KEGG   PATHWAY: ssc05217
Entry
ssc05217                    Pathway                                

Name
Basal cell carcinoma - Sus scrofa (pig)
Description
Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC.
Class
Human Diseases; Cancer: specific types
Pathway map
ssc05217  Basal cell carcinoma
ssc05217

Organism
Sus scrofa (pig) [GN:ssc]
Gene
397276  TP53; cellular tumor antigen p53 [KO:K04451]
100152215  CDKN1A; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1 [KO:K06625]
100152997  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
733669  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100621090  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
396633  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
397543  BAK1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021]
100513197  DDB2; DNA damage-binding protein 2 isoform X2 [KO:K10140]
100518650  POLK; LOW QUALITY PROTEIN: DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
100512749  SHH; sonic hedgehog protein preproprotein [KO:K11988]
100627504  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
100515110  SMO; smoothened homolog [KO:K06226]
100624604  KIF7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
100155412  SUFU; LOW QUALITY PROTEIN: suppressor of fused homolog [KO:K06229]
100520490  GLI1; zinc finger protein GLI1 [KO:K16797]
100520334  GLI2; zinc finger protein GLI2 [KO:K16798]
100516888  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
100157103  BMP2; bone morphogenetic protein 2 precursor [KO:K21283]
100113425  BMP4; bone morphogenetic protein 4 precursor [KO:K04662]
100525059  HHIP; hedgehog-interacting protein isoform X1 [KO:K06231]
100623280  PTCH2; protein patched homolog 2 isoform X1 [KO:K11101]
100525462  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100516839  WNT2; protein Wnt-2 [KO:K00182]
100520560  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
100514950  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
100519512  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
100327037  WNT4; protein Wnt-4 [KO:K00408]
100516268  WNT5B; LOW QUALITY PROTEIN: protein Wnt-5b [KO:K00444]
100627056  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100622044  WNT6; protein Wnt-6 [KO:K00445]
100153445  WNT7A; protein Wnt-7a [KO:K00572]
100626947  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
100513655  WNT8B; protein Wnt-8b isoform X1 [KO:K00714]
100739710  WNT8A; protein Wnt-8a [KO:K00714]
100512949  WNT9A; protein Wnt-9a [KO:K01064]
100738655  WNT9B; protein Wnt-9b [KO:K01064]
100126276  WNT10B; protein Wnt-10b precursor [KO:K01357]
100623646  WNT10A; LOW QUALITY PROTEIN: protein Wnt-10a [KO:K01357]
100521912  WNT11; protein Wnt-11 [KO:K01384]
100511484  WNT16; protein Wnt-16 [KO:K01558]
100513691  FZD7; frizzled-7 [KO:K02432]
110262227  FZD1; frizzled-1 [KO:K02432]
100337669  FZD2; frizzled-2 precursor [KO:K02235]
100153078  FZD3; frizzled-3 isoform X1 [KO:K02329]
100520319  FZD4; LOW QUALITY PROTEIN: frizzled-4 [KO:K02354]
100519058  FZD5; frizzled-5 [KO:K02375]
110255708  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
100157360  FZD6; frizzled-6 precursor [KO:K02376]
100511782  FZD10; frizzled-10 [KO:K02842]
100625784  FZD9; frizzled-9 [KO:K02842]
100525170  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
100621038  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100625452  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
100126852  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
100523725  AXIN1; axin-1 isoform X1 [KO:K02157]
100739604  AXIN2; axin-2 isoform X1 [KO:K04385]
100517932  APC; adenomatous polyposis coli protein [KO:K02085]
100579172  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
397657  CTNNB1; catenin beta-1 [KO:K02105]
100512951  TCF7; transcription factor 7 isoform X1 [KO:K02620]
100523899  TCF7L1; LOW QUALITY PROTEIN: transcription factor 7-like 1 [KO:K04490]
100153922  TCF7L2; transcription factor 7-like 2 isoform X26 [KO:K04491]
100170126  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
Compound
C00187  Cholesterol
Reference
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
Reference
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
  Authors
Wu F, Zhang Y, Sun B, McMahon AP, Wang Y
  Title
Hedgehog Signaling: From Basic Biology to Cancer Therapy.
  Journal
Cell Chem Biol 24:252-280 (2017)
DOI:10.1016/j.chembiol.2017.02.010
Reference
  Authors
Otsuka A, Levesque MP, Dummer R, Kabashima K
  Title
Hedgehog signaling in basal cell carcinoma.
  Journal
J Dermatol Sci 78:95-100 (2015)
DOI:10.1016/j.jdermsci.2015.02.007
Related
pathway
ssc04110  Cell cycle
ssc04115  p53 signaling pathway
ssc04310  Wnt signaling pathway
ssc04340  Hedgehog signaling pathway
ssc04350  TGF-beta signaling pathway
KO pathway
ko05217   
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