-like isoform X1 [KO:K10030]
111664505  interleukin-8-like [KO:K10030]
111647131  permeability factor 2-like [KO:K10030]
111671736  insulin-like growth factor-binding protein 3 [KO:K10138]
111670503  insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138]
111654376  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
111652867  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
111658248  eukaryotic translation initiation factor 4E-binding protein 1-like isoform X1 [KO:K07205]
111667810  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
111667188  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04443] [EC:2.7.11.1]
111673128  zfp36l1; mRNA decay activator protein ZFP36L1 [KO:K18753]
111667904  mRNA decay activator protein ZFP36L1-like [KO:K18753]
111661101  mRNA decay activator protein ZFP36L1-like [KO:K18753]
111669470  zfp36l2; mRNA decay activator protein ZFP36L2 isoform X1 [KO:K18753]
111647540  mRNA decay activator protein ZFP36L1-like [KO:K18753]
111670707  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
111660720  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
111660386  trpv4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
111659123  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
111668118  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
111647234  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
111647455  calpain-2 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
111669491  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
111651024  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
111649592  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111669521  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111669522  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111658604  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111655985  calmodulin [KO:K02183]
111653819  calml6; calmodulin-like protein 6 [KO:K02183]
111673711  calmodulin [KO:K02183]
111670884  calmodulin-like protein 4 [KO:K02183]
111670124  calml4; calmodulin-like protein 4 [KO:K02183]
111669508  calm2; calmodulin-2 [KO:K02183]
111672568  calmodulin isoform X1 [KO:K02183]
111666135  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111646476  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111649908  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111647988  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111671162  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like [KO:K04348] [EC:3.1.3.16]
111652641  calcineurin subunit B type 1-like [KO:K06268]
111661987  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
111652920  calcineurin subunit B type 1-like [KO:K06268]
111658107  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111645629  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
111660684  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
111644232  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
111659127  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111654253  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
111668383  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
111653189  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
111667746  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
111655344  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
111673377  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
111664080  slc25a4; ADP/ATP translocase 1 [KO:K05863]
111666210  ADP/ATP translocase 2 [KO:K05863]
111666356  ADP/ATP translocase 3 [KO:K05863]
111668969  ADP/ATP translocase 1-like [KO:K05863]
111648165  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
111659977  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
111670041  voltage-dependent anion-selective channel protein 2 [KO:K15040]
111657081  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
111665991  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
111666020  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
111658957  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
slal04020  Calcium signaling pathway
slal04068  FoxO signaling pathway
slal04110  Cell cycle
slal04115  p53 signaling pathway
slal04150  mTOR signaling pathway
KO pathway
ko04218   
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