Entry
Name
Pathways in cancer - Sus scrofa (pig)
Class
Human Diseases; Cancer: overview
BRITE hierarchy
Pathway map
Ortholog table
Organism
Sus scrofa (pig) [GN:
ssc ]
Gene
100523899 TCF7L1; LOW QUALITY PROTEIN: transcription factor 7-like 1 [KO:K04490 ]
397266 BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731 ]
100515777 LRP6; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6 [KO:K03068 ]
100524299 LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068 ]
100525170 DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353 ]
100621038 DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
100625452 DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
100525156 GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346 ]
100522824 GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639 ]
100523324 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X5 [KO:K07532 ]
100157291 ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331 ]
100518073 ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X11 [KO:K12330 ]
100516377 PLEKHG5; pleckstrin homology domain-containing family G member 5 isoform X1 [KO:K19464 ]
494460 CXCL12; stromal cell-derived factor 1 precursor [KO:K10031 ]
100144421 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
100144419 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
397523 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
100515879 PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258 ]
396811 PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260 ]
397652 PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345 ] [EC:2.7.11.11 ]
110261346 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
100516546 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
100154522 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
100524280 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
100157949 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
102165618 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
100620948 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1 [KO:K04540 ]
102167388 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
102166994 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
100621275 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
100622520 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544 ]
100515992 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 isoform X1 [KO:K04545 ]
100522202 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
100270820 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
100511870 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
100519790 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548 ]
110255211 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X2 [KO:K04549 ]
100515336 COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237 ]
100620724 COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237 ]
100621403 COL4A4; LOW QUALITY PROTEIN: collagen alpha-4(IV) chain [KO:K06237 ]
100621504 COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237 ]
396707 LAMB1; LOW QUALITY PROTEIN: laminin subunit beta-1 [KO:K05636 ]
100518131 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100621789 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100622559 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100511937 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
100739510 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100623707 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
751869 NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580 ]
100153829 NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469 ]
100622859 baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060 ]
100622590 BIRC3; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 3 [KO:K16060 ]
110257375 BIRC7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061 ]
396616 TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849 ]
100521065 BAD; LOW QUALITY PROTEIN: bcl2-associated agonist of cell death [KO:K02158 ]
397584 CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624 ]
100152215 CDKN1A; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
397550 STAT5A; signal transducer and activator of transcription 5A [KO:K11223 ]
397340 STAT5B; signal transducer and activator of transcription 5B [KO:K11224 ]
654405 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
733588 GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635 ]
100152679 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
100157641 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
100516581 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
100525148 PLCB3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
397076 IL12B; interleukin-12 subunit beta precursor [KO:K05425 ]
100153724 IFN-ALPHA-8; uncharacterized protein LOC100153724 precursor [KO:K05414 ]
100157766 IFN-ALPHA-9; uncharacterized protein LOC100157766 precursor [KO:K05414 ]
100152100 IFN-ALPHA-13; uncharacterized protein LOC100152100 precursor [KO:K05414 ]
100152504 IFN-ALPHA-15; uncharacterized protein LOC100152504 precursor [KO:K05414 ]
100157735 IFN-ALPHA-16; uncharacterized protein LOC100157735 precursor [KO:K05414 ]
100154938 IFN-ALPHA-17; uncharacterized protein LOC100154938 precursor [KO:K05414 ]
396814 IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
100621776 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
397156 IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070 ]
397614 IL4R; interleukin-4 receptor subunit alpha precursor [KO:K05071 ]
100137085 IL5RA; interleukin-5 receptor subunit alpha isoform X2 [KO:K05067 ]
399522 IL6R; interleukin-6 receptor subunit alpha precursor [KO:K05055 ]
100271900 IL12RB1; interleukin-12 receptor subunit beta-1 precursor [KO:K05063 ]
397178 IL12RB2; interleukin-12 receptor subunit beta-2 precursor [KO:K05064 ]
397615 IL13RA1; interleukin-13 receptor subunit alpha-1 precursor [KO:K05076 ]
733692 IL15RA; interleukin-15 receptor subunit alpha isoform X2 [KO:K05074 ]
396658 IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130 ]
100515021 EML4; echinoderm microtubule-associated protein-like 4 isoform X3 [KO:K15420 ]
733648 STAT3; signal transducer and activator of transcription 3 [KO:K04692 ]
396655 STAT1; signal transducer and activator of transcription 1 [KO:K11220 ]
396923 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
397261 STAT4; signal transducer and activator of transcription 4 [KO:K11222 ]
100153518 STAT6; signal transducer and activator of transcription 6 isoform 1 [KO:K11225 ]
397157 VEGFA; vascular endothelial growth factor A precursor [KO:K05448 ]
100521837 VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858 ]
397484 TGFA; protransforming growth factor alpha precursor [KO:K08774 ]
397083 EGF; pro-epidermal growth factor precursor [KO:K04357 ]
100519764 PDGFA; platelet-derived growth factor subunit A isoform X5 [KO:K04359 ]
397491 IGF1; insulin-like growth factor I precursor [KO:K05459 ]
396916 IGF2; insulin-like growth factor II preproprotein [KO:K13769 ]
100156242 FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358 ]
100516830 RASSF1; ras association domain-containing protein 1 isoform X2 [KO:K09850 ]
100521638 RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015 ]
100152497 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
100518663 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
100623661 CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183 ]
397674 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515 ] [EC:2.7.11.17 ]
397394 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515 ] [EC:2.7.11.17 ]
100626014 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X7 [KO:K04515 ] [EC:2.7.11.17 ]
100516166 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
100513970 RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732 ]
780428 CDC42; cell division control protein 42 homolog [KO:K04393 ]
100621675 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
110255928 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
397671 PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530 ]
397306 RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524 ]
396710 RARB; LOW QUALITY PROTEIN: retinoic acid receptor beta [KO:K08528 ]
397297 PPARD; peroxisome proliferator-activated receptor delta [KO:K04504 ]
100625290 ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055 ]
396709 RARA; retinoic acid receptor alpha isoform X2 [KO:K08527 ]
397307 CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055 ]
100620339 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066 ]
100622336 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
100620358 ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500 ]
397227 CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685 ]
100520183 LOW QUALITY PROTEIN: S-phase kinase-associated protein 1 [KO:K03094 ]
100152997 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
733669 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
100621090 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
397543 BAK1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021 ]
414902 MITF; microphthalmia-associated transcription factor [KO:K09455 ]
397078 TGFB1; transforming growth factor beta-1 precursor [KO:K13375 ]
397084 TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376 ]
397400 TGFB3; transforming growth factor beta-3 precursor [KO:K13377 ]
397260 SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605 ]
397142 SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501 ]
100512158 MSH3; LOW QUALITY PROTEIN: DNA mismatch repair protein Msh3 [KO:K08736 ]
100624979 BRCA2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein [KO:K08775 ]
396726 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
396826 FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
595129 FADD; FAS-associated death domain protein [KO:K02373 ]
594852 BID; BH3-interacting domain death agonist [KO:K04726 ]
397278 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131 ]
100513283 APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084 ]
100516343 NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X4 [KO:K05638 ]
396653 ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097 ]
100157219 ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X3 [KO:K15589 ]
102164419 SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299 ]
100153369 NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994 ]
100144522 NOTCH4; neurogenic locus notch homolog protein 4 precursor [KO:K20996 ]
100152404 HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091 ]
100157952 HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2 [KO:K09091 ]
100518256 HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091 ]
100155412 SUFU; LOW QUALITY PROTEIN: suppressor of fused homolog [KO:K06229 ]
397028 HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079 ]
Compound
C00681 1-Acyl-sn-glycerol 3-phosphate
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C16038 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
Reference
Authors
Weinberg RA.
Title
The biology of cancer
Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
Authors
Hanahan D, Weinberg RA
Title
The hallmarks of cancer.
Journal
Reference
Authors
Grady WM.
Title
Genomic instability and colon cancer.
Journal
Reference
Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
Title
Microsatellite instability in colorectal cancer.
Journal
Reference
Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
Title
Hereditary non-polyposis colorectal cancer: an updated review.
Journal
Reference
Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
Title
Colorectal cancer: genetics of development and metastasis.
Journal
Reference
Authors
Lynch HT, de la Chapelle A.
Title
Hereditary colorectal cancer.
Journal
Reference
Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
Title
The significance of unstable chromosomes in colorectal cancer.
Journal
Reference
Authors
Behrens J.
Title
Cadherins and catenins: role in signal transduction and tumor progression.
Journal
Reference
Authors
Behrens J.
Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
Journal
Reference
Authors
Behrens J, Lustig B.
Title
The Wnt connection to tumorigenesis.
Journal
Reference
Authors
Polakis P.
Title
The adenomatous polyposis coli (APC) tumor suppressor.
Journal
Reference
Authors
Janssen KP.
Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
Journal
Reference
Authors
Adjei AA.
Title
Blocking oncogenic Ras signaling for cancer therapy.
Journal
Reference
Authors
Arakawa H.
Title
Netrin-1 and its receptors in tumorigenesis.
Journal
Reference
Authors
Mehlen P, Fearon ER.
Title
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
Journal
Reference
Authors
Peltomaki P.
Title
DNA mismatch repair and cancer.
Journal
Reference
Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
Title
TGF-beta signaling in colon cancer cells.
Journal
Reference
Authors
Roman C, Saha D, Beauchamp R.
Title
TGF-beta and colorectal carcinogenesis.
Journal
Reference
Authors
Watson AJ.
Title
An overview of apoptosis and the prevention of colorectal cancer.
Journal
Reference
Authors
Watson AJ.
Title
Apoptosis and colorectal cancer.
Journal
Reference
Authors
Houlston RS.
Title
What we could do now: molecular pathology of colorectal cancer.
Journal
Reference
Authors
Von Hoff D, Evans D, Hruban R (ed).
Title
Pancreatic cancer
Journal
Jones and Bartlett publishers (2005)
Reference
Authors
Niitsu Y, Yokota J (ed).
Title
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese)
Journal
Nankodo (1999)
Reference
Authors
Bardeesy N, DePinho RA.
Title
Pancreatic cancer biology and genetics.
Journal
Reference
Authors
Bardeesy N, Sharpless NE, DePinho RA, Merlino G.
Title
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
Journal
Reference
Authors
Cowgill SM, Muscarella P.
Title
The genetics of pancreatic cancer.
Journal
Reference
Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
Title
Genetics and biology of pancreatic ductal adenocarcinoma.
Journal
Reference
Authors
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ.
Title
Understanding Ras: 'it ain't over 'til it's over'.
Journal
Reference
Authors
Holbro T, Civenni G, Hynes NE.
Title
The ErbB receptors and their role in cancer progression.
Journal
Reference
Authors
Marmor MD, Skaria KB, Yarden Y.
Title
Signal transduction and oncogenesis by ErbB/HER receptors.
Journal
Reference
Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
Journal
Reference
Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
Journal
Reference
Authors
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M.
Title
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
Journal
Reference
Authors
Schmid RM.
Title
Genetic basis of pancreatic cancer.
Journal
Reference
Authors
Elliott RL, Blobe GC.
Title
Role of transforming growth factor Beta in human cancer.
Journal
Reference
Authors
Rudkin TM, Foulkes WD.
Title
BRCA2: breaks, mistakes and failed separations.
Journal
Reference
Authors
Venkitaraman AR.
Title
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
Journal
J Cell Sci 114:3591-8 (2001)
Reference
Authors
Soni D, King JA, Kaye AH, Hovens CM.
Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
Journal
Reference
Authors
Zhu Y, Parada LF.
Title
The molecular and genetic basis of neurological tumours.
Journal
Reference
Authors
Holland EC.
Title
Gliomagenesis: genetic alterations and mouse models.
Journal
Reference
Authors
Bansal K, Liang ML, Rutka JT.
Title
Molecular biology of human gliomas.
Journal
Reference
Authors
Tabuchi K (ed).
Title
[Gliomas: Research and therapy] (In Japanese)
Journal
Springer-Verlag Tokyo (2006)
Reference
Authors
Kapoor GS, O'Rourke DM.
Title
Mitogenic signaling cascades in glial tumors.
Journal
Reference
Authors
Hulleman E, Helin K.
Title
Molecular mechanisms in gliomagenesis.
Journal
Reference
Authors
Schlessinger J.
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Ng HK, Lam PY.
Title
The molecular genetics of central nervous system tumors.
Journal
Reference
Authors
Knobbe CB, Merlo A, Reifenberger G.
Title
Pten signaling in gliomas.
Journal
Reference
Authors
Kondo T, Ezzat S, Asa SL.
Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
Journal
Reference
Authors
Chiloeches A, Marais R.
Title
Is BRAF the Achilles' Heel of thyroid cancer?
Journal
Reference
Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
Journal
Reference
Authors
Santoro M, Melillo RM, Fusco A.
Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
Journal
Reference
Authors
Pierotti MA, Greco A.
Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
Journal
Reference
Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
Title
Molecular pathology of well-differentiated thyroid carcinomas.
Journal
Reference
Authors
Gimm O.
Title
Thyroid cancer.
Journal
Reference
Authors
Williams D.
Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
Journal
Reference
Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
Title
The molecular pathogenesis of acute myeloid leukemia.
Journal
Reference
Authors
Tenen DG.
Title
Disruption of differentiation in human cancer: AML shows the way.
Journal
Reference
Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
Title
Signal transduction of oncogenic Flt3.
Journal
Reference
Authors
Stirewalt DL, Radich JP.
Title
The role of FLT3 in haematopoietic malignancies.
Journal
Reference
Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
Journal
Reference
Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
Journal
Reference
Authors
Lorsbach RB, Downing JR.
Title
The role of the AML1 transcription factor in leukemogenesis.
Journal
Reference
Authors
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H.
Title
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
Journal
Reference
Authors
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C.
Title
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
Journal
Reference
Authors
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.
Title
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
Journal
Reference
Authors
Ren R.
Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
Journal
Reference
Authors
Deininger MW, Goldman JM, Melo JV.
Title
The molecular biology of chronic myeloid leukemia.
Journal
Blood 96:3343-56 (2000)
Reference
Authors
Calabretta B, Perrotti D.
Title
The biology of CML blast crisis.
Journal
Reference
Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
Title
The biology of chronic myeloid leukemia.
Journal
Reference
Authors
Mitani K.
Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
Journal
Reference
Authors
Dong M, Blobe GC.
Title
Role of transforming growth factor-beta in hematologic malignancies.
Journal
Reference
Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
Journal
Blood 92:4003-12 (1998)
Reference
Authors
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA.
Title
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
Journal
Haematologica 88:622-30 (2003)
Reference
Authors
Baldwin AS.
Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
Journal
Reference
Authors
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL.
Title
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
Journal
Reference
Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
Journal
Reference
Authors
Saldanha G, Fletcher A, Slater DN.
Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
Journal
Reference
Authors
Daya-Grosjean L, Couve-Privat S.
Title
Sonic hedgehog signaling in basal cell carcinomas.
Journal
Reference
Authors
Tsai KY, Tsao H.
Title
The genetics of skin cancer.
Journal
Reference
Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
Title
Hedgehog signalling in skin development and cancer.
Journal
Reference
Authors
Rubin AI, Chen EH, Ratner D.
Title
Basal-cell carcinoma.
Journal
Reference
Authors
Saldanha G.
Title
The Hedgehog signalling pathway and cancer.
Journal
Reference
Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
Journal
Reference
Authors
Pasca di Magliano M, Hebrok M.
Title
Hedgehog signalling in cancer formation and maintenance.
Journal
Reference
Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
Journal
Reference
Authors
Cohen MM Jr.
Title
The hedgehog signaling network.
Journal
Reference
Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
Journal
Reference
Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
Journal
Reference
Authors
Toftgard R.
Title
Hedgehog signalling in cancer.
Journal
Reference
Authors
Miller AJ, Mihm MC Jr.
Title
Melanoma.
Journal
Reference
Authors
Chin L.
Title
The genetics of malignant melanoma: lessons from mouse and man.
Journal
Reference
Authors
Takata M, Saida T.
Title
Genetic alterations in melanocytic tumors.
Journal
Reference
Authors
Chudnovsky Y, Khavari PA, Adams AE.
Title
Melanoma genetics and the development of rational therapeutics.
Journal
Reference
Authors
Merlino G.
Title
Cancer biology: the weakest link?
Journal
Reference
Authors
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.
Title
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
Journal
Reference
Authors
Levy C, Khaled M, Fisher DE.
Title
MITF: master regulator of melanocyte development and melanoma oncogene.
Journal
Reference
Authors
Tsao H, Goel V, Wu H, Yang G, Haluska FG.
Title
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
Journal
Reference
Authors
Gruss C, Herlyn M.
Title
Role of cadherins and matrixins in melanoma.
Journal
Reference
Authors
Thompson JF, Scolyer RA, Kefford RF.
Title
Cutaneous melanoma.
Journal
Reference
Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
Authors
Hussein MR.
Title
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
Journal
Reference
Authors
Lazar-Molnar E, Hegyesi H, Toth S, Falus A.
Title
Autocrine and paracrine regulation by cytokines and growth factors in melanoma.
Journal
Reference
Authors
Cohen HT, McGovern FJ.
Title
Renal-cell carcinoma.
Journal
Reference
Authors
Pavlovich CP, Schmidt LS.
Title
Searching for the hereditary causes of renal-cell carcinoma.
Journal
Reference
Authors
Linehan WM, Walther MM, Zbar B.
Title
The genetic basis of cancer of the kidney.
Journal
Reference
Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
Title
Met, metastasis, motility and more.
Journal
Reference
Authors
Kim WY, Kaelin WG.
Title
Role of VHL gene mutation in human cancer.
Journal
Reference
Authors
Sudarshan S, Linehan WM, Neckers L.
Title
HIF and fumarate hydratase in renal cancer.
Journal
Reference
Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
Journal
Reference
Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
Title
Understanding familial and non-familial renal cell cancer.
Journal
Reference
Authors
Mitra AP, Datar RH, Cote RJ.
Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
Journal
Reference
Authors
Wolff EM, Liang G, Jones PA.
Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
Journal
Reference
Authors
Wu XR.
Title
Urothelial tumorigenesis: a tale of divergent pathways.
Journal
Reference
Authors
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R.
Title
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
Journal
Cancer Res 60:6298-302 (2000)
Reference
Authors
Bellmunt J, Hussain M, Dinney CP.
Title
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.
Journal
Reference
Authors
Sugano K, Kakizoe T.
Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
Journal
Reference
Authors
Dunn KL, Espino PS, Drobic B, He S, Davie JR.
Title
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling.
Journal
Reference
Authors
Williams SG, Stein JP.
Title
Molecular pathways in bladder cancer.
Journal
Reference
Authors
Nelson WG, De Marzo AM, Isaacs WB.
Title
Prostate cancer.
Journal
Reference
Authors
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC.
Title
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
Journal
Reference
Authors
Pienta KJ, Bradley D.
Title
Mechanisms underlying the development of androgen-independent prostate cancer.
Journal
Reference
Authors
Feldman BJ, Feldman D.
Title
The development of androgen-independent prostate cancer.
Journal
Reference
Authors
Heinlein CA, Chang C.
Title
Androgen receptor in prostate cancer.
Journal
Reference
Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
Journal
Am J Pathol 152:1-9 (1998)
Reference
Authors
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D.
Title
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
Journal
Reference
Authors
Macri E, Loda M.
Title
Role of p27 in prostate carcinogenesis.
Journal
Reference
Authors
Steers WD.
Title
5alpha-reductase activity in the prostate.
Journal
Reference
Authors
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF.
Title
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
Journal
Cancer Res 54:4920-6 (1994)
Reference
Authors
Grimes CA, Jope RS.
Title
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
Journal
Reference
Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
Title
Endometrial cancer.
Journal
Reference
Authors
Lax SF.
Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
Journal
Reference
Authors
Shiozawa T, Konishi I.
Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
Journal
Reference
Authors
Hecht JL, Mutter GL.
Title
Molecular and pathologic aspects of endometrial carcinogenesis.
Journal
Reference
Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
Title
Molecular pathology of endometrial hyperplasia and carcinoma.
Journal
Reference
Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
Journal
Reference
Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
Journal
Cancer Res 55:5693-8 (1995)
Reference
Authors
Kim D, Chung J.
Title
Akt: versatile mediator of cell survival and beyond.
Journal
Reference
Authors
Sanchez-Cespedes M.
Title
Dissecting the genetic alterations involved in lung carcinogenesis.
Journal
Reference
Authors
Kaye FJ.
Title
Molecular biology of lung cancer.
Journal
Reference
Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
Title
Apoptosis and lung cancer: a review.
Journal
Reference
Authors
Sartorius UA, Krammer PH.
Title
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
Journal
Reference
Authors
Adhikary S, Eilers M.
Title
Transcriptional regulation and transformation by Myc proteins.
Journal
Reference
Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
Journal
Reference
Authors
Buttery RC, Rintoul RC, Sethi T.
Title
Small cell lung cancer: the importance of the extracellular matrix.
Journal
Reference
Authors
Yamada KM, Araki M.
Title
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
Journal
J Cell Sci 114:2375-82 (2001)
Reference
Authors
Rintoul RC, Sethi T.
Title
The role of extracellular matrix in small-cell lung cancer.
Journal
Reference
Authors
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
Title
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
Journal
Reference
Authors
Osada H, Takahashi T.
Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
Journal
Reference
Authors
Yokota J, Nishioka M, Tani M, Kohno T.
Title
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
Journal
Reference
Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
Title
K-ras mutations in non-small-cell lung carcinoma: a review.
Journal
Reference
Authors
Pfeifer GP, Dammann R.
Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
Journal
Reference
Authors
Altucci L, Gronemeyer H.
Title
The promise of retinoids to fight against cancer.
Journal
Reference
Authors
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
Journal
Reference
Authors
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA.
Title
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
Journal
Reference
Authors
Panani AD, Roussos C.
Title
Cytogenetic and molecular aspects of lung cancer.
Journal
Reference
Authors
Mitsuuchi Y, Testa JR.
Title
Cytogenetics and molecular genetics of lung cancer.
Journal
Reference
Authors
Breuer RH, Postmus PE, Smit EF.
Title
Molecular pathology of non-small-cell lung cancer.
Journal
Reference
Authors
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.
Title
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung.
Journal
Clin Cancer Res 8:734-44 (2002)
Reference
Authors
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K.
Title
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
Journal
Reference
Authors
Lappano R, Maggiolini M
Title
G protein-coupled receptors: novel targets for drug discovery in cancer.
Journal
Reference
Authors
O'Hayre M, Degese MS, Gutkind JS
Title
Novel insights into G protein and G protein-coupled receptor signaling in cancer.
Journal
Reference
Authors
Dorsam RT, Gutkind JS
Title
G-protein-coupled receptors and cancer.
Journal
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ssc04060 Cytokine-cytokine receptor interaction
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