KEGG   PATHWAY: slal04920
slal04920                   Pathway                                

Adipocytokine signaling pathway - Seriola lalandi dorsalis (Yellowtail amberjack)
Increased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin.
Leptin is an important regulator of energy intake and metabolic rate primarily by acting at hypothalamic nuclei. Leptin exerts its anorectic effects by modulating the levels of neuropeptides such as NPY, AGRP, and alpha-MSH. This leptin action is through the JAK kinase, STAT3 phosphorylation, and nuclear transcriptional effect.
Adiponectin lowers plasma glucose and FFAs. These effects are partly accounted for by adiponectin-induced AMPK activation, which in turn stimulates skeletal muscle fatty acid oxidation and glucose uptake. Furthermore, activation of AMPK by adiponectin suppresses endogenous glucose production, concomitantly with inhibition of PEPCK and G6Pase expression.
The proinflammatory cytokine TNFalpha has been implicated as a link between obesity and insulin resistance. TNFalpha interferes with early steps of insulin signaling. Several data have shown that TNFalpha inhibits IRS1 tyrosine phosphorylation by promoting its serine phosphorylation. Among the serine/threonine kinases activated by TNFalpha, JNK, mTOR and IKK have been shown to be involved in this phosphorylation.
Organismal Systems; Endocrine system
Pathway map
slal04920  Adipocytokine signaling pathway

Seriola lalandi dorsalis (Yellowtail amberjack) [GN:slal]
111645657  tumor necrosis factor-like [KO:K03156]
111655660  tumor necrosis factor-like isoform X1 [KO:K03156]
111669911  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
111666877  uncharacterized protein LOC111666877 [KO:K03158]
111646245  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
111657911  tumor necrosis factor receptor superfamily member 1B-like [KO:K05141]
111647918  TNF receptor-associated factor 2-like [KO:K03173] [EC:]
111666015  TNF receptor-associated factor 2-like [KO:K03173] [EC:]
111664872  TNF receptor-associated factor 2-like [KO:K03173] [EC:]
111656119  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:]
111656807  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:]
111658196  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:]
111664771  mitogen-activated protein kinase 8 [KO:K04440] [EC:]
111646556  mitogen-activated protein kinase 9-like [KO:K04440] [EC:]
111655428  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:]
111658207  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:]
111665990  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:]
111659926  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
111672507  NF-kappa-B inhibitor alpha-like [KO:K04734]
111673714  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
111661549  nfkbie; NF-kappa-B inhibitor epsilon [KO:K05872]
111665614  LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
111670446  rela; transcription factor p65 isoform X1 [KO:K04735]
111657717  socs3; suppressor of cytokine signaling 3 [KO:K04696]
111673508  suppressor of cytokine signaling 3-like [KO:K04696]
111665735  insulin receptor substrate 1-B-like [KO:K16172]
111646010  insulin receptor substrate 2-like [KO:K07187]
111665377  insulin receptor substrate 1-like [KO:K07187]
111667114  insulin receptor substrate 2-B-like [KO:K07187]
111662143  irs2; insulin receptor substrate 2 [KO:K07187]
111665447  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:]
111659458  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:]
111673263  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
111653974  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:]
111645313  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:]
111660053  cd36; platelet glycoprotein 4 [KO:K06259]
111657379  acsl6; long-chain-fatty-acid--CoA ligase 6 [KO:K01897] [EC:]
111646477  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:]
111662439  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:]
111654481  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:]
111667608  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:]
111663892  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:]
111651836  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:]
111656174  acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:]
111653979  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:]
111664013  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:]
111671267  acsl3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:]
111654910  long-chain-fatty-acid--CoA ligase ACSBG2-like [KO:K15013] [EC:]
111664226  long-chain-fatty-acid--CoA ligase ACSBG1-like [KO:K15013] [EC:]
111645377  acsbg2; long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1 [KO:K15013] [EC:]
111666975  acsbg1; long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1 [KO:K15013] [EC:]
111661316  prkcq; protein kinase C theta type [KO:K18052] [EC:]
111656484  leptin-B-like [KO:K05424]
111645375  lepr; leptin receptor isoform X1 [KO:K05062]
111665981  jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:]
111651535  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:]
111660433  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
111665689  pro-opiomelanocortin-like [KO:K05228]
111650570  pro-opiomelanocortin-like [KO:K05228]
111657888  pro-opiomelanocortin [KO:K05228]
111646907  pro-opiomelanocortin-like [KO:K05228]
111649950  5'-AMP-activated protein kinase catalytic subunit alpha-2-like isoform X1 [KO:K07198] [EC:]
111650214  serine/threonine protein kinase OSK1-like [KO:K07198] [EC:]
111668062  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:]
111655957  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
111654804  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
111645026  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
111673153  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
111647310  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
111648137  5'-AMP-activated protein kinase subunit gamma-2-like [KO:K07200]
111667735  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
111670476  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
111644420  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
111649676  uncharacterized protein LOC111649676 isoform X1 [KO:K05231]
111652978  uncharacterized protein LOC111652978 isoform X1 [KO:K05231]
111667241  uncharacterized protein LOC111667241 isoform X1 [KO:K05231]
111661274  agouti-related protein-like [KO:K05231]
111666577  uncharacterized protein LOC111666577 isoform X1 [KO:K05231]
111670101  npy; pro-neuropeptide Y [KO:K05232]
111665947  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
111648212  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:]
111652122  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:]
111654531  g6pc2; glucose-6-phosphatase 2 [KO:K01084] [EC:]
111656130  glucose-6-phosphatase-like [KO:K01084] [EC:]
111656159  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:]
111656166  g6pc; glucose-6-phosphatase [KO:K01084] [EC:]
111666017  ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:]
111656118  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:]
111650434  peroxisome proliferator-activated receptor alpha-like [KO:K07294]
111651966  ppara; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
111655951  rxra; retinoic acid receptor RXR-alpha [KO:K08524]
111661213  retinoic acid receptor RXR-beta-A isoform X1 [KO:K08525]
111656331  retinoic acid receptor RXR-gamma-B isoform X1 [KO:K08526]
111663680  adiponectin receptor protein 2-like [KO:K07297]
111667831  adipor1; adiponectin receptor protein 1 [KO:K07297]
111652612  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:]
111652996  calcium/calmodulin-dependent protein kinase kinase 2-like isoform X1 [KO:K07359] [EC:]
111660366  acacb; acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:]
111658709  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:]
111671246  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:]
111662452  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:]
111661771  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:]
111657929  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
111658845  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
111646791  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
111650692  slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
C00040  Acyl-CoA
C00083  Malonyl-CoA
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00638  Long-chain fatty acid
C15493  9-cis-Retinoic acid
Gual P, Le Marchand-Brustel Y, Tanti JF.
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
Biochimie 87:99-109 (2005)
Hardie DG, Scott JW, Pan DA, Hudson ER.
Management of cellular energy by the AMP-activated protein kinase system.
FEBS Lett 546:113-20 (2003)
Hurley RL, Anderson KA, Franzone JM, Kemp BE, Means AR, Witters LA.
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.
J Biol Chem 280:29060-6 (2005)
Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG.
Central nervous system control of food intake.
Nature 404:661-71 (2000)
Munzberg H, Myers MG Jr.
Molecular and anatomical determinants of central leptin resistance.
Nat Neurosci 8:566-70 (2005)
Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM.
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.
Nature 423:550-5 (2003)
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM.
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
Nature 413:131-8 (2001)
Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto M, Furukawa K, Hashimoto N, Kido Y, Mori T, Sakaue H, Teshigawara K, Jin S, Iguchi H, Hiramatsu R, LeRoith D, Takeda K, Akira S, Kasuga M.
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.
Nat Med 10:168-74 (2004)
Zhou YT, Shimabukuro M, Wang MY, Lee Y, Higa M, Milburn JL, Newgard CB, Unger RH.
Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells.
Proc Natl Acad Sci U S A 95:8898-903 (1998)
Kelley DE, Mandarino LJ.
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
Diabetes 49:677-83 (2000)
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T.
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase.
Nat Med 8:1288-95 (2002)
Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T.
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
Nat Med 7:941-6 (2001)
Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferre P, Birnbaum MJ, Stuck BJ, Kahn BB.
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.
Nature 428:569-74 (2004)
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr.
Obesity is associated with macrophage accumulation in adipose tissue.
J Clin Invest 112:1796-808 (2003)
slal04010  MAPK signaling pathway
slal04910  Insulin signaling pathway
KO pathway

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