KEGG   PATHWAY: spen03410
Entry
spen03410                   Pathway                                

Name
Base excision repair - Solanum pennellii
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
Pathway map
spen03410  Base excision repair
spen03410

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Solanum pennellii [GN:spen]
Gene
107012220  formamidopyrimidine-DNA glycosylase isoform X1 [KO:K10563] [EC:3.2.2.23 4.2.99.18]
107004889  N-glycosylase/DNA lyase OGG1 [KO:K03660] [EC:3.2.2.- 4.2.99.18]
107029184  endonuclease III homolog 1, chloroplastic-like isoform X1 [KO:K10773] [EC:4.2.99.18]
107021495  endonuclease III homolog 1, chloroplastic-like [KO:K10773] [EC:4.2.99.18]
107012202  uncharacterized protein LOC107012202 isoform X1 [KO:K10773] [EC:4.2.99.18]
107011951  probable DNA-3-methyladenine glycosylase 2 [KO:K01247] [EC:3.2.2.21]
107015801  DNA-3-methyladenine glycosylase 1 isoform X1 [KO:K01247] [EC:3.2.2.21]
107005300  uncharacterized protein LOC107005300 isoform X1 [KO:K01246] [EC:3.2.2.20]
107002537  uncharacterized protein LOC107002537 [KO:K01246] [EC:3.2.2.20]
107011440  uncharacterized protein LOC107011440 [KO:K01246] [EC:3.2.2.20]
107015923  uncharacterized protein LOC107015923 [KO:K01246] [EC:3.2.2.20]
107017304  uncharacterized protein LOC107017304 [KO:K01246] [EC:3.2.2.20]
107015505  uncharacterized protein LOC107015505 [KO:K01246] [EC:3.2.2.20]
107008743  uracil-DNA glycosylase, mitochondrial [KO:K03648] [EC:3.2.2.27]
107029692  adenine DNA glycosylase isoform X2 [KO:K03575] [EC:3.2.2.31]
107032385  DNA-3-methyladenine glycosylase isoform X1 [KO:K03652] [EC:3.2.2.21]
107008783  methyl-CpG-binding domain protein 4-like protein isoform X1 [KO:K10801] [EC:3.2.2.-]
107015682  DNA-(apurinic or apyrimidinic site) lyase, chloroplastic [KO:K01142] [EC:3.1.11.2]
107012604  DNA-(apurinic or apyrimidinic site) lyase 2 [KO:K10772] [EC:4.2.99.18]
107025748  DNA polymerase I B, chloroplastic/mitochondrial [KO:K02335] [EC:2.7.7.7]
107020345  DNA polymerase lambda isoform X1 [KO:K03512] [EC:2.7.7.7 4.2.99.-]
107029349  high mobility group B protein 1 [KO:K10802]
107021301  DNA-repair protein XRCC1 [KO:K10803]
107023890  proliferating cell nuclear antigen [KO:K04802]
107002797  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
107015118  DNA polymerase delta small subunit [KO:K02328]
107032134  nucleolar protein dao-5 [KO:K03504]
107019852  DNA polymerase delta subunit 4-like [KO:K03505]
107029494  uncharacterized protein LOC107029494 [KO:K03505]
107004841  DNA polymerase epsilon catalytic subunit A-like isoform X1 [KO:K02324] [EC:2.7.7.7]
107012565  DNA polymerase epsilon subunit B isoform X1 [KO:K02325] [EC:2.7.7.7]
107003250  DNA polymerase epsilon subunit 3 [KO:K02326] [EC:2.7.7.7]
107005036  DNA ligase 1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
107011627  DNA ligase 6 isoform X2 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
107015088  poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
107027814  LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 2-like [KO:K10798] [EC:2.4.2.30]
107004468  poly [ADP-ribose] polymerase 3 [KO:K10798] [EC:2.4.2.30]
107027002  poly [ADP-ribose] polymerase 2-like [KO:K10798] [EC:2.4.2.30]
107016634  poly [ADP-ribose] polymerase 3-like [KO:K10798] [EC:2.4.2.30]
107001612  flap endonuclease 1 isoform X1 [KO:K04799] [EC:3.-.-.-]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   
LinkDB

DBGET integrated database retrieval system