KEGG   PATHWAY: tng04530
Entry
tng04530                    Pathway                                
Name
Tight junction - Tetraodon nigroviridis (spotted green pufferfish)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
tng04530  Tight junction
tng04530

Other DBs
GO: 0005923
Organism
Tetraodon nigroviridis (spotted green pufferfish) [GN:tng]
Gene
GSTEN00003537G001  unnamed protein product [KO:K06087]
GSTEN00003932G001  unnamed protein product [KO:K06087]
GSTEN00000428G001  unnamed protein product [KO:K06087]
GSTEN00003466G001  unnamed protein product [KO:K06087]
GSTEN00024810G001  unnamed protein product [KO:K06087]
GSTEN00024812G001  unnamed protein product [KO:K06087]
GSTEN00035177G001  unnamed protein product [KO:K06087]
GSTEN00035178G001  unnamed protein product [KO:K06087]
GSTEN00035179G001  unnamed protein product [KO:K06087]
GSTEN00035180G001  unnamed protein product [KO:K06087]
GSTEN00035181G001  unnamed protein product [KO:K06087]
GSTEN00035182G001  unnamed protein product [KO:K06087]
GSTEN00035183G001  unnamed protein product [KO:K06087]
GSTEN00035184G001  unnamed protein product [KO:K06087]
GSTEN00035202G001  unnamed protein product [KO:K06087]
GSTEN00035204G001  unnamed protein product [KO:K06087]
GSTEN00014988G001  unnamed protein product [KO:K06087]
GSTEN00012016G001  unnamed protein product [KO:K06087]
GSTEN00031328G001  unnamed protein product [KO:K06087]
GSTEN00012713G001  unnamed protein product [KO:K06087]
GSTEN00019590G001  unnamed protein product [KO:K06087]
GSTEN00022126G001  unnamed protein product [KO:K06087]
GSTEN00012115G001  unnamed protein product [KO:K06087]
GSTEN00020360G001  unnamed protein product [KO:K06087]
GSTEN00025378G001  unnamed protein product [KO:K06087]
GSTEN00024357G001  unnamed protein product [KO:K06087]
GSTEN00021171G001  unnamed protein product [KO:K06087]
GSTEN00036520G001  unnamed protein product [KO:K06087]
GSTEN00036521G001  unnamed protein product [KO:K06087]
GSTEN00008207G001  unnamed protein product [KO:K06087]
GSTEN00010384G001  unnamed protein product [KO:K06087]
GSTEN00024770G001  unnamed protein product [KO:K06087]
GSTEN00029918G001  unnamed protein product [KO:K06087]
GSTEN00029919G001  unnamed protein product [KO:K06087]
GSTEN00029920G001  unnamed protein product [KO:K06087]
GSTEN00029921G001  unnamed protein product [KO:K06087]
GSTEN00029922G001  unnamed protein product [KO:K06087]
GSTEN00029923G001  unnamed protein product [KO:K06087]
GSTEN00029924G001  unnamed protein product [KO:K06087]
GSTEN00029925G001  unnamed protein product [KO:K06087]
GSTEN00029926G001  unnamed protein product [KO:K06087]
GSTEN00037698G001  unnamed protein product [KO:K06087]
GSTEN00029586G001  unnamed protein product [KO:K06087]
GSTEN00010870G001  unnamed protein product [KO:K06087]
GSTEN00011593G001  unnamed protein product [KO:K06087]
GSTEN00014178G001  unnamed protein product [KO:K06087]
GSTEN00027787G001  unnamed protein product [KO:K06087]
GSTEN00035203G001  unnamed protein product [KO:K06087]
GSTEN00033993G001  unnamed protein product [KO:K06087]
GSTEN00006823G001  unnamed protein product [KO:K06087]
GSTEN00032092G001  unnamed protein product [KO:K06087]
GSTEN00007898G001  unnamed protein product [KO:K06088]
GSTEN00025305G001  unnamed protein product [KO:K06088]
GSTEN00019295G001  unnamed protein product [KO:K06088]
GSTEN00020894G001  unnamed protein product [KO:K06088]
GSTEN00022119G001  unnamed protein product [KO:K06089]
GSTEN00025959G001  unnamed protein product [KO:K06735]
GSTEN00030027G001  unnamed protein product [KO:K06785]
GSTEN00026534G001  unnamed protein product [KO:K21108]
GSTEN00023599G001  unnamed protein product [KO:K04393]
GSTEN00004992G001  unnamed protein product [KO:K04393]
GSTEN00014160G001  unnamed protein product [KO:K04393]
GSTEN00013459G001  unnamed protein product [KO:K06093]
GSTEN00023001G001  unnamed protein product [KO:K06091]
GSTEN00016935G001  unnamed protein product [KO:K06091]
GSTEN00006313G001  unnamed protein product [KO:K06091]
GSTEN00031900G001  unnamed protein product [KO:K21109]
GSTEN00005934G001  unnamed protein product [KO:K21109]
GSTEN00024703G001  unnamed protein product [KO:K06097]
GSTEN00021331G001  unnamed protein product [KO:K06095]
GSTEN00009017G001  unnamed protein product [KO:K06095]
GSTEN00008686G001  unnamed protein product [KO:K18952] [EC:2.7.11.13]
GSTEN00027773G001  unnamed protein product [KO:K06069] [EC:2.7.11.13]
GSTEN00016312G001  unnamed protein product [KO:K16819]
GSTEN00028395G001  unnamed protein product [KO:K06104]
GSTEN00024197G001  unnamed protein product [KO:K20638]
GSTEN00033410G001  unnamed protein product [KO:K20638]
GSTEN00009736G001  unnamed protein product [KO:K04392]
GSTEN00024153G001  unnamed protein product [KO:K04392]
GSTEN00029973G001  unnamed protein product [KO:K16684]
GSTEN00029042G001  unnamed protein product [KO:K16684]
GSTEN00003855G001  unnamed protein product [KO:K06094]
GSTEN00021701G001  unnamed protein product [KO:K06094]
GSTEN00011480G001  unnamed protein product [KO:K12076]
GSTEN00025568G001  unnamed protein product [KO:K16175]
GSTEN00034910G001  unnamed protein product [KO:K04382] [EC:3.1.3.16]
GSTEN00004657G001  unnamed protein product [KO:K04382] [EC:3.1.3.16]
GSTEN00029892G001  unnamed protein product [KO:K04382] [EC:3.1.3.16]
GSTEN00005281G001  unnamed protein product [KO:K03456]
GSTEN00031664G001  unnamed protein product [KO:K04354]
GSTEN00024949G001  unnamed protein product [KO:K04354]
GSTEN00033040G001  unnamed protein product [KO:K04354]
GSTEN00009388G001  unnamed protein product [KO:K04354]
GSTEN00024586G001  unnamed protein product [KO:K04354]
GSTEN00015223G001  unnamed protein product [KO:K04237]
GSTEN00016585G001  unnamed protein product [KO:K04237]
GSTEN00018899G001  unnamed protein product [KO:K05731]
GSTEN00035201G001  unnamed protein product [KO:K05731]
GSTEN00025602G001  unnamed protein product [KO:K05701]
GSTEN00017845G001  unnamed protein product [KO:K05701]
GSTEN00025029G001  unnamed protein product [KO:K06105]
GSTEN00016333G001  unnamed protein product [KO:K12075]
GSTEN00031229G001  unnamed protein product [KO:K21098]
GSTEN00017703G001  unnamed protein product [KO:K10591] [EC:2.3.2.26]
GSTEN00014415G001  unnamed protein product [KO:K13305] [EC:2.3.2.26]
GSTEN00032593G001  unnamed protein product [KO:K06102]
GSTEN00033968G001  unnamed protein product [KO:K06102]
GSTEN00017714G001  unnamed protein product [KO:K21110]
GSTEN00025613G001  unnamed protein product [KO:K21110]
GSTEN00011538G001  unnamed protein product [KO:K12791]
GSTEN00002215G001  unnamed protein product [KO:K04513]
GSTEN00011459G001  unnamed protein product [KO:K04513]
GSTEN00027973G001  unnamed protein product [KO:K04513]
GSTEN00027366G001  unnamed protein product [KO:K04513]
GSTEN00030351G001  unnamed protein product [KO:K09183]
GSTEN00017736G001  unnamed protein product [KO:K21099]
GSTEN00011825G001  unnamed protein product [KO:K21099]
GSTEN00019882G001  unnamed protein product [KO:K04440] [EC:2.7.11.24]
GSTEN00014434G001  unnamed protein product [KO:K04440] [EC:2.7.11.24]
GSTEN00030625G001  unnamed protein product [KO:K04440] [EC:2.7.11.24]
GSTEN00020512G001  unnamed protein product [KO:K04448]
GSTEN00015028G001  unnamed protein product [KO:K04448]
GSTEN00013845G001  unnamed protein product [KO:K04448]
GSTEN00029830G001  unnamed protein product [KO:K05031] [EC:5.6.1.6]
GSTEN00033818G001  unnamed protein product [KO:K02089] [EC:2.7.11.22]
GSTEN00033148G001  unnamed protein product [KO:K06100]
GSTEN00028590G001  unnamed protein product [KO:K04802]
GSTEN00026524G001  unnamed protein product [KO:K04503]
GSTEN00035042G001  unnamed protein product [KO:K05083] [EC:2.7.10.1]
GSTEN00034595G001  unnamed protein product [KO:K08367]
GSTEN00017023G001  unnamed protein product [KO:K09489]
GSTEN00004202G001  unnamed protein product [KO:K13365]
GSTEN00021816G001  unnamed protein product [KO:K13365]
GSTEN00030411G001  unnamed protein product [KO:K08007]
GSTEN00019935G001  unnamed protein product [KO:K08007]
GSTEN00029180G001  unnamed protein product [KO:K05762]
GSTEN00027138G001  unnamed protein product [KO:K05762]
GSTEN00029348G001  unnamed protein product [KO:K05763]
GSTEN00022235G001  unnamed protein product [KO:K05763]
GSTEN00018762G001  unnamed protein product [KO:K18050] [EC:2.7.11.13]
GSTEN00009554G001  unnamed protein product [KO:K18050] [EC:2.7.11.13]
GSTEN00013465G001  unnamed protein product [KO:K05692]
GSTEN00034905G001  unnamed protein product [KO:K05692]
GSTEN00022583G001  unnamed protein product [KO:K04851]
GSTEN00027380G001  unnamed protein product [KO:K04851]
GSTEN00026353G001  unnamed protein product [KO:K04431] [EC:2.7.12.2]
GSTEN00033858G001  unnamed protein product [KO:K05704] [EC:2.7.10.2]
GSTEN00036856G001  unnamed protein product [KO:K05704] [EC:2.7.10.2]
GSTEN00002055G001  unnamed protein product [KO:K06106]
GSTEN00008340G001  unnamed protein product [KO:K06106]
GSTEN00023828G001  unnamed protein product [KO:K06106]
GSTEN00005649G001  unnamed protein product [KO:K17260]
GSTEN00018695G001  unnamed protein product [KO:K17260]
GSTEN00033110G001  unnamed protein product [KO:K18584]
GSTEN00038514G001  unnamed protein product [KO:K05757]
GSTEN00038515G001  unnamed protein product [KO:K05757]
GSTEN00015842G001  unnamed protein product [KO:K05758]
GSTEN00005335G001  unnamed protein product [KO:K05756]
GSTEN00027278G001  unnamed protein product [KO:K05755]
GSTEN00013640G001  unnamed protein product [KO:K05755]
GSTEN00033634G001  unnamed protein product [KO:K05754]
GSTEN00033675G001  unnamed protein product [KO:K05754]
GSTEN00018022G001  unnamed protein product [KO:K20479]
GSTEN00019760G001  unnamed protein product [KO:K04345] [EC:2.7.11.11]
GSTEN00026232G001  unnamed protein product [KO:K04345] [EC:2.7.11.11]
GSTEN00022860G001  unnamed protein product [KO:K04345] [EC:2.7.11.11]
GSTEN00016205G001  unnamed protein product [KO:K04345] [EC:2.7.11.11]
GSTEN00033936G001  unnamed protein product [KO:K06109]
GSTEN00027766G001  unnamed protein product [KO:K21066]
GSTEN00028882G001  unnamed protein product [KO:K21066]
GSTEN00016121G001  unnamed protein product [KO:K04514] [EC:2.7.11.1]
GSTEN00016969G001  unnamed protein product [KO:K17388] [EC:2.7.11.1]
GSTEN00023147G001  unnamed protein product [KO:K17388] [EC:2.7.11.1]
GSTEN00021603G001  unnamed protein product [KO:K10351]
GSTEN00035940G001  unnamed protein product [KO:K10351]
GSTEN00028502G001  unnamed protein product [KO:K07298] [EC:2.7.11.1]
GSTEN00014369G001  unnamed protein product [KO:K07198] [EC:2.7.11.31]
GSTEN00012912G001  unnamed protein product [KO:K07198] [EC:2.7.11.31]
GSTEN00028481G001  unnamed protein product [KO:K07199]
GSTEN00021633G001  unnamed protein product [KO:K07199]
GSTEN00019662G001  unnamed protein product [KO:K07199]
GSTEN00025314G001  unnamed protein product [KO:K07200]
GSTEN00027156G001  unnamed protein product [KO:K07200]
GSTEN00027259G001  unnamed protein product [KO:K07200]
GSTEN00029111G001  unnamed protein product [KO:K07200]
GSTEN00028347G001  unnamed protein product [KO:K07200]
GSTEN00007249G001  unnamed protein product [KO:K10352]
GSTEN00032517G001  unnamed protein product [KO:K10352]
GSTEN00027242G001  unnamed protein product [KO:K12751]
GSTEN00036213G001  unnamed protein product [KO:K12751]
GSTEN00034636G001  unnamed protein product [KO:K12755]
GSTEN00031784G001  unnamed protein product [KO:K12757]
GSTEN00034513G001  unnamed protein product [KO:K12757]
GSTEN00008736G001  unnamed protein product [KO:K06786]
GSTEN00012411G001  unnamed protein product [KO:K05631]
GSTEN00021024G001  unnamed protein product [KO:K05631]
GSTEN00017138G001  unnamed protein product [KO:K21112]
GSTEN00026683G001  unnamed protein product [KO:K05699]
GSTEN00012749G001  unnamed protein product [KO:K05699]
GSTEN00015696G001  unnamed protein product [KO:K21068]
GSTEN00027746G001  unnamed protein product [KO:K07901]
GSTEN00015981G001  unnamed protein product [KO:K07902]
GSTEN00029876G001  unnamed protein product [KO:K08020]
GSTEN00013536G001  unnamed protein product [KO:K04353]
GSTEN00023474G001  unnamed protein product [KO:K04353]
GSTEN00016578G001  unnamed protein product [KO:K05719]
GSTEN00015212G001  unnamed protein product [KO:K05719]
GSTEN00035441G001  unnamed protein product [KO:K05702]
GSTEN00005611G001  unnamed protein product [KO:K06098]
GSTEN00007214G001  unnamed protein product [KO:K06098]
GSTEN00024432G001  unnamed protein product [KO:K08018]
GSTEN00031205G001  unnamed protein product [KO:K07839]
GSTEN00007897G001  unnamed protein product [KO:K17291]
GSTEN00025303G001  unnamed protein product [KO:K17291]
GSTEN00020895G001  unnamed protein product [KO:K17291]
GSTEN00002827G001  unnamed protein product [KO:K07374]
GSTEN00002999G001  unnamed protein product [KO:K07374]
GSTEN00020082G001  unnamed protein product [KO:K07374]
GSTEN00020083G001  unnamed protein product [KO:K07374]
GSTEN00019439G001  unnamed protein product [KO:K07374]
GSTEN00016928G001  unnamed protein product [KO:K07374]
GSTEN00030484G001  unnamed protein product [KO:K07374]
GSTEN00030485G001  unnamed protein product [KO:K07374]
GSTEN00023375G001  unnamed protein product [KO:K07374]
GSTEN00023377G001  unnamed protein product [KO:K07374]
GSTEN00023378G001  unnamed protein product [KO:K07374]
GSTEN00023379G001  unnamed protein product [KO:K07374]
GSTEN00023472G001  unnamed protein product [KO:K07374]
GSTEN00031836G001  unnamed protein product [KO:K07374]
GSTEN00004476G001  unnamed protein product [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
tng04520  Adherens junction
tng04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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